51results about How to "Easy retention" patented technology

The present invention relates to novel drug depot implant designs for optimal delivery of therapeutic agents to subjects. The invention provides a method for alleviating pain associated with neuromuscular or skeletal injury or inflammation by targeted delivery of one or more therapeutic agents to inhibit the inflammatory response which ultimately causes acute or chronic pain. Controlled and directed delivery can be provided by drug depot implants, comprising therapeutic agents, specifically designed to deliver the therapeutic agent to the desired location by facilitating their implantation, minimizing their migration from the desired tissue location, and without disrupting normal joint and soft tissue movement.

The present invention relates to novel drug depot implant designs for optimal delivery of therapeutic agents to subjects. The invention provides a method for alleviating pain associated with neuromuscular or skeletal injury or inflammation by targeted delivery of one or more therapeutic agents to inhibit the inflammatory response which ultimately causes acute or chronic pain. Controlled and directed delivery can be provided by drug depot implants, comprising therapeutic agents, specifically designed to deliver the therapeutic agent to the desired location by facilitating their implantation, minimizing their migration from the desired tissue location, and without disrupting normal joint and soft tissue movement.

Methods and apparatus for treatment of patent foramen ovale (PFO) generally involve use of a catheter having at least one closure device at its distal end. In some embodiments, the catheter also includes one or more energy transmission members for delivering energy to the closure device(s) and to the tissue adjacent the PFO to induce closure of the PFO. Closure devices may comprise, for example, a bioresorbable matrix or a non-resorbable matrix. In some embodiments, the closure device contains particles dispersed within the closure device to increase conductance and / or to reduce resistance and / or impedance. An exemplary method involves advancing a catheter to position its distal end into the tunnel of the PFO and fixing the closure device within the tunnel of the patent foramen PFO.

The present invention is in the field of plant genetics and biochemistry. More specifically, the present invention relates to genes and polypeptides associated with the tocopherol biosynthesis pathway, namely those encoding 4-Hydroxyphenylpyruvate Dioxygenase activity, and uses thereof.

A high efficiency heat transfer device utilizes carbon nanotube deposits that are formed directly on the outer surface of the device to replace conventional cooling fins. A catalyst is used to facilitate retention of the nanotubes on the device before they are deposited. In addition, the nanotubes are infused with a protective outer layer, such as silicon. The protective layer penetrates the deposition, fills-in the voids between nanotubes, and then deposits on the surface of the nanotubes layer.

A microsurgical instrument is described for ophthalmologic microsurgery in the eye which comprises a housing configured as a handle with a functional unit supporting a probe and a rod co-axially supported in the probe having a head piece configured as a grasping element with two arms that can be brought into a spread apart first position and a second closed position, wherein each arm has a recess which upon closing are flush pressed together thereby forming a larger recess for unobstructed grasping, retaining and holding microstructures such as blood vessels without squeezing or pinching the microstructures.

The present invention relates to the design and composition of a depot implant for optimal delivery of growth factors to treat bone avascular necrosis, in that such depot implant is constructed to be in a cylinder (rod) or sphere shape and have a natural or synthetic polymer scaffold with or without impregnated calcium phosphate particles. The density of the depot is higher than a typical BMP sponge carrier to facilitate it's implantation and slower release of the growth factor. The scaffold is such that it has adequate porosity and pore size to facilitate growth factor seeding and diffusion throughout the whole of the bone structure resulting in increased new blood vessel growth and density in the avascular necrotic bone. In addition, the shape of the depot implant allows for delivery through a cannula or large bore needle.

A medical treatment device that includes a medical adhesive and a medical device. The medical adhesive is formulated to at least partially physically retain the medical device in a particular form until the medical device is at least partially deployed to a treatment area and / or to at least partially physical connect the medical device to a deployment device until the medical device is at least partially deployed to a treatment area. The medical adhesive can include at least one biological agent.

The present invention is in the field of plant genetics and biochemistry. More specifically, the present invention relates to genes and polypeptides associated with the tocopherol biosynthesis pathway, namely those encoding 4-Hydroxyphenylpyruvate Dioxygenase activity, and uses thereof.

Dietary micronutrient supplement formulations for specific ages, gender, special requirements and health conditions comprising, vitamins, minerals, fish and plant oils, amino acids, enzymes, phytochemicals, herb and fruit extracts and other natural compounds grouped into morning, mid-day and evening formulas based on their synergism and antagonism with each other, their interactions with ingredients in the food consumed during each meal and their bioavailability. The dietary micronutrient formulations are optimized to meet the Recommended Daily Allowances (RDA) and Adequate Intake (AI) standards for each segment of the population with larger amounts of nutrients used in condition-specific formulas.

An automated transaction machine (600) includes a note receiving storage and dispensing mechanism (624). The mechanism (624) includes a stacker mechanism (654). The stacker mechanism collects in a stack notes such as currency bills that are to be dispensed from the machine to a user, and the stack is then presented to the user from the machine. The stacker mechanism includes a stack support member (668), a flexible member (692) and spaced supports (694). Notes are engaged in supporting connection with the stack support member as the stack support member is rotated in a first rotational direction. After the stack is accumulated, rotation of the stack support member in an opposed rotational direction delivers the stack from the stacker mechanism.

An apparatus and method for using nanostructures, such as nanopores, nanofibers, nanowells, or nanocones as carriers for drugs, biomarkers and / or biomolecules. The apparatus and method for use on implant surfaces to retain and release drugs, biomarkers and / or biomolecules on command by an external stimulus.

Various embodiments of mosaicplasty constructs and methods for implanting the constructs into anatomical structures. The mosaicplasty constructs may be formed from artificial materials and may include a hard articulating portion and a relatively softer elastic, support portion. The mosaicplasty constructs may include bone ingrowth materials to facilitate ingrowth of bone and other tissues into the construct. The mosaicplasty constructs may also be at least partially formed of hydrogel materials.

The invention relates to a method for maintaining the temperature of fluid media in pipes even in the event of an interruption of the fluid media flow. In a first step, a heat reservoir layer (1) is produced comprising a latent heat reservoir material (2) and a matrix material (3). In a second step, the heat reservoir layer (1) is either arranged around a pipe (4) and subsequently encased with a heat damping material (5) or the heat reservoir layer (1) is brought into contact with heat damping material (5), whereby a heat reservoir damper composite (51) is obtained, and the pipe (4) is then encased with the heat reservoir damper composite (51) such that the heat reservoir layer (1) of the heat reservoir damper composite (51) lies between the pipe (4) and the heat damping material (5) of the heat reservoir damping composite (51).

A medication delivery device for treatment of a pulmonary disorder in a patient includes an elongate member, an expandable member is coupled to a distal end of the elongate member, and an agent delivery portion coupled to an external surface of the expandable member. The agent delivery portion includes an agent that disrupts nerve activity.

Embodiments of the invention disclose a system for controlled oral drug delivery. The system comprising a removable device comprising a drug to be delivered, wherein the drug is delivered based on osmotic pressure generated in the removable device. Further, the system comprises a receptacle to hold the removable device in an oral cavity, and a base station configured to dock the removable device for determining information about one or more characteristics of the removable device.

The orthodontic assembly is used in a user's mouth to facilitate tooth movement. The orthodontic assembly includes an interchangeable clip member configured to be removably affixed to a frame member such that the clip member engages at least one of the user's teeth. The orthodontic assembly further includes a frame member configured to be removably positioned proximate the lingual portion of user's teeth. The frame member includes a fastening mechanism configured to cooperatively engage the clip member such that the clip member may be removably affixed to the frame member.

Method and apparatus that facilitates customer retention, churn reduction, and customer satisfaction by predicting customer churn and taking an appropriate action to retain a customer is described. In an example, a customer retention method acquires information indicative of customer service usage by customers. The customer retention method then provides an analysis of the acquired information. The analysis predicts the likelihood of churn for each customer. The customer retention method then identifies affected customers based on the analysis. The customer retention method then automatically selects customer support executives to initiate an action for each of the affected customers. The customer retention method selects the customer support executives based on skill in handling the affected customers, among other factors.

Method and apparatus that facilitates customer retention, churn reduction, and customer satisfaction by predicting customer churn and taking an appropriate action to retain a customer is described. In an example, a customer retention method acquires information indicative of customer service usage by customers. The customer retention method then provides an analysis of the acquired information. The analysis predicts the likelihood of churn for each customer. The customer retention method then identifies affected customers based on the analysis. The customer retention method then automatically selects customer support executives to initiate an action for each of the affected customers. The customer retention method selects the customer support executives based on skill in handling the affected customers, among other factors.

A new and improved pacifier including a novel nipple structure is disclosed. The nipple structure includes a short nipple that allows the tongue, during sucking and swallowing, to be naturally positioned adjacent to the hard palate. The nipple structure includes a thin and pliable web which extends beyond the tip of the nipple and, in use, is received between the tongue and the palate. Preferably, the web terminates near the mid-point, front to back, of the hard palate of a user. The web is so thin and pliable that it will deform to conform to the shape of a hard palate when pressed by a tongue thereagainst. Preferably, the web has a featheredge. The web, when received between the tongue and the hard palate, will facilitate the retention of the pacifier in the mouth.

A method for packaging cotton sliver for efficient transport includes the steps of laying the sliver in a uniform-density pattern onto a bottom cap, placing a top cap on the sliver, applying pressure to the top and bottom caps to compress the sliver to a higher second density at which the compressed sliver is rigid, and strapping the compressed sliver and caps in order to form a rigid package for handling and transport. A packaging system includes an oblong can that receives the sliver, a compression baler for compressing the sliver to a high density, and a strapping apparatus for strapping the compressed sliver and caps to retain the compression.

A process and apparatus are provided for cooling gaseous effluent from a hydrocarbon pyrolysis furnace, the cooling conduit apparatus comprising: (i) an inner wall for contacting the effluent, the inner wall defining a bore extending a length of the cooling conduit, the inner wall including a perimeter opening along the bore; (ii) an outer wall external to the inner wall and substantially coaxial to the inner wall; (iii) a substantially annular cavity external to the inner wall and including at least a portion of the outer wall, the annular cavity fluidly and remotely connected to the perimeter opening, the annular cavity externally surrounding a perimeter of the inner wall, the annular cavity including at least a portion of the outer wall; and (iv) a peripheral channel extending around a perimeter of the inner wall, the peripheral channel providing a channel flow path that fluidly connects the annular cavity with the remotely connected perimeter opening along the perimeter of the inner wall.

Handle lock structure includes: left and right lock members provided on a body of a working machine for movement into engagement with engaging portions of left and right handle sections of a handle as the handle is pivotally moved in a deploying direction from a stored position toward a deployed position, thereby locking the handle sections in the deployed position; and a lock cancellation lever for moving the left and right lock members out of the engagement with the engaging portions to compulsorily cancel the locking, by the left and right lock members, of the left and right handle sections in the deployed position.

A visual display mounted on a musical instrument for use as a teaching aid, for teaching fingerings and chords, a performing aid for displaying information relevant to a user's performance, and a visual effects aid, for displaying visual effects to an audience while a user is performing.

A system of combining decorative ornaments with fasteners may comprise a topper assembly, magnets aligned in series and a lower fastener system. A topper assembly or decorative ornament may comprise one or more cloth flowers or other ornaments that sandwich or encase a magnet. A plurality of decorative ornaments may be magnetically aligned in series such that each north end is next to a south end. The most bottom portion of a decorative ornament or series of decorative ornaments may comprise a lower faster, with the fastener comprising a ferrous section so as to attract the adjacent magnet. The artful use of magnets in series allows for decorative ornaments to be well secured, but yet facilitate toolless exchanges of decorative ornaments such that a consumer needs only one lower fastener.

A steel for metal-cutting tools comprising carbon, chromium, molybdenum, vanadium, aluminum and nitrogen in certain concentration ranges. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

A waist-attachable mounting assembly for fastening and selective positioning a communication device from the waist. The mounting assembly is mountable to the waist for retention, accessibility, and selective positioning of the communication device. The mounting assembly provides a waist mount plate that attaches to the waist, a device mount plate that slidably receives the communication device, and multiple articulating arms arranged in an accordion relationship between the mount plates. The articulating arms join from their ends at spherical bearings that enable selective rotational motion, pivotal motion, and translational displacement of the communication device. Alternative articulating arms can be added or removed from this arrangement to increase or decrease the range of the communication device.