37 results about "Ringers solution" patented technology

The invention discloses a human umbilical cord mesenchymal stem cell (HUMSC) anti-hepatic fibrosis injection and a preparation method thereof. The injection is composed of 10%-50% of human albumin stock solution, 49.5%-89.5% of acetated Ringer's solution and 0.5% of heparin calcium, wherein, the concentration of the human albumin stock solution is 10%, and 1ml of the injection contains 6*10<5>-7*10<5> HUMSCs. The preparation method comprises the following steps: providing an MSC preserving fluid and pre-cooling the MSC preserving fluid for later use, wherein, the MSC preserving fluid comprises the human albumin stock solution, the Acetated Ringer's solution and the heparin calcium; providing the HUMSCs and adding the HUMSCs to the MSC preserving fluid; and adjusting the number of the HUMSCs added to the MSC preserving fluid to be 6*10<5>-7*10<5> HUMSCs / ml by means of re-suspending. The injection provided by the invention has the advantages of obvious curative effect and high stability, and is convenient in storage and transport and safe in use, thus being capable of bringing gospel to patients with hepatic fibrosis.

Tissue (10) from the colon or bowel is pretreated with a Ringers solution and mounted onto a ring (12) submerged in oxygenated Ringers solution (32), with first and second current electrodes (34,36) and first and second voltage electrodes (38,40) positioned within the solution (32) closely adjacent the tissue. A sequence of current pulses of different frequencies (44) covering a broad frequency range are applied via electrodes (34,36) to the tissue and corresponding impedance and resistance values are obtained (46). Comparison of impedance / resistance values establishes separate and distinct ranges of values for normal, cancerous and premalignant tissues.

The invention provides a novel nanometer lipid carrier containing a taxol substance for injection and a method for preparing the same. Mixed lipids are used as materials; liquid lipid and solid lipid with different physical states are mixed according to the proportion of between 0 and 100 percent to obtain the nanometer lipid carrier (NLC) which is prepared by a mixed solid-liquid substrate and has different crystalline states; and microemulsion (ME) prepared by a full liquid substrate and solid lipid nanoparticles (SLC) prepared by a full solid substrate are also obtained. The new nanometer lipid carrier can increase or improve the encapsulation efficiency and the release property of drug and has the characteristics of high drug-loading amount, good stability and low toxicity. The taxol substance, a carrier material, a surfactant and injection water are respectively stirred to form two phases of oil and water; the oil phase and the water phase are mixed and emulsified to obtain primary emulsion; further taxol substance nanometer lipid carrier injection or suspension type injection which meets the requirement of intravenous injection is prepared by a high-pressure homogenization process; or a protective agent is added into the injection to prepare solid powder for injection by vacuum freeze drying or spray drying; before use, normal saline, a glucose solution or a Ringer solution is used for dilution; and the solid powder can be rapidly dissolved. Experiments show that the prepared nanometer lipid carrier containing the taxol substance for injection can improve targeting property to tumor cells, improve curative effect, greatly reduce toxic and side effects, has simple preparation process and low cost and is suitable for large-scaled industrialized production.

This invention prevents the danger of falling of body temperature by making the blood temperature similar to the body temperature in the injection of Ringer's solution fluid or blood transfusion, and also alleviates the patient's pain and improves the speed at which Ringer's solution fluid or blood enters the body. The warming device is much cheaper than previously released products, and small and light in weight, and allows blood or solution fluids to flow most effectively by allowing sufficient time for heat transfer as a pack type. The operation is convenient and sanitary in its single usage only. The inventive purpose has the methods of utilizing the temperature sensor in adjusting temperature by utilizing them PTC heating element's resistance specialty against the temperature as well as temperature sensor.

An eyelid scrub composition comprising polyhexamethylene biguanide (PHMB), 1,2-hexanediol, 1,2-octanediol, and a pH stabilizing surfactant solution present in an amount effective to control the pH level of the composition between 5.5 and 7.5. The composition can further comprise moisturizers and foam stabilizers. The composition can be combined with a fabric pad for use as an eyelid scrub, where the fabric pad is pre-moistened with the composition and packaged for use. The composition may be applied to the eyelid scrub and rubbed to induce foaming. The composition is produced by preparing a modified Ringer's solution and adding 1,2-hexanediol, 1,2-octanediol, and an effective amount of one or more pH stabilizing surfactants. The mixture is then heated and allowed to cool before polyhexamethylene biguanide is added.

An eyelid scrub composition comprising polyhexamethylene biguanide (PHMB), 1,2-hexanediol, 1,2-octanediol, and a pH stabilizing surfactant solution present in an amount effective to control the pH level of the composition between 5.5 and 7.5. The composition can further comprise moisturizers and foam stabilizers. The composition can be combined with a fabric pad for use as an eyelid scrub, where the fabric pad is pre-moistened with the composition and packaged for use. The composition may be applied to the eyelid scrub and rubbed to induce foaming. The composition is produced by preparing a modified Ringer's solution and adding 1,2-hexanediol, 1,2-octanediol, and an effective amount of one or more pH stabilizing surfactants. The mixture is then heated and allowed to cool before polyhexamethylene biguanide is added.

The invention relates to pelteobagrus fulvdraco sperm ultralow temperature freezing storage and recovery method. Parent pelteobagrus fulvdraco which is in good shape and good growth, has no disease and is sexually mature is selected, 30Mug / kg LHRH-A2 intraperitoneal injection is carried out to induce sperm increasing, after 36 hours, dissection is carried out to obtain spermary, and the spermary is cut into pieces in a clean mortar cooled in a refrigerator at 4 DEG C in advance, the pieces are diluted by Ringers solution in the proportion of 1:6, balancing is carried out for 30min at 4 DEG C, 10% methyl alcohol is added, and mixing to be uniform is carried out, packaging is carried out, balancing is carried out for 10min 6cm above liquid nitrogen surface, and balancing is carried out for 5min on the liquid nitrogen surface, and then the product is thrown into liquid nitrogen to be stored. Water bath ate 37 DEG C is carried out, activation solution SM is used for activation, pelteobagrus fulvdraco roe is extruded into a container, frozen sperm is added in drops in the sperm roe quantity ratio of 105:1, stirring to be uniform is carried out, then appropriate activation solution SM is added in drops, and stirring to be uniform is carried out, so that fertilization of roe is carried out. The sperm stored by the invention has high quality, has insemination capability and has important theoretical significance and application value on seed quality saving, inheritance breeding, sustainable culture and disease control of pelteobagrus fulvdraco.

The invention relates to the technology of chromosome operation, in particular to a method for inducing turbot homogenesis gynogenesis fry by using the theory that heredity inactivated sperms are used to perform artificial insemination and a fertilized ovum is restrained from cleavage through hydrostatic pressure. Sexually mature turbot parent fishes are selected, seminal fluid and spawn are collected respectively, insemination is performed on the seminal fluid and the spawn in a volume ratio of 1:100-200, and a control group is formed. The surplus seminal fluid is diluted by a precooled Ringer solution, and sperms are inactivated by ultraviolet rays. Insemination is performed on the inactivated seminal fluid and ova in a volume ratio of 1:10-20. In the 10-20 min before the first fertilized ovum crack appears, the fertilized ovum is placed in a hydrostatic press pressurizing vessel, and processing is performed by the hydrostatic pressure of 55-75 MPa for 6-8 min. Through the method, the 100% turbot homogenesis gynogenesis fry can be inducing obtained efficiently, stably and reliably.

The invention relates to the field of medicines, and particularly relates to an operation irrigating solution and a preparation method thereof. The irrigating solution comprises sodium hyaluronate and a solvent. The irrigating solution is characterized in that the solvent is normal saline, injection water, a ringer solution irrigating solution, a glucose irrigating solution, a mannitol irrigating solution, a chlorhexidine irrigating solution, a gentamycin normal saline irrigating solution, a povidone iodine irrigating solution, a bromogeramine irrigating solution, a glycine irrigating solution, a metronidazole irrigating solution or a physiological balanced solution; and the concentration of the sodium hyaluronate in the operation irrigating solution is 0.1-10g / L. The operation irrigating solution has the effects of operation irrigation, has functions of preventing adhesion and promoting wound healing after operation, and has the advantages of no toxic or side effect, good stability and excellent effect.

The invention discloses a method for preparing a functional artificial skin scaffold material. According to the method, gelatin having a relative molecular mass of over 10000 serving as a main base material, genipin serving as a crosslinking agent and deionized water, distilled water, normal saline, injection water or Ringer solution serving as a solvent are frozen and formed in a special forming mould by a temperature gradient formed in the vertical direction to obtain a porous material. According to the porous material having a skin biotic structure, a honeycomb porous structure is formed inside the material, the pore diameters are gradient from big to small from the lower surface to the upper surface, wherein the pore diameter of the upper surface is 5-70mu m, the pore diameter of the lower surface is 50-200mu m; adjacent holes are communicated. The preparation process is simple and easily controlled and has low manufacture cost; the prepared product has high and stable quality, has a skin simulation structure, and has excellent moisture absorption, biodegradability and biocompatibility.

The invention discloses a preparation method of a human skin simulation material with a three-dimensional gradient hole structure. The preparation method is characterized by taking sodium alginate or oxidized sodium alginate of which the relative molecular mass is more than 100,000 as a solute and deionized water, distilled water, normal saline, water for injection or ringer solution as a solvent, forming temperature gradient freezing molding in a dedicated forming die in the vertical direction, and then carrying out a cross-linking reaction, thus obtaining a porous material, wherein the inner part of the porous material is in a honeycomb shape, a plurality of numbers of holes are formed in the porous material, the pore diameter of each hole is respectively in gradient change from large to small from the lower surface to the upper surface, the pore diameter of the upper surface is 5 to 70 mum, the pore diameter of the lower surface of 50 to 200 mum, every two adjacent holes are communicated with each other, and the porous material has a skin simulation structure. According to the preparation method disclosed by the invention, the preparation technology is simple and is easy to control, the preparation cost is low, and a prepared product is good and stable in quality, has the skin simulation structure and has good water absorbing performance, good biodegradability and good biocompatibility.

A ganciclovir-sodium lactate liquid injection is proportionally prepared from ganciclovir or its derivative or its medicinal salt, sodium lactate, sodium chloride, potassium chloride, calcium chloride and the water for injection through dissolving carrier in the water for injection to obtain isotonic solution, dissolving ganciclovir in it, adding the water for injection, stirring, regulating pH=6.0-8.5, adding the water for injection, ultrafiltering to remove heat source, and high-pressure sterilizing.

The invention discloses an immune cell preparation. The preparation consists of immune cells and and an immune cell preservation re-infusion liquid which is free from dimethyl sulfoxide and dextran 40, wherein the immune cell preservation re-infusion liquid consists of the following components: an electrolyte solution which is isosmotic with plasma, a human serum albumin injection and a glucose injection, wherein the electrolyte solution is any one of a sodium chloride injection, a compound sodium chloride injection, a compound electrolyte injection and a lactated Ringer's solution. The immunecell preparation provided by the invention conforms to the characteristic that China is concentrated and dense in population; and the immune cell preparation is applicable to an immune cell preparation center close to a treatment agency, and the immune cell preparation only needs to be preserved at 4-15 DEG C. With the application of the immune cell preparation provided by the invention, in particular the chimeric antigen receptor T cell preparation, a preparation process can be simplified, logistics cost can be greatly reduced, the safety of the preparation can be improved and a treatment cycle can be shortened; therefore, treatment cost of the chimeric antigen receptor T cell preparation can be reduced, so as to benefit broad patients.

The invention belongs to the field of biological medicines, and discloses a microcarrier culture system of umbilical cord mesenchymal stem cells (MSC), and preparation and applications of an MSC preserving fluid. The microcarrier culture system is characterized by preparing a heparin crosslinking sephadex microcarrier and a mating microcarrier culture medium, and a high-efficiency MSC culture system can be built. MSC cells can be efficiently and fast prepared within a short period by utilizing the microcarrier culture system of the MSC. The MSC preserving fluid is characterized by adding human albumin, heparin sodium, estrogen and IL-1beta into a ringer solution, the cell activity of the MSC cells can be kept unchanged within 24 hours by utilizing the preserving fluid, and the level of cell factors can be improved by about five times on average. The microcarrier culture system is applied to being developed into large-batch preparation of umbilical cord MSC for clinical use and laboratories, and provides a specific preserving method for MSC for treating systemic lupus erythematosus, and establishes a basis for the clinical application of the MSC.

A medicinal fluid injector having branch lines to inject a ringer solution together with a treatment solution is provided. If the vein of the patient is clogged, the treatment solution is not injected into the patient, but flows back into the ringer solution, which is injected into the patient through a free fall scheme. If the vein is open, the medicinal fluid is excessively injected at a time, causing fatal accident to the patient. To solve this problem, a check valve is installed in an injection tube to prevent the medicinal fluid or the blood from flowing back into the ringer solution even if pressure difference occurs in the medicinal fluid injector. If the medicinal fluid stagnates, an alarm is generated to notify medical staffs of the emergency, so that medicinal fluid injector is safely used.

An eyelid scrub composition comprising polyhexamethylene biguanide (PHMB), 1,2-hexanediol, 1,2-octanediol, and a pH stabilizing surfactant solution present in an amount effective to control the pH level of the composition between 5.5 and 7.5. The composition can further comprise moisturizers and foam stabilizers. The composition can be combined with a fabric pad for use as an eyelid scrub, where the fabric pad is pre-moistened with the composition and packaged for use. The composition may be applied to the eyelid scrub and rubbed to induce foaming. The composition is produced by preparing a modified Ringer's solution and adding 1,2-hexanediol, 1,2-octanediol, and an effective amount of one or more pH stabilizing surfactants. The mixture is then heated and allowed to cool before polyhexamethylene biguanide is added.

The invention relates to an artificial induced spawning technology, in particular to an efficient loach artificial fertilization technology. The efficient loach artificial fertilization technology particularly comprises the following steps of determining the induced spawning date, determining the proportion of males and females, preparing and spraying medicine soup, carrying out prevention before induced spawning and injecting odinagogue, wherein the time is 15-20 hours, the water temperature is determined to range from 20 DEG C to 25 DEG C, loach is wrapped with a towel, a mixture of 0.1-0.2 milliliter is injected to each piece of loach, and the mixture includes 75% of chorionic gonadotropin and 25% of a Ringer solution. The efficient loach artificial fertilization technology has the advantages that the loach absorbs the medicine soup before induced spawning is carried out, so that the quality of seminal fluid and eggs is improved, the loach is better protected through a prevention mixture, the amount of survival young loach is large, yield is high, and the efficient loach artificial fertilization technology is unique, simple, good in effect and easy to popularize in family cultivation.

The invention discloses a method for increasing the transcaucasian barb artificial reproduction fertility rate. The method comprises the following steps of 1, parent fish preparation; 2, artificial hormone injection, wherein a two-time injection method is adopted for performing artificial hormone injection, and the time interval between two times of needle injection is 24 h; according to the female transcaucasian barb injection dosage, the first-time injection dosage is 4 micrograms per kilogram of parent transcaucasian barb, and the second-time injection dosage is 4 micrograms of LRH-A, 800 IU of HCG, 3-5 of PG and 2,800 IG of LRH-A per kilogram of parent transcaucasian barb, and the male transcaucasian barb injection dosage is 1 / 2 of the female transcaucasian barb injection dosage; 3, artificial insemination; 4, micro running water culture fertility rate. The two-time injection method is adopted for artificial injection, and the time interval is 24 h; a semidry method is adopted for artificial insemination, a certain amount of ringer solution is added, and the transcaucasian barb artificial reproduction fertility rate can be remarkably increased, so that the key technical problem of transcaucasian barb artificial reproduction is solved, and then guarantees are provided for fry culture and commercial fish artificial reproduction.

The invention provides an injection containing bone marrow mesenchymal stem cells. The injection containing the bone marrow mesenchymal stem cells is mainly prepared by mixing serum, a ringer's solution, glucose, glycine, selenylation astragalus polysaccharide, lentinan and the bone marrow mesenchymal stem cells, has no toxic side effects and is good in safety. The injection has sodium and potassium elements needed for the body due to the presence of ringer's solution. The glycine can remove free radicals in the body and promote the paracrine effect of stem cell secretory factors. The selenylation astragalus polysaccharide and the lentinan can prolong the duration of continuous action of the stem cell secretory factors and enhance a non-specific immune function of the body.

The invention relates to a wound dressing (2) for wound treatment in a damp environment. The wound dressing comprises a fibre fleece-based suction / irrigation body (4) in which a super absorbent material is accommodated in a distributed manner, wherein the suction / irrigation body (4) is supplied with a salt-containing aqueous solution, particularly a Ringer's solution, preferentially a solution comprising antibacterial compounds, by the manufacturer, and comprises a packaging (6) forming the outer visible sides of the wound dressing. The packaging (6) comprises a layer (9) made from a flat textile material, especially a braided fabric, a textile fabric or a fabric, on the side of the wound dressing facing the wound. The layer (9) made from the flat textile material on the side facing the wound comprises an outer-side, partially and structurally applied atraumatically effective coating (22) made of silicone preferentially and having a degree of coverage of at most 70 %. The wound dressing is characterized in that the packaging (6) comprises a fibre fleece layer (12) on the side of the wound dressing facing away from the wound, which forms the outer visible side (14) of the wound dressing facing away from the wound, a liquid-impermeable plastic film layer (16) is arranged on the side of the fibre fleece layer (12) facing the wound, and the fibre fleece layer (12), the plastic film layer (16), the suction / irrigation body (4) and the layer (9) made from the flat textile material are not connected extensively to one another, but rather lie with the flat sides thereof loosely and movably against one another and are only connected with one another along the peripheral edges (18) of same by means of a joint connection.

The invention discloses an instrument bag for fast building tissue engineering skin. The instrument bag comprises a bag body and surgical supplies arranged in the bag body, and the surgical supplies comprise digestive enzyme solution freeze-dried powder, decellularized allosome dermis stroma, a No.23 surgical knife blade, dressing forceps, an injector, an injector needle, a first sodium lactate Ringer solution, a second sodium lactate Ringer solution, a filter screen, sterile water and a micro heater. The instrument bag has the advantages of being fast, needing no cell subculturing, achieving one-time complement, being fast in built tissue engineering skin union and capable of restoring the function of the skin and the like.

A process for preparing bioceramics beta-TCP with flaky cleavage grain structure includes proportionally mixing bihydrated calcium hydrogen phosphate with calcium carbonate, heating to 930 deg.C, holding the temp for 3 hr, suddenly cooling in liquid nitrogen, suddenly heating to 930 deg.C, natural cooling, immersing in original Ringer solution at 37 deg.C for 7 days, and drying. The said bioceramics can be easily degradated in human body.

The invention discloses a preparation of a platelet washing solution. The platelet washing solution comprises two solutions as follows: 500ml of a bicarbonate Ringer solution and 20-30ml of an ACD-A anticoagulant. The platelet washing solution prepared from 500ml of the bicarbonate Ringer solution and 25ml of the ACD-A anticoagulant is optimal in washing effect. According to the preparation of the platelet washing solution, two solutions with permission to the clinical application at present are mixed at a certain ratio; the platelet washing solution is used for washing and preparing plasma-poor platelet; by virtue of the clinical application of the plasma-poor platelet, the untoward effects of platelet transfusion caused by plasma proteins can be solved. The platelet washing solution is simple in components and liable to depolymerize; the recovery rate of the platelet is increased; the agglomeration force is improved; the safety is guaranteed.

The invention discloses Ringer's solution for animals. The composition and ratio of raw materials are as follows: VA with a content of 50%, VD3 with a content of 52.5%, VK3 with a content of 0.96%, VB1 with a content of 1%, and a content of 0.8 % VB2, 0.98% VB6, 0.01% VB12, 0.98% L‑VC, 0.98% Niacin, 0.98% Folic Acid, 0.8% Calcium Pantothenate, The content is 0.02% biotin, 0.01% sodium selenite, NaCl, KCl, sodium citrate, no fruit sugar, and the weight ratio is disclosed. The invention also discloses a preparation method. It solves the problems of increasing animal sub-health groups, body fluid imbalance and electrolyte disorder, serious imbalance of yin and yang, and limited productivity.

The invention discloses a liver preservation solution which contains the following components in per 100ml: 7-8g of 1,6-fructose diphosptate, 1-2g of glutathione, 2-3g of allopurinol, 0.3-0.5g of traditional Chinese medicine ligustrazine, 8-12mg of traditional Chinese medicine anisodamine and the balance of Ringer's solution added to 100ml. Proved by a large number of experiments, the liver preservation solution has a statistical meaning compared with an experiment contrast group, and two treatment groups (a group of the invention and an American UW treatment group) do not have the statistical meaning. The invention provides an excellent guarantee for long-acting liver preservation, has simple prescription and saves production and inspection cost for production and clinical application.

The invention relates to the technology of chromosome operation, in particular to a method for inducing turbot homogenesis gynogenesis fry by using the theory that heredity inactivated sperms are used to perform artificial insemination and a fertilized ovum is restrained from cleavage through hydrostatic pressure. Sexually mature turbot parent fishes are selected, seminal fluid and spawn are collected respectively, insemination is performed on the seminal fluid and the spawn in a volume ratio of 1:100-200, and a control group is formed. The surplus seminal fluid is diluted by a precooled Ringer solution, and sperms are inactivated by ultraviolet rays. Insemination is performed on the inactivated seminal fluid and ova in a volume ratio of 1:10-20. In the 10-20 min before the first fertilized ovum crack appears, the fertilized ovum is placed in a hydrostatic press pressurizing vessel, and processing is performed by the hydrostatic pressure of 55-75 MPa for 6-8 min. Through the method, the 100% turbot homogenesis gynogenesis fry can be inducing obtained efficiently, stably and reliably.

The invention discloses a preparation method of a human skin simulation material with a three-dimensional gradient hole structure. The preparation method is characterized by taking sodium alginate or oxidized sodium alginate of which the relative molecular mass is more than 100,000 as a solute and deionized water, distilled water, normal saline, water for injection or ringer solution as a solvent, forming temperature gradient freezing molding in a dedicated forming die in the vertical direction, and then carrying out a cross-linking reaction, thus obtaining a porous material, wherein the inner part of the porous material is in a honeycomb shape, a plurality of numbers of holes are formed in the porous material, the pore diameter of each hole is respectively in gradient change from large to small from the lower surface to the upper surface, the pore diameter of the upper surface is 5 to 70 mum, the pore diameter of the lower surface of 50 to 200 mum, every two adjacent holes are communicated with each other, and the porous material has a skin simulation structure. According to the preparation method disclosed by the invention, the preparation technology is simple and is easy to control, the preparation cost is low, and a prepared product is good and stable in quality, has the skin simulation structure and has good water absorbing performance, good biodegradability and good biocompatibility.

A process for preparing bioceramics beta-TCP with flaky cleavage grain structure includes proportionally mixing bihydrated calcium hydrogen phosphate with calcium carbonate, heating to 930 deg.C, holding the temp for 3 hr, suddenly cooling in liquid nitrogen, suddenly heating to 930 deg.C, natural cooling, immersing in original Ringer solution at 37 deg.C for 7 days, and drying. The said bioceramics can be easily degradated in human body.