47 results about "Pyrazoline derivatives" patented technology

The present invention relates to new pyazoline derivatives of formula and to physiologically acceptable salts thereof, to the method for their preparation and to their application as medicaments.

The invention discloses an application of a 3-(1,5-diphenyl-4,5-dihydro-1H-pyrazole-3-group)-7-hydroxyl-2H-chromene-2-ketone in the preparation of a drug for stabilizing an arteriosclerosis plaque, wherein the dose of the 3-(1,5-diphenyl-4,5-dihydro-1H-pyrazole-3-group)-7-hydroxyl-2H-chromene-2-ketone for effectively stabilizing the arteriosclerosis plaque is 1 mg / kg / day. The experiment proves that the 3-(1,5-diphenyl-4,5-dihydro-1H-pyrazole-3-group)-7-hydroxyl-2H-chromene-2-ketone has the advantages of being capable of significantly reducing the apoptosis rate of endothelial cells in aortic plaques and the apoptosis rate of cells in aortic root plaques; improving the structure of the plaques; improving the stability of the plaques; being capable of being used as an effective tool for studying an unstable molecular mechanism of the atherosclerosis plaque; laying a groundwork for developing the drug to treat arteriosclerosis.

Provided are 1-amidino-3-aryl-2-pyrazoline derivatives which exhibit antagonizing activity towards serotonin 5-HT 2B receptors and pharmaceutical compositions containing these derivatives. Also provided is the use of the compounds as a medicament and for the treatment of fibrosis, cardiovascular diseases, pain, IBD, and other inflammatory diseases.

The invention relates to an environmental-friendly method for catalytic synthesis of a 1,3,5-triple substituent-2-pyrazoline derivative through ionic liquid. The method comprises the following steps: mixing a chalcone derivative, a substituted hydrazine and an ionic liquid catalyst under solvent-free conditions, ultrasonically oscillating and dissolving, heating, refluxing, stirring and reacting at the temperature of 50-60 DEG C for 0.5-1 hour, cooling, filtering and recrystallizing the reaction solution, thereby obtaining the product, wherein the molar ratio of the chalcone derivative to the substituted hydrazine to the ionic liquid catalyst is 1:(1.2-1.5):(3-6). According to the preparation method disclosed by the invention, a solvent is not needed, the reaction time is reduced by a half, the reactants are synthesized under the catalysis action of the functional ionic liquid, the functional ionic liquid can be recycled, use of an organic reagent is greatly reduced, the reaction temperature is reduced from the original about 110 DEG C to about 50 DEG C, the aftertreatment is relatively simple, and energy conservation and high efficiency of environment-friendly chemical synthesis can be realized.

The invention relates to the technical field of metal pickling corrosion and protection, and especially relates to an application of a type of pyrazoline derivatives as a metal pickling corrosion inhibitor. The pyrazoline derivatives have a molecular structure as the following, wherein R1 is N-substituted amino or alkyl comprising N-substituted amino; R2 is N-substituted amino, alkyl comprising N-substituted amino or methoxy; and R3 is H, alkyl, aryl or substituted aryl. According to the invention, the pyrazoline derivative is added as a pickling corrosion inhibitor into pickling media with different concentrations, such that an obtained concentration is 60-120mg / L, and an effective metal corrosion inhibition effect can be obtained.

The invention discloses a new method for preparing a 1,3,5-thriaryl substituted pyrazoline derivant. According to the method, the 1,3,5-thriaryl substituted pyrazoline derivant is prepared from 1,3-binary substituted benzotriazole salt, alkali and aryl-ethylene compound through a one-pot method. The method is mild in reaction conditions, fast in speed and good in selectivity, pyrazoline with a single structure is obtained, the product is easy to separate, and the method is simple to operate.

The present invention relates to pyrazoline derivatives prepared from salicylaldehyde, characterized by having the following general formula:(img file ='DSA00000789205900011.tif' wi='756' he ='453' / ),where R1 is one of the following groups:-F, -Cl,-Br,-CH3, and -OCH3,and R2 is one of the following groups: -H, -C1, -Br. The present invention discloses a preparation method of the pyrazoline derivatives.

The invention relates to a positive charge storage material for all-solid-state electrical energy storage devices, which is mainly a pyrazoline derivative with a high positive charge transfer rate. Through introducing substituent groups into pyrazoline molecules, the properties such as positive charge transfer rate and the like of the positive charge storage material are improved, thereby improving the working properties of devices. According to the invention, through applying a pyrazoline derivative, namely, a positive charge storage material to an all-solid-state electrical energy storage device, an energy storage device which is high in energy density and power density, environmental-friendly and high in safety is obtained.

The invention discloses a preparation method of pyrazoline derivatives and application of the pyrazoline derivatives as a Zn<2+> fluorescent probe. The structural formula of the pyrazoline derivatives is disclosed as Formula (I). The pyrazoline derivatives do not fluoresce, and the fluorescence can be enhanced by 40 times after the pyrazoline derivatives act with Zn<2+> in an EtOH / HEPES (20mM, pH 7.2, 1:1 volume ratio) buffer solution. When being used as a Zn<2+> fluorescent probe, the pyrazoline derivatives have high selectivity, have the fluoroscopic examination limit of 6.1*10<-7>M for Zn<2+>, and can be used for fluorescent imaging and locating detection of Zn<2+> in PC12 cells.