An on-rocket integrated comprehensive radio frequency system comprises a comprehensive measurement module, a comprehensive radio frequency front end and a comprehensive measurement antenna, wherein the comprehensive measurement module is connected with the comprehensive radio frequency front end through a VPX bus interface; the comprehensive radio frequency front end is connected with the comprehensive measurement antenna; the comprehensive measurement module is used for collecting multiple analog quantities, processing telemetry data, externally measurement uplink and downlink communication,safety control uplink and self-destruction control and third-party monitoring; the comprehensive radio frequency front end is used for telemetering downlink amplification and filtering, external measurement uplink amplification and filtering, external measurement downlink method and filtering, and safety control uplink amplification and filtering; and the comprehensive measurement antenna is integrated with a remote / external measurement downlink antenna, an external measurement uplink antenna and a safety control uplink antenna. By the scheme, the functions of collecting, remote measuring, external measuring and safety control are integrated, scattered independent single-machine products are integrally designed into a 3U VPX module, a power amplifier and an antenna, the size and the systemcomplexity are reduced, and meanwhile the utilization rate of computing resources is increased.