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Medicine for treating radiation diseases

A radiation sickness and drug technology, which can be used in drug combinations, pharmaceutical formulations, plant raw materials, etc., to solve problems such as changes in blood hypercoagulability, enhanced platelet aggregation, and thrombocytopenia.

Inactive Publication Date: 2008-04-16
西安亨通光华制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 2. Lymphocytes are highly sensitive to ionizing radiation. Lymphocytes in the spleen, thymus, lymph nodes, and intestinal lymphocytes are reduced or completely disappeared, and the immune function of the body is reduced, which is prone to infection
[0009] 3. The blood coagulation system can be activated in the early stage after high-dose irradiation, the platelet aggregation reaction is enhanced, the blood viscosity is increased, and blood hypercoagulability changes appear, resulting in the formation of microthrombosis and microcirculation disturbance, and insufficient production due to increased consumption of coagulation factors , thrombocytopenia, decreased aggregation function, often leading to bleeding syndrome
[0013] 7. Radiation damage to the skin first occurs with dilation of small blood vessels, which may be accompanied by edema and degeneration of epidermal cells

Method used

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  • Medicine for treating radiation diseases
  • Medicine for treating radiation diseases
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Examples

Experimental program
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Effect test

preparation example Construction

[0037] The preparation process of space mutagenesis strains to produce mannan peptides:

[0038] The mannan peptide produced by the space mutagenic strains of the present invention is prepared by the following method: preparation of space strains --- primary fermentation --- secondary fermentation --- fermentation liquid purification, finally producing nectar Glycan peptides.

[0039] ① Space strain preparation:

[0040] The α-hemolytic streptococcus carefully selected through space mutation breeding is used as the production strain.

[0041] A. Slant seed medium: 0.5% beef extract, 0.6% yeast extract, 0.5% peptone, 0.4% glucose, 0.5% sodium chloride, 3% agar, 8% sheep blood; pH7.4.

[0042] The slant seed medium is sterilized at a temperature of 121°C for 30 minutes and a steam pressure of 0.12Mpa.

[0043] Unseal the strain freezing tube, dilute it with sterile broth medium, insert it into the blood slant under aseptic conditions, and culture it at 38°C for 30 hours after...

Embodiment 1

[0097] Example 1 Take 100 mg of the above-mentioned α-mannan peptide, 3 g of vitamin C, 100 g of ginkgo biloba, 120 g of Codonopsis pilosula, 100 g of astragalus, 100 g of angelica, 80 g of peach kernel, 80 g of panax notoginseng, 80 g of pangolin, 150 g of medlar, and 100 g of licorice, and make capsules , 5g per capsule.

[0098] Preparation process: decoct the above traditional Chinese medicine → extract medicinal juice → filter and remove residue → carry out alcohol precipitation and concentration → dry and spray → pulverize → mix with α-mannan peptide and vitamin C → granulate → pass the quality inspection → make capsules Filling→packing the finished product.

[0099] The specific production method is carried out according to the preparation process of a capsule of the Pharmacopoeia of the People's Republic of China 2000 edition (edited by the National Pharmacopoeia Committee, published by the Chemical Industry Press).

[0100] Other embodiments are different from embodi...

Embodiment 2

[0101] 1000 g of the drug in Example 2 contains 270 g of α-mannan peptide, 50 g of Rhizoma Chuanxiong, 50 g of Danshen, 50 g of Angelica, 50 g of Polygonum multiflorum, 80 g of Poria cocos, 80 g of Schisandra chinensis, 30 g of ginseng, 50 g of Codonopsis pilosula, 50 g of astragalus, 50 g of Ligustrum lucidum, and 30 g of antler , Cordyceps 30g, Epimedium 30g, Cuscuta 50g, Cornus officinalis 50g.

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Abstract

The present invention is a medicine for treating radiation diseases, especially a medicine prepared by biological preparation and Chinese traditional medicine for treating radiation diseases. It is characterized in that it mainly includes Alpha-mannan peptides 10-40%, and free radical removing Chinese traditional medicine 60-90%. The medicine includes Alpha-mannan peptides 10-40%, free radical removing Chinese traditional medicine 10-60%, and strengthening middle-burner and benefit vital energy Chinese traditional medicine 10-50%. The medicine includes Alpha-mannan peptides 10-40%, free radical removing Chinese traditional medicine 10-50%, strengthening middle-burner and benefit vital energy Chinese traditional medicine 10-40%, activating blood and removing stasis Chinese traditional medicine 10-30%. The medicine is a capsule prepared by biological preparation and Chinese traditional medicine, and combines the current medicine with traditional medicine, and plays their cooperating function, and has unique curative effect for the damnification caused by radiation and has no toxic and side effect, and can be taken conveniently.

Description

Technical field [0001] The invention belongs to a medicine for treating radiation sickness, in particular to a medicine prepared by coordinating biological preparations and traditional Chinese medicines for treating radiation sickness. Background technique [0002] Radiation sickness is the damage caused by uniform or relatively uniform whole-body irradiation of large doses of strong penetrating rays. Radiation sickness can be divided into acute radiation sickness and chronic radiation sickness according to the length of exposure and the number of exposures. Acute radiation sickness refers to systemic diseases caused by the human body being exposed to one or more large doses of radiation within a short period of time (usually several days); chronic radiation sickness refers to the continuous or discontinuous exposure to ionizing radiation exceeding the equivalent dose limit for a long period of time. The effect of radiation is a systemic disease that causes multi-system dam...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/16A61P39/00A61K36/232A61K36/258A61K36/481
Inventor 赵恒
Owner 西安亨通光华制药有限公司
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