Acanthopanacis senticosi radix et rhizoma seu caulis and herba hedyotis diffusae capsule and application thereof to treatment of leukopenia

A technology of Acanthopanax and Hedyotis diffusa, applied in capsule delivery, extracellular fluid diseases, medical preparations containing active ingredients, etc., can solve the problem of strong toxicity, low potency of sulfur-containing radiation prevention drugs, long-term Problems such as side effects are not easy to overcome

Inactive Publication Date: 2017-03-15
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still many shortcomings in practical use: the potency of sulfur-containing radiation preventive drugs is generally not strong, and the compound with the strongest potency at present, such as WR-2721, is very toxic; the effective dose of estrogen radiation damage prevention drugs is physiological concentration Thousands of times that, the side effects of long-term use are not easy to overcome
[0004] At present, the equipment of natural medicines for radiation damage protection is mainly rubia dibasin, and the existing equipment medicines can only solve the problem of prevention and treatment of moderate acute radiation sickness

Method used

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  • Acanthopanacis senticosi radix et rhizoma seu caulis and herba hedyotis diffusae capsule and application thereof to treatment of leukopenia
  • Acanthopanacis senticosi radix et rhizoma seu caulis and herba hedyotis diffusae capsule and application thereof to treatment of leukopenia
  • Acanthopanacis senticosi radix et rhizoma seu caulis and herba hedyotis diffusae capsule and application thereof to treatment of leukopenia

Examples

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Comparison scheme
Effect test

Embodiment 1

[0059] Embodiment 1, the preparation of thorn white capsule

[0060] The formula of Cibai jiaonang of the present invention (Cibai jiaonang) is as follows: Acanthopanax 200g, Hedyotis diffusa 300g, Dodder 150g, Psoralen 150g, Angelica 150g, Astragalus 200g, Chishao 100g, Rehmannia glutinosa 150g, Lycium barbarum 150g, Spatholobus 150g. The specific preparation method is as follows:

[0061] 1. Add 200g Acanthopanax 200g and add water to decoct twice, add 8 times the amount of water each time, 3 hours each time, combine the decoction, filter, concentrate the filtrate into extract, and obtain Acanthopanax extract;

[0062] 2. Add 150g of dodder, 150g of psoralen, 150g of spatholobus and 300g of Hedyotis diffusa to reflux three times with 75% ethanol aqueous solution, 8 times the amount of 75% ethanol aqueous solution for 2 hours each time, and combine the ethanol extracts, Filtrate, recover the ethanol from the filtrate under reduced pressure until there is no alcohol smell, a...

Embodiment 2

[0065] Example 2, the application of Libai Capsules in the treatment of leukopenia caused by low-dose radiation

[0066] The present invention observes the effect of thorn white capsule on 1.0Gy 60 The effects of Coγ-ray whole-body irradiation on peripheral blood leukocytes, CFU-GM, CFU-Mix, BFU-E, and CFU-E in mice for 3 consecutive days were studied, and its therapeutic effect on leukopenia in mice irradiated with low dose was studied. Specific steps are as follows:

[0067] (1) Experimental materials and methods

[0068] 1. Experimental materials

[0069] BALB / C mice, 5-6 weeks old, weighing 16-20g. Experimental Animal Quality Certificate No. SCXK-(Army) 2007-004, Animal Experimental Facility License No. SYXK-(Army) 2007-004.

[0070] 2. Experimental method

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Abstract

The invention discloses an acanthopanacis senticosi radix et rhizoma seu caulis and herba hedyotis diffusae capsule and application thereof to the treatment of leukopenia. Proved through an experiment, the acanthopanacis senticosi radix et rhizoma seu caulis and herba hedyotis diffusae capsule provided by the invention can be used for effectively promoting the recovery of the peripheral hemogram and a hematopoietic colony after whole-body irradiation by 1.0Gy<60>Co[gamma] for continuous 3 days; the effect is obviously superior to that of a positive contrast drug 408; through approaches of stimulating the proliferation of a bone marrow stem / progenitor cell, lightening the injury extent of the bone marrow stem / progenitor cell, recovering the quantity of peripheral-blood white blood cells, regulating the immune function of an organism, and the like, the treatment effect on the leukopenia caused by small-dose, particularly low-dose radiation is achieved. The acanthopanacis senticosi radix et rhizoma seu caulis and herba hedyotis diffusae capsule not only has indeed curative effects on the later-period recovery of the small-dose radiation and a radiation disease, but also has important effects on the deficiency supplying, the matching, the upgrading and the updating of a radiation injury protecting drug.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a thorn white capsule and its application in the treatment of leukopenia. Background technique [0002] Leukopenia caused by low-dose radiation, according to its main symptoms are fatigue, dizziness, palpitations, insomnia, poor appetite, low-grade fever, sore throat, tongue loss, etc. , "febrile disease" and other syndrome categories. Traditional Chinese medicine believes that it is due to insufficient congenital endowment, acquired lack of nourishment, and loss of body; or exogenous pathogenic factors; or chronic illness and wrong treatment; or Qi stagnation and blood stasis; Visceral loss. Traditional Chinese medicine believes that "blood is the essence of water and grain, which is biochemical in the spleen". The spleen is the acquired foundation, governing movement and transformation, governing the limbs, and governing muscles. The kidney governs the bones, produce...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61K9/48A61P7/00A61P7/06
CPCA61K36/254A61K9/48A61K36/232A61K36/39A61K36/43A61K36/481A61K36/486A61K36/487A61K36/65A61K36/71A61K36/748A61K36/804A61K36/815A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 高月李琼马增春谭洪玲常虎刘建丁德红聂啸军赵永红肖成荣孙云波
Owner INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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