The invention discloses a system and a method of vehicle management based on Beidou satellite navigation. A vehicle-mounted Beidou positioning terminal comprises a microcontroller, a wireless communication module, a Beidou positioning module, a speed sensor, an accumulated driving time recording module, a fuel quantity detecting sensor, a fuel cutoff control interface, a fatigue detection device and an engine start-up / shutdown state detection device; a vehicle management server comprises a fatigue driving analysis and alarm module, a boundary violation alarm module, a remote fuel cutoff module, a sub-meter positioning and navigation service module and an all-time and all-weather navigation positioning and timing service module. The driver's accumulated driving time can be reliably recorded by a timer and a pressure sensor arranged on a driver's seat; the detection and identification of fatigue driving can be realized comprehensively in the combination of driver's sitting time on the driver's seat, clock-punching time, fatigue detection based on eyes' image identification and engine start / shutdown states; high accuracy and good reliability can be realized and the driver's fatigue driving state can be identified effectively.