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Plant lactobacillus composition and its application in strengthening intestinal immunobarrier

A technology of Lactobacillus plantarum and composition, applied in the direction of medical preparations containing active ingredients, drug combinations, bacteria, etc., can solve problems such as inability to effectively correct intestinal immune barrier function

Inactive Publication Date: 2007-06-27
SHANGHAI JIAODA ONLLY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, common enteral nutrition preparations cannot effectively correct the intestinal immune barrier function

Method used

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  • Plant lactobacillus composition and its application in strengthening intestinal immunobarrier
  • Plant lactobacillus composition and its application in strengthening intestinal immunobarrier
  • Plant lactobacillus composition and its application in strengthening intestinal immunobarrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: animal experiments

[0031] 1. Establishment of rat severe acute pancreatitis (Severe Acute Pancreatitis, SAP) model

[0032] The present invention uses male SD rats with a body weight of 250 to 300 g (provided by the Animal Center of Fudan University School of Medicine), fasted with water for 12 hours, injected intraperitoneally with 20 g / L ketamine hydrochloride (100 mg / kg body weight) for anesthesia, and fixed the rats in a Supine position, neck and abdomen hair removal, 1g / L new Jieermi tincture disinfection, spread sterile towels. A midline incision was made to open the abdominal cavity, and the pancreas and bile duct distributed in sheets were found on the inner side of the duodenum. A 4.5-gauge needle was retrogradely inserted into the bile duct through the intestinal wall on the opposite side of the mesentery, the end of the bile duct and the needle were ligated, and the bile duct at the hepatic hilum was clamped with non-invasive vascular clips. ...

Embodiment 2

[0072] Example 2: Effect of the combination of Lactobacillus plantarum LP-Onlly and enteral nutrition on the natural course of severe pancreatitis

[0073] 1. Screening of patients with severe acute pancreatitis

[0074] Select 30 patients who meet the diagnostic criteria of acute severe pancreatitis. Among the 30 patients, there were 17 males and 13 females; the age ranged from 20 to 87 years old (average 59.9±16.4 years old); the average time from onset to admission was 25.6±15.6 hours; all 30 patients had symptoms of abdominal pain and fever (T>38℃ ), WBC increased (>10 9 / L), blood / urine amylase increased (blood amylase>110U / L; urine amylase>641U / L); blood amylase was up to 6500U / L, with an average of 1236±1373U / L; urine amylase was up to 20000U / L L, average 5636±6439U / L. On admission, 18 cases were accompanied by jaundice (total bilirubin>18 μmol / L); 13 cases were accompanied by abnormal liver function (ALT>65U / L or AST>37U / L); 6 cases were accompanied by abnormal rena...

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Abstract

The present invention relates to a kind of composition containing plant lactobacillus LP-Onlly strain and its application in strengthening intestinal immunobarrier. The composition of the present invention can intervene the homing of intestinal lymphocyte, control the number of intestinal tract secretive IgA and intestinal lymphocyte, lower the endotoxin level, improve intestinal tract immunobarrier and prevent damage of intestinal tract immunobarrier caused by hunger, malnutrition, infection, etc, and prevent and treat intestinal inflammation, infectious diseases and immune disorder diseases.

Description

technical field [0001] The invention relates to a composition containing Lactobacillus genus, plant Lactobacillus species and plant Lactobacillus strain LP-Onlly and its application in enhancing intestinal immune barrier. Background technique [0002] The intestine is not only an important place for digestion, absorption and synthesis of nutrients, but also the largest immune organ of the human body. 70% of human immune tissue exists in the intestinal tract, which constitutes Gut-Associated Lymphoid Tissue (GALT), and the number of lymphocytes contained is much higher than that of other lymphoid tissues. Therefore, the intestinal immune barrier is very important for resisting bacteria. , the invasion of viruses, antigens and endotoxins, maintaining the stability of the intestinal immune environment, and preventing the occurrence of inflammation play a very important role. The homing of intestinal lymphocytes is one of the important immune activities of the intestinal mucosa...

Claims

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Application Information

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IPC IPC(8): A61K35/74A61K38/00C12N1/20A61P1/00A61P1/12A61K31/198A61K31/185A61K35/747
Inventor 兰先德范小兵杭晓敏张和春杨国潘玉辉
Owner SHANGHAI JIAODA ONLLY CO LTD
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