33 results about "Terbutaline sulphate" patented technology

The invention relates to a preparation method of terbutaline sulphate. The technical problems that according to an existing preparation method of terbutaline sulphate, high-pressure hydrogenation and other high-risk operations, and lithium methide, azomethane and other high-risk reagents exist, and cost is high are solved through the preparation method. 3,5-resacetophenone serves as a raw material, and terbutaline sulphate is obtained through hydroxyl protection, the bromination reaction, carbonyl reduction, the condensation reaction and sulphating. The preparation method can be suitable for industrially-produced terbutaline sulphate.

The invention relates to a preparation method of terbutaline sulfate, which comprises the following steps: dissolving a compound of formula I or formula II into a solvent A, adding a metal catalyst for catalytic hydrogenation, so as to obtain 5-[2-[(1,1-dimethylethyl)amido]-1-ethoxyl]-1,3-resorcinol; after the reaction is finished, filtering, collecting filter liquor, adding a certain amount of concentrated sulfuric acid in the filter liquor, after stirring is stopped, recycling the solvent A, adding a solvent B into a residue, stirring to separate out a white crystal substance, performing suction filtration, thus obtaining the terbutaline sulfate. According to the method provided by the invention, the treating difficulty after the reaction is greatly reduced, the introduction of water and inorganic salt is avoided, and the product content is high; furthermore, the stability of the terbutaline sulfate is obviously improved by distilling the product under acidic conditions, the catalyst and the reaction solvents are recyclable, so that the environmental protection pressure is greatly reduced.

The invention provides a method for preparing terbutaline sulphate B crystal form. The method comprises: selecting a solvent, dissolving 1-(3,5-dibenzyloxy phenyl)-2-n-tert-butyl aminoethanol into the solvent, removing benzyl groups through hydrogenolysis by a general method, obtaining terbutaline free alkali, and adding sulfuric acid into the terbutaline free alkali to form terbutaline sulphate of crystal form B; or dissolving terbutaline sulphate of non-crystal form B into the solvent, stirring the terbutaline sulphate of the non-crystal form B in the solvent at a certain temperature until the terbutaline sulphate of the non-crystal form B is converted into the terbutaline sulphate B crystal form through dissolution and lixiviation, and reclaiming the leached terbutaline sulphate B crystal form. The method has the advantage of obtaining the terbutaline sulphate B crystal form which has stable chemical and physical properties and meets the requirements of medical preparation.

The invention belongs to the field of pharmacy, and in particular relates to a preparation method of terbutaline. The technical points are as follows: a method for preparing terbutaline, S1. Add compound I and methylene chloride into the reaction kettle, stir and dissolve and then add acid anhydride; S2. After the reaction is completed, add dilute alkaline water into the system to fully stir and wash , collect the dichloromethane phase, and distill under reduced pressure to obtain a yellow oily substance, which is compound II; S3. add compound II, ethyl acetate, tert-butylamine, sodium hydroxide and oxidation protection agent to the reaction kettle; S4. step S3 completes the reaction Then add purified water to the system to wash the reaction solution in step S3, collect the ethyl acetate phase, and distill the ethyl acetate phase under reduced pressure to obtain terbutaline. The technical solution provided by the invention reduces the difficulty of post-reaction treatment, makes the intermediate compound easy to separate from the reaction system, avoids the occurrence of side reactions such as epoxy bond hydrolysis, and increases the stability and stability of the final product terbutaline. yield.