The invention provides a Chinese patent medicine for treating spleen deficiency syndrome postoperative fatigue syndrome and a preparation method thereof. Every 100g of the Chinese patent medicine is prepared from 20-50g of radix aucklandiae,10-30g of fructus amomi, 20-50g of atractylodes macrocephala koidz, 30-70g of prepared fingered citron, 20-50g of steamed pericarpium citri reticulatae, 20-50gof cooked codonopsis pilosula, 20-50g of poria cocos, 10-30g of honey-fried licorice root, 10-30g of ginger processed pinellia, 20-50g of radix salviae miltiorrhizae, 12-35g of sun-dried ginseng, 30-70g of coix seeds, 30-70g of caulis spatholobi, 30-70g of Chinese dates, 20-50g of capillary wormwood, 20-50g of endothelium corneum gigeriae galli and 20-50g of radix dipsaci. Clinical experiments prove that when the Chinese patent medicine is used for treating the spleen-deficiency syndrome postoperative fatigue syndrome, the number of T lymphocytes of a patient can be effectively increased, thepostoperative fatigue degree and the spleen-deficiency syndrome of the patient are improved, and the overall treatment effect on the disease is improved. Particularly, compared with a decoction usingthe same prescription, the Chinese patent medicine is better in curative effect due to the fact that medicinal components in medicinal materials can be better extracted and retained by means of the preparation method.