58 results about "Library search" patented technology

A computer-implemented method serves electronic document information in response to a user query identifying a target electronic document. The user query prompts a library search of library-stored electronic documents to determine whether the target electronic document corresponds to a library-stored electronic document. When the target electronic document corresponds to a library-stored electronic document, the library-stored electronic document is presented for review by the user. Also presented is information associated with the relationship between the library-stored electronic document and the target electronic document. In some embodiments, if the target electronic document does not correspond to the library-stored electronic documents, the method includes providing-link information for user access to the target web page.

Methods for determining the chemical structures, substructures and / or ionic structural arrangements of unknown or partially structurally characterized compounds from mass spectrometric data are disclosed. The methods of the invention are directed to elucidating the molecular structures of compounds by identifying the structures of ions generated from those compounds through the use of tandem mass spectrometry and subsequently conducting a library search of structurally characterized tandem product spectra from known ions for specific matches. The collective structural information and / or alternative structural candidates are then constructed from the determined ion structures and other structural characteristics using a structure generator and / or a structure assembly and / or a structure reduction system. The structure or substructure determination process can be continuously improved by adding additional data, e.g., information obtained from molecules previously structurally characterized using this method.

The invention relates to an analytical method for researching protein structure or protein-protein interaction. The method comprises the following steps: performing crosslinking and enzymolysis on a protein composite in a cell by using a crosslinking agent with reactive groups on two sides and a breakable group, and taking a part of the enzymatic hydrolysate for a derivatization reaction for mass spectrometry; after breaking the crosslinking agent by means of a chemical method for the other part of the enzymatic hydrolysate, enriching peptide sections with an enriching material, and performing mass spectrometry on the enzymatic hydrolysate without the enriched peptide sections; determining the crosslinked peptide sections according to a library searching result so as to establish a peptide section library; finding out a candidate peptide section from the peptide section library according to N-terminal amino acid information of the crosslinked peptide section determined in the mass spectrogram of the crosslinked peptide section; and determining the crosslinked peptide section sequence by combining the mass spectrogram m / z of the crosslinked peptide section and the characteristic ions of the peptide section so as to obtain the protein structure and protein-protein interaction information. The method has the advantage of being simple to operate, and is applied to structural analysis of proteins and analysis of protein-protein composite interaction.

The invention generates mass scale comparability between mass spectra which are acquired in time-of-flight mass spectrometers, particularly with ionization by matrix-assisted laser desorption. Always slightly distorted mass scales of different mass spectra from the same type of sample can be aligned. The flight times of identical ions always differ slightly from one mass spectrum to the next due to non-reproducible processes in the ionization method. Thus the apparent mass values of ion signals of identical substances in different mass spectra do not match even if the flight times are converted into mass values with the identical calibration equation. After alignment of the mass scales, mass spectra can be reliably compared with respect to deviations in intensities of bio-makers, or be added together without deterioration in the mass resolution, and improved reference spectrum libraries can be created. Furthermore, the invention allows more reliable library searches to be carried out.

The invention generates mass scale comparability between mass spectra which are acquired in time-of-flight mass spectrometers, particularly with ionization by matrix-assisted laser desorption. Always slightly distorted mass scales of different mass spectra from the same type of sample can be aligned. The flight times of identical ions always differ slightly from one mass spectrum to the next due to non-reproducible processes in the ionization method. Thus the apparent mass values of ion signals of identical substances in different mass spectra do not match even if the flight times are converted into mass values with the identical calibration equation. After alignment of the mass scales, mass spectra can be reliably compared with respect to deviations in intensities of bio-makers, or be added together without deterioration in the mass resolution, and improved reference spectrum libraries can be created. Furthermore, the invention allows more reliable library searches to be carried out.

The invention relates to a method for screening illegal additives in health food, wherein illegally added drugs in health food are screened and confirmed by using high performance liquid chromatography-ion trap-time of flight tandem mass spectrometry. According to the present invention, the known and non-target compound can be detected through spectrum library search, molecular formula predictionand multi-stage fragment ion mass spectrum identification, and the cleavage law can be inferred based on fragment ion information; and the method is simple and rapid, can detect and analyze the non-target compound, has wide screening range, can obtain the accurate and reliable conclusions without the use of standard substances or control materials, and is suitable for the rapid screening and identification of weight-reducing-based illegal additives and other illegal additives in food and medicine.

The invention discloses a co-elution peak analysis and library searching method based on gas chromatography-mass spectrometry analysis. The co-elution peak analysis and library searching method comprises the steps of firstly, judging whether a peak is an overlap peak of multiple components by peak-shape and peak-purity analysis, namely judging whether the peak is a co-elution peak; secondly, conducting one-to-more matching on a mass spectrogram which is formed by the composition of multiple materials in a library with the mass spectrogram of the co-elution peak and judging the components according to the matching degree; and thirdly, comparing the three-dimensional spectrograms of different samples, conducting one-to-one or one-to-more library searching by aiming at a difference mass spectrogram, thus determining the material differences of the samples and determining the nature of the different components. The co-elution peak analysis and library searching method based on gas chromatography-mass spectrometry analysis can rapidly realize analysis on the co-elution peak and the component difference of different samples.

The invention relates to a production and transportation cooperative scheduling method and a production and transportation cooperative scheduling system based on improved harmony search. The production and transportation cooperative dispatching method comprises the steps of: 1, performing group batching on work pieces; 2, setting algorithm parameters; 3, generating an initial harmony library; 4, calculating an adaption degree value; 5, acquiring a negative ideal solution of the harmony library; 6, generating a new harmony; 7, performing harmony library searching operation on the new harmony, and updating the new harmony; 8, comparing the new harmony with the negative ideal solution, if the new harmony is superior to the negative ideal solution, substituting the negative ideal solution and updating the harmony library; 9, updating a global optimal solution; 10, and judging whether a termination condition is satisfied, if so, outputting the global optimal solution, otherwise, returning to the step 4. The production and transportation cooperative scheduling method and the production and transportation cooperative scheduling system can realize the optimization of overall efficiency of the supply chain, thereby reducing cost of the supply chain, and enhancing customer satisfaction level.

The invention provides a method for analyzing data of prokaryotic proteogenomics rapidly and automatically. Users only need to provide mass spectral data and a corresponding database file and set a simple retrieval parameter; retrieval of data of proteogenomics can be completed; simultaneously, a user defined data retrieval result can also be compatible; therefore, the identification coverage rate of the data of proteogenomics is increased; in the method disclosed by the invention, library search engines of different algorithms are integrated in advance; disadvantages of a single retrieval method are made up; a user defined library search result can also be compatible; the method has good compatibility; the peptide fragment identification coverage rate is increased to the most extent; in the method disclosed by the invention, functional annotation of new genes is automatically completed; large-scale identification of protein post-translational modification and analysis of non-labelled quantitative proteomics are realized for the first time; and automatic and rapid deep analysis of the data of proteogenomics is really realized.

The present invention discloses a qualitative and quantitative analysis method for element sulfur in liquefied petroleum gas (LPG) by using gas chromatography-mass spectrometry combination, and relates to the field of analytical chemistry. According to the qualitative method, a scanning way is adopted to analyze a large amount of LPG samples; according to analysis of the resulting mass spectrometry spectrogram, a mass spectrometry standard library search is combined, comparison with an element sulfur standard sample retention time is performed, and element sulfur structure analysis is performed. According to the quantitative method, an internal standard is adopted, n-hendecane is adopted as an internal standard substance, and a quadratic fit standard curve is established by selecting an ion monitoring way to carry out quantitative analysis. A LPG sample requiring detection is treated by a toluene solvent, and then is directly subjected to structure and content analysis of element sulfur. The method of the present invention has characteristics of low detection limit, high accuracy, no interference during analysis, and short analysis time, and provides strong technical supports for guidance of normal LPG production and prevention of processing apparatuses and transport equipment from sulfur corrosion.

The invention discloses a detection method of biocontrol bacterium volatile metabolites. The detection method comprises the following steps: (1) smearing a bacterium fermenting solution on a culture medium, and placing the culture medium into a head space bottle; (2) collecting bacterium volatile matters by using a solid-phase micro extraction technology; (3) identifying the bacterium volatile matters by using a gas chromatograph-mass spectrometer with a multi-mode sample inlet in combination with commercial spectrum library searching and an n-alkanes retention index under a full-scanning mode, and quantitatively analyzing the content of the bacterium volatile matters according to a compound molecular identification result. By adopting the detection method, the problems for collecting, identifying and quantitatively detecting the unstable and easy-to-degrade active volatile matters can be effectively solved, the space-time dynamic information of the extracellular volatile metabolite molecules can be grasped, support is provided for researching the antibacterial mechanism, an acting way and application of the biocontrol bacterium in a biological control field, and a theoretical foundation is provided for enriching the type of the antibacterial substances and digging novel antibacterial genes.

A tandem mass spectrometer is provided in the present invention. The mass spectrometer includes an ion source, a quadrupole mass filter located at downstream side of the ion source, a linear ion trap disposed at downstream side of the mass filter and an ion detector placed on the side of the ion trap, all of which are placed in a vacuum environment. The instrument can obtain MS meeting the standard spectral library search criteria by the quadrupole mass filter cooperating with linear ion trap, realize any multi-stage MS under two modes of axial collision and resonance excitation, and predict and optimize the inflow amount and types of samples under the ion trap analysis mode by the quadrupole. A tandem MS analysis method is also provided, which can repeatedly provide precursor ion selection, ion acceleration, achieve high-energy collision dissociation, low product ion mass discrimination effect.

Generating a simulated collaborative mix workload for determining the performance of enterprise software executed on a hardware platform. The collaborative mix workload includes a combination of mail, instant messaging, electronic meetings, documents, and electronic learning. The workload is generated by executing a team spaces path, documents path, learning path, messaging path, web conference path, or various combinations thereof. The team spaces path generates a simulated discussion with team members and generates a search query for locating a forum within the team space. The documents path generates a library search to locate a document, opens the document, reads the document, and generates a simulated chat about the document. The learning path launches a simulated course and assessment activity. The messaging path reads a simulated email, attaches a document to the email, and sends the email with the attached document. The web conference path generates a web conference attended by a plurality of simulated users. At least one of the team spaces path, documents path, learning path, or messaging path are performed more than once.

The embodiment of the invention provides an index library construction method and device and an index library search method and device. The index library construction method comprises: scanning the steps that a data source of interest points Poi, and determining attribute information and city information of the Poi; creating an inverted index of the Poi according to the attribute information of each Poi; segmenting the inverted index of the Poi according to the city information to obtain index blocks based on the city information; and constructing a Poi index library according to the index blocks. According to the embodiment of the invention, a Poi index library is constructed based on urban index blocks; the purpose of storing the Poi according to the cities to which the Poi belongs is achieved, so that in the subsequent searching process, searching can be conducted according to the index blocks, corresponding to the cities to which the Poi belongs, in the Poi index library, the searching range is narrowed, and then the searching efficiency is improved.

An approach for integrated development environment (IDE)-based program code library selection in a networked computing environment (e.g., a cloud computing environment) is provided. Under this approach, a search results file is received in a library selection IDE from a library searching IDE. It may then be determined whether to perform a micro-benchmarking on the at least one method and the at least one class. Based on the determination, the micro-benchmarking may then be performed on the at least one method and the at least one class. A set of code style similarity scores may then be calculated that indicate a similarity between the at least one method and the at least one class with the methods and classes of a second program code file. An ordered list of the methods and classes of the second program code file may then be provided.

The invention discloses an active power distribution system optimization scheduling method considering electric energy quality improvement. The active power distribution system optimization scheduling method specifically comprises the steps of obtaining a control variable of schedulable resource from the active power distribution system, establishing an active power distribution system optimization scheduling model, and then performing initialization on power distribution network parameters, and generating a new solution vector which satisfies constraint conditions, and namely a new harmonic, by three ways of memory library searching, local disturbance and random selection; and removing the worst solution from a harmonic library, meanwhile, putting the new harmonic vector into a harmonic memory library, repeatedly executing the step 4 of generating the new harmonic vector, and a step 5, generating new harmonic through iteration in many times so as to update the harmonic memory library, when updating achieves the maximum iteration number of times, outputting the optimal solution, namely the harmonic with the minimum target function value, and namely, the optimal scheduling scheme. The active power distribution system optimization scheduling method overcomes the shortcoming that the existing single-target optimization method does not consider the voltage regulation capability of the distributed power supply, and is simple in principle and easy to realize.

The invention discloses a method for analyzing short-chain chlorinated paraffin in an environment sample by a comprehensive two-dimensional gas chromatography-flight time mass spectrometry, which belongs to the technical field of analytical testing. The method comprises the following steps: 1) performing enrichment extraction on SCCPs in the environment sample; 2) employing a comprehensive two-dimensional gas chromatography-electron bombardment ionization source-low resolution time-of-flight mass spectrometer for detection; 3) employing library searching and a retention time index for determining the nature of the SCCPs component in the sample; and 4) employing an internal standard curve method for determining total amount of SCCPs. The pre-treatment method has the advantages of high extraction efficiency, good purifying effect, and wide application scope; the used apparatus has the advantages of high analysis efficiency, good separating effect, and strong anti-interference capability;the qualitative method is fast and accurate, and does not depend on a standard substance; the quantification method has the advantages of low detecting limit, low sensitivity, wide linearity range, and good repeatability, and the analysis requirement of SCCPs in the practical environment sample can be satisfied.

This invention discloses a Reverse Intensity Correction method for spectral library search to correct for instrument response without the side effect of magnifying the noise in the low responsivity region of test spectra. Instead of applying relative intensity correction to the sample test spectra to match the standardized library spectra, a reverse intensity correction is applied to the standardized library spectra to match the uncorrected sample spectrum. This simple procedural change improves library search performance, especially for dispersive CCD Raman analyzers using NIR excitations, where the instrument response often varies greatly across the spectral range, and SNR in the low responsivity regions is typically poor.

In a database MSn spectrum search, search of a known compound whose principal chain is identical to that of an unknown compound is enabled, thereby allowing analysis of an entire structure even if the entire structures of the known compound in database and that of the measured unknown compound are not identical. The MSn spectrum obtained in the MSn measurement of the unknown compound is compared with all the MSm spectra (m≧1) in the database regardless of MSn generation. In the MSn measurement of a series of related compounds including various types of different side chains of the same principal chain, such as in the case of biopolymers, it becomes possible to determine the structure of the principal chain using a database search even if the entire structure is not clear. And the estimation of the entire structure is made possible on the basis of the principal chain structure.

The invention discloses a method and a device for distinguishing a fake certificate picture. The method comprises steps of: extracting image features of a to-be-detected picture; according to the image features, searching a similar picture in a picture library searching system; calculating similarity of the to-be-detected picture and the similar picture; and when the similarity exceeds a set threshold value, determining that the to-be-detected picture is a fake certificate picture. According to the invention, whether a to-be-detected picture is a fake certificate picture is distinguished by searching a similar picture in the picture library searching system, so accuracy of detection of certificate pictures is improved.

The invention discloses a development method and system for automatic testing scripts. The method comprises the following steps: designing a test case, configuring test equipment and defining a configuration library; judging and selecting library files in the configuration library defined by the test case in the designing process of the test case; leading one or more library files in the selected configuration library to a test case generation engine; searching the led-in configuration library through the test case generation engine, and automatically generating testing scripts in the corresponding formats or languages according to the content in the configuration library. According to the invention, modularized configuration libraries corresponding to various configuration modes are led in to generate the testing scripts realized by various configuration modes and different languages, so that the testing efficiency is improved; due to the introduction of the modularized configuration libraries, not only are the independent portability and the reusability of the libraries improved, but also the library searching efficiency is greatly improved, and the maintenance of the testing scripts is facilitated.

An approach for integrated development environment (IDE)-based program code library selection in a networked computing environment (e.g., a cloud computing environment) is provided. Under this approach, a search results file is received in a library selection IDE from a library searching IDE. It may then be determined whether to perform a micro-benchmarking on the at least one method and the at least one class. Based on the determination, the micro-benchmarking may then be performed on the at least one method and the at least one class. A set of code style similarity scores may then be calculated that indicate a similarity between the at least one method and the at least one class with the methods and classes of a second program code file. An ordered list of the methods and classes of the second program code file may then be provided.

This invention discloses a method for material identification by analyzing the LIBS spectrum of the sample. The LIBS spectrum is pre-processed to equalize the contribution of elements with strong and weak emission lines. In the meantime, the number of spectral variables is reduced to enhance the specificity and minimize the influence of instrument noise. Commonly used spectrum identification and library search algorithms are then applied to the pre-processed LIBS spectrum for material identification.

Described are computer-based methods and apparatuses, including computer program products, for monitoring, detecting, and quantifying chemical compounds in a sample. A sample measurement comprising a digitized spectroscopic profile is received. A multivariate multistage background model comprising a first model that models a first time effect, a second model that models a second time effect that is different than the first time effect, or both is calculated. A background corrected sample measurement based on the sample measurement and the multivariate multistage background model is generated. A multivariate multistage library search, fault detection, and quantification algorithm is executed to identify one or more primary chemicals in the background corrected sample measurement. The search, detection, and quantification algorithm includes identifying one or more candidate chemicals in the background corrected sample measurement based on a multivariate statistical process control and identifying and quantifying a first primary chemical based on a focused chemical evaluation of the one or more candidate chemicals.

Systems and methods for mass spectrometry dynamic library searching are provided for use with mass spectrometer spectra. A composite spectrum is created from multiple spectra. The multiple spectra are collected at varying collision energies from a mass spectrometer. Dynamic searching algorithms are utilized for assigning a degree of importance to ions depending upon the identity of the ions, and for assigning a degree of importance to the ion ratios. A search is performed against a library of composite spectra that includes data for adduct, dimer, and oligomer ions. The systems and methods determine a match quality value that takes into account any or all ions in the spectrum along with the ions' ratios and degrees of importance.

A sample introduction unit 2 regularly collects a sample from a sample passage 1. A measurement unit 3 performs an LC / MS analysis for the collected sample. A spectrum matching judgment section 42 performs image recognition referring to mass spectra in a normal condition accumulated in a normal spectrum database 44, to determine whether a measured mass spectrum is in a normal condition. If the mass spectrum is non-normal, an abnormal peak locator 45 locates a peak which should not be detected in the normal condition, and an MSn analysis with the located peak selected as the target is performed in the measurement unit 3 under an MSn analysis execution commander 46. An identification processor 47 performs substance identification by a library search based on an acquired MSn spectrum. Upon successful identification, an alert commander 49 issues an alert. Thus, the system can automatically monitor hazardous substances with high accuracy.

This invention discloses a Reverse Intensity Correction method for spectral library search to correct for instrument response without the side effect of magnifying the noise in the low responsivity region of test spectra. Instead of applying relative intensity correction to the sample test spectra to match the standardized library spectra, a reverse intensity correction is applied to the standardized library spectra to match the uncorrected sample spectrum. This simple procedural change improves library search performance, especially for dispersive CCD Raman analyzers using NIR excitations, where the instrument response often varies greatly across the spectral range, and SNR in the low responsivity regions is typically poor.

The invention relates to an MRM qualitative detection method for cubilose and four common adulterants (pigskin, tremella, egg white and fish maw) thereof. According to the method, water solution containing 7M urea and 2M thiourea is used for extracting proteins in cubilose and common adulterants thereof; overnight enzyme digestion is carried out on the extracted proteins through trypsin; peptide fragments are analyzed by using a high-resolution tandem mass spectrum of an nL liquid chromatogram after being desalted; Proteinpilot 5.0 softawre is utilized to carry out library search authentication on data obtained by the high-resolution mass spectrum; high-response, miss cut-free and modification-free peptide fragments, the lengths of which are smaller than 25 amino acids, are selected to undergo Blast comparison on NCBI, so as to mine specific peptide fragments of the cubilose and common adulterants thereof; and SKYLINE software is utilized to construct MRM ion pairs for the cubilose andcommon adulterants thereof. The method is simple to operate, high in correctness and good in stability, and is capable of identifying the cubilose and common adulterants (one or several of pigskin, tremella, egg white and fish maw) thereof through one experiment, so as to provide technical support for maintaining normal market order of cubilose consumption.

The invention provides system and method for validity verification of a certificate in a mobile backhaul net. The method comprises the following steps of: when the validity of a domain certificate is verified, the client side of an online certificate status protocol (OCSP) sends an OCSP search request to an OCSP responser, and a request certificate table is carried; after the OCSP responser receives the OCSP search request, a certificate library is requested to verify the validity of the certificate in the request certificate table, and the certificate library searches the validity of the certificate in the request certificate table and transmits the search results of the validity of the certificate to the OCSP client side by the OCSP responser. The invention can efficiently verify the validity of the certificate in the mobile backhaul net in real time.