The invention discloses a laser-assisted full-reflection X-fluorescence uranium ore trace element analysis device. The device comprises an excitation light source, a detection device, a sample table,a laser-assisted analysis device, an analyzer and circuit output equipment. The device disclosed by the invention has the advantages that the sample positioning and area and thickness monitoring can be quickly and effectively realized, the influence on the full-reflection optics by the thickness and area change of the sample can be overcome, and the TXRF measurement accuracy is improved. By adopting the full-reflection X-ray fluorescence analysis principle is adopted, the content of the trace heavy metal in the sample can be quickly detected, the detection is simple and fast and low in cost; the precision is high, the measurement time is short, the personal error is small, and the operator labor intensity is low; the X-fluorescence heavy metal measurement instrument is free from chemical pollution and radioactive pollution, short in measurement time, high in precision, simple in structure, safe and reliable, and convenient for use.