113 results about "Physiological model" patented technology

Methods and apparatus for qualifying and quantifying excitation-dependent physiological information extracted from wearable sensors in the midst of interference from unwanted sources are provided. An organism is interrogated with at least one excitation energy, energy response signals from two or more distinct physiological regions are sensed, and these signals are processed to generate an extracted signal. The extracted signal is compared with a physiological model to qualify and / or quantify a physiological property. Additionally, important physiological information can be qualified and quantified by comparing the excitation wavelength-dependent response, measured via wearable sensors, with a physiological model.

In one embodiment of the invention, a portable device with multiple integrated sensors for vital signs scanning and method of using said device is disclosed. The portable personal scanning device includes multiple sensors such as a plurality of ECG, thermometer, PPG, accelerometer, and microphone for determining a user's vital signs. The method includes concurrently scanning with one or more sensors, validating and enhancing the results of each sensor scan with other concurrent sensor scan and patient interaction models, processing the sensor scans separately or in combination to extract user's vital signs, validating the vital signs extracted by comparison to physiological models, and fusing the similar vital signs extracted from more than one process according to a determination of the measure of quality of the process that produced the vital sign.

A method and system for patient-specific modeling of the whole heart anatomy, dynamics, hemodynamics, and fluid structure interaction from 4D medical image data is disclosed. The anatomy and dynamics of the heart are determined by estimating patient-specific parameters of a physiological model of the heart from the 4D medical image data for a patient. The patient-specific anatomy and dynamics are used as input to a 3D Navier-Stokes solver that derives realistic hemodynamics, constrained by the local anatomy, along the entire heart cycle. Fluid structure interactions are determined iteratively over the heart cycle by simulating the blood flow at a given time step and calculating the deformation of the heart structure based on the simulated blood flow, such that the deformation of the heart structure is used in the simulation of the blood flow at the next time step. The comprehensive patient-specific model of the heart representing anatomy, dynamics, hemodynamics, and fluid structure interaction can be used for non-invasive assessment and diagnosis of the heart, as well as virtual therapy planning and cardiovascular disease management. Parameters of the comprehensive patient-specific model are changed or perturbed to simulate various conditions or treatment options, and then the patient specific model is recalculated to predict the effect of the conditions or treatment options.

A method and system for determining the position of a sound source in relation to a reference position, comprising the steps of generating a sound signal emitted from the sound source, detecting the emitted sound signal, processing the sound signal by the use of a physiological model of the ear, deducing at least one of lateral deviation in relation to the reference position, time delay of the sound signal from the sound source to the reference position, and the sound level of the detected sound signal.

A method and system for modeling the aortic valve in 4D image data, such as 4D CT and echocardiography, is disclosed. An initial estimate of a physiological aortic valve model is determined for at least one reference frame of a 4D image sequence based on anatomic features in the reference frame. The initial estimate is refined to generate a final estimate in the reference frame. A dynamic model of the aortic valve is then generated by estimating the physiological aortic valve model for each remaining frame of the 4D image sequence based on the final estimate in the reference frame. The aortic valve can be quantitatively evaluated using the dynamic model.

A method and system for modeling the aortic valve in 4D image data, such as 4D CT and echocardiography, is disclosed. An initial estimate of a physiological aortic valve model is determined for at least one reference frame of a 4D image sequence based on anatomic features in the reference frame. The initial estimate is refined to generate a final estimate in the reference frame. A dynamic model of the aortic valve is then generated by estimating the physiological aortic valve model for each remaining frame of the 4D image sequence based on the final estimate in the reference frame. The aortic valve can be quantitatively evaluated using the dynamic model.

Methods and systems may be used for performing computer-simulated evaluation of treatments. For example, the method may include: for each of a plurality of patients, receiving one or more patient-specific anatomical and / or physiological models; selecting, from the plurality of patients, a set of patients that have one or more common characteristics; for each patient in an experimental group, modifying at least one model of the respective one or more patient-specific models to obtain at least one modified patient-specific model that models an effect of an evaluation treatment on the respective patient, and calculating a value of an evaluation endpoint based on the respective at least one modified patient-specific model; and comparing the calculated values of the evaluation endpoint with one or more control values of the evaluation endpoint for patients that satisfy the one or more selection criterion.

A method and system for registering ultrasound images and physiological models to x-ray fluoroscopy images is disclosed. A fluoroscopic image and an ultrasound image, such as a Transesophageal Echocardiography (TEE) image, are received. A 2D location of an ultrasound probe is detected in the fluoroscopic image. A 3D pose of the ultrasound probe is estimated based on the detected 2D location of the ultrasound probe in the fluoroscopic image. The ultrasound image is mapped to a 3D coordinate system of a fluoroscopic image acquisition device used to acquire the fluoroscopic image based on the estimated 3D pose of the ultrasound probe. The ultrasound image can then be projected into the fluoroscopic image using a projection matrix associated with the fluoroscopic image. A patient specific physiological model can be detected in the ultrasound image and projected into the fluoroscopic image.

The present invention relates to a system for the estimation of the systolic (SBP), diastolic (DBP) and average (MAP) blood pressure. Said system establishes a physiological model of the pulse wave combined with its energy for, afterwards, generating a fixed length vector containing the previous model's values with other variables related to the user like, for example, age, sex, height, weight, etc... This fixed length vector is used as an input of a function estimator system based on "random forests" for the calculation of the three variables of interest. The main advantage of this function estimator lies in that it does not impose any restriction beforehand over the function to be estimated, and it is also very reliable with heterogeneous data, as in the present invention's case.

Provided is a rice plant type quantitative design method integrating a crop virtual growth model. The crop virtual growth model is constructed, effective correlation and combination of the main plant physiological process, morphological structures and a light environmental model are achieved, and visual virtual growth of crop plants can be achieved; in the crop virtual growth model, morphologies of crops at different growth periods are set up through a structure model, a physiological model is used for realizing dynamic prediction of production, distribution and final yield of crop assimilates, and the light environmental model is used for computing crop canopy light radiation quantity and crop individual fractional interception of photosynthetic active radiation; the crop plant type structure is continuously changed through an optimization algorithm, so that simulation results of different adaption degrees are obtained, and the optimal crop plant type based on different targets can be obtained; the different adaption degrees are used as optimization results of the targets and set as morphological parameters of the virtual growth model, analog operation is carried out, horizontal and longitudinal comparison is carried out, and the optimal plant type data of crops are verified and determined.

A method and system for determining the position of a sound source in relation to a reference position, comprising the steps of generating a sound signal emitted from the sound source, detecting the emitted sound signal, processing the sound signal by the use of a physiological model of the ear, deducing at least one of lateral deviation in relation to the reference position, time delay of the sound signal from the sound source to the reference position, and the sound level of the detected sound signal.