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Non-starch lily polysaccharide NSLP-1 and application thereof

A technology of NSLP-1, lily polysaccharide, applied in the field of medicine, to achieve the effect of improving sleep disorders and improving intestinal health

Active Publication Date: 2021-12-31
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There are many varieties of lily polysaccharides. Modern medicine shows that lily crude polysaccharides have various pharmacological activities, such as lowering blood sugar, anti-oxidation, anti-tumor, anti-fatigue, and enhancing the body's immunity , Improve the transformation rate of lymphocytes [Research progress on the pharmacological effects and mechanism of lily polysaccharides], but there are no relevant research reports on the effects of lily polysaccharides on intestinal flora and sleep disorders

Method used

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  • Non-starch lily polysaccharide NSLP-1 and application thereof
  • Non-starch lily polysaccharide NSLP-1 and application thereof
  • Non-starch lily polysaccharide NSLP-1 and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1 Extraction and identification of non-starch lily polysaccharide NSLP-1

[0057] 1. Extraction method

[0058] S1. Preparation of crude polysaccharides: Lily bulbs were dried and crushed, 1g of powder was weighed and 70% ethanol was added to 10mL ultrasonic (400W, 40Hz) for 1h, the lily bulbs after alcohol extraction were dried, and 15 times the amount of deionized water was added to ultrasonic (400W , 40Hz) extraction 3 times, each time 1h, the water extract was concentrated and then slowly added to absolute ethanol, stirring while adding to make the final volume concentration of ethanol 90%, after stirring evenly, place it in a refrigerator at 4°C for alcohol precipitation for 12h, The solution after alcohol precipitation is centrifuged, and the lower precipitate is collected to obtain the lily crude polysaccharide;

[0059] S2. Removal of starch and protein: add 1g of lily crude polysaccharide to 250mL of deionized water to dissolve, add high temperature re...

Embodiment 2

[0105] Example 2 Effect of non-starch lily polysaccharide NSLP-1 on rat models of insomnia and sleep disorders established by long-term overload swimming exercise

[0106] 1. Experimental grouping and processing

[0107] (1) 28 SD male rats of SPF grade, 5-6 weeks old and weighing 120-150 g were purchased from the Guangdong Provincial Medical Experimental Animal Center (certificate of qualification: NO.44007200069456; license number: SCXK (Guangdong) 2018- 0002) were randomly divided into 4 groups after one week of adaptive feeding in the SPF environment: blank group, model group, positive control group, and NSLP-1 group.

[0108] (2) Experimental group treatment

[0109] Blank group: no swimming, no medicine, normal feeding;

[0110] Model group: swimming modeling, normal breeding;

[0111] Positive control group: swimming is the same as the model group, feeding with diazepam 2mg / kg + normal feeding;

[0112] NSLP-1 group: Swimming is the same as the model group, taking n...

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Abstract

The invention belongs to the technical field of medicines, and discloses non-starch lily polysaccharide NSLP-1 and application thereof. The non-starch lily polysaccharide NSLP-1 is separated and extracted from lily, and has effects of inflammation resistance, intestinal flora disorder regulation and control, and sleep disorder improvement, and provides a natural and novel drug source for development of prevention or treatment of intestinal flora disorder or diseases induced by intestinal flora disorder.

Description

technical field [0001] The invention belongs to the technical field of medicine. More specifically, it relates to a non-starch lily polysaccharide NSLP-1 and its application. Background technique [0002] Lily is a traditional Chinese herbal medicine that can be used for both medicine and food, and is a treasure of Chinese medicine. The earliest record of lily as medicine is found in "Shen Nong's Herbal Classic". According to the 2020 Pharmacopoeia of the People's Republic of China, it is the dried fleshy bulb of Lilium lancifolium, Lilium lancifolium, or Lilium pumilum. There are medicinal lily, lily lily, lily lily, lily lily, and lily lily in our country. The three varieties that are clinically used for medicine are the three varieties recorded in the Pharmacopoeia, namely, lily lily, lily lily, and lily lily. Sweet and cold, has the effects of clearing the heart and calming the nerves, nourishing yin and moistening the lungs, and has the dual value of medicine and foo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715A61K36/8967A61P25/20A61P29/00
CPCC08B37/0003C08B37/006A61K31/715A61P29/00A61P25/20A61K36/8967Y02A50/30
Inventor 芮雯陈宏远
Owner GUANGDONG PHARMA UNIV
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