47 results about "Pyrazoline derivatives" patented technology

Compounds of formula (I) wherein: X is selected from the group consisting of trihalomethyl, C1-C6 alkyl, and a group of formula (II) wherein: R3 and R4 are independently selected from the group consisting of hydrogen; halogen; hydroxyl; nitro; C1-C6 alkyl; C1-C6 alkoxy; carboxy; C1-C6 trihaloalkyl; and cyano; Z is selected from the group consisting of substituted and unsubstituted aryl; or a pharmaceutically acceptable salt thereof. The compounds are inhibitors of cyclooxygenase-2 activity. They are useful for treating cyclooxygenase-mediated disorders, including, for example, inflamation, neoplastic disorders and angiogenesis-mediated disorders.

The invention discloses a pyrazoline derivative Zn<2+> fluorescence probe, which is 5-phenyl-3-(2-hydroxy-4-chlorine)phenyl-1-(2-pyridine)pyrazoline and has a chemical structural formula as shown in formula (1). In an HEPES (pHH=7.2) buffer solution of acetonitrile / water (v / v=1 / 1), the fluorescence probe provided by the invention has unique fluorescence selectivity, high sensitivity and low detection limit (0.12 micron) for Zn<2+> and strong anti-interference capability against other ions, and has a huge application prospect.

The invention relates to an N-para-sulfonium salt substituted pyrazoline derivative shown as the following formula (I) in the specification, a photocurable composition, and a preparation method of theN-para-sulfonium salt substituted pyrazoline derivative shown as the following formula (I). The N-para-sulfonium salt substituted pyrazoline derivative shown as formula (I) has good absorption at a wavelength of 350nm or above, and compared with a 5-substituted sulfonium salt, the N-para-sulfonium salt substituted pyrazoline derivative has the advantages of simpler and more convenient molecule synthesis steps and reduced cost of raw materials, and is more suitable for industrial production and application.

The invention belongs to the field of catalysts, and particularly relates to 1,3,5-trisubstitution-2-pyrazole derivatives which are synthesized by the photochemical method. In the presence of a bivalent platinum complex catalyst with catalytic amount, and in the atmosphere of inert gas, an organic solvent containing the 1,3,5-trisubstitution-2-pyrazole derivatives is dissolved by the irradiation of visible light(lambda is more than 400nm and less than 570nm) so as to obtain the 1,3,5-trisubstitution-2-pyrazole derivatives. The method has the advantages of highly efficient reaction, easy separation and repeated use of the catalyst.

Disclosed is a synthesis method of pyrazoline derivatives emitting olivine light, in which the pyrazoline derivative, 1-phenyl-3-[4-(N-phenyl-1-naphthylamine)ethylene]-5-[4-(N-phenyl-1-naphthylamine)phenyl]-2-pyrazoline brown-green crystals are finally prepared through three-times intermediates, by selecting material, preparing sollution, chemical combination reaction, heating, mixing, water-circulation condensation, ice water washing, argon protection, column chromatography purification, recrystallization purification, vacuum filtering, evaporation and drying, the products are grain diamond-shaped, the color coordinate is that x=0.3257, y=0.5452, the maximal emission wavelength of photoluminescence spectrum is 523 nm and the full width at half maximum is 96 nm. The products have high purity, pure color, excellent irradiance performance, high irradiance intensity and high lighteness, the products are also capable of improving the stability, reliability and life time of organic electroluminescent devices, being used in the fields of advance electronic display and irradiance illumination technology, the method of the invention is strictness and reasonable.

The invention relates to the technical field of metal pickling corrosion and protection, and especially relates to an application of a type of pyrazoline derivatives as a metal pickling corrosion inhibitor. The pyrazoline derivatives have a molecular structure as the following, wherein R1 is N-substituted amino or alkyl comprising N-substituted amino; R2 is N-substituted amino, alkyl comprising N-substituted amino or methoxy; and R3 is H, alkyl, aryl or substituted aryl. According to the invention, the pyrazoline derivative is added as a pickling corrosion inhibitor into pickling media with different concentrations, such that an obtained concentration is 60-120mg / L, and an effective metal corrosion inhibition effect can be obtained.

The invention relates to a method for preparing antiseptic triaryl-2-pyrazoline derivative by microwave, which is characterized by taking alpha, alpha'-dibenzyl cyclohexanone derivative having alpha, beta-unsaturated carboxide structure and phenyl hydrazine derivative as main raw materials; the raw materials react for 5-10min in sodium alcoholate and alcohol solution under the condition that the microwave power is 200-500W to be directly cyclized and synthesized to be the antiseptic triaryl-2-pyrazoline derivative which maintains one double-bond and has alpha-benzal cyclohexyl and pyrazoline ring structure. Therefore, the method has the advantages of high reaction selection, production rate and purity of the product, easy purification, etc.

Diarylpyrazolylaniline compounds are characterized in that the compounds have a general formula shown in the specification; and in the general formula, R1 is 4-Cl, a nitro group, a methyl group or a methoxy group, and R2 is 4-Br, Cl, a methoxy group or an oxyethyl group. The above diarylpyrazolylaniline derivatives can inhibit HCT116 propagation, so the above pyrazoline derivatives can be used as latent colorectal cancer prevention medicines. The invention discloses a preparation method of the compounds.

The invention discloses a preparation method of pyrazoline derivatives and application of the pyrazoline derivatives as a Zn<2+> fluorescent probe. The structural formula of the pyrazoline derivatives is disclosed as Formula (I). The pyrazoline derivatives do not fluoresce, and the fluorescence can be enhanced by 40 times after the pyrazoline derivatives act with Zn<2+> in an EtOH / HEPES (20mM, pH 7.2, 1:1 volume ratio) buffer solution. When being used as a Zn<2+> fluorescent probe, the pyrazoline derivatives have high selectivity, have the fluoroscopic examination limit of 6.1*10<-7>M for Zn<2+>, and can be used for fluorescent imaging and locating detection of Zn<2+> in PC12 cells.

The invention relates to 2'-aminochalcone-zole compounds with structures shown in general formulas (I, II, III, IV and XIII) and pharmaceutically acceptable salts thereof, wherein amine groups are introduced onto chalcone skeletons while the zole-ring displacement of alpha-site can be realized; and the invention also relates to 2'-aminochalcone-zole compound-based pyrazoline derivatives with structures shown in the general formulas (V, VI, VII, VIII, XIV and XV) and pharmaceutically acceptable salts thereof, and relates to 2'-aminochalcone-zole compound-based cyclopropyl zole derivatives with structures shown in general formulas (IX, X, XI, XII, XVI and XVII) and pharmaceutically acceptable salts thereof. The invention relates to the antimicrobial activities and antitumor activities of the 2'-aminochalcone-zole compounds, the pyrazoline derivatives and cyclopropyl zole derivatives and the pharmaceutically acceptable salts. The invention also relates to medical applications of the compounds.

The present application relates to an epoxide-substituted pyrazoline derivative represented by the following formulae (I) and (II), a photocurable composition, and a method for preparing the epoxide-substituted pyrazoline derivative represented by the following formulae (I) and (II). The epoxide-substituted pyrazoline derivatives represented by the formula (I) and the formula (II) have good absorption at a wavelength of 350 nm or more, and can be used as sensitizers for photocuring polymerization. The synthesis steps of molecules are simple, and the method is suitable for industrial productionand application; meanwhile, the molecule can form chemical bond bonding with a photocuring product, so that the mobility of the molecule is reduced.

The invention discloses an N-formamido pyrazoline derivative, a compound represented by a general formula (I) or an enantiomer, a diastereoisomer, an epimer, a racemate or pharmaceutically acceptablesalt thereof. The compound is an antagonist of a ligand gated non-selective cationic channel receptor subtype P2X3, and can be used for treating or preventing various diseases mediated by a P2X3 receptor.

The invention discloses a new method for preparing a 1,3,5-thriaryl substituted pyrazoline derivant. According to the method, the 1,3,5-thriaryl substituted pyrazoline derivant is prepared from 1,3-binary substituted benzotriazole salt, alkali and aryl-ethylene compound through a one-pot method. The method is mild in reaction conditions, fast in speed and good in selectivity, pyrazoline with a single structure is obtained, the product is easy to separate, and the method is simple to operate.

The present invention relates to 1-amidino-3-aryl-2-pyrazoline derivatives of the general formula I The invention specifically relates to such derivatives which exhibit antagonizing activity towards serotonin 5-HT2B receptors. The present invention also relates to use of said compounds as a medicament and for the treatment of fibrosis, cardiovascular diseases, pain, IBD, and other inflammatory diseases, as well as pharmaceutical compositions comprising one or more of said compounds and methods of treatment.

The invention aims at providing a pyrazoline derivative and a preparation method thereof. A structural formula of the derivative is shown in the attached figure, wherein R1 is selected from -ClC6H4, -BrC6H4, -NO2C6H4, -t-Bu, -OMeC6H4, -CH3C6H4, and the like; R2 is selected from -Ts and the like. Compared with the existing method of synthesizing the pyrazoline derivative, the method has the advantages that (A) the low-cost and environment-friendly anhydrous copper acetate is used as a catalyst, but the high-cost transition metal catalyst is not used; (B) the reaction can be performed at room temperature, the universality is good, and the yield rate is higher; (C) the experiment operation is simple, the target product is single, and the post-treatment is convenient; the moderate reaction conditions, simple operation, low-cost and easy-obtaining catalyst, and higher yield rate can lay a foundation for the wide application and industrialized production of the pyrazoline derivative.

The invention belongs to the field of pesticides, and particularly relates to a substituted phenyl pyrazoline derivative or a pesticide acceptable salt, a composition and application of the substituted phenyl pyrazoline derivative or the pesticide acceptable salt, the compound has a structure shown in a formula (I), and all groups in the formula are defined in the specification. According to the compound disclosed by the invention, a substituted pyrazole group is introduced on the basis of the structure of a phenyl pyrazoline derivative, and the compound which can be used as a herbicide and / or a bactericide is developed and obtained and has very outstanding biological activity and crop safety.

The invention relates to an environmental-friendly method for catalytic synthesis of a 1,3,5-triple substituent-2-pyrazoline derivative through ionic liquid. The method comprises the following steps: mixing a chalcone derivative, a substituted hydrazine and an ionic liquid catalyst under solvent-free conditions, ultrasonically oscillating and dissolving, heating, refluxing, stirring and reacting at the temperature of 50-60 DEG C for 0.5-1 hour, cooling, filtering and recrystallizing the reaction solution, thereby obtaining the product, wherein the molar ratio of the chalcone derivative to the substituted hydrazine to the ionic liquid catalyst is 1:(1.2-1.5):(3-6). According to the preparation method disclosed by the invention, a solvent is not needed, the reaction time is reduced by a half, the reactants are synthesized under the catalysis action of the functional ionic liquid, the functional ionic liquid can be recycled, use of an organic reagent is greatly reduced, the reaction temperature is reduced from the original about 110 DEG C to about 50 DEG C, the aftertreatment is relatively simple, and energy conservation and high efficiency of environment-friendly chemical synthesis can be realized.

The invention discloses an application of a 3-(1,5-diphenyl-4,5-dihydro-1H-pyrazole-3-group)-7-hydroxyl-2H-chromene-2-ketone in the preparation of a drug for stabilizing an arteriosclerosis plaque, wherein the dose of the 3-(1,5-diphenyl-4,5-dihydro-1H-pyrazole-3-group)-7-hydroxyl-2H-chromene-2-ketone for effectively stabilizing the arteriosclerosis plaque is 1 mg / kg / day. The experiment proves that the 3-(1,5-diphenyl-4,5-dihydro-1H-pyrazole-3-group)-7-hydroxyl-2H-chromene-2-ketone has the advantages of being capable of significantly reducing the apoptosis rate of endothelial cells in aortic plaques and the apoptosis rate of cells in aortic root plaques; improving the structure of the plaques; improving the stability of the plaques; being capable of being used as an effective tool for studying an unstable molecular mechanism of the atherosclerosis plaque; laying a groundwork for developing the drug to treat arteriosclerosis.

The invention discloses an intramolecular sensitized macromolecular photoinitiator containing pyrazoline and alpha-aminoketone as well as a preparation method and application of the intramolecular sensitized macromolecular photoinitiator, and belongs to the technical field of new material organic chemicals. The invention relates to an intramolecular sensitized macromolecular photoinitiator containing pyrazoline and alpha-aminoketone. The intramolecular sensitized macromolecular photoinitiator containing pyrazoline and alpha-aminoketone is a macromolecular photoinitiator I which is formed by jointly grafting an alpha-aminoketone micromolecular photoinitiator PI containing double bonds, a pyrazoline derivative A containing double bonds and a polythiol compound B through a thiol-olefin click reaction. The modified initiator can effectively reduce the odor of a photoinitiator curing product, and meanwhile, the modified initiator can utilize a current hottest LED light source as an excitation light source when a curing system is initiated for curing.

The invention belongs to the field of building materials, particularly relates to a production process of an EVA (Ethylene Vinyl Acetate) colored solar film, and provides the following scheme aiming at the problems of low viscosity and low elongation of the existing film. Comprising the following steps that materials including 100 parts of EVA resin, 1-5 parts of a color pigment powder bag, 5-15 parts of a luminescence agent, 60-85 parts of a mixed solution, 60-85 parts of hydrochloric acid and 45-65 parts of macromolecular wax are prepared, and the luminescence agent comprises an anhydride monomer, a pyrazoline derivative, nickel dioxide powder, a coumarin derivative and hyaluronic acid; the EVA resin can be better fused with other materials through modification of the EVA resin, the viscosity of the EVA resin can be ensured not to be interfered by utilizing the treated colored pigment powder bag and the luminous agent, the layering phenomenon is avoided, the luminous agent and the macromolecular wax can also enhance the strength of the film, increase the elongation of the film and reduce the risk of film breakage, and the service life of the film is prolonged. And the product quality is ensured.

The invention relates to an environmental-friendly method for catalytic synthesis of a 1,3,5-triple substituent-2-pyrazoline derivative through ionic liquid. The method comprises the following steps: mixing a chalcone derivative, a substituted hydrazine and an ionic liquid catalyst under solvent-free conditions, ultrasonically oscillating and dissolving, heating, refluxing, stirring and reacting at the temperature of 50-60 DEG C for 0.5-1 hour, cooling, filtering and recrystallizing the reaction solution, thereby obtaining the product, wherein the molar ratio of the chalcone derivative to the substituted hydrazine to the ionic liquid catalyst is 1:(1.2-1.5):(3-6). According to the preparation method disclosed by the invention, a solvent is not needed, the reaction time is reduced by a half, the reactants are synthesized under the catalysis action of the functional ionic liquid, the functional ionic liquid can be recycled, use of an organic reagent is greatly reduced, the reaction temperature is reduced from the original about 110 DEG C to about 50 DEG C, the aftertreatment is relatively simple, and energy conservation and high efficiency of environment-friendly chemical synthesis can be realized.

The invention discloses a new method for preparing a 1,3,5-thriaryl substituted pyrazoline derivant. According to the method, the 1,3,5-thriaryl substituted pyrazoline derivant is prepared from 1,3-binary substituted benzotriazole salt, alkali and aryl-ethylene compound through a one-pot method. The method is mild in reaction conditions, fast in speed and good in selectivity, pyrazoline with a single structure is obtained, the product is easy to separate, and the method is simple to operate.

The present application relates to an acrylate-substituted pyrazoline derivative represented by formula (I), a photocurable composition, and a preparation method and application of the acrylate-substituted pyrazoline derivative represented by formula (I). The acrylate-substituted pyrazoline derivative shown in the formula (I) has good absorption at the wavelength of 350 nm or above, compared with a common sensitizer, the synthesis steps of the molecule are simpler and more convenient, and the molecule can react with polymerizable components in the radiation curing process and can be connected with a polymer system through chemical bonds, so that the low mobility of small molecule components in the formula is reduced.

The invention discloses a preparation method of pyrazoline derivatives and application of the pyrazoline derivatives as a Zn<2+> fluorescent probe. The structural formula of the pyrazoline derivatives is disclosed as Formula (I). The pyrazoline derivatives do not fluoresce, and the fluorescence can be enhanced by 40 times after the pyrazoline derivatives act with Zn<2+> in an EtOH / HEPES (20mM, pH 7.2, 1:1 volume ratio) buffer solution. When being used as a Zn<2+> fluorescent probe, the pyrazoline derivatives have high selectivity, have the fluoroscopic examination limit of 6.1*10<-7>M for Zn<2+>, and can be used for fluorescent imaging and locating detection of Zn<2+> in PC12 cells.

Disclosed herein is a composition comprising: A) at least one component selected from the group consisting of: 1) unsaturated polyester resins; and 2) organic peroxide initiators; and B) and at least one dye that is compatible with any organic peroxide present and is selected from the group consisting of anthraquinone derivatives, pyrazalone derivatives, and mixtures thereof.