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104 results about "Intra arterial" patented technology
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Deployment system for intraluminal devices
ActiveUS20060015171A1Short working lengthRisk minimizationStentsDiagnosticsProsthesisBiomedical engineering
A constraining sheath for use around an endoprosthesis (e.g., a stent device, with or without a graft covering), which may be a balloon expandable endoprosthesis but more preferably is a self-expanding prosthesis. The endoprosthesis is coaxially enclosed within and substantially covered by the constraining sheath, which is an outer, removable tubular sheath, preferably made of ePTFE. The sheath is preferably corrugated circumferentially along at least a portion of the length of the endoprosthesis. The constraining sheath and endoprosthesis are preferably mounted together as an assembly at the distal end of a delivery means such as a catheter shaft, for delivery of the endoprosthesis to a desired location within a body conduit such as an artery. The constraining sheath is removed by the application of tension to a tensile member such as a tether to cause sequential pulling out of the corrugations followed by release and deployment of the endoprosthesis. The use of a corrugated constraining sheath in comparison to a non-corrugated sheath results in a more smoothly applied tensile force to effect the endoprosthesis release as well as requiring less maximum force.
Owner:WL GORE & ASSOC INC
Apparatus and method for inserting an intra-aorta catheter through a delivery sheath
An introducer system delivers therapy locally to a renal system in a patient. A proximal coupler assembly is coupled to an introducer sheath that delivers multiple devices simultaneously into a location within an abdominal aorta associated with first and second renal artery ostia. The coupler assembly has a network of branch lumens arranged to allow for smooth slideable engagement of multiple coupled devices without substantial interference therebetween. A first branch lumen typically introduces a percutaneous translumenal interventional device such as an angiography or guiding catheter into the introducer sheath and is substantially aligned with a longitudinal axis of the sheath. One or more other branch lumen are off-axis from the longitudinal axis by about 30 degrees or less and introduce components of a bilateral renal delivery assembly into the introducer sheath in conjunction with the other device. Novel insertion devices are provided to coordinate the coupling of the multiple devices.
Owner:ANGIODYNAMICS INC
Method and apparatus for the noninvasive determination of arterial blood pressure
InactiveUS6514211B1Blood flow measurement devicesEvaluation of blood vesselsUltrasonic sensorTransmural pressure
Owner:TENSYS MEDICAL INC
Method and apparatus for measuring pulsus paradoxus
InactiveUS6869402B2Accurate measurementReliable measurementCatheterDiagnostic recording/measuringTime domainPulsus paradoxus
A method and apparatus are disclosed of utilizing a source of arterial and / or arteriolar pulse waveform data from a patient for the purpose of measuring pulsus paradoxus. The arterial pulse waveform data source described is a pulse oximeter plethysmograph but can be any similar waveform data source, including intra-arterial transducer, blood pressure transducer, or plethysmograph. Through incorporation of the measurements of values, such as the area under the pulse waveform curve, that are time-domain functions of a change in height of the pulse waveform over at least a partial duration of the waveform, embodiments of the present invention represent a significant improvement upon previously described methods of measuring pulsus paradoxus and, further, produce improved accuracy in measurement of the multiple contributing variables generating pulsus paradoxus, in particular the contribution of diastolic events, to the extent that the physical signs so measured can be regarded as “Revised Pulsus Paradoxus.”
Owner:PRECISION PULSUS
Method and device for determining oxygen saturation of hemoglobin, for determining hematocrit of blood, and/or for detecting macular degeneration
InactiveUS20100030042A1Accurately determineImprove accuracyMaterial analysis by optical meansDiagnostic recording/measuringFiberOptical density measurement
A method and device for accurately determining oxygen saturation of hemoglobin by the measurement of the optical density of a sample, such as a blood vessel, in response to illumination by light having at least three wavelengths (λi, λ2, λ3, . . . ) within a range of about 460 nm to about 523 nm. The hematocrit of a sample may be determined from optical density measurements at the three or more wavelengths in conjunction with a known path length. The device may be an intravenous or intra-arterial fiber optic catheter used to deliver the interrogating light signal to the blood and to detect the reflected signal. A method and device of determining the thickness of the retinal well using spectroscopic information are also disclosed.
Owner:UAB RES FOUND +1
Electronic Anti-coagulation stent for intra-arterial deployment
InactiveUS20060106451A1Sufficient maneuverabilitySolve the lack of spaceStentsInternal electrodesMedicineInsertion stent
An electronic anti-coagulation stent structure is disclosed. The stent structure comprises a pair of coaxial metal stents having a layer of dielectric material between the stents. A battery is operatively connected preferably near or adjacent to the upstream end upon deployment of the stent. The positive battery terminal establishes an electrical connection to the outer metal stent and the negative terminal establishes an electrical connection to the inner metal stent and this exhibits a capacitor-like properties. The inner metal stent, being negatively charged, promotes a platelet repellent, anti-thrombotic effect.
Owner:BUSIASHVILI YURI
Administration of a thiol-based chemoprotectant compound
InactiveUS20060177523A1Treat and mitigate side effectProtect from harmBiocideDipeptide ingredientsAbnormal tissue growthSide effect
A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.
Owner:OREGON HEALTH & SCI UNIV +1
Fluoroscopy-independent, endovascular aortic occlusion system
ActiveUS20130102926A1Quick measurementIncrease perfusionBalloon catheterOther printing matterArterial occlusionsLeft subclavian artery
A system for deploying and selectively inflating a thoracic aortic balloon at a desired location within the thoracic aorta for resuscitative aortic occlusion, inferior to the left subclavian artery, without the aid of fluoroscopy is described. Using CT imaging data, a distance between readily identifiable and consistently located external landmarks of torso extent is measured. Next, using the same data, a second distance from the femoral artery to a desired aortic occlusion location inferior to the left subclavian artery is determined. A correlation between the external measure of torso extent and the desired intra-arterial (i.e. endovascular) distance within the torso is made. Using a nomogram, a calibrated endovascular resuscitative thoracic aortic occlusion system can be positioned to this desired location on any injured individual with end-stage shock and impending cardiovascular collapse or death without the aid of fluoroscopy for delivery or balloon inflation.
Owner:RGT UNIV OF MICHIGAN +1
Method for transcatheter intra-arterial perfusion magnetic resonance imaging
A method to serially determine changes in perfusion to tissues is provided. This method involves injecting contrast material into a catheter that is positioned in the blood supply proximal to the targeted tissue of interest, acquiring a time series of images that depicts the uptake of this contrast material within the tissue, deriving semi-quantitative or quantitative perfusion metrics based upon the time series of perfusion images, altering perfusion to the targeted tissue by means of injecting pharmacologic agents or embolic agents into the blood vessels supplying the targeted tissue, repeating the acquisition of perfusion images to serially monitor changes in tissue perfusion after each alteration, and calculating changes in perfusion metrics after each series of perfusion images. This method is used to monitor changes in perfusion to various tissues, including a diverse array of tumors. The perfusion imaging method can be acquired using magnetic resonance, x-ray computed tomography, or radionuclide imaging. The perfusion metric is serially measured during an embolization procedure as a means of measuring changes in tissue perfusion or to target an endpoint based upon a specific alteration in the calculated perfusion metric.
Owner:NORTHWESTERN UNIV
Nanoparticles and their use for multifunctional bioimaging
InactiveUS8128908B2Remarkable brightnessRemarkable photostabilityUltrasonic/sonic/infrasonic diagnosticsPowder deliveryBrain mappingNanoparticle
The present invention relates to fluorescent, radio-opaque and magnetic quantum nanoparticles, useful as multifunctional contrast agents or probes for in vivo bioimaging, and methods of their use. The invention provides for multifaceted bioimaging (e.g., intra-arterial pre-operative brain mapping and broad based in vivo diagnostic imaging), including imaging of various cell types, such as stem cells.
Owner:UNIV OF FLORIDA RES FOUNDATION INC
Apnea detection system
A method and apparatus are described for utilizing a source of vascular pulse waveform data from a patient for the purpose of measuring pulsus paradoxus. The arterial pulse waveform data source described is a pulse oximeter plethysmograph but can be any similar waveform data source, including an intra-arterial transducer, external blood pressure transducer, or plethysmograph. Through incorporation of measurements of values, such as an area under a pulse waveform curve, that are time-domain functions of a change in amplitude of the pulse waveform over a duration of the waveform, embodiments of the present invention represent a significant improvement upon previously described methods of measuring pulsus paradoxus.
Owner:PRECISION PULSUS
Methods of diagnosis using pulse volume measurement
ActiveUS20050070807A1Increase usageMore and more conditionCatheterDiagnostic recording/measuringCongestive heart failure chfIntra-aortic balloon pump
The utility of pulse volume measurement is expanded to detection of many conditions which have previously not been detected or have been detected using more complicated techniques. Such conditions include blood loss, septic shock, cardiogenic shock, neonatal sepsis, patent ductus arteriosus, limb ischemia, intra-aortic balloon pump performance, peripheral vascular disease, congestive heart failure, the effectiveness of vasoactive medications, syncope, dehydration, pre-eclampsia, deep vein thrombosis, thermal injuries, vascular instability due to renal dialysis, compromising of circulation to the hand caused by radial artery harvesting, changes in cardiac output, and hypertension. According to the present invention, such diagnoses can be performed by taking one measurement, by taking measurements over time to detect a change or by taking measurements before and after application of a treatment or stimulus.
Owner:SMITHMARKS INC
Devices and methods for control of blood pressure
Apparatus and methods are described, including identifying a subject as suffering from hypertension. In response to the identifying (a) a radius of curvature of a first set of at least three regions of an arterial wall of the subject is increased at a given longitudinal location, while (b) allowing the first set of regions of the arterial wall to pulsate. A device is implanted inside the artery at the longitudinal location such that the device applies pressure to the arterial wall at a second set of at least three regions of the artery, but does not contact the first set of regions, the first set of regions and the second set of regions alternating with each other. Other embodiments are also described.
Owner:VASCULAR DYNAMICS
Magnetic resonance angiography method and magnetic resonance angiography system
InactiveCN103110420AQuality improvementImprove clinical utilityDiagnostic recording/measuringSensorsArteriolar VasoconstrictionPhase gradient
The invention discloses a magnetic resonance angiography method. The magnetic resonance angiography method includes applying a flowing sensitive dispersed phase gradient magnetic field in the readout direction and / or the phase encoding direction and / or the layer selection direction in a vasoconstriction period and then applying a residual magnetic moment removing gradient magnetic field after the flowing sensitive dispersed phase gradient magnetic field is applied; collecting blood flow images in the vasoconstriction period; collecting blood flow images in a vasodilatation period; and carrying out subtraction on the blood flow images in the vasoconstriction period and the blood flow images in the vasodilatation period to obtain blood flow images. The invention further discloses a magnetic resonance angiography system. According to the magnetic resonance angiography method and the magnetic resonance angiography system, in the specific implementation method, the flowing sensitive dispersed phase is used in the vasoconstriction period imaging process, so that intra-arterial self-spin dispersed phase can significantly lower arterial blood signals, and therefore the influence on imaging due to the velocity and the direction of blood flow can be reduced, high-quality peripheral arterial images can be obtained, and clinical practicability of the non-enhanced magnetic resonance angiography technology is improved.
Owner:SHENZHEN INST OF ADVANCED TECH
Intrapelvic perfusion therapy with cancer therapeutic agent and apparatus for intrapelvic perfusion with cancer therapeutic agent
An intra pelvic cancer therapeutic agent perfusion apparatus and method for administering a cancer therapeutic agent to and recovering same from a cancer tissue site within the pelvis. The tip of a first sheath is percutaneously inserted into the femoral artery and the tip of a second sheath is inserted into the femoral vein. A first balloon catheter is inserted into the aorta through the femoral artery and a second balloon catheter is inserted into the vena cava through the femoral vein. The first balloon catheter is used to block the blood flow and the second balloon is inflated to form an intravenous closed region between the site of insertion in the vena cava and a lower limb side venous site. A body fluid containing a cancer therapeutic agent is administered to the intra arterial closed region through the first sheath and is removed therefrom through the second sheath.
Owner:KUMAZAKI TATSUO +1
Method for measuring arterial blood pressure by using pulse wave and apparatus thereof
InactiveCN1127939CEvaluation of blood vesselsAngiographyLinear relationDecreased mean arterial pressure
The present invention relates to a method for measuring arterial pressure by using pulse wave and its device. Its method is as follows: a. measuring arterial pressure value when the human palm is placed on the horizontal surface of the heart and pulse wave conduction time; b. using static fluid mechanics equation and distance of that the palm is departed from the horizontal surface of the heart to calculate the pulse wave conduction time when the human palm is placed on non-horizontal surface of the heart; c. using the above-metnioned calculated valve values to calculate the regression coefficient and constant of linear relation between arterial pressure and pulse wave conduction time; d. using the above-mentioned linear relation to measure pulse wave conduction time so as to obtain the blood pressure value of human body.
Owner:北京新兴生物医学工程研究发展中心
Method and apparatus for measuring pulsus paradoxus
A method and apparatus are disclosed of utilizing a source of arterial and / or arteriolar pulse waveform data from a patient for the purpose of measuring pulsus paradoxus. The arterial pulse waveform data source described is a pulse oximeter plethysmograph but can be any similar waveform data source, including intra-arterial transducer, blood pressure transducer, or plethysmograph. Through incorporation of the measurements of values, such as the area under the pulse waveform curve, that are time-domain functions of a change in height of the pulse waveform over at least a partial duration of the waveform, embodiments of the present invention represent a significant improvement upon previously described methods of measuring pulsus paradoxus and, further, produce improved accuracy in measurement of the multiple contributing variables generating pulsus paradoxus, in particular the contribution of diastolic events, to the extent that the physical signs so measured can be regarded as “Revised Pulsus Paradoxus.”
Owner:PRECISION PULSUS
High coverage and low profile electrode assembly for angioplasty shockwave catheter
The invention discloses a shock wave generating system for an angioplasty catheter. The system includes an elongate member, wire electrodes, a non-conductive gap, each wire electrode attached to an electrical output terminal of a high voltage power source by an electrical wire extending from a terminal on an outer surface of the elongate member to the wire electrode. The system is an electrode assembly of a shock wave generating angioplasty catheter for treating calcified arteries. Shock waves are impact in nature and can impact and decompose hard calcified platelets deposited on the inner wall of the artery. Once these deposits are fragmented, the space of the arterial lumen expands, thereby improving blood flow.
Owner:谱创医疗科技(上海)有限公司
System and Method for Determining Arterial Compliance and Stiffness
A system and method for calculating the arterial compliance, stiffness, and arterial flow and resistance indices for any artery in issue of a subject having a blood pressure monitoring device configured to calculate systolic and diastolic blood pressure readings for an artery of the subject, a blood flow velocity monitoring device configured to calculate the velocity of blood flowing within the artery of the subject at a peak point of a systolic phase of contraction of the subject's heart muscle, peak-systolic velocity, and the velocity of blood flowing within the artery of the subject at an end point of a diastolic phase of the subject's heart muscle, end-diastolic velocity, and a central processing unit comprising a computer readable program embodied within the central processing unit configured to calculate the arterial compliance, stiffness, and arterial flow and resistance indices as a function of the area of the artery under initial systolic and end diastolic pressure, the area of the artery generating arterial elastic recoil pressure for continuous flow during the systolic and diastolic phases, peak-systolic and end-diastolic arterial flow velocities, and systolic and diastolic blood pressure.
Owner:KURI YAMIL
Administration of a thiol-based chemoprotectant compound
InactiveUS7022315B2Avoid problemsTreat and mitigate side effectCosmetic preparationsBiocideSide effectWilms' tumor
A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.
Owner:GOVERNMENT OF THE US THE +1
Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs
InactiveUS20180017577A1Delayed complicationsIncreased riskPeptide/protein ingredientsMammal material medical ingredientsCord blood stem cellCell therapy
Ischemia is treated to prevent or manage disease by delivering stem cells derived from cord blood and / or tissue. A patient suffering from disease caused in at least some part by ischemia is selected. At least one dose consisting of an effective amount of stem cells is administrated through intravenous (IV), intra thecal, intra-arterial, via catheter into the organ, via Myostar catheter into the heart, intracoronary, intrapericardial, and / or by direct injection into the organ. Effectiveness of the administration is monitored at selected time periods to determine whether there exists an improved clinical indication. A second dose is administered by a method that is at least invasive as that utilized in the prior dose, and the steps are repeated until the clinical indication shows improvement or until there is contraindication to continued treatment. Diseases include at least one of Ischemia, arteriosclerosis, complications of ischemia, decreased perfusion, aging or diabetes.
Owner:FRANCO WAYNE P
Fluoroscopy-independent, endovascular aortic occlusion system
ActiveUS9131874B2Quick measurementIncrease perfusionOther printing matterBalloon catheterLeft subclavian arteryArterial occlusions
A system for deploying and selectively inflating a thoracic aortic balloon at a desired location within the thoracic aorta for resuscitative aortic occlusion, inferior to the left subclavian artery, without the aid of fluoroscopy is described. Using CT imaging data, a distance between readily identifiable and consistently located external landmarks of torso extent is measured. Next, using the same data, a second distance from the femoral artery to a desired aortic occlusion location inferior to the left subclavian artery is determined. A correlation between the external measure of torso extent and the desired intra-arterial (i.e. endovascular) distance within the torso is made. Using a nomogram, a calibrated endovascular resuscitative thoracic aortic occlusion system can be positioned to this desired location on any injured individual with end-stage shock and impending cardiovascular collapse or death without the aid of fluoroscopy for delivery or balloon inflation.
Owner:GOVERNMENT OF THE UNITED STATES SEC OF THE AIR FORCE +2
The quality control method and application of a kind of ganoderma lucidum spore oil fat emulsion
This invention discloses a kind of quality control method and application of Ganoderma lucidium spore oil fat emulsion. Which includes Ganoderma lucidium spore oil 2˜25%, emulsifier 0.5˜10%, isosmotic agent 0.2˜5%, the remaining content is water and the final pH of Fat emulsion is adjusted to 6˜9. The quality control method of this invention can accurately determine the content of 1,2-oleic-3-palmitic triglyceride and glycerol trioleate in the preparation, and accurately determine the ergosterol content, which serves as the method and basis for quality control of this product. Fingerprints are utilized to grasp the product quality from the overall characteristics of Chromatogram. This invention has clearly defined active ingredients, with excellent bioactivity, and is capable of tumor treatment, while improving the organism's immunity, as well as the life quality of tumor patients undergoing radiotherapy and chemotherapy, and relieving the drug toxicity after treatment. This invention is particularly suitable for both intra-arterial injection and intravenous injection, enabling the Ganoderma lucidium spore oil to directly gain access to the human blood circulation, with short time to onset and complete absorption as well as high security, reliable quality, and low drug toxicity.
Owner:GUANGZHOU HANFANG NATURAL MEDICINE RES & DEV
Intra-arterial heating infusion set and method
The invention discloses an intravessel heating infusion device, comprising a transfusion bottle, a transmission pipe and a puncture needle; wherein, an electric heater is arranged in or on the puncture needle, and the electric heater is connected with a power supply and used for heating liquid which flows in the puncture needle. The intravessel heating infusion device does not need complicated medical equipment during the implementation process, only an ordinary drop device and a corresponding temperature monitoring device are needed for the infusion, the process is simple and convenient, a patient can be directly treated at an out-patient department without the need of being in a hospital; when in whole body hyperthermia, the speed of the temperature increase of the machine body is rapid. Blood circulation can transmit the heat to the whole body within dozens of minutes.
Owner:TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
Ablation system and nerve detection device thereof
ActiveCN112336445AReduce excessive injuryPrecise positioningControlling energy of instrumentSurgical systems user interfaceCatheterMeasured blood pressure
The invention provides an ablation system and nerve detection equipment thereof. The nerve detection equipment comprises a power supply module, a calculation and control module, an energy generation module and a blood pressure monitoring module, the calculation and control module is electrically connected with the energy generation module and the blood pressure monitoring module. The energy generation module is used for being connected with a detection catheter and detecting a specific part in an artery by outputting first energy to the detection catheter. The blood pressure monitoring moduleis used for being connected with a blood pressure sensor, the blood pressure sensor monitors the blood pressure of a patient and outputs a blood pressure monitoring result before the energy generationmodule detects a specific part with first energy and in the detection process, and the blood pressure monitoring module transmits the blood pressure monitoring result to the calculation and control module; and the calculation and control module is used for judging whether the specific part has the ablation target according to the blood pressure monitoring result. According to the scheme, the ablation target can be accurately positioned in a detection mode in the ablation process, and the effectiveness and safety of an ablation operation are improved.
Owner:SHANGHAI HONGDIAN MEDICAL TECH CO LTD
Field sterilizer and vascular connector kit
ActiveUS20170274223A1Avoid infectionKeep injections safeMedical devicesLight therapySterile environmentVascular Access Devices
Placement of a vascular access device (intravenous, intra-arterial and / or intra-osseous vascular access) in a non-sterile environment greatly increases the risk of infection via the vascular access device. This invention provides an approach for accomplishing sterilization of the site where vascular access will be attempted under non-sterile field conditions. In addition, this invention provides a sterile vascular connector pre-loaded with an antimicrobial, e.g., Taurolidine. Use of the vascular connector provides the antimicrobial concurrently with achieving vascular access, which limits the risk of infection despite access placement under non-sterile field conditions.
Owner:CORMEDIX
Intra-Aortic Device
An intra-aortic device comprising a filter and a frame defining the shape of the filter, wherein the frame is intrinsically curved in a superior direction by a proximal superior bend and / or a distal superior bend, whereupon installation in an aorta, the frame flattens.
Owner:KEYSTONE HEART
Method and Apparatus for Measuring Blood Pressure
ActiveUS20140316288A1Easy to adjustMinimize complexityEvaluation of blood vesselsCatheterPeripheral pulsesDiastolic phase
Embodiments of the present invention provide an improved transformation method whereby the peripheral pulse waveform is filtered to separate different phases which make up the waveform. The separate phases are transformed before being re-combined to provide an estimated intra-arterial transfer function. For example, in one embodiment the peripheral pulse waveform is filtered by a first high pass filter, and a copy of the peripheral pulse waveform filtered by a second high pass filter, having a different cut-off frequency. The two filtered waveforms may then be further processed, for example by being added back to original wave-form, and are then multiplexed together in a time division manner to provide a final waveform. For example, the part of the first filtered waveform corresponding to the systolic phase may be combined with the part of the second filtered waveform corresponding to the diastolic phase to produce the final waveform, and the respective filter cut-off frequencies may be chosen to extract characteristics of the respective phases of the heart.
Owner:SUNTECH MEDICAL
Aorta blocking-free anastomosis auxiliary device and using method thereof
PendingCN111603216AAchieve sealingGuaranteed not to seep (spray) bloodSuture equipmentsAnatomyTunica intima
The invention discloses an aorta blocking-free anastomosis auxiliary device and a using method thereof. The aorta blocking-free anastomosis auxiliary device comprises an air conveying pipe and a working air bag arranged at one end of the air conveying pipe and communicated with the air conveying pipe, and the working air bag is inserted into an aorta from the aorta punching position; when the working air bag is in a full state, the upper side face of the working air bag is tightly attached to the aorta intima, the joint of the upper side face of the working air bag and the aorta intima is located on the periphery of the circumference of the aorta hole, and a suture position is reserved on the circumference of the aorta hole. The device is simple in structure, the aorta anastomosis device is simple in structure and convenient to use, a conventional surgical suture mode is broken through, namely anastomosis (suture) of the aorta can be completed under non-blocking of the aorta, normal flowing of blood in the aorta during surgery is guaranteed, damage caused by insufficient blood supply of organs of a patient under complete blocking of the aorta is avoided, blood loss in the surgicalsuture process is reduced, and the device is more suitable for aorta calcification patients.
Owner:程兆云
Methods of treating and preventing acute myocardial infarction
The present disclosure provides methods and compositions for treating coronary tissue damaged as a result of a cardiac disorder such as ischemia, acute myocardial infarction, vulnerable plaques, or reperfusion injury. Specifically, the cardiac disorder is treated using a multivalent molecule that is specific for a marker located, in or near the damaged coronary tissue and a marker located on a target cell (e.g., a stem cell). The multivalent molecule may be administered by intravenous injection, intra-arterial catheter, intramyocardial injection, or implantable device (e.g, stent).
Owner:X CELL MEDICAL
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