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Application of compound pachymic acid in preparing medicines

A technology of poiaic acid and compound is applied in the directions of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc. It can solve the problem that there is no single compound application, and achieves reduction of peripheral blood lymphocyte apoptosis, strong pharmacological effect, Effect of Adjusting Quantity Percentage

Inactive Publication Date: 2013-03-27
张学峰 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The molecular formula of this compound is C 33 h 52 o 5 , white needle-like crystal, molecular weight 528, this compound can be extracted from the traditional Chinese medicine Poria cocos, and there is no application of this single compound in pharmaceuticals

Method used

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  • Application of compound pachymic acid in preparing medicines
  • Application of compound pachymic acid in preparing medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Use 150kg of white poria cocos powder, soak in ether three times, each time for 48 hours, filter, take the cold extract, recover the ether under reduced pressure to obtain a light yellow extract (150g), pass through Si-gel C.C.CHCl 3 : MeOH (50:1-20:1) treatment, Fr.1, Fr.2, Fr.3 (20g), Fr.4 and Fr.5, five substances were obtained, Fr.3 (20g) was taken again Si-gel C.C.CHCl 3 :MeOH (50:1) treatment, get Fr.3.1, Fr.3.2 (15g) and Fr.3.3 three substances, take Fr.3.2 (15g) and give ODS C.C.MeOH:H 2 0 (85:15) treatment, Fr.3.2.1, Fr.3.2.2, Fr.3.2.3 (8g) Fr.3.2.4 and Fr.3.2.5 five substances, take Fr.3.2.3 (8g) Repeated recrystallization of methanol, compound pachynic acid-white crystals (1500mg). Mix it with olive oil to form a mixture with a concentration of 100mg / ml, sterilize it, and seal it to make a product.

Embodiment 2

[0029] The compound pachynic acid-white crystal obtained in Example 1 was mixed with olive oil to form a mixture with a concentration of 10 mg / ml, sterilized, and sealed to make a product.

Embodiment 3

[0031] Compound pachymic acid-white crystal 200mg obtained in Example 1 is made into capsules according to a known method to become a product.

[0032] Additional material:

[0033] The relevant technical information of the present invention has been published by magazines such as Chinese Medical Journal (Chinese Medical Journal) and Chinese Journal of Microbiology and Immunology. The relevant literature information is as follows, and the original copy is attached, please refer to it.

[0034] 1. ZHANG Fan Zhang Fan, ZHANG Xuefeng Zhang Xuefeng, WANG Baichun Wang Baichun, et al. Pachymic acid, a novel compound for anti-rejection: effect in rats following cardiac allograft transplantation. Chinese Medical Journal. 2009; 122(23): 2898- 2902

[0035] 2. Liu Hongyu, Zhang Xuefeng, Zhang Fan, et al. Poria cocos extract pachymic acid effect on peripheral blood CD4 in rats + and CD8 + Regulation of lymphocyte numbers. Chinese Journal of Microbiology and Immunology. 2008, 28(12): ...

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PUM

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Abstract

The invention relates to an application of a compound pachymic acid in the field of pharmacy. With the product, rejection reaction against transplant after transplant operation can be reduced, peripheral blood lymphocyte mitochondrial membrane potential stability can be protected; peripheral blood lymphocyte apoptosis percentage can be reduced, peripheral blood CD8+ lymphocyte number percentage can be stabilized, and so on. Under a non-transplant condition, peripheral blood lymphocyte percentage can be reduced, CD4+ and CD8+ lymphocyte number percentage can be regulated, and so on. When the compound is used for treating, transplant rejection reactions of transplantations of animal and human organ, tissue, cell, and the like can be reduced; and body lymphocyte number, proportion, and function can be regulated and stabilized.

Description

Technical field: [0001] The present invention relates to the application of the compound pachynic acid (3β acetoxyl 16α hydroxy lanoster 8,24(31) diene 21 acid), especially the application in the field of pharmacy. Background technique: [0002] The structural formula of the compound pachynic acid is [0003] [0004] The molecular formula of this compound is C 33 h 52 o 5 , white needle-like crystal, molecular weight 528, this compound can be prepared by extracting from the traditional Chinese medicine Poria cocos, and there is no application of this single compound in pharmaceuticals at present. Contents of the invention [0005] The purpose of the present invention is to provide a new application of the compound pachynic acid, that is, a new application in pharmacy. [0006] In fact, this project involves the application of compound pachymic acid as a medicine for treating or preventing rejection after transplantation. [0007] The invention relates to the appli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61P37/06A61P7/00
Inventor 张学峰张帆
Owner 张学峰
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