32 results about "Radiation sickness" patented technology

The invention relates to chemistry of organic substances, pharmacology and medicine, and concerns treating diseases associated and with aberrant activity of cells of the immune system, more particularly for treating lung, respiratory tract and abdominal diseases, radiation sickness, pain syndrome and other diseases by using compounds of formula (A), wherein R1 is a -C(O)-R2-C(O)- or -R2-C(O)- group, where R2 is a -(CH2)n- group optionally substituted with one or two C1-C6 alkyls, or phenyl, and n is an integer from 0 to 4; wherein the compounds are selected from a group consisting of the compounds as set out in the description. These compounds, as well as pharmaceutically acceptable salts thereof, are highly effective in inhibiting glutaminyl cyclase, which is involved, in particular, in post-translational modification of chemokines and chemotaxis of monocytes, macrophages and other cells of the immune system. This invention also relates to pharmaceutical compositions comprising a therapeutically effective amount of the compounds of formula (A) as defined above.

Provided is an animal motion sickness inducing device. The problem that simple stimulation-induced modeling and diversified experiment factors of rodent motion sickness in the prior art influence determination data and enable the data to be unreliable and the like is solved. The animal motion sickness inducing device comprises a base, a rotary table assembled on the base through a rotary shaft and used for driving an experimental animal to move and a drive device. The technical point is that at least two animal limiting movement devices are fixed on the rotary table, and each animal limiting movement device comprises a support, a base provided with an excrement collecting trough, a walking mechanism fixed on the base, a trunk limiting cover and a head fixing device. The rotary shaft is assembled on the base through a bearing seat, and a rotary shaft drive device comprises a motor, a driven wheel fixed on the rotary shaft, a driving wheel driven by the motor and a transmission belt tensioned on the driving wheel and the driven wheel. The animal motion sickness inducing device is reasonable in structural design, convenient to operate, safe and reliable in use, effectively establishes an animal experimental model inducing the motion sickness and facilitates control of research, development and screening of anti-motion-sickness drugs and guidance of clinical treatment.

The invention belongs to the technical field of medicine, and more specially discloses applications of MPLA (Monophosphoryl lipid A) in preparation of drugs used for preventing and treating ionizationradiation induced intestinal injuries. Toxic and side effect of MPLA as a drug used for preventing and treating ionization radiation induced intestinal injuries is low, curative effect on ionizationradiation induced intestinal injuries is excellent, and drug using is safe and convenient. MPLA possesses unique advantages in preventing and treating ionization radiation induced intestinal injuries,and a novel method is provided for preventing and treating ionization radiation induced intestinal injuries. Effective preventing and treating methods on intestinal radiation injuries and intestinalradiation disease are few at home and abroad, development of the methods is a key problem in the field of radioactive medicine, so that application prospect of MPLA as a drug used for preventing and treating ionization radiation induced intestinal injuries is promising.

The invention discloses the application of Brusatol in the preparation of anti-radiation damage drugs. The invention firstly discovers and confirms that Brusatol has a new application of anti-radiation damage, and can significantly improve the survival period and survival rate of mice after radiation. The drug combination containing Brusatol The drug can be used to prevent or treat acute radiation sickness, nuclear and radiation damage, and radiation damage caused by tumor radiotherapy, and can also be used as a tool drug for researching anti-radiation damage. The present invention provides for the research and development of anti-radiation damage drugs. A brand-new idea and strategy with broad application prospects.

Disclosed are methods of use of analogs of quinic acids or shikimic acids for protection from the harmful effects of radiation when administered either prior to radiation exposure, after radiation exposure, or both. These methods are useful for treating humans and animals exposed to radiation and at risk for radiation sickness and / or death as the result of radiation exposure.

The present invention is a medicine for treating radiation diseases, especially a medicine prepared by biological preparation and Chinese traditional medicine for treating radiation diseases. It is characterized in that it mainly includes Alpha-mannan peptides 10-40%, and free radical removing Chinese traditional medicine 60-90%. The medicine includes Alpha-mannan peptides 10-40%, free radical removing Chinese traditional medicine 10-60%, and strengthening middle-burner and benefit vital energy Chinese traditional medicine 10-50%. The medicine includes Alpha-mannan peptides 10-40%, free radical removing Chinese traditional medicine 10-50%, strengthening middle-burner and benefit vital energy Chinese traditional medicine 10-40%, activating blood and removing stasis Chinese traditional medicine 10-30%. The medicine is a capsule prepared by biological preparation and Chinese traditional medicine, and combines the current medicine with traditional medicine, and plays their cooperating function, and has unique curative effect for the damnification caused by radiation and has no toxic and side effect, and can be taken conveniently.

The invention relates to the application of sialic acid in the preparation of medicines for protecting intestinal tract or DNA damage caused by ionizing radiation, and discloses the dosage forms and administration methods. The protective drug for intestinal damage caused by ionizing radiation with sialic acid as the active ingredient provided by the present invention has the advantages of small toxic and side effects, significant curative effect, convenient and safe medication, etc. It is applicable to different personnel such as patients, and can be used before treatment or during tasks and work. At the same time, the invention provides a new application, treatment concentration and treatment mode of sialic acid as a DNA damage repair protein DNA-PKcs activator, and has broad potential application prospects in the field of biomedicine.

The invention relates to a method of using an S1P receptor conditioning agent to prevent and / or cure stomach and intestine organization damages caused by ionising radiation, concretely to individually use, or combined with other treatment methods, the S1P receptor conditioning agent to prevent and / or cure intestinal radiation sickness and radiation enteritis caused by tumour radiation treatment.