Method and system for comprehensive patient-specific modeling of the heart

Abstract

A method and system for patient-specific modeling of the whole heart anatomy, dynamics, hemodynamics, and fluid structure interaction from 4D medical image data is disclosed. The anatomy and dynamics of the heart are determined by estimating patient-specific parameters of a physiological model of the heart from the 4D medical image data for a patient. The patient-specific anatomy and dynamics are used as input to a 3D Navier-Stokes solver that derives realistic hemodynamics, constrained by the local anatomy, along the entire heart cycle. Fluid structure interactions are determined iteratively over the heart cycle by simulating the blood flow at a given time step and calculating the deformation of the heart structure based on the simulated blood flow, such that the deformation of the heart structure is used in the simulation of the blood flow at the next time step. The comprehensive patient-specific model of the heart representing anatomy, dynamics, hemodynamics, and fluid structure interaction can be used for non-invasive assessment and diagnosis of the heart, as well as virtual therapy planning and cardiovascular disease management. Parameters of the comprehensive patient-specific model are changed or perturbed to simulate various conditions or treatment options, and then the patient specific model is recalculated to predict the effect of the conditions or treatment options.

Description

[0001] This application claims U.S. Provisional Application No. 61 / 366,294, filed July 21, 2010, U.S. Provisional Application No. 61 / 383,942, filed September 17, 2010, and U.S. Provisional Application No. 61 / 409,633, the disclosure of which is incorporated herein by reference. technical field [0002] The present invention relates to modeling the heart using medical images, and more particularly to patient-specific comprehensive modeling of the heart based on 4D medical image data. Background technique [0003] Heart disease is the leading cause of death for both men and women in the United States and accounts for no less than 30 percent of all deaths worldwide. Although medical advances in recent years have provided important improvements in the diagnosis and treatment of complex heart disease such as valvular disease, thoracic aortic aneurysm, and tetralogy of Fallot, premature onset still occurs in large numbers and death (morality). Large amounts of morphological and ...

AI Technical Summary

Problems solved by technology

But due to lags in data understanding, physicians are forced to make critically important decisions based on a limited range of measurements and methods

These limitations are due at least in part to the lack of efficient and accurate estimation of patient-specific parameters describing cardiac-aortic anatomy, physiology, and hemodynamics, and the absence of disease progression models

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