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Application of hepcidin antagonist LDN193189 and derivatives thereof to drug preparation

A technology of LDN193189 and antagonist, applied in the field of medicine, can solve the problem of no bone marrow acute radiation sickness and radiotherapy-induced cytopenia drugs, etc., and achieve the effect of inhibiting the occurrence of cell ferroptosis, the recovery of the number, and the increase of the number

Active Publication Date: 2020-01-10
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0006] So far, there is no relevant report on the use of LDN193189 in the preparation of drugs for the treatment of myeloid acute radiation sickness and radiotherapy-induced cytopenias

Method used

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  • Application of hepcidin antagonist LDN193189 and derivatives thereof to drug preparation
  • Application of hepcidin antagonist LDN193189 and derivatives thereof to drug preparation
  • Application of hepcidin antagonist LDN193189 and derivatives thereof to drug preparation

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Embodiment Construction

[0021] The present invention is described in detail below in conjunction with accompanying drawing and specific embodiment:

[0022] The LDN193189 used in this example was purchased from APExBIO (CAS number: 1062368-62-0).

[0023] 1. The effect of LDN193189 on the survival rate of lethal dose irradiated mice

[0024] ICR mice were divided into four groups: 0 Gy group, 0 Gy + LDN193189 group, 10 Gy group, 10 Gy + LDN193189 group, 10 mice in each group; 0 Gy and 10 Gy groups included solvent control; Co 60 Gamma-ray irradiated mice were injected intraperitoneally with LDN193189 (3 mg / kg, dissolved in distilled water) on the first and second days after irradiation, and then observed the survival of irradiated mice to study the effect of LDN193189 on the survival of lethal doses of irradiated mice. rate impact.

[0025] Such as figure 1 As shown, the survival rate of the mice in the 10Gy group was 0% on the 16th day after irradiation, while the survival rate of the mice in the...

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Abstract

The invention discloses application of a hepcidin antagonist LDN193189 and derivatives thereof to drug preparation, belongs to the technical field of medicine and provides new application of the hepcidin antagonist LDN193189 and the derivatives thereof to preparation of drugs for treating bone marrow form acute radiation sickness and radiation-induced hemocytopenia. The LDN193189 and derivatives thereof are adopted for intraperitoneal injection of mice irradiated by the lethal dose so that the survival rate of the irradiated mice can be increased to 40% (120 days), and the numbers of peripheral blood leukocytes and lymphocytes are obviously increased; the number of bone marrow granulocyte and megakaryocytic hematopoietic progenitor cells is obviously recovered; the survival rate of spleniclymphocytes is obviously recovered; and the number of the splenic lymphocytes is obviously increased (HE splices), and the LDN193189 and the derivatives thereof have good effects on treatment of bonemarrow form acute radiation sickness and radiation-induced hemocytopenia.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of hepcidin antagonist LDN193189 and its derivatives in the preparation of medicines. Background technique [0002] The extensive application of nuclear technology in the military and energy fields has greatly promoted the development of human society, but the application of these nuclear technologies also poses a serious threat to the survival of human society. According to available records, there have been at least 1,054 nuclear tests, 2 atomic bomb explosions, 7 submarine nuclear reactor accidents, and more than 100 nuclear power accidents worldwide. The most common consequence of human exposure to ionizing radiation from nuclear weapons / radiation accidents is the occurrence of myeloid acute radiation sickness. Bone marrow acute radiation sickness is a systemic radiation injury induced by acute exposure to ionizing radiation, mainly bone marrow t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61P43/00
CPCA61K31/519A61P43/00
Inventor 张晓红田梦馨刘慧文张海黔
Owner NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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