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43 results about "Reproductive disease" patented technology
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Reproductive system disease, any of the diseases and disorders that affect the human reproductive system. They include abnormal hormone production by the ovaries or the testes or by other endocrine glands, such as the pituitary, thyroid, or adrenals.
Method of producing a vaccine which raises an immunological response against a virus causing a porcine respiratory and reproductive disease
InactiveUS6251404B1Efficient responseAntibacterial agentsSsRNA viruses positive-senseInfectious agentRespiratory disease
The present invention provides a vaccine which protects pigs from a virus and / or an infectious agent causing a porcine respiratory and reproductive disease, a method of protecting a pig from a disease caused by a virus and / or an infectious agent which causes a respiratory and reproductive disease, a method of producing a vaccine against a virus and / or an infectious agent causing a porcine reproductive and respiratory disease, and a biologically pure sample of a virus and / or infectious agent associated with a porcine respiratory and reproductive disease, particularly the Iowa strain of porcine reproductive and respiratory syndrome virus (PRRSV), and an isolated polynucleotide which is at least 90% homologous with a polynucleotide obtained from the genome of a virus and / or infectious agent which causes a porcine respiratory and reproductive disease.
Owner:ZOETIS WHC 2
Isolated porcine respiratory and reproductive virus, vaccines and methods of protecting a pig against a disease caused by a porcine respiratory and reproductive virus
InactiveUS6110467AEfficient responseAntibacterial agentsSsRNA viruses positive-senseInfectious agentRespiratory disease
The present invention provides a vaccine which protects pigs from a virus and / or an infectious agent causing a porcine respiratory and reproductive disease, a method of protecting a pig from a disease caused by a virus and / or an infectious agent which causes a respiratory and reproductive disease, a method of producing a vaccine against a virus and / or an infectious agent causing a porcine reproductive and respiratory disease, and a biologically pure sample of a virus and / or infectious agent associated with a porcine respiratory and reproductive disease, particularly the Iowa strain of porcine reproductive and respiratory syndrome virus (PRRSV), and an isolated polynucleotide which is at least 90% homologous with a polynucleotide obtained from the genome of a virus and / or infectious agent which causes a porcine respiratory and reproductive disease.
Owner:ZOETIS WHC 2
Cattle reproductive disease vaccines
InactiveUS20070298053A1Avoid infectionAntibacterial agentsSsRNA viruses negative-senseBovine Viral Diarrhea VirusesVirus type
The present invention relates to combination vaccines and methods for treating or preventing diseases or disorders in an animal caused by infection by Bovine Viral Diarrhea Virus (BVDV) Types 1 and 2, Bovine Herpes Virus Type-1 (BHV-1), Bovine Respiratory Syncytial Virus (BRSV), Parainfluenza Virus (PI3), Campylobacter fetus, Leptospira canicola, Leptospira grippotyphosa, Leptospira hardj-prajitno, Leptospira icterohaemmorrhagiae, Leptospira hardjo-bovis and Leptospira pomona by administering to the animal an effective amount of a combination vaccine. The combination vaccine can be a whole or partial cell inactivated or modified live preparation.
Owner:PFIZER INC
Indoledione derivative
ActiveUS20100056597A1Enhanced inhibitory effectBiocideOrganic active ingredientsReproductive system diseaseDigestive tract disease
A compound represented by the general formula (I-a):[wherein R1a and R2a each means hydrogen, lower cycloalkyl, lower alkyl, etc.; R3a means hydrogen, lower cycloalkyl, lower alkyl, etc.; R4a and R5a each means lower alkyl, lower cycloalkyl, etc. or R4a and R5a are bonded to each other to form lower cycloalkylidene; and R6a means lower alkyl, lower haloalkyl, etc.]. This compound functions as an LCE inhibitor and is useful as a therapeutic agent for various circulatory diseases, nervous diseases, metabolic diseases, reproductive diseases, digestive tract diseases, neoplasm, infectious diseases, etc.
Owner:MSD KK
Applications of cyanidin-3-O-glucoside in preparation of medicines treating diseases caused by 3-chloropropane-1,2-diol
InactiveCN107485616AImprove growth retardationAntagonistic destructionOrganic active ingredientsAccessory food factorsDiseaseEpithelium
Applications of cyanidin-3-O-glucoside in preparation of medicines treating and / or preventing diseases caused by 3-chloropropane-1,2-diol are provided. The cyanidin-3-O-glucoside (C3G) can improve rat ingestion decrease and growth retardation which are caused by 3-MCPD poisoning, can effectively resist rat antioxidant system damage caused by 3-MCPD poisoning, and can activate and adjust BTB structural functions of sustentacular cells through inhibiting an MAPK signaling pathway, thus relieving seminiferous epithelium injuries caused by the 3-MCPD, maintaining stability of a spermatogenic microenvironment, regulating spermatogenic cell proliferation and differentiation, and improving dyszoospermia. In addition, the C3G can improve sperm activity through adjusting sperm energy metabolism related enzymes. The C3G can regulate rat sex hormone secretion disorders caused by 3-MCPD poisoning and can maintain normal levels of sex hormone in serum and androgen in testis inner environments. The applications provide theoretical foundations for 3-MCPD reproduction toxicity nutritional intervention utilizing anthocyanin.
Owner:JINAN UNIVERSITY
Novel FSH-Fc fusion protein as well as preparation method and application thereof
ActiveCN106496331AEasy to prepareProlong half-life in vivoPeptide/protein ingredientsAntibody mimetics/scaffoldsFollicle-stimulating hormoneHalf-life
The invention belongs to the field of human reproductive disease treatment and assisted reproduction and relates to a novel long-acting follicle stimulating hormone (FSH) and a preparation method and application thereof to assisted reproduction. In the invention, under the double actions of non-covalent combination between an FSH [alpha] subunit and an FSH [beta] subunit and holes type and knobs type Fc knobs-into-holes buckle structures, a stable FSH fusion protein in a form of a heterodimer is folded. The novel long-acting FSH fusion protein provided by the invention not only realizes the goals of keeping the activity of the natural FSH and introducing an Fc fragment to prolong the half-life period of the FSH, but also overcomes the defect of a production process for recombination of the FSH-Fc fusion protein caused by the use of the homologous Fc fragment, thereby having a high practical value.
Owner:泰泽惠康生物医药有限责任公司
Methods for preventing cattle reproductive diseases
InactiveUS20070154943A1Avoid infectionAntibacterial agentsSsRNA viruses negative-senseBovine Viral Diarrhea VirusesHeifer calf
The present invention relates to methods for treating or preventing diseases or disorders in a pregnant cow and calf nursing a pregnant cow caused by infection by Bovine Viral Diarrhea Virus (BVDV) Types 1 and 2, Bovine Herpes Virus Type-1 (BHV-1), Bovine Respiratory Syncytial Virus (BRSV), Parainfluenza Virus (PIV3), Campylobacter fetus, Leptospira canicola, Leptospira grippotyphosa, Leptospira hardj-prajitno, Leptospira icterohaemmorrhagiae, Leptospira hardjo-bovis and Leptospira pomona by administering to the animal an effective amount of a safe modified live viral combination vaccine further combined with a multivalent bacterin vaccine.
Owner:ZOETIS SERVICE LLC
GPR1 antagonistic polypeptide and derivative and application thereof
ActiveCN109942670APrevent proliferationPromote apoptosisPeptide/protein ingredientsMetabolism disorderAmino acid side chainChemerin
The invention discloses a GPR1 antagonistic polypeptide and a derivative and application thereof and particularly relates to a GPR1 antagonistic polypeptide shown in SEQ ID No.1-3 and a derivative thereof. The derivative of the binding peptide is a product obtained in the mode that conventional modification is conducted on a GPR1 binding peptide amino acid side chain group and an amino terminal ora carboxyl terminal of a GPR1 antagonistic polypeptide fragment or a product obtained in the mode that a label for detection or purification of polypeptide or protein is linked to the GPR1 antagonistic polypeptide. The binding peptide and the derivative thereof can be combined with GPR1 in vitro, by stopping combination of chemerin and GPR1, increase of the cAMP concentration is promoted, the (Ca2+) influx caused by chemerin is inhibited, proliferation of breast cancer cells can be inhibited, the cell cycle of the breast cancer cells is blocked, apoptosis of the breast cancer cells is promoted, effective micromolecule treatment drugs are provided for female reproductive diseases such as breast cancer, and the GPR1 antagonistic polypeptide can be widely applied in the fields of medicine and biology.
Owner:SHENZHEN INST OF ADVANCED TECH
Toxin transforming and bacteria removing Chinese medicine composition for treating reproductive diseases and preparation method of Chinese medicine composition
ActiveCN102764394ASignificant effectHeavy metal active ingredientsSexual disorderBiotechnologyRhizome
The invention discloses a toxin transforming and bacteria removing Chinese medicine composition for treating reproductive diseases and a preparation method of the Chinese medicine composition. The toxin transforming and bacteria removing Chinese medicine composition for treating the reproductive diseases is mainly prepared with raw materials including, by weight, 35-45 parts of Chinese yam, 35-45 parts of wild chrysanthemum, 35-45 parts of calcined talc schist, 35-45 parts of calcined actinolite, 25-35 parts of epimedium, 25-35 parts of honeysuckle, 25-35 parts of golden cypress, 15-25 parts of china root, 15-25 parts of Szechuan peppers, 15-25 parts of dandelion, 15-25 parts of leonurus, 15-25 parts of atratylodes rhizome, 25-35 parts of herba violae, 25-35 parts of fructus forsythiae, 25-35 parts of areca nut, 35-45 parts of ginseng, 25-35 parts of astragalus, 10-20 parts of red flower, 25-35 parts of spreading hedyotis herb, 10-20 parts of liquorice, 10-20 parts of eupatorium, 15-25 parts of plantain seed, 25-35 parts of dittany bark, 25-35 parts of selinum japenious seed, 25-35 parts of kuh-seng and 65-75 parts of mirabilite. By the aid of the Chinese medicine composition for treating the reproductive diseases, the curative ratio is higher than 90%, the effective rate is 98%, and the recurrence rate of the reproductive diseases treated by a traditional method is reduced from the original 80% to less than 20%, so that the Chinese medicine composition for treating the reproductive diseases has remarkable treatment effects.
Owner:孟文彦
Artificial insemination method for breeding rabbit feeding
InactiveCN102204847AReduce feedingAvoid direct contactAnimal reproductionEconomic benefitsFemale rabbit
The invention relates to an artificial insemination method for breeding rabbit feeding, which comprises the following steps of: preparation in a laboratory, selection of breeding rabbits, preparation before semen collection, processing of seminal liquid, semen deposition and the like. By using the method, the feeding number of male rabbits can be decreased, wastes are reduced, the feeding and management of breeding rabbit crowds are facilitated, the labor productivity is increased, and thus, the feeding cost is decreased and the economic benefit is increased; the utilization rate of excellent breeding male rabbits is improved, because the number of the male rabbits required in artificial insemination is decreased, the selection intensity is enhanced to make full use of the male rabbits with best quality, and an obvious effect of improving the genetic constitution of offspring is achieved; and the male rabbits and the female rabbits are prevented from direct contact, so that the spreading of various diseases, especially reproductive diseases, is prevented.
Owner:QINGDAO KANGDA LVBAO FOOD
Cattle Reproductive Disease Vaccines
ActiveUS20100266629A1Avoid infectionSsRNA viruses negative-senseAntibacterial agentsBovine Viral Diarrhea VirusesGenus Campylobacter
The present invention relates to combination vaccines and methods for treating or preventing diseases or disorders in an animal caused by infection by Bovine Viral Diarrhea Virus (BVDV) Types 1 and 2, Bovine Herpes Virus Type-1 (BHV-1), Bovine Respiratory Syncytial Virus (BRSV), Parainfluenza Virus (PI3), Campylobacter fetus, Leptospira canicola, Leptospira grippotyphosa, Leptospira hardj-prajitno, Leptospira icterohaemmorrhagiae, Leptospira hardjo-bovis and Leptospira pomona by administering to the animal an effective amount of a combination vaccine. The combination vaccine can be a whole or partial cell inactivated or modified live preparation.
Owner:ZOETIS SERVICE LLC
CMKLR1 antagonistic polypeptide and derivative and application thereof
ActiveCN109942684APrevent proliferationPromote apoptosisPeptide/protein ingredientsAntipyreticAmino acid side chainBinding peptide
The invention discloses a CMKLR1 antagonistic polypeptide and a derivative and application thereof and particularly relates to a CMKLR1 antagonistic polypeptide shown in SEQ ID No.1-24 and a derivative thereof. The derivative of the binding peptide is a product obtained in the mode that conventional modification is conducted on a CMKLR1 binding peptide amino acid side chain group and an amino terminal or a carboxyl terminal of a CMKLR1 antagonistic polypeptide fragment or a product obtained in the mode that a label for detection or purification of polypeptide or protein is linked to the CMKLR1antagonistic polypeptide. The binding peptide and the derivative thereof can be combined with CMKLR1 in vitro, by stopping combination of chemerin / RvE1 and CMKLR1, increase of the cAMP concentrationis promoted, the calcium influx caused by chemerin and cell chemotaxis caused by chemerin are inhibited, proliferation of ovarian carcinoma cells can be inhibited, apoptosis of the ovarian carcinoma cells is promoted, and effective micromolecule treatment drugs are provided for female reproductive diseases such as ovarian cancer.
Owner:SHENZHEN INST OF ADVANCED TECH
Methods for reducing cattle reproductive diseases
InactiveUS7563449B2Avoid infectionSsRNA viruses negative-senseAntibacterial agentsBovine Viral Diarrhea VirusesIndividual animal
The present invention relates to methods for treating or preventing diseases or disorders in a pregnant cow and calf nursing a pregnant cow caused by infection by Bovine Viral Diarrhea Virus (BVDV) Types 1 and 2, Bovine Herpes Virus Type-1 (BHV-1), Bovine Respiratory Syncytial Virus (BRSV), Parainfluenza Virus (PIV3), Campylobacter fetus, Leptospira canicola, Leptospira grippotyphosa, Leptospira borgpetersenii hardjo-prajitno, Leptospira icterohaemorrhagia, Leptospira hardjo-bovis and Leptospira pomona by administering to the animal an effective amount of a safe modified live viral combination vaccine further combined with a multivalent bacterin vaccine.
Owner:ZOETIS SERVICE LLC
Application of NSC-156529 as T-type calcium channel antagonist
The invention discloses an application of a compound NSC-156529 in preparation of a T-type calcium channel antagonist. The compound inhibits the T-type calcium channel current in a dose-dependent manner through non-G-protein and non-Akt dependent ways. The T-type calcium channel antagonist drug containing the NSC-156529 structure can be constructed to be used for treating or preventing neuropsychiatric diseases (such as primary tremor, prosopalgia, cancer pain, schizophrenia, epilepsy, Parkinson's disease and depression) and reproductive diseases (such as varicocele infertility and sexual dysfunction) related to T-type calcium channel dysfunction.
Owner:SUZHOU UNIV
Polypeptide having Anti-angiogenic activity
InactiveUS20090270314A1Reduce molecular weightUseful in therapySenses disorderNervous disorderVascular diseaseVascular endothelium
The present inventors found out four kinds of fragments (42 kD, 36 kD, 32 kD, 27 kD) by forcibly expressing vasohibin in a vascular endothelial cell. The present inventors analyzed those fragments and, as a result, found out low molecular weight vasohibin which has an anti-angiogenic activity. The low molecular weight vasohibin is useful as a therapeutic agent for various diseases such as a vascular disease associated with angiogenesis, an inflammatory disease, an entoptic neovascular disease, a reproductive disease, a central nervous system disease and cancer and the like. In addition, the low molecular weight vasohibin is also useful as a marker for angiogenesis.
Owner:SHIONOGI & CO LTD +1
Methods for preventing cattle reproductive diseases
InactiveUS20070172877A1Avoid infectionSsRNA viruses negative-senseAntibacterial agentsBovine Viral Diarrhea VirusesHeifer calf
Owner:PFIZER INC +1
Traditional Chinese medicine feed additive for improving reproductive capacity of male horses
InactiveCN111034866AImprove conception rateReduce lossesFood processingAnimal feeding stuffBiotechnologyAgastache rugosa
The invention discloses a traditional Chinese medicine feed additive for improving reproductive capacity of male horses, which is prepared by the following method: 15g of morinda officinalis, 10g of cistanchedeserticola, 10g of semen cuscutae, 20g of cinnamon, 60g of Chinese yam, 10g of flatstem milkvetch seed, 20g of monkshood, 20g of dried orange peel, 35g of poriacocos, 40g of Lycium barbarum,10 g of radix rehmanniaepreparata, 30 g of caulis akebiae, 30 g of radix aucklandiae, 30 g of wrinkled gianthyssop herb, 40 g of lotus paste and 100 g of honey. The traditional Chinese medicine feed additive for improving the reproductive capacity of the male horses, provided by the invention, can ensure the reproductive capacity of the male horses and treatment reproductive diseases of the male horses, so that the conception rate of the female horses is increased and the loss is reduced.
Owner:JILIN UNIV
CMKLR1 antagonistic polypeptide and derivatives and application thereof
ActiveCN109942682APrevent proliferationPromote apoptosisPeptide/protein ingredientsMetabolism disorderAmino acid side chainChemerin
The invention discloses a CMKLR1 antagonistic polypeptide and derivatives and application thereof, and particularly relates to analogs of the CMKLR1 antagonistic polypeptide shown in sequences SEQ IDNO.1-17 and derivatives thereof. The derivatives of the binding peptide are products obtained after conventional modification of amino terminals or carboxyl terminals on CMKLR1 binding peptide amino acid side chain groups and CMKLR1 antagonistic polypeptide fragments. The binding peptide and the derivatives thereof can be bonded with CMKLR1 in vitro, and by blocking the bond of chemerin and CMKLR1, cAMP concentration increase is promoted, calcium influx caused by chemerin is inhibited and cell chemotaxis caused by chemerin is inhibited. Besides, proliferation of ovarian cancer cells can be inhibited, the cell cycle is blocked, apoptosis of the ovarian cancer cells is promoted, and effective small-molecular treatment drugs are provided for female reproductive diseases such as ovarian cancer.
Owner:SHENZHEN INST OF ADVANCED TECH
Lys-pro-val dimer, formulations and applications
The present invention is directed to a system for treating uro-genital conditions. One aspect of this invention involves the treatment system comprising one or more polypeptides with a amino acid sequence including KPV (SEQ. ID. NO. 1), MEHFRWG (SEQ. ID. NO. 2) HFRWGKPV (SEQ. ID. NO. 3), SYSMEHFRWGKPV (SEQ. ID. NO. 4), for treatment of uro-genital conditions. The one or more polypeptides can also be a dimer formed from any of the amino acid sequence above. Uro-genital conditions can include infections, inflammation, or both. In one preferred embodiment of the invention, the uro-genital condition includes infection and / or inflammation of the vagina, vulva, urinary tract, penis, and / or the rectum. In another preferred embodiment of the invention, the one or more polypeptides are dissolved in a carrier. In another preferred embodiment of the invention, the one or more polypeptides are associated with a tampon for preventing toxic shock syndrome. In another preferred embodiment, the one or more polypeptides are associated with a contraceptive for prevention of sexually transmitted diseases or infections. In another preferred embodiment, the one or more polypeptides are associated with a suppository for insertion into the vagina or rectum.
Owner:CATANIA ANNA P +1
Breeding method for improving reproductive rate of beef cattle
InactiveCN109169496AReduce aging deathDeep insemination siteFood processingAnimal feeding stuffLivestock breedingLiving environment
The invention discloses a breeding method for improving the reproductive rate of beef cattle and relates to the technical field of livestock breeding. The method comprises the methods of (1) cattle herd structure adjustment, wherein the adjustment at the end of a year is 80% of basic cattle, 10% of reserved cattle and 10% of bred cattle, (2) breeding control including (a) the selection of high-quality breeding cattle, (b) the nutritional supply of female beef cattle, (c) reproductive disease control, (d) estrus identification and breeding insemination, (3) fetus protection after insemination including feeding management, environmental control and appropriate exercise, (4) pregnancy check and re-examination and secondary insemination, performing pregnancy check after 20 days to 1 month of female cattle insemination, and performing complementary insemination non-pregnant female cattle, and (5) delivery and postpartum care. According to the method, the purpose of improving the reproductive rate of the beef cattle is achieved by the strict control of the living environment of the pregnant cattle, timely insemination and post-natal care and the strengthened management of the aspects ofmaternal health, conception rate, and complementary insemination for non-pregnancy.
Owner:马边下溪镇青山莲畜禽养殖专业合作社
Organic anion transport protein TCH229
InactiveUS7355001B2Reduced expression levelBoost expression levelOrganic active ingredientsCell receptors/surface-antigens/surface-determinantsBovine respiratory diseaseMyelitis
Novel proteins of the present invention that have an organic anion transport activity are useful as, for example, a diagnostic marker for kidney diseases, liver diseases, pancreas diseases, immunological diseases associated with thymus failures, reproductive diseases, digestive diseases, spleen diseases, cancer, respiratory diseases, myelitis, diabetes, hypertension, reperfusion injury following ischemia, retinitis, central nervous diseases, skin diseases, thyroid hormone-associated diseases, etc. Compounds that promote or inhibit the activity of the above protein, which are obtained by a screening method using the protein, can be used as, for example, prophylactic / therapeutic agents for the above-described diseases.
Owner:TAKEDA PHARMA CO LTD
Acylglycerol Acyltransferase-Like Protein Mgat-X1 and Uses Thereof
InactiveUS20080311102A1Reduced activityHigh activityOrganic active ingredientsBacteriaMedicineDermatological diseases
The present invention is directed to a polynucleotide sequence of a novel acylglycerol acyltransferase-like protein MGAT-X1. The invention also provides the human MGAT-X1 associated with the dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases. The invention also provides assays for the identification of compounds useful for the modulation of dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases for treating of such diseases associated with expression of the MGAT-X1. The invention also features compounds which bind to and / or activate or inhibit the activity of MGAT-X1 as well as pharmaceutical compositions comprising such compounds.
Owner:BAYER INTELLECTUAL PROPERTY GMBH
A kind of gpr1 antagonistic polypeptide and its derivatives and application
ActiveCN109942680BPrevent proliferationPromote apoptosisPeptide/protein ingredientsAntipyreticAmino acid side chainBinding peptide
The invention discloses a GPR1 antagonistic polypeptide and a derivative and application thereof and particularly relates to a GPR1 antagonistic polypeptide shown in SEQ ID No.1-25 and a derivative thereof. The derivative of the binding peptide is a product obtained in the mode that conventional modification is conducted on a GPR1 binding peptide amino acid side chain group and an amino terminal or a carboxyl terminal of a GPR1 antagonistic polypeptide fragment or a product obtained in the mode that a label for detection or purification of polypeptide or protein is linked to the GPR1 antagonistic polypeptide. The binding peptide and the derivative thereof can be combined with GPR1 in vitro, by stopping combination of chemerin and GPR1, increase of the cAMP concentration is promoted, the (Ca2+) influx caused by chemerin is inhibited, proliferation of breast cancer cells can be inhibited, the cell cycle of the breast cancer cells is blocked, apoptosis of the breast cancer cells is promoted, effective micromolecule treatment drugs are provided for female reproductive diseases such as breast cancer, and the GPR1 antagonistic polypeptide can be widely applied in the fields of medicine and biology.
Owner:SHENZHEN INST OF ADVANCED TECH
CMKLR1 antagonistic polypeptide and derivative and application thereof
ActiveCN109942677APrevent proliferationPromote apoptosisMetabolism disorderAntipyreticAmino acid side chainApoptosis
The invention discloses a CMKLR1 antagonistic polypeptide and a derivative and application thereof and particularly relates to a CMKLR1 antagonistic polypeptide shown in SEQ ID No.1-15 and a derivative thereof. The derivative of the binding peptide is a product obtained in the mode that conventional modification is conducted on a CMKLR1 binding peptide amino acid side chain group and an amino terminal or a carboxyl terminal of a CMKLR1 antagonistic polypeptide fragment or a product obtained in the mode that a label for detection or purification of polypeptide or protein is linked to the CMKLR1antagonistic polypeptide. The binding peptide and the derivative thereof can be combined with CMKLR1 in vitro, by stopping combination of chemerin / RvE1 and CMKLR1, the cAMP concentration is changed,the calcium influx caused by chemerin and cell chemotaxis caused by chemerin are inhibited, proliferation of ovarian carcinoma cells can be inhibited, apoptosis of the ovarian carcinoma cells is promoted, and effective micromolecule treatment drugs are provided for female reproductive diseases.
Owner:SHENZHEN INST OF ADVANCED TECH
Biomarker group and application thereof
InactiveCN112813157AMicrobiological testing/measurementDNA/RNA fragmentationPhysiologyMale reproductive system
The invention discloses a biomarker group and application thereof, and belongs to the technical field of bioengineering. By applying an RNA-seq technology, the result shows that the mRNA expression level of an mt-Nd6 gene in a male reproductive system is lowered, and meanwhile the mRNA expression level of an Slc12a4 gene in the male reproductive system is raised; and therefore, the Slc12a4 gene and the mt-Nd6 gene can serve as the biomarker group for diagnosing male reproductive toxicity caused by prochloraz. By studying the mechanism that prochloraz affects the male reproductive system, the invention provides the biomarker group for diagnosing the male reproductive toxicity caused by prochloraz, the Slc12a4 gene and the mt-Nd6 gene can provide an important basis for preventing and treating male reproductive diseases caused by prochloraz for human, and the study has practical significance.
Owner:HUNAN UNIV OF HUMANITIES SCI & TECH
cow farrowing monitor
ActiveCN104224404BAvoid harmEasy dischargeAnimal reproductionAnthropod material medical ingredientsEngineeringVagina
Owner:INST OF ANIMAL SCI & VETERINARY MEDICINE SHANDONG ACADEMY OF AGRI SCI +1
Fumigation device for reproductive medicine department and pharmaceutical composition used by fumigation device
InactiveCN109998902ATo achieve the effect of direct fumigationPrevents direct dripping from being inconvenient to handleMedical devicesBathing devicesSide effectEngineering
The invention relates to the technical field of medical treatment, in particular to a fumigation device for the reproductive medicine department and a pharmaceutical composition used by the fumigationdevice. The fumigation device comprises a seat plate, a supporting plate, a uniform fumigation mechanism, a liquefied water treatment mechanism and a dustproof cover, wherein the side face of the bottom of the seat plate is welded with the top of the supporting plate, the uniform fumigation mechanism and the liquefied water treatment mechanism are both connected in the middle of the seat plate, the right side of the dustproof cover is movably connected with the right side of the top of the seat plate through a hinge, and the composition is composed of common carpesium fruits, common cnidium fruits, radix astragali, the rhizome of chuanxiong, radix paeoniae alba and wormwood in proportion. The fumigation device has the advantages that the uniform fumigation mechanism is guided into the female genitalia, so that the effect of directly fumigating the inner portion of the female genitalia is achieved, female reproductive diseases are treated by directly reaching to the lesion, a traditional Chinese medicine composition rectification solution with functions of diminishing inflammation, killing bacteria and clearing dump is taken as fumigation solution, compared with western medicine, the side effects are smaller, and the important drug property is milder, and the fumigation device is more suitable for the treatment of the female reproductive diseases.
Owner:代红梅 +1
A cmklr1 antagonistic polypeptide and its derivatives and applications
ActiveCN109942684BPrevent proliferationPromote apoptosisPeptide/protein ingredientsAntipyreticAmino acid side chainProtein detection
The invention discloses a CMKLR1 antagonistic polypeptide and its derivatives and applications, specifically related to the sequence of SEQ ID No.1‑24 and its derivatives, the derivatives of the binding peptide are CMKLR1 binding peptide amino acid side chain group, CMKLR1 The product obtained by conventional modification of the amino-terminal or carboxyl-terminal of the antagonistic polypeptide fragment, or the product obtained by linking a tag for polypeptide or protein detection or purification on the CMKLR1 antagonistic polypeptide; the binding peptide and its derivatives can bind CMKLR1 in vitro , by blocking the combination of chemerin / RvE1 and CMKLR1, it promotes the increase of cAMP concentration, inhibits the calcium influx caused by chemerin, inhibits the cell chemotaxis caused by chemerin, and can inhibit the proliferation of ovarian cancer cells and promote the apoptosis of ovarian cancer cells. Small molecule drugs provide effective treatments for female reproductive diseases such as ovarian cancer.
Owner:SHENZHEN INST OF ADVANCED TECH
Ointment for treating reproductive diseases
InactiveCN110123856AIncrease libidoRegulate physiological balanceAmphibian material medical ingredientsHydroxy compound active ingredientsSulfurTribulus terrestris
The invention relates to a traditional Chinese medicine ointment, and in particular, relates to an ointment for treating reproductive diseases. The ointment for treating reproductive diseases comprises the following components in parts by mass: 1-3 parts by mass of musk, 40-60 parts by mass of toad, 40-60 parts by mass of asarum sieboldii, 40-60 parts by mass of tribulus terrestris, 5-15 parts bymass of borneol, 20-40 parts by mass of sulfur, and 100-2000 parts by mass of vaseline. The ointment for treating reproductive diseases can take treatment of reproductive diseases of both men and women into account, and has positive curative effect.
Owner:张翔瑜
3-substituted sulfonyl piperidine derivative
[Problem] There is provided a compound useful as a preventive or remedy for cardiovascular disease, neurologic disease, metabolic disease, reproductive disease, and digestive disease.[Means for Resolution] A compound or a pharmaceutically acceptable salt thereof represented by the following Formula (I)wherein Z representswherein n1, n2, and n3 are 0, 1, or 2, respectively; R1 represents C1-6 alkyl, C3-8 cycloalkyl, or the like; R2 represents aryl or heteroaryl; R3 represents a hydrogen atom, C1-6 alkyl, or the like; and M1, M2, M3, and M4 independently represent a hydrogen atom, C1-6 alkyl, or the like, or M1, together with M2, M3, or M4, forms —CH2— or the like.
Owner:MSD KK
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