The invention discloses a fusion reactor water-helium cold ceramic breeder cladding, which comprises parts such as a first wall, a cooling plate, separators and side plates. The cladding simultaneously adopts water and helium as a coolant, the water is used for cooling the first wall, and the helium is used for cooling the parts except the first wall. The first wall is a U-shaped plate; the cooling plate is in a shape like a Chinese character ao; the cooling plate is located at the inner side of the first wall and is connected with the side wall of the first wall; the cooling plate is crossed with the separators and the side plates, the inner space of the cladding is divided to multiple independent cavities arranged along a radial direction, cavities contacted with the first wall are filled with Li2TiO3 / Be12Ti mixed ball beds as tritium breeding zones, and cavities not contacted with the first wall are filled with Be ball beds as neutron multiplication zones. The fusion reactor water-helium cold ceramic breeder cladding has the advantages that the surface heat flow endurance capability is strong, the tritium production performance is good, the coolant outlet temperature is high, the coolant is well compatible with the neutron multiplication zone material, the flow of the coolant is easy to control, and the development prospect is good.