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Preparation of platelet washing solution

A washing solution and platelet technology, applied in the medical field, can solve the problems of infusion safety and complex components, and achieve the effect of solving adverse reactions of infusion, simple components, and improved recovery rate

Inactive Publication Date: 2015-06-17
王丹 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Self-made cleaning solutions with various formulas are complex and self-prepared, so the safety of infusion cannot be guaranteed

Method used

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  • Preparation of platelet washing solution
  • Preparation of platelet washing solution
  • Preparation of platelet washing solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] In the embodiment of the present invention, when preparing the platelet washing liquid, two liquids are used: 1) bicarbonated Ringer's solution (BRS), Otsuka Pharmaceutical 500ml package, containing: 2.92g NaCl, 0.15g KCl, 0.11g CaCl 2 2H 2 O, 0.10g MgCl 2 ·6H 2 O, 1.175g NaHCO 3 , 0.10g sodium citrate dihydrate. 2) ACD-A anticoagulant (Shandong Weigao), 1000ml package, containing: 22g trisodium citrate dihydrate, 8g citric acid monohydrate, 24.5g glucose monohydrate.

[0013] Preparation method: Mix 20ml of ACD-A anticoagulant with 500ml of BRS to make BRS-A solution, which is to prepare platelet washing solution for this research. The above two liquids are clinically approved drugs, mixed in sterile connection, can be used for washing platelets, and can be used directly in clinic.

[0014] Platelet washing and detection: After uniformly mixing 2 parts of apheresis platelets with the same ABO blood type, divide them into 2 parts, one part is used as a control, an...

Embodiment 2

[0018] In the embodiment of the present invention, when preparing the platelet washing solution, 25ml of ACD-A anticoagulant was mixed with 500ml of BRS to form a BRS-A solution, which was the configured platelet washing solution of the present invention. The above two liquids are clinically approved drugs, mixed in sterile connection, can be used for washing platelets, and can be used directly in clinic. Other specific steps are the same as those in Embodiment 1, and will not be repeated here. The results are shown in Table 2.

[0019] Table 2

[0020]

Embodiment 3

[0022] In the embodiment of the present invention, when preparing platelet washing liquid, get 30ml ACD-A anticoagulant and mix with 500ml BRS, configure BRS-A solution, promptly configure platelet washing liquid for this research institute. Other specific steps are the same as those in Embodiment 1, and will not be repeated here. The results are shown in Table 3.

[0023] table 3

[0024]

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PUM

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Abstract

The invention discloses a preparation of a platelet washing solution. The platelet washing solution comprises two solutions as follows: 500ml of a bicarbonate Ringer solution and 20-30ml of an ACD-A anticoagulant. The platelet washing solution prepared from 500ml of the bicarbonate Ringer solution and 25ml of the ACD-A anticoagulant is optimal in washing effect. According to the preparation of the platelet washing solution, two solutions with permission to the clinical application at present are mixed at a certain ratio; the platelet washing solution is used for washing and preparing plasma-poor platelet; by virtue of the clinical application of the plasma-poor platelet, the untoward effects of platelet transfusion caused by plasma proteins can be solved. The platelet washing solution is simple in components and liable to depolymerize; the recovery rate of the platelet is increased; the agglomeration force is improved; the safety is guaranteed.

Description

technical field [0001] The invention relates to the medical field, in particular to a platelet washing liquid formula. Background technique [0002] Platelet transfusion is suitable for the prevention and treatment of bleeding in patients with thrombocytopenia or platelet function deficiency, and is an important supportive therapy in clinical practice. Platelets currently used clinically are suspended in plasma, containing a certain amount of plasma protein, leukocytes and other biologically active substances, which are the main cause of adverse reactions to blood transfusions. Some patients may experience varying degrees of allergic reactions, abnormal Hemolytic febrile reactions, and even transfusion-related acute lung injury, may pose a fatal risk to patients, and there are concerns about re-treatment with blood products. [0003] The use of machine-collected and washed platelets in patients with reactions can avoid the recurrence of such reactions. At present, the main...

Claims

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Application Information

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IPC IPC(8): C12N5/078
Inventor 王丹邓小军
Owner 王丹
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