Method and apparatus for multiple patient parameter variability analysis and display

Abstract

A method and apparatus (100) for providing continuous analysis and display of the variability of multiple patient parameters monitored by multiple beside monitors (106a-106c) for each patient (102). Each monitor is connected to a patient interface and to a patient data storage unit (115) and a processor (113). Each monitored patient parameter is measured in real-time. Data artifacts are removed, and variability analysis is performed based upon a selected period of observation. Variability analysis yields variability of the patient parameters, which represents a degree to which the patient parameters fluctuate over time, to provide diagnostic information particularly useful in the detection, prevention and treatment of multiple organ dysfunction syndrome (MODS).

Description

[0001]This application is a reissue of U.S. Pat. No. 7,038,595, which issued from U.S. Ser. No. 10 / 312,177, which is a U.S. national phase of PCT International Application No. PCT / CA01 / 00979 filed on Jul. 3, 2001, which claims priority from U.S. Provisional Application No. 60 / 216,374, filed on Jul. 5, 2000. TECHNICAL FIELD[0002]The present invention relates medical monitoring of patients and more particularly to a method and apparatus for real time monitoring and display of the variability of multiple patient parameters using data collected by an intensive care monitoring unit.BACKGROUND OF THE INVENTION[0003]Remarkable advances have been made in the care of post-operative and post-injury patients. Because of improvements in the care of acutely injured persons as well as advances in providing organ-specific supportive care, a new class of patients has been created. These patients represent the chronically critically ill. Multiple Organ Dysfunction Syndrome (MODS), defined by having ...

AI Technical Summary

Benefits of technology

"The invention provides a method and system for evaluating physiological parameters in real-time to improve the modulation of the human host response and reduce mortality rates due to MODS. The method involves collecting data points from multiple monitoring interfaces, removing artifacts from the data, and continuously computing a measure of variability for each physiological parameter to detect altered emergent properties of a complex non-linear system. The system allows for simultaneous monitoring of multiple organ systems and provides a correlation between the variability of the physiological parameters to determine changes in variability over time. The technical effects include improved individualization of treatment strategies and reduced mortality rates."

Problems solved by technology

MODS is the leading cause of mortality in ICU patients.

MODS represents the sequential deterioration of organ function, usually leading to death, occurring in patients who are on the most advanced ICU life support technology possible.

At present, there is no active treatment that has proven successful for patients with MODS.

In over 30 randomized, controlled trials to treat patients with severe infection leading to organ dysfunction, despite compelling supportive laboratory experiments, all attempts at active treatment through immunomodulation have failed.

Thus, active treatment of patients with MODS has eluded surgeons and intensivists who care for these patients.

Evaluation of variability of patient parameters has only recently come under investigation in medical science, and is generally not used in routine clinical practice.

To date, there has been no attempt to provide clinicians with variability analysis of multiple patient parameters simultaneously, nor provide the capability for continuous real-time variability analysis and display.

The teachings of Atlas cannot be profitably applied to active therapeutic intervention.

Unfortunately, current monitoring systems including that of Falcone, and Weinberg et al. do not provide sufficient prospective evaluation and analysis to identify and quantify changes to the systemic host response, necessary to perform active therapeutic intervention with MODS.

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