The invention discloses a moxa stick and a preparation method of the moxa stick. The moxa stick comprises 600-1000 parts of folium artemisiae argyi, 25-35 parts of mulberry bark, 20-40 parts of wingceltis bark, 5-20 parts of broadleaf holly leaf and 10-25 parts of cotton fiber according to weight. The preparation method comprises the following steps: 1, weighing the medicinal materials; 2, preparing moxa; 3, preparing paper; 4, rolling to form a stick; 5, fermenting; 6, sealing and storing. The moxa is clear and not turbid; the heat is high, and the defects of large smoke, low heat, weak combustion of the traditional moxa stick are made up for; the moxa stick does not cause internal heat, has a faint scent, and does not affect the lung; the moxa ash is not produced; the moxa stick is strong in penetrating power, the infrared powder and the frequency of the internal organ are consisten; the moxa stick dredges the channel, accelerates the qi-blood circulation; the emitted smell sterilizes, purifies the air, and makes a user feel refreshed.