34results about How to "Improve drug quality" patented technology

The present invention is directed to novel therapeutic compounds comprised of an amino acid bonded to a medicament or drug having a hydroxy, amino, carboxy or acylating derivative thereon. These high therapeutic index derivatives have the same utility as the drug from which they are made, and they have enhanced pharmacological and pharmaceutical properties. In fact, the novel drug derivatives of the present invention enhance at least one therapeutic quality, as defined herein. The present invention is also directed to pharmaceutical compositions containing same.

The invention relates to medicinal composition solution. The medicinal composition solution comprises 2-methy-5-imido-benzo-[d][1,3] oxazine [5-b] pyrazole, arginine, an antioxidant and a solvent, wherein the weight ratio of the 2-methy-5-imido-benzo-[d][1,3] oxazine [5-b] pyrazole, the arginine, the antioxidant to the solvent is 1:0.5 to 15:0.1 to 1.5:10 to 400; and the solvent is pharmaceutical water. The medicinal composition has high water dissolubility, and is difficult to degrade under the protection of the antioxidant. The medicinal composition solution has stable injection exposure, has stable effect of inhibiting coloring change, is not hemolytic, does not separate crystal in serum out and is safe to use.

The invention relates to medicinal composition solution. The medicinal composition solution comprises 2-methy-5-imido-benzo-[d][1,3] oxazine [5-b] pyrazole, arginine, an antioxidant and a solvent, wherein the weight ratio of the 2-methy-5-imido-benzo-[d][1,3] oxazine [5-b] pyrazole, the arginine, the antioxidant to the solvent is 1:0.5 to 15:0.1 to 1.5:10 to 400; and the solvent is pharmaceuticalwater. The medicinal composition has high water dissolubility, and is difficult to degrade under the protection of the antioxidant. The medicinal composition solution has stable injection exposure, has stable effect of inhibiting coloring change, is not hemolytic, does not separate crystal in serum out and is safe to use.

The invention provides a traditional Chinese medicine composition, in particular to a medicinal syrup for treating wind-heat common cold in children, wherein each ml of syrup comprises 0.0024-0.02 mg of β-pinene, 0.0050-0.2 mg of menthol, 0.068-3 mg of continuous Aromain and 0.64-5mg of gardeniside, the syrup raw materials include forsythia, light tempeh, mint, nepeta, gardenia, rhubarb, artemisia, red peony, betel nut, magnolia, skullcap, pinellia, bupleurum , Licorice. The syrup has clear active ingredients and stable quality. In the preparation process, some traditional Chinese medicines are steamed and assisted by microwave extraction, which improves the efficiency and curative effect.

The invention relates to a capsule real-time inspection method with double detection, which comprises the following steps: 1) providing a capsule real-time test platform with double detection, which includes a near-infrared detection mechanism, a visible light detection mechanism and a main controller, wherein the near-infrared detection mechanism and the visible light detection mechanism respectively perform defect detection to every capsule and the main controller is respectively connected to the near-infrared detection mechanism and the visible light detection mechanism for determining a capsule rejection strategy according to a defect detection result from the near-infrared detection mechanism and the visible light detection mechanism; and 2) performing inspection with the test platform. According to the method, there are two detection methods are available to detect the capsules, thereby improving reliability of capsule test.

The invention discloses a kind of cinnamon twig and tuckahoe pellets, which are coated pellets, including a core and a film coating wrapped around the core, wherein: the core is composed of cinnamon twigs, poria cocos, cortex moutan, and red peony The five raw materials of peach kernel and peach kernel are made with a weight ratio of 1:1:1:1:1, and the diameter of the pellet core is 1.5mm to 2.0mm; the coating material used for the film coating is an alcohol-soluble gastric-soluble film coating pre- Mixture; the weight of the film coating layer is 1.8-2.2% of the weight of the ball core. The Guizhi Fuling pellet has the effects of promoting blood circulation and removing blood stasis, eliminating phlegm and relieving pain, and regulating qi and blood; and the drug quality is stable, the distribution area of ​​the drug on the surface of the gastrointestinal tract is increased, the irritation is small, the bioavailability is high, and the curative effect is good. The invention also discloses a preparation method of the cinnamon twig and poria pellets. The pellets are prepared by a specific process and then coated. The sterilization effect is good, the molding process is stable, and the quality of the prepared medicine is reliable.

The invention relates to a traditional Chinese medicine, in particular to a Chinese medicinal compound suppository for treating endometritis of livestock and a preparation method thereof. The Chinese medicinal compound suppository is prepared by mixing 1 to 2 parts of golden thread, 1 part of cortex phellodendri, 1 part of lightyellow sophora root, 1 to 2 parts of leonurus heterophyllus, 1 to 2 parts of safflower, 1 to 2 parts of Chinese angelica, 1 part of astragalus and a suppository matrix. The method for preparing the Chinese medicinal compound suppository for treating the endometritis ofthe livestock comprises the following steps of: extraction of active ingredients of each traditional Chinese medicine, concentrating, drying, pulverizing and preparation of the suppository. The suppository has the advantages of pure Chinese medicinal preparation, no problem of antibiotic residues, stable medicinal quality and easy carrying and storage. For the acute endometritis and hidden endometritis of dairy cattle, the two Chinese medicinal suppositories are put into uteruses once every other day, and after the Chinese medicinal suppositories are used continuously for three times, the curative rate reaches 83 percent; and for the hidden endometritis of the dairy cattle during oestrum, the two suppositories are dissolved in 50 milliliters of physiological saline to perform the treatment of intrauterine administration, the suppositories are used once every other day and are used continuously for three times, and the curative rate reaches 62.5 percent.

The invention relates to a traditional Chinese medicine composition for treating leucopenia caused by cancer chemotherapy and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. According to the technical scheme, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 15-90 parts of astragalus membranaceus, 10-70 parts of ox horn bone, 15-60 parts of caulis spatholobi, 15-60 parts of hairyvein agrimony and 10-50 parts of pine nodular branch. The astragalus membranaceus is used as the monarch, the ox horn bone is used as the minister, the caulis spatholobi and the hairyvein agrimony are used as the assistant, and the pine nodular branch is used as the minister, which is in line with the theory of traditional Chinese medicine in treating asthenia. The invention also aims to provide a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition can also be added with pharmaceutically acceptable carriers, and the carriers comprise but are not limited to excipients, flavoring agents, filling agents, adhesives, wetting agents, disintegrating agents and lubricating agents. Clinical embodiments show that the traditional Chinese medicine preparation disclosed by the invention is a medicine for treating leucopenia caused by cancer chemotherapy, which is reliable in curative effect, safe and effective, and is worthy of further popularization.

The invention relates to a traditional Chinese medicine composition for treating leukopenia caused by cancer chemotherapy and a preparation method thereof, belonging to the technical field of traditional Chinese medicine preparations. The adopted technical scheme is prepared from the following raw materials: 15-90 parts of Astragalus membranaceus, 10-70 parts of ox horn gills, 15-60 parts of Gallatia chinensis, 15-60 parts of Agrimony, and 10-50 parts of turpentine share. In the prescription, Astragalus is the king, ox horn and gills are the ministers, galanthus and Agrimony are the ministers, and the pine knot is the minister, which is in line with the theory of traditional Chinese medicine for treating consumptive labor. Another object of the present invention is to provide a preparation method of the traditional Chinese medicine composition of the present invention. The traditional Chinese medicine composition of the present invention can also be added with pharmaceutically acceptable carriers, which include but are not limited to excipients, flavoring agents, fillers, binders, wetting agents, disintegrating agents and lubricants. Clinical examples show that the traditional Chinese medicine preparation of the present invention is a reliable, safe and effective medicine for treating leukopenia caused by cancer chemotherapy, and is worthy of further promotion.

The invention relates to the technical field of medicine purification, and discloses a highly-pure tacrolimus compound and a preparation method thereof. The method comprises the following steps: preprocessed crude tacrolimus undergoes silver-containing polymer resin column chromatography elution, the above obtained eluate is concentrated, and the above obtained concentrate is re-crystallized to obtain highly-pure tacrolimus. The method has the advantages of simplicity in large-scale production operation, small use amount of a solvent, short production period, low cost and environmental protection; and an HPLC detection result shows that ascomycin and dihydrotacrolimus which are most difficult to separate in the crude tacrolimus are completely removed. The normalization purity of tacrolimus is 99% or above, and obtained tacrolimus crystals have the characteristics of uniform particle size distribution, small internal stress and bulk density, and good stability, fluidity, dispersibility and dissolvability. The quality and the medication safety of tacrolimus are improved.

The invention provides a separated compound which is a cytarabine prodrug related substance. The invention also provides application of the compound, and the compound is used for preparing a cytarabine prodrug or a composition containing the cytarabine prodrug.

The invention discloses a koji-making method for medium-high temperature Daqu without turning the koji. In the heat preservation room, the pressed pieces are placed on the frame or shelf, evenly placed in the room, and fans and air ducts are introduced. During the fermentation process of Daqu, the temperature of Daqu is divided into constant temperature according to the change of the temperature of the core. There are six stages: entry stage, low temperature heating stage, medium temperature heating stage, high temperature constant stage, medium high temperature cooling stage, and low temperature constant stage. The temperature control of each stage is realized by adjusting the frequency of fresh air valve and fan and external heating source. The environmental parameters of each position of the Qufang are adjusted by means of wind circulation, so as to ensure that there is basically no difference in the environment of each Qufang, and to realize the normal fermentation of the Qufang Daqu.

The invention discloses an angelica and light yellow sophora root micropill, comprising a pill core and a film coat coating the pill core, wherein, the pill core is prepared by bulk drugs, such as angelica and light yellow sophora root of which the proportion by weight is 1 to 1; during the preparation of the pill core, water is used as a binding agent, and 15 ml to 20 ml of water matches 100g ofmedicine powder; and coating materials of the film coat is gastric solubility film coating premix, and the weight of the film coat is 2 to 3 percent of the weight of the pill core. The medicine containing the bulk drugs, such as the angelica and the light yellow sophora root, is processed into micropills by the specific auxiliary material formula and the coating process; and the moulding process and the medical quality are stable, the distribution area of the medicine on the gastrointestinal tract surface is expanded, and the micropill has low stimulation, high bioavailability and stable and reliable clinical efficacy. The invention also discloses a method for preparing the angelica and light yellow sophora root micropill.

The present invention provides an anhydrous crystal of polymyxin B1 sulfate, polymyxin B2 sulfate or a mixture thereof and a preparation method thereof. The preparation method comprises using an organic solvent to precipitate a solid from a saturated solution of polymyxin B1 sulfate, polymyxin B2 sulfate or a mixture thereof, drying it under vacuum to obtain an anhydrous crystal of polymyxin B1 sulfate, polymyxin B2 sulfate or a mixture thereof.

The invention relates to a real-time capsule checkout platform through double detection. The real-time capsule checkout platform through double detection comprises a near-infrared detecting mechanism, a visible light detecting mechanism and a master controller, wherein the near-infrared detecting mechanism and the visible light detecting mechanism performs defect detection on each capsule, the master controller is connected with the near-infrared detecting mechanism and the visible light detecting mechanism, and a capsule rejecting strategy is determined on the basis of defect detection results of the near-infrared detecting mechanism and the visible light detecting mechanism. By means of the real-time capsule checkout platform through double detection, to-be-checked capsules can be detected through two detecting modes, and the reliability of capsule detection is improved.

The invention relates to a real-time capsule checkout platform through double detection. The real-time capsule checkout platform through double detection comprises a near-infrared detecting mechanism, a visible light detecting mechanism and a master controller, wherein the near-infrared detecting mechanism and the visible light detecting mechanism performs defect detection on each capsule, the master controller is connected with the near-infrared detecting mechanism and the visible light detecting mechanism, and a capsule rejecting strategy is determined on the basis of defect detection results of the near-infrared detecting mechanism and the visible light detecting mechanism. By means of the real-time capsule checkout platform through double detection, to-be-checked capsules can be detected through two detecting modes, and the reliability of capsule detection is improved.