Compound preparations for treating hypertension and method for preparing the same

Abstract

The present invention discloses one kind of hypertension treating compound preparation and its preparation process. The compound preparation includes one tablet core containing diuretic in effective treating amount and pharmaceutically acceptable carrier, and one coating containing telmisartan in effective treating amount and pharmaceutically acceptable carrier. The content of diuretic is 1.5-10 wt% of the tablet core, and that of telmisartan is 3.5-25 wt% of the coating. The compound preparation is prepared through preparing the tablet core pellet and the coating pellet separately with medicine material and supplementary material and the subsequent pressing the coated tablet in a rotary coating machine. The hypertension treating compound preparation has reliable and safe blood pressure reducing effect and high stability.

Description

technical field [0001] The invention relates to a pharmaceutical preparation for treating hypertension and a preparation method thereof, in particular to a compound preparation containing telmisartan and a diuretic and a preparation method thereof. Background technique [0002] Hypertension is a major risk factor for heart, brain, and renal vascular diseases. In most countries, as high as 15%-25% of adults suffer from hypertension. Hypertension is the leading cause of death and disability in adults. [0003] In the past 40 years, researchers have researched and developed several new drugs to treat hypertension; diuretics in the 1960s, beta blockers in the 1970s, and calcium channel antagonists ( calcium channel blockers) and angiotensin converting enzyme inhibitors (Angiotens in-Converting-Enzyme Inhibitors, referred to as ACEI). After years of clinical application, the therapeutic efficacy of these drugs has been affirmed by clinicians and patients. However, in the course...

AI Technical Summary

Problems solved by technology

[0013] Telmisartan and diuretics are granulated separately, and the antihypertensive preparations obtained after the granules are mixed and pressed into tablets. When the two antihypertensive active ingredients are disintegrated and released at the same time, the synergistic antihypertensive effect may lead to the occurrence of hypotensive adverse reactions; In addition, the above two components may cause poor stability of the tablet preparation due to the interaction

For example, telmisartan is insoluble in water but easily soluble in lye, while hydrochlorothiazide is unstable in alkali. If hydrochlorothiazide and telmisartan are granulated separately, the granules are mixed and pressed into tablets, the content of hydrochlorothiazide will decrease and degrade Increased product, affecting the stability of the drug

Images