63 results about "Oxygen metabolism" patented technology

An embodiment of the invention includes a device, system and method for determining the characteristics of deep tissue. The novel method includes measuring blood flow rate and oxygenation characteristics of the tissue, and determining oxygen metabolism of the tissue as a function of the measure blood flow rate and measure oxygenation. The blow flow rate characteristics are measured as a function of light fluctuations caused by the tissue, while the oxygenation characteristics are measured as a function of transmission of light through the tissue with respect to the wavelength of light. The tissue may be layered tissue, for example, a portion of a brain. The tissue characteristics may be measured during times of varying levels of exercise intensity.

In an implantable medical device for monitoring glucose concentration in the blood, a blood-glucose concentration analysis is performed using correlations of blood-glucose concentration with measures of metabolic oxygen consumption including oxymetric, and / or temperature. Analysis of electrocardiographic data is used in a parallel method to detect and / or confirm the onset and / or existence and / or extent of hypoglycemia and / or hyperglycemia. Blood-glucose concentration calculation is enhanced by using the combination of the oxygen metabolism analysis and electrocardiographic analysis.

A new class of micro- and nano-particulate paramagnetic spin probes useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.

A method of measuring a blood volume, includes: reading individual specific information of a patient; estimating oxygen metabolism relating to a cardiac output of the patient; and acquiring the cardiac output based on the estimated oxygen metabolism.

A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.

An antioxidizing health-care nutritive liquid is prepared from haw and red sage root and features use of saccharomyces cerevisiae (CGMCC No.0775) for high-purity fermentation. Its advantage is its high health-care actions of removing free radicals of oxygen, regulating internal secretion, lowering blood sugar, blood fat and blood pressure, preventing and treating cardiovascular and cerebrovascular diseases and cancers, delaying senility and beautifying skin.

The invention discloses a drug combination as iron supplementary agent, which is characterized in that the drug combination comprises carbonyl iron, and natural anti-oxidant components with drug activity; the drug combination can also have pharmaceutical carrier. The invention also discloses the preparation comprising the drug combination, the preparation methods of the combination and the preparation, and the function of preventing and curing iron deficiency of the drug combination. The drug combination has the advantages that the iron deficiency anemia is treated effectively; the production of free radical in human body is inhibited; the oxygen metabolism balance in human body is maintained; the physical quality of the patient is enhanced; and the immunity of body is improved.

The invention discloses a muscle fatigue detection method combining surface myoelectricity and myocrismus with a near infrared spectrum, and relates to the field of human motionfunction detection andevaluation. Constant length static contraction is adopted, and muscle fatigue is made; surface myoelectricity, myocrismus and a near infrared spectrum signal in the muscle activity are recorded synchronously; corresponding fatigue parameters are built in the five aspects of muscle fiber action potential collection characteristics, action potential conductivity, muscle fiber low-frequency vibrationcharacteristics, hemodynamic characteristics and blood oxygen metabolism, and a muscle fatigue mechanism is analyzed and evaluated. Accordingly, the muscle fatigue is detected and analyzed in an noninvasive mode; by measuring the myoelectricity and myocrismus and the near infrared signal simultaneously, more reliable muscle fatigue information is obtained; the muscle fatigue is comprehensively detected in the five aspects of the muscle fiber action potential collection characteristics, the action potential conductivity, the muscle fiber low-frequency vibration characteristics, the hemodynamiccharacteristics and the blood oxygen metabolism, and cognition on the fatigue mechanism is deepened.

The invention discloses a dynamic measurement device and method for microcirculation metabolism of living tissue. The device comprises a multi-wavelength low-coherence light source, a beam expanding and Bessel transformation lens assembly, a microscopic imaging lens assembly, a high-speed CCD (charge coupled device) camera, a control circuit and a computer. With the adoption of the device and themethod, red cell velocity and metabolic state in human microcirculation can be monitored, the advantages of accuracy and rapidness are achieved, a blood-oxygen metabolism dynamic result with high spatial resolution and time resolution can be obtained, and powerful technical support is provided for diagnosis, long-term monitoring and therapeutic effect evaluation of acute and chronic diseases clinically.

The invention relates to a method and system for estimating oxygen metabolism parameters. The method comprises the following steps that an image is obtained, wherein a magnetic sensitiveness weighted imaging figure or a quantitative magnetic sensitiveness image is obtained; phase differences and sensitiveness variation are calculated, wherein the position of the blood vessel is determined from the magnetic sensitiveness weighted imaging figure or the quantitative magnetic sensitiveness image, the phase differences of the blood vessel and the surrounding tissues are calculated, and local magnetic sensitiveness variation among the tissues is calculated according to the phase differences of the blood vessel and the surrounding tissues; oxygen saturation is estimated, wherein oxygen saturation is estimated according to the local magnetic sensitiveness variation among the tissues. According to the method and system for estimating oxygen metabolism parameters, magnetic sensitiveness variation can be obtained according to the phase differences, the oxygen saturation parameters can be obtained according to the magnetic sensitiveness variation, the method for estimation the oxygen metabolism parameters is free of harm and side effects, and the safety of oxygen saturation parameter estimation is improved.

The invention proposes a large-visual field multi-modal imaging system. The system includes an illumination subsystem, an infinity relay imaging subsystem and a data processing subsystem; and the dataprocessing subsystem is used to calculate a blood flow velocity in an area to be measured according to a speckle signal received by an image sensor, calculate a hemoglobin concentration in the area to be measured according to a reflected light intensity signal received by the image sensor, and calculate a relative oxygen metabolism rate according to registration of the obtained blood flow velocity and hemoglobin concentration. According to the large-visual field multi-modal imaging system provided by embodiments of the invention, the infinity relay imaging subsystem is added, so that a spectroscopic component can be conveniently inserted into the relay subsystem to provide more imaging optical paths, and the system realizes data collection of the blood flow velocity and the hemoglobin concentration without switching light sources and is conducive to real-time, large-visual field multi-modal tissue hemodynamic parameter monitoring.

The invention discloses a multi-parameter intrusive medical probe which comprises a probe shell, a temperature sensing element and at least one other physiological parameter sensing element. The probeshell comprises a closed head portion used for intruding a monitored part, the middle of the probe shell is provided with a blind hole used for assembly of the temperature sensing element, and the lateral side of the probe shell is provided with at least one clamping groove used for assembly of the at least one other physiological parameter sensing element. The temperature sensing element is mounted in the blind hole, and the at least one other physiological parameter sensing element is mounted in the at least one clamping groove. By adoption of one miniature probe, real-time continuous monitoring of various human body physical signals such as internal pressure, temperature and oxygen metabolism is realized, height uniformity of detecting positions is achieved as various sensing elementsare all positioned at the top of the probe, and thus, real-time temperature compensation can be completed by other physiological parameters such as a pressure sensor and an oxygen partial pressure sensor according to temperature sensing data. The multi-parameter intrusive medical probe is wide in application range and high in practicality and accuracy.

The invention discloses a new magnetic susceptibility artifact removing method for exerting self-adaptive change shimming gradient (Z-shimming Gradient) in a selection layer direction on the basis of a multi-echo asymmetrical spin-echo fast imaging technology (MASE). The method involves a data collecting module, a delta B signal attenuation model processing module and a magnetic susceptibility artifact removing module. An optimized Z-Shimming gradient method and a sinc model of MR signal attenuation caused by magnetic susceptibility artifacts are well combined through a system, the Z-Shimming gradient is exerted in a self-adaptive mode according to different delta TE times, finally efficiency is improved through a model fitting method, and data for establishing delta B are obtained within 24 seconds; data of delta B and data for estimating oxygen metabolism indexes such as oxygen extraction fraction (OEF) can be obtained through once scanning according to a Z-MASE sequence in the new method, no geometric distribution difference exists between the two types of data, and the magnetic susceptibility artifact removing treatment is more convenient, accurate and robust.

Provided are compositions containing an emulsion containing a perfluorinated compound, as well as methods for preparation of the compositions. Also provided are formulations containing a complex of oxygen-17 and the emulsion compositions. Additionally provided are methods for the preparation of the formulations as well as kits containing the formulations. Further provided are methods of use of the formulations in imaging of tissues using a magnetic resonance imaging system.

The invention provides a brain blood oxygen level measuring method based on magnetic resonance. The measuring method includes acquiring an amplitude diagram and a phase diagram of brain tissues; standardizing the amplitude diagram into a noise SD diagram, and acquiring a standardized diagram Ic according to linear fitting of the noise SD diagram; unwrapping the phase diagram to acquire a standard field diagram; putting the standard field diagram and the standardized diagram Ic into a regularization constraint rule to acquire a magnetism sensitiveness matrix without an ambient field; acquiring a vein oxygen saturation value and an oxygen metabolism parameter according to the magnetism sensitiveness matrix. The brain blood oxygen level measuring method has the advantages that magnetic field phase changes generated by air tissues are removed, so that magnetism sensitiveness values of the tissues are regained better, and venous blood oxygen saturation Yv and residual saturation of hemoglobin in venous blood, namely an oxygen extraction fraction (OEF), are acquired.

The invention relates to an apparatus for noninvasive determination of the oxygen turnover and data derived therefrom with an optical sensor (S) to be placed on the tissue with one or more light sources (W, L) which send light through the optical fibers to the sensor (S), one or more detectors (DD, DR) which receive light backscattered by the tissue through optical fibers, and an evaluation unit.

The invention discloses a method for dynamically measuring cerebral oxygen metabolism rate. According to the method, a perfusion multiecho asymmetric spin echo technology are adopted, namely, a multiecho signal acquisition mode formed by alternately switching a layer selection inversion mark and a non-layer selection inversion mark is adopted, oxygen extraction fraction (OEF) and cerebral blood flow (CBF) weighted images are synchronously obtained in a mode of adding / subtracting layer selection signals and non-layer selection signals, and measurement of dynamic change of the cerebral metabolicrate of oxygen (CMO2) is finally realized by combining Fick's law. According to the invention, a series of problems caused by gas calibration required by calibrating a blood oxygen level dependent (BOLD) method are fundamentally solved, so that the comfort level of a subject is greatly improved, the applicable population is enlarged, and complexity of operation and measurement cost are greatly reduced. Furthermore, research on brain health and brain disease mechanisms of different populations is expected to be established, and development of neuroscience and clinical medicine is promoted.

The invention discloses a hawthorn leaf injection for treating cardiovascular diseases, which is prepared from hawthorn leaf extract and a solvent for injection, and the solution contains total flavonoids in an effective therapeutic amount. The hawthorn leaf extract is prepared by the following method: a. take hawthorn leaves, add 40-60% ethanol to extract, filter, recover ethanol, concentrate to a relative density of 1.12-1.14, dilute with water, and refrigerate for 12-24 hours. Aspirate the supernatant, filter the lower layer, combine the filtrate and the supernatant, and elute until the reaction of concentrated sulfuric acid of α-naphthol is negative; b. Collect the ethanol eluate until the reaction of magnesium hydrochloride powder is negative, recover the ethanol, concentrate, Extract with ethyl acetate, recover ethyl acetate from the extract and concentrate to dryness to obtain extract I; extract the water layer with n-butanol and concentrate to dry to obtain extract II; the present invention has effects on the ejection ability and oxygen metabolism of the heart It has obvious improvement effect, can significantly increase cardiac output and stroke volume, reduce arterial blood oxygen content, increase venous blood oxygen content, reduce myocardial oxygen consumption and myocardial oxygen utilization rate, and improve myocardial blood and oxygen supply.

The invention discloses a system for monitoring ARDS development of patients. The system comprises a master micro controller unit (MCU), wherein the master micro controller unit (MCU) is separately connected to data interfaces of a mechanical ventilation-respiratory mechanics monitoring module, a pulse index continuous cardiac output monitoring module, a central venous pressure and pulmonary artery pressure monitoring module, an oxygen metabolism dynamic monitoring module, a fibreoptic bronchoscopy module, an end-tidal carbon dioxide monitoring module and a broncholveolr lvge fluid and pulmonary tissue pathological examination module through bidirectional buses; an output end of the master micro controller unit (MCU) is also connected to an input end of a critical degree judgment module; the output end of the critical degree judgment module is also connected to the input end of a communication module; and the output end of the communication module is connected to the input end of a center console. According to the system, real-time monitoring data can be acquired, so that comprehensive examination of the patients is facilitated, differential diagnosis of an ARDS and multiple diseases is facilitated, and meanwhile, level judgment is more conducive to follow-up treatment on different patients.

The invention provides a composition for preventing and treating cardiovascular and cerebrovascular diseases. The composition achieves an aim of effectively preventing and treating cardiovascular andcerebrovascular diseases by starting from pathogenesis of the cardiovascular and cerebrovascular diseases, namely hypertension, hyperlipemia and hyperglycemia. According to the composition provided bythe invention, firstly, through the synergistic effect of flavonoids in kudzuvine root powder and effective substances in soybean phospholipid, the effects of promoting oxygen metabolism, promoting metabolism and improving human microcirculation are achieved, brain cells are activated, repair of damaged parts of cardiovascular and cerebrovascular vessels is promoted, metabolism of lipids and saccharides is promoted, and normalization of blood fat, blood sugar and blood pressure is promoted; secondly, through the synergistic effect of nattokinase in natto freeze-dried powder and an effective substance monacolin in red yeast rice powder, the synthesis speed of cholesterol is limited, and thrombolysis is promoted; and finally, through effective substances in a cassia seed extract, immunity of human bodies is improved, and prevention and treatment effects on cardiovascular and cerebrovascular diseases are further improved.

An apparatus for measuring a blood volume, includes: a first calculator which calculates a first blood volume by using information on a cardiac output of a subject; and a second calculator which calculates a second blood volume by using information on oxygen metabolism of the subject.

The utility model relates to a test method and device for respiratory system function. The device comprises: a breathing gas circuit unit, an oscillating pressure generating unit, a pressure and flowdetection unit, an oxygen and nitrogen concentration control unit, a gas concentration sensor, and one-way valve or air-resistor, a cerebral oxygen metabolism detection unit, a data acquisition and control unit, a computing unit. The mechanical properties of the respiratory system are measured while the gas exchange, oxygen metabolism and reserve capacity of the cardiopulmonary system are assessed, high-frequency gas oscillations are produced by forced oscillation technique, and the respiratory system of a subject is stimulated, the mechanical characteristics of respiratory system are obtainedby the system identification algorithm, while the forced oscillation excitation is detected, the concentration and duration of inhaled oxygen and nitrogen are controlled, the oxygen saturation curveand descent curve are determined, the time-delay and time constant are determined, and the gas exchange, oxygen metabolism efficiency and oxygen reserve capacity of the subject are evaluated accordingly.

The invention relates to a method for synchronously measuring time allocation and oxygen consumption under a simulated environment of low temperature, rain, snow and freezing, which specifically comprises following steps: preparing small animals; filling an ice storage room with natural ice and snow or making ice until the environment temperature is lower than 0 DEG C of and the relative humidity is greater than 60%, and putting three layers of filter paper on the ice surface; debugging an oxygen consumption measurement device and a video capture device, and inputting a video information to a computer synchronously; putting the small animals on the filter paper, starting a time process and to capture the video, and recording the cumulative oxygen consumption every five minutes; inputting the results of cumulative oxygen consumption to the computer, and calculating the time of each behavior or state and the oxygen metabolism evaluation index; calculating the occurrence frequency of oxygen metabolism signals of each behavior or state; and concluding cold-adapted behavior rules and an energy balance strategy during exposure process according to the calculation results. The biological exposure process in duration of low temperature, rain, snow and freezing weather can be accurately simulated. The method for synchronously measuring the time allocation and the oxygen consumption of exposure bodies under a simulated environment of low temperature, rain, snow and freezing is provided. The essential data is provided for an analysis of cold-adaption strategy of exposure in low temperature, rain, snow and freezing environment.

The invention provides a motion function monitoring management method based on myoelectricity and muscle oxygen signals. The method comprises: synchronously collecting multi-channel myoelectricity and muscle oxygen signals in different motion modes; preprocessing the myoelectricity and muscle oxygen signals; performing feature extraction on the preprocessed signal; constructing a multi-modal feature inter-index regression analysis model, carrying out regression analysis on feature indexes, and researching a relationship between every two indexes; constructing a muscle-blood vessel state monitoring model based on multi-modal characteristic indexes, and achieving objective description and accurate monitoring of the motion function. According to the method, multi-modal correlation and coupling analysis methods are developed and researched, single-modal and transmembrane coupling characteristic indexes for effectively describing multi-level coupling characteristics are constructed from the aspects of muscle coordination characteristics, tissue blood oxygen metabolism, muscle-blood vessel nonlinear coupling characteristics and the like, and multi-level information interaction characteristics between muscles and blood vessels are comprehensively described; and multi-level effective description and accurate monitoring management of the motion function are realized.