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179results about How to "Efficient modulation" patented technology
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Electronically tuned power amplifier
InactiveUS7202734B1Maximum efficiencyMaintain efficiencyGain controlTransmissionWidebandAudio power amplifier
A circuit and method for electronically tuning an RF power amplifier. The output filter includes at least one electronically variable reactance. The electronically tuned power amplifier may be tuned rapidly to a selected frequency, to a selected impedance, or to produce a selected output amplitude. An optional controller translates frequency, impedance, or modulation inputs into tuning signals. High-efficiency, wideband amplitude modulation is produced by varying the amplifier load impedance along preferred loci.
Owner:RAAB FREDERICK HERBERT
Substituted benzoazepines as toll-like receptor modulators
ActiveUS20110118235A1Efficient modulationAntibacterial agentsBiocideTLR8Graft versus host disease induction
Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and / or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
Owner:ARRAY BIOPHARMA +1
Methods and compositions for the production of guide RNA
Various aspects and embodiments of the present disclosure relate to methods and compositions that combine multiple mammalian RNA regulatory strategies, including RNA triple helix structures, introns, microRNAs, and ribozymes with Cas-based CRISPR transcription factors and ribonuclease-based RNA processing in human cells. The methods and compositions of the present disclosure, in some embodiments, enable multiplexed production of proteins and multiple guide RNAs from a single compact RNA-polymerase-II-expressed transcript for efficient modulation of synthetic constructs and endogenous human promoters.
Owner:MASSACHUSETTS INST OF TECH
Method for administering a cytokine to the central nervous system and the lymphatic system
InactiveUS6991785B2Provide effectModulate immune and inflammatory responseBiocideNervous disorderImmunologic disordersInterferon alpha
The present invention is directed to a method for delivering cytokines to the central nervous system and the lymphatic system by way of a tissue innervated by the trigeminal nerve and / or olfactory nerve. Cytokines include tumor necrosis factors, interleukins, interferons, particularly interferon-β and its muteins such as IFN-βser17. Such a method of delivery can be useful in the treatment of central nervous system disorders, brain disorders, proliferative, viral, and / or autoimmune disorders such as Sjogren's disorder.
Owner:CHIRON CORP
Biodegradable immunomodulatory formulations and methods for use thereof
InactiveUS7250403B2Increasing interferon-gammaImprove the situationAntibacterial agentsOrganic active ingredientsImmunomodulationsPolynucleotide
The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide / microcarrier (IMP / MC) complexes. The IMP / MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a biodegradable microcarrier or noncarrier.
Owner:DYNAVAX TECH CORP
Intercalated superlattice compositions and related methods for modulating dielectric property
ActiveUS20070181961A1Low working voltageDrain current increasesMaterial nanotechnologyLiquid surface applicatorsDielectricSuperlattice
Compositions, methods of using inorganic moieties for dielectric modulation, and related device structures.
Owner:NORTHWESTERN UNIV
Immunomodulatory formulations and methods for use thereof
InactiveUS7129222B2Increasing interferon-gammaImprove the situationAntibacterial agentsOrganic active ingredientsNanocarriersImmunomodulations
The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide / microcarrier (IMP / MC) complexes. The IMP / MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a nonbiodegradable microcarrier or nanocarrier.
Owner:DYNAVAX TECH CORP
Immunomodulatory formulations and methods for use thereof
InactiveUS7183111B2Regulate immune responseMore resistant to immunomodulationOrganic active ingredientsNanotechNanocarriersImmunomodulations
Owner:DYNAVAX TECH CORP
Method and apparatus for multiple patient parameter variability analysis and display
InactiveUSRE41236E1Efficient modulationReduce rateProgramme controlElectric signal transmission systemsMultiple organ dysfunction syndromeDiagnostic information
A method and apparatus (100) for providing continuous analysis and display of the variability of multiple patient parameters monitored by multiple beside monitors (106a-106c) for each patient (102). Each monitor is connected to a patient interface and to a patient data storage unit (115) and a processor (113). Each monitored patient parameter is measured in real-time. Data artifacts are removed, and variability analysis is performed based upon a selected period of observation. Variability analysis yields variability of the patient parameters, which represents a degree to which the patient parameters fluctuate over time, to provide diagnostic information particularly useful in the detection, prevention and treatment of multiple organ dysfunction syndrome (MODS).
Owner:SEELY ANDREW J E
Compositions and methods for treating inflammatory disorders
InactiveUS20050112118A1Preventing and ameliorating diseaseEfficient modulationHydrolasesPeptide/protein ingredientsAssayProtein-protein complex
Protein complexes are provided comprising at least one interacting pair of proteins. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes, and in treating and / or preventing diseases and disorders associated with the protein complexes and / or their constituent interacting members.
Owner:MYRIAD GENETICS
Formulation comprising histone deacetylase inhibitors
InactiveUS20070232528A1Inhibition becomes largerInhibit HDAC target enzymesBiocideSenses disorderValproic AcidApoptosis
The present invention relates to an orally available galenics formulation of Valproic Acid or derivatives thereof exhibiting a specific bi-phasic pharmacokinetic profile optimized for maximum inhibition of histone deacetylases in a therapeutic setting. This specific galenics formulation is designed for the treatment of malignant diseases and diseases associated with hypoacetylation of histones or in which induction of hyperacetylation has a beneficial effect, e.g., by induction of differentiation and / or apoptosis. Due to the bi-phasic release pattern the resulting pharmacokinetic profile is able to inhibit HDAC target enzymes most efficiently and to subsequently induce histone hyperacetylation in a rapid as well as a long-lasting fashion. This profile secures the efficient modulation of a desired target gene expression profile which contributes to the therapeutic benefit.
Owner:TOPOTARGET GERMANY AG +1
Method for allocating group resource in broadband wireless access system
InactiveUS20120320837A1Reduce waste of resourcesReduce message overheadBroadcast service distributionInter user/terminal allocationBroadbandBitmap
A method of transmitting a signal from a base station to a mobile station through Group Resource Allocation (GRA) includes allocating the mobile station to any one of a plurality of groups each including one or more mobile stations, transmitting, to the mobile station, a group configuration message including one or more pieces of burst size information used in the group, to which the mobile station is allocated, and one or more pieces of resource allocation bitmap information which is differently configured according to burst sizes, and transmitting bursts to the mobile station through a resource unit indicated by the resource allocation bitmap.
Owner:LG ELECTRONICS INC
Method and apparatus for multiple patient parameter variability analysis and display
InactiveUS7038595B2Efficient modulationReduce rateProgramme controlElectric signal transmission systemsMultiple organ dysfunction syndromeContinuous analysis
A method and apparatus (100) for providing continuous analysis and display of the variability of multiple patient parameters monitored by multiple bedside monitors (106a–106c) for each patient (102). Each monitor is connected to a patient interface and to a patient data storage unit (115) and a processor (113). Each monitored patient parameter is measured in real-time. Data artifacts are removed, and variability analysis is performed based upon a selected period of observation. Variability analysis yields variability of the patient parameters, which represents a degree to which the patient parameters fluctuate over time, to provide diagnostic information particularly useful in the detection, prevention and treatment of multiple organ dysfunction syndrome (MODS).
Owner:SEELY ANDREW J E
Laser radar system
PendingCN109188451AAvoid the disadvantage of not being able to eliminate dark countsAccurate measurementElectromagnetic wave reradiationRadar systemsThree-dimensional space
The invention relates to a laser radar system. The laser radar system comprises a light emitting unit, a light receiving unit and a control unit, wherein the light emitting unit comprises a light source and a scanning unit, and the scanning unit is configured to reflect light from the light source at a controllable deflection angle to scan a target object; the light receiving unit is used for receiving the light reflected from the target object and outputting a detection value, and the light receiving unit comprises a photoelectric sensor device; and a light path from the light emitted by thelight emitting unit to the target object is non-coaxial with a light path from the light reflected from the target object to the light receiving unit. According to the laser radar system, the defect that an SPAD detector in an optical sensor cannot eliminate dark counts in the prior art is overcome; distance information of a surrounding three-dimensional space environment can be accurately measured; and the influence of background light and other stray light can be greatly inhibited, so that spatial light can be quickly and efficiently modulated.
Owner:ZVISION TECH CO LTD
Methods and compositions for detecting and quantifying sappb
InactiveUS20090162878A1Treating and preventing and ameliorating effectEfficient modulationImmunoglobulins against animals/humansBiological material analysisBiochemistryΒ amyloid
The present invention provides methods (assays) for detecting and / or quantifying sAPPβ, a secreted β-secretase (BACE1) cleavage fragment of the β-amyloid precursor protein (APP), in a biological sample. One such method includes contacting a biological sample with a first antibody that selectively binds to a BACE1 cleavage site on sAPPβ and detecting the presence of the antibody. Also provided are compositions, including antibodies that selectively bind to the BACE1 cleavage site of sAPPβ. Kits containing such compositions are also provided. Methods of diagnosing a neurodegenerative disease, such as AD, using the methods and compositions of the present invention are further provided. Methods for identifying BACE1 modulators, candidate compounds that are BACE1 modulators, and methods for treating, preventing or ameliorating neurodegenerative disease, such as AD, using such compounds or pharmaceutical compositions containing such compounds are also provided.
Owner:THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
Biodegradable immunomodulatory formulations and methods for use thereof
InactiveUS8124590B2Regulate immune responseMore resistant to immunomodulationSenses disorderAntipyreticNanocarriersImmunomodulations
The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide / microcarrier (IMP / MC) complexes. The IMP / MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a biodegradable microcarrier or nanocarrier.
Owner:DYNAVAX TECH CORP
Methods and apparatus for mitigating rain fading over SATCOM links via information throughput adaptation
ActiveUS7174179B2Maximize information throughputImprove data throughputBroadcast transmission systemsRadio transmissionTelecommunicationsSignal quality
A remote communications terminal accesses a terrestrial network or information source via a SATCOM link with an earth station hub linked to the network or information source. Information throughput adaptation (ITA) is employed on the SATCOM link to maximize information throughput over the SATCOM link while ensuring acceptable signal quality under varying rain fading conditions. Sufficient power margin is built into the SATCOM link such that, under severe rain fading conditions, the lowest system throughput rate still provides acceptable signal quality. Under lesser rain fading conditions, the data throughput rate is increased via more bandwidth efficient modulation and coding schemes permitted by the higher signal quality which results from greater power margin. The earth station hub and remote terminals monitor the signal quality and communicate to adaptively adjust the modulation and coding used on the forward and return links to maximize information throughput under varying rain fading conditions.
Owner:HARRIS CORP
Compositions and methods for treating neurological disorders and diseases
InactiveUS20070225209A1Relieve symptomsPromote formationCompound screeningNervous disorderNeurological disorderPharmacology
Owner:MYRIAD GENETICS INC (US)
Therapeutic Modulation of Ocular Surface Lubrication
ActiveUS20110070222A1Protect conjunctivaProtect corneaOrganic active ingredientsSenses disorderBoundary lubricationOcular surface
Provided herein are ophthalmically acceptable pharmaceutical compositions comprising a PRG4 inducing compound in combination with PRG4 (including a lubricant fragments, homologs, or isoforms thereof), and methods of using the same. The PRG4 inducing compound in the pharmaceutical composition of the present invention upregulates PRG4 expression and localization in the ocular surface for efficient surface boundary lubrication. In some instances, pharmaceutical compositions described herein are utilized for treating ophthalmic conditions, e.g., ocular boundary deficiency and symptoms associated therewith.
Owner:RGT UNIV OF CALIFORNIA +1
Fluid-Expandable Body Articulation of Catheters and Other Flexible Structures
ActiveUS20170021143A1Improve axial stiffnessEfficient modulationBalloon catheterSurgical navigation systemsHelical coilCatheter
Articulation devices, systems, methods for articulation, and methods for fabricating articulation structures will often include simple balloon arrays, with inflation of the balloons interacting with elongate skeletal support structures so as to locally alter articulation of the skeleton. The balloons can be mounted to a substrate of the array, with the substrate having channels that can direct inflation fluid to a subset of the balloons. The articulation array structure may be formed using simple planar 3-D printing, extrusion, and / or micromachining techniques. The skeleton may comprise a simple helical coil, and the array can be used to locally deflect or elongate an axis of the coil under control of a processor. Inflation fluid may be directed to the balloons from an inflation fluid reservoir of an inflation system, with the inflation system preferably including valves controlled by the processor. The articulation structures can be employed in minimally invasive medical catheter systems, and also for industrial robotics, for supporting imaging systems, for entertainment and consumer products, and the like.
Owner:PROJECT MORAY INC
Modulation circuit for a vehicular traffic surveillance Doppler radar system
ActiveUS7049999B1Eliminates look-past errorEfficient modulationRadio wave reradiation/reflectionVoltage regulationVaricap
A modulation circuit for a traffic surveillance Doppler radar system is disclosed. In one embodiment, the modulation circuit is utilized in a vehicular traffic surveillance Doppler radar system that processes a reflected double-modulated FM signal to determine a target range based upon a phase angle signal differential associated with the target. The modulation circuit may include a digital-to-analog (D / A) converter / voltage regulator / oscillator arrangement or a D / A converter / varactor device / oscillator arrangement. The modulation circuit generates a double-modulated FM signal based upon a frequency versus voltage characteristic associated with the oscillator.
Owner:APPLIED CONCEPTS
Biodegradable immunomodulatory formulations and methods for use thereof
InactiveUS20110038896A1Regulate immune responseMore resistant to immunomodulationSenses disorderAntipyreticNanocarriersImmunomodulations
The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide / microcarrier (IMP / MC) complexes. The IMP / MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a biodegradable microcarrier or nanocarrier.
Owner:DYNAVAX TECH CORP
Polar modulator and method for modulation of a signal
InactiveUS20060160499A1Reduce power supply voltageFunction increaseResonant long antennasModulated-carrier systemsCarrier signalEngineering
A modulated carrier signal is produced from a phase modulation signal in a phase locked loop in a polar modulator. This carrier signal is converted via a limiting amplifier to a square-wave signal, which is supplied to an amplifier. At the same time, an amplitude modulation signal at one input is connected to a control input of a controllable current source. The controllable current source is designed to emit a supply current at a current output as a function of the amplitude modulation signal at the control input. The current output of the controllable current source is connected to a supply input of the amplifier. The supply current for the amplifier is thus modulated on the basis of the amplitude information to be transmitted. The processing of the amplitude information within the current domain makes it possible to produce the polar modulator according to the invention as an integrated circuit, using CMOS technology.
Owner:INFINEON TECH AG
Nitride semiconductor material, semiconductor element, and Manufacturing method thereof
ActiveUS20080121896A1Reduce irregularitiesAtomic migration can be promotedSemiconductor/solid-state device detailsSolid-state devicesNitrogenNitride semiconductors
The nitride semiconductor material according to the present invention includes a group III nitride semiconductor and a group IV nitride formed on the group III nitride semiconductor, where an interface between the group III nitride semiconductor and the group IV nitride has a regular atomic arrangement. Moreover, an arrangement of nitrogen atoms of the group IV nitride in the interface and an arrangement of group III atoms of the group III nitride semiconductor in the interface may be substantially identical.
Owner:PANASONIC CORP
Distributor power line communication system
InactiveUS20100204850A1Reliable powerReduce recurring operating and maintenance costMechanical power/torque controlSystems using filtering and bypassingFrequency bandCommunications server
Distributor power line communication system comprising a communication server (1) sending and receiving messages over a telecommunication network (2), a power distribution substation (3) to which a power distribution network (4) towards end users (5) is connected, at least one gateway (6; 18) transferring messages from the telecommunication network (2) onto the power distribution network (4) in a predetermined frequency band, a plurality of smart metering devices (7; 17; 27) at end user mains networks for measuring power consumption and comprising a power line communication modem (8; 18) sending and receiving messages within the predetermined frequency band over the power distribution network (4), power line communication filters (10, 11) on power lines connecting the power distribution network and the end user mains networks and on power lines connecting the power distribution network to the power distribution substation, each filter blocking frequencies within the predetermined frequency band.
Owner:EANDIS
Intercalated superlattice compositions and related methods for modulating dielectric property
ActiveUS7678463B2Low working voltageDrain current increasesMaterial nanotechnologySolid-state devicesCrystallographyDielectric
Compositions, methods of using inorganic moieties for dielectric modulation, and related device structures.
Owner:NORTHWESTERN UNIV
Methods of treating conditions associated with an Edg-7 receptor
InactiveUS20040167165A1Modulating biological activityEfficient modulationBiocideAnimal repellantsDrug biological activityEdg-7 Receptor
In one aspect, the present invention provides a method for modulating an Edg-7 receptor mediated biological activity in a cell. A cell expressing the Edg-7 receptor is contacted with a modulator of the Edg-7 receptor which is capable of modulating an Edg-7 receptor mediated biological activity. In another aspect, the present invention provides a method for modulating an Edg-7 receptor mediated biological activity in a subject. A therapeutically effective amount of a modulator of the Edg-7 receptor is administered to the subject.
Owner:MANIV ENERGY CAPITAL
Glycan therapeutic compositions and related methods thereof
InactiveUS20180147221A1Reduce inflammationReduce immune responseOrganic active ingredientsMetabolism disorderDrugCancer therapy
Owner:DSM NUTRITIONAL PROD
Terahertz modulator based on low-dimension electron plasma waves and manufacturing method thereof
InactiveCN105204190AImprove modulation efficiencyEfficient modulationSemiconductor/solid-state device manufacturingNon-linear opticsResonant cavityGrating
Owner:SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
Optic modulator and method of manufacturing the same
ActiveUS20150346520A1Effectively modulateChange effective refractive indexOptical waveguide light guideNon-linear opticsOptical modulatorRidge
An optic modulator may include: an optical waveguide including a ridge-shaped portion having a first region and a second region over the first region; a slab-shaped portion being in contact with a first region of the ridge-shaped portion; an optical waveguide electrode forming a Schottky contact with a second region of the ridge-shaped portion; metal plugs being in contact with the slab-shaped portion and the optical waveguide electrode, respectively; and metal pads connected to the respective metal plugs.
Owner:SK HYNIX INC +1
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