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Method for screening illegal additives in health food

A technology for health food and illegal additions, applied in instruments, measuring devices, scientific instruments, etc., can solve problems such as hindering health food safety monitoring and early warning systems, unable to screen illegal additions, etc., and achieve fast and convenient screening and identification. Effect

Active Publication Date: 2018-08-10
HUNAN ACADEMY OF INSPECTION & QUARANTINE +1
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Problems solved by technology

Therefore, it is impossible to conduct a comprehensive and rapid screening of illegal additives in health food, which hinders the establishment of health food safety monitoring and early warning system

Method used

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  • Method for screening illegal additives in health food
  • Method for screening illegal additives in health food

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Embodiment 1

[0011] 1. Establish a high-resolution mass spectrometry screening library of the name of the weight-loss compound, the corresponding molecular formula, the precise molecular weight of the second-order fragment ion, the third-order fragment ion, and the N-order fragment ion, and the retention time.

[0012] 2. Take a commercially available slimming capsule sample, pour out the contents and mash the capsule shell together, and mix well to obtain the sample.

[0013] 3. Using acetonitrile as solvent, ultrasonic extraction, and C18 powder purification for sample pretreatment.

[0014] Weigh 1.000g sample into a 25mL centrifuge tube, add 15mL acetonitrile, ultrasonically extract for 20min, let cool to room temperature, transfer all the sample to a 25mL volumetric flask, wash the centrifuge tube with 10mL acetonitrile several times, and combine the cleaning solution into the volumetric flask and dilute to the mark with acetonitrile, shake well, and let stand for 5 minutes. Take 2mL...

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Abstract

The invention relates to a method for screening illegal additives in health food, wherein illegally added drugs in health food are screened and confirmed by using high performance liquid chromatography-ion trap-time of flight tandem mass spectrometry. According to the present invention, the known and non-target compound can be detected through spectrum library search, molecular formula predictionand multi-stage fragment ion mass spectrum identification, and the cleavage law can be inferred based on fragment ion information; and the method is simple and rapid, can detect and analyze the non-target compound, has wide screening range, can obtain the accurate and reliable conclusions without the use of standard substances or control materials, and is suitable for the rapid screening and identification of weight-reducing-based illegal additives and other illegal additives in food and medicine.

Description

technical field [0001] The invention relates to a method for screening illegal additives in health food, belonging to the technical field of food and drug detection. Background technique [0002] At present, there have been many research reports on the detection of illegally added chemical substances in health products at home and abroad, mainly focusing on the qualitative and quantitative analysis of known compounds. Analysis methods include ultraviolet spectrophotometry, thin layer chromatography, high performance liquid chromatography, high performance liquid phase-tandem mass spectrometry, etc. The main hidden dangers of adding illegal drugs in health food are unclear dosage, inaccurate compatibility, unknown drug sources, and unclear drug impurities. This brings difficulty to the selection of screening targets, and it is necessary to establish a sensitive and specific analysis method to identify and detect illegally adulterated chemicals in health food. High performan...

Claims

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Application Information

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IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/884
Inventor 黄志强王美玲张帆张莹颜鸿飞
Owner HUNAN ACADEMY OF INSPECTION & QUARANTINE
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