A kind of Guizhi Fuling pellet and preparation method thereof

Abstract

The invention discloses a kind of cinnamon twig and tuckahoe pellets, which are coated pellets, including a core and a film coating wrapped around the core, wherein: the core is composed of cinnamon twigs, poria cocos, cortex moutan, and red peony The five raw materials of peach kernel and peach kernel are made with a weight ratio of 1:1:1:1:1, and the diameter of the pellet core is 1.5mm to 2.0mm; the coating material used for the film coating is an alcohol-soluble gastric-soluble film coating pre- Mixture; the weight of the film coating layer is 1.8-2.2% of the weight of the ball core. The Guizhi Fuling pellet has the effects of promoting blood circulation and removing blood stasis, eliminating phlegm and relieving pain, and regulating qi and blood; and the drug quality is stable, the distribution area of ​​the drug on the surface of the gastrointestinal tract is increased, the irritation is small, the bioavailability is high, and the curative effect is good. The invention also discloses a preparation method of the cinnamon twig and poria pellets. The pellets are prepared by a specific process and then coated. The sterilization effect is good, the molding process is stable, and the quality of the prepared medicine is reliable.

Description

technical field [0001] The invention relates to Guizhi Fuling pellets and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Cinnamomum twig is the dry twig of lauraceae tree plant cinnamon; nature and flavor: pungent, sweet, warm; chemical composition contains 0.2-0.9% of volatile oil, the main component of the oil is cinnamaldehyde accounting for 70-80%, for sedative and analgesic , Antipyretic active ingredients, as well as trans-cinnamic acid, coumarin, β-sitosterol, protocatechuic acid, glucoside, etc. Efficacy: Sweating and relieving muscles, warming the meridians, helping yang to transform qi, calming and lowering qi. It is clinically used for anemofrigid cold, cold pain in the abdomen, amenorrhea due to cold in blood, arthralgia, phlegm retention, edema, palpitation, and galloping. Modern pharmacological practice has proved that it has the effects of sedative, analgesic, antipyretic and antic...

AI Technical Summary

Problems solved by technology

However, for different raw materials, the excipients (including their proportions) and preparation processes that can be selected when making pellets are also different, as well as suitable coating materials and coating processes. The subject of research; especially the research on pellets of compound Chinese medicine preparations, which can not only affect the stability of the preparation molding process and drug quality, but also affect the normal use of the drug characteristics of the compound Chinese medicine, such as monarchs, ministers, assistants, etc.

Therefore, there is no one-size-fits-all adjuvant formula and / or preparation process that can be commonly used in the pellet preparations of all drugs