Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Medicament composition for treating colpitis symptoms and preparation method thereof

A composition and drug technology, which is applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., can solve the problems of easy loss of ointment, backward dosage form, strong water irritation, etc., and achieve environmental pollution reduction and hygienic use The effect of convenience and stable drug quality

Active Publication Date: 2009-08-12
YANGTAI PHARMA SHANDONG
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above listed dosage forms and patent reported dosage forms and their preparation methods generally have disadvantages such as backward dosage forms, low bioavailability, and inconvenient use. Regular and sleek, it is used in winter, and the vagina is often damaged during the process of being inserted into the vagina; in summer, it is easy to melt and stick to hands; and the suppository is easy to be lost when it is melted at body temperature, affecting the curative effect, polluting clothes, and causing discomfort to the patient, and the retention time of the suppository is too long (6 —8 hours) and absorb the moisture in the vagina, which is highly irritating, burying hidden dangers for recurrence, and easily destroying the acid-base balance; the ointment is delivered with a special device, which is easy to be administered unevenly, and the ointment is also easy to lose, so that the lesion cannot be obtained. Therapeutic amount of medicine is also easy to contaminate clothes; the bioavailability of effervescent tablets is reduced when the disintegration is not complete, and the above dosage forms need to be operated by hand, which is not hygienic and easy to cross-contaminate. patient discomfort
[0004] Existing various dosage form preparations all do not well solve above-mentioned problem, therefore need to provide a kind of medicaments for the treatment of vaginitis that can be convenient for patients to use, can effectively improve therapeutic effect at the same time

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicament composition for treating colpitis symptoms and preparation method thereof
  • Medicament composition for treating colpitis symptoms and preparation method thereof
  • Medicament composition for treating colpitis symptoms and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A foam for vaginal administration, the foam is composed of the following components, the proportion of each bottle is: metronidazole 3.00g, clotrimazole 2.00g, chlorhexidine acetate 0.10g, Tween-800.50 g, sodium lauryl sulfate 1.00g, water 13.10g, ethanol 6.00, glycerol 1.5g, tetrafluoroethane 2.80g, make solution type foaming agent, its preparation method is as follows:

[0040] (1) Metronidazole, clotrimazole, and chlorhexidine acetate of prescription quantity are stirred and dissolved in ethanol, glycerin, water mixed solvent;

[0041] (2) adding sodium lauryl sulfate of recipe quantity, Tween-80 stirs and makes it mix and dissolve;

[0042] (3) Check the content of the prepared medicinal liquid, and pour the qualified medicinal liquid into the pressure-resistant container;

[0043] (4) Cover the valve and seal it, and fill it with the prescribed amount of propellant.

[0044] It is also possible to directly assemble a mechanical pump that generates foam without us...

Embodiment 8

[0048] A foam for vaginal administration, the foam consists of the following ingredients, the proportion of each bottle is: Metronidazole 2.00g, clotrimazole 2.00g, chlorhexidine acetate 0.20g, Span-850.20 g, 0.80g sodium lauryl sulfate, 1.20g cetyl alcohol, 0.60g stearic acid, 0.01g essence, 19.99g water, 3.00g tetrafluoroethane, made into suspending foam, the preparation method is as follows :

[0049] (1) Weigh the prescription amount of cetyl alcohol, stearic acid, and Span-85 in a water bath and heat it to 50-70°C to dissolve it, and prepare it as liquid A for later use;

[0050] (2) Take 80% of the prescription amount of water, slowly heat it to 60-70 ° C, add the prescription amount of sodium lauryl sulfate, stir to dissolve, and it is B liquid; slowly add solution A to solution B while it is hot, and add While stirring, homogeneously emulsify to make emulsion;

[0051] (3) When the room temperature of the emulsion drops below 40°C, add micronized metronidazole, clotr...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a drug combination for curing the inflammation of vagina, which adopts the form of a foaming agent, in particular to a foaming agent with the principle agents being metronidazole, clotrimazole and chlorhexidine acetate. The drug combination has the advantages of even distribution, wide coating area and better effect in the vagina by adopting the form, and meanwhile, the drug combination feels more comfortable and has stronger retention property than other forms. In the formula of the foaming agent, the drug combination can permeate into the mucosal folds of the vagina rapidly and effectively by dispersing atomizing particles with the particle diameter being a few micrometers in a foaming manner under the action of pressure; the drug combination has higher absorption rate than the spraying agent with water being the only solvent with the assistance from various fat-soluble auxiliary materials; the drug contamination and the cross contamination are avoided during the administration; the invention has the advantages that the curative effect is fully produced, the administration is sanitary, convenient, safe and reliable without causing the foreign body sensation, and the drug combination is easily accepted by patients; and the invention further has the advantages of drug stability, form stability and long effective duration.

Description

technical field [0001] The invention relates to the reform of traditional dosage forms of medicines, in particular to a novel compound foaming agent using metronidazole, clotrimazole and chlorhexidine acetate as main ingredients and a preparation method thereof. Background technique [0002] Bacterial vaginitis, fungal vaginitis, trichomonas vaginitis and bacterial fungal trichomonas mixed infection vaginitis are common and frequently-occurring diseases in women, which seriously affect women's health. [0003] At present, metronidazole, cotrimecilazole, and chlorhexidine acetate single-component are used as antibacterial and anti-inflammatory dosage forms, but the single component lacks synergistic effect, especially for the treatment of mixed infections. The Shuangzotai suppository (recorded in the second part of the Chinese Pharmacopoeia 2000 edition) prepared from the drug compound of metronidazole, clotrimazole and chlorhexidine acetate, has been clinically used for many...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4174A61K31/4164A61K31/155A61K9/12A61J3/00A61P15/02A61P31/04A61P31/10
Inventor 李铁军于云涛毛德香
Owner YANGTAI PHARMA SHANDONG
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products