168 results about "Fundus (eye)" patented technology

A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.

A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.

An ophthalmic photographing apparatus includes: an interference optical system including a splitter that splits light, emitted from a measurement light source, into measurement light and reference light, and synthesizing the measurement light reflected on an eye with the reference light to guide the synthesized light to a detector; a driving part that moves an optical member arranged in the optical path to adjust an optical-path difference between the measurement light and the reference light; an image obtaining part that obtains a tomographic image of a fundus or an anterior segment based on a light receiving signal output from the detector; and a driving control unit that controls driving of the driving part to locate the optical member in a predetermined position corresponding to either a photographing mode for photographing the tomographic image of the fundus or a photographing mode for photographing the tomographic image of the anterior segment.

A system for diagnostically evaluating the health of tissue within the fundus of an eye includes a f s laser source, an adaptive optical assembly, an imaging unit, and a computer. The adaptive optical assembly focuses a laser beam to a focal point in the fundus of the eye, and scans the fundus tissue according to a predetermined scanning pattern. Illumination of anisotropic tissue within the fundus, such as the photoreceptors and the Henle-fiber layer, induces a Second Harmonic Generation (SHG) response. Red photons, with a wavelength (λ) of about 880 nm, are converted to blue photons, with a wavelength of λ / 2, through the process of photon conversion. An imaging unit senses the blue photon return light, and uses the return light to generate an image of the fundus. The computer processes the image, and compares it to a template of healthy tissue to evaluate the health of the imaged tissue.

An OCT appliance (optical coherence tomography appliance) comprises an OCT module and a camera for observing the fundus of an eye. By recognizing characteristic features (biometric features), the means defining the region observed by the OCT module, in particular the scanner of the OCT module, is adjusted so that a predefined region of interest is imaged by the OCT module. In preferred embodiments, the apparatus is apt to be operated by a patient himself, and the data are transferred to a clinical server so that a more frequent, hence closer observation of the eyes of the patient is possible.

The invention relates to a measurement system and a method for detecting ocular fundus blood flow velocity with high resolution. The measurement system is characterized in that a bacon light source is focused on the fundus by a human eye through a plurality of optical components to form a bacon spot; the spot is transformed into parallel light through the eye after backward reflection, and reaches a wavefront sensor through a wavefront phase corrector and a series of optical components to realize the process of self adaptive aberration correction; the imaging light source is focused on the front focus of the eye through the optical components, and is collimated by the eye into the parallel light to illuminate the retinal vascular microcirculation system; a laser speckle interferometry is formed on the surfaces of the fundus blood vessels illuminated; the interference field enters into wavefront phase corrector through the optical components and is reflected and finally focused on a photodetector through the series of optical components; a light speckle imaging process is realized. The measurement method has the advantage of enabling the whole system to overcome negative influences from the aberration of human eyes on capturing laser speckle interference field images, thus facilitating to obtain fundus velocity graph of high precision and resolution.

An ophthalmic instrument (for obtaining high resolution, wide field of area multi-spectral retinal images) including a fundus retinal imager, (which includes optics for illuminating and imaging the retina of the eye); apparatus for generating a reference beam coupled to the fundus optics to form a reference area on the retina; a wavefront sensor optically coupled to the fundus optics for measuring the wavefront produced by optical aberrations within the eye and the imager optics; wavefront compensation optics coupled to the fundus optics for correcting large, low order aberrations in the wavefront; a high resolution detector optically coupled to the imager optics and the wavefront compensation optics; and a computer (which is connected to the wavefront sensor, the wavefront compensation optics, and the high resolution camera) including an algorithm for correcting, small, high order aberrations on the wavefront and residual low order aberrations

A portable retinal imaging device for imaging the fundus of the eye. The device includes an ocular imaging device containing ocular lensing and filters, a fixation display, and a light source, and is configured for coupling to a mobile device containing a camera, display, and application programming for controlling retinal imaging. The light source is configured for generating a sustained low intensity light (e.g., IR wavelength) during preview, followed by a light flash during image capture. The ocular imaging device works in concert with application programming on the mobile device to control subject gaze through using a fixation target when capturing retinal imaging on the mobile device, which are then stitched together using imaging processing into an image having a larger field of view.

Short sight, visual fatigue and ischemic ophthalmopathy belong to the cataract diseases of oculopathy and are mostly caused by emotion problems or body fluid loss, blood shortage, weak kidney and liver which lead to the disorder of entrails, no moistening of eyes, blood stasis, etc., thus causing the loss of sight and even other neopathy. The treatment principle is that the traditional Chinese medicine components which can strengthen the liver and the kidney, supplement blood and body fluid, activate blood circulation to dissipate blood stasis, invigorate the spleen, and be beneficial for moistening are selected; the medicinal materials are extracted (63 percent of effective components, 30 percent of film-forming agent and 7 percent of plasticizer) and blended evenly to make the Chinese medicinal plaster with the thickness of 0.08 to 0.12cm and the plaster is then dried at the normal temperature (the temperature is controlled below 40 DEG C), cut and packaged into a finished product. The medicine can be applied to the skin around the eye and be finally acted on the target area in the ocular fundus after being absorbed by capillary vessels of the skin into the blood circulation of the eye.

Provided is an ocular optical system, which permits a measuring beam scanned by two scanning units disposed close to each other to enter an anterior ocular segment of an eye to be inspected and to irradiate a fundus. The ocular optical system includes an optical unit which is disposed at a position of an intermediate image, which is optically conjugate to the fundus, and has a surface having different optical powers corresponding to scan directions of the two scanning units.

The invention discloses a multi-functional ophthalmic full-automatic measurement method and system. The multi-functional ophthalmic full-automatic measurement method comprises the steps that a three-dimensional movement control unit is adjusted to automatically adjust a probe assembly after a to-be-measured eye is monitored to be located right in front of an eye objective lens; a control device ina body module drives a first mobile control unit to control an anterior segment OCT insertion mirror to be inserted into an optical path or moved out of the optical path and adjust an optical path adjusting device; measurement light provided by the body module enters the to-be-measured eye and is focused in the anterior segment of the to-be-measured eye or the fundus of the to-be-measured eye soas to return an anterior segment optical signal or a posterior segment optical signal to be transmitted to the body module; and the body module provides reference light and can utilize the reference light to interfere with the anterior segment optical signal or the posterior segment optical signal and collect the anterior segment interference optical signal or the posterior segment interference optical signal obtained through interference so as to respectively collect an anterior segment OCT image or a posterior segment OCT image of the eye to be measured. The measurement convenience can be improved, and the measurement accuracy can be improved.

The invention discloses a human eye aberration measuring system based on phase diversity, which comprises an optical illuminating system, a pupil aligning system, an optical staring system and an optical imaging system. The optical illuminating system is mainly an optical system which illuminates the fundus oculi of a human eye by the aid of infrared during detection, the pupil aligning system is a system for aligning the human eye with an optical axis of the optical illuminating system and an optical axis of the optical imaging system before detection, the optical staring system is mainly an optical system for fixing the position of the eyeball of the human eye during detection, and the optical imaging system is mainly a system for realizing observation imaging for the area of the fundus oculi illuminated by the illuminating system. The human eye aberration measuring system overcomes shortcomings that in the prior art, objective aberration measurement time is long, individual aberration correction cannot be guided, measurement accuracy is low, a measurement range is small and the like.

The invention discloses a fundus blood vessel image segmentation adversarial sample generation method and a segmentation network security evaluation method. The fundus blood vessel image segmentationadversarial sample generation method comprises the steps: 1, establishing a fundus blood vessel image segmentation network; 2, collecting an original fundus blood vessel image, marking blood vessels in the collected image, and constructing a training sample to train a fundus blood vessel image segmentation network; 3, constructing a generative disturbance network to generate an adversarial sampleimage; 4, inputting the generated adversarial sample image into a trained fundus blood vessel image segmentation network to obtain a segmentation result, calculating an objective function, and updating parameters of a generated disturbance network by minimizing the objective function to obtain an optimized generated disturbance network; and 5, generating disturbance by using the optimized disturbance generation network, and adding the disturbance to the original fundus blood vessel image to obtain an adversarial sample image. According to the fundus blood vessel image segmentation adversarialsample generation method, the adversarial sample image which is indistinguishable with the human eyes of the original image can be obtained, and the obtained generative disturbance network can betterlearn the characteristics of the segmentation network.

Methods and systems for imaging the fundus of the eye are disclosed, in which the fundus is illuminated through a mask which blocks light from reaching one or more masked regions within a peripheral area surrounding a target area of interest, such as the macular region. An image is obtained of both the target area and the peripheral area. A scattered light value is derived from the image intensity within the masked regions, and this is used to compensate and adjust the measured intensity of light within the target area. When employed in the measurement of macular pigment optical degeneration, an improved measurement is obtained in which the specific image(s) used for measurement have a specifically calculated correction factor applied to compensate for light scatter, rather than relying on population-based average scattering values.

The invention provides an automatic alignment and focusing fundus or anterior segment imaging system. The system is placed on an X-Y-Z three-axis electric platform. The system comprises an illumination unit, an imaging unit, a guide alignment unit, an optical coherence tomography (OCT) unit and an eyepiece (201). The imaging unit comprises an imaging light path and a light path conversion device.When the system performs anterior segment imaging, the light path conversion device is moved into the imaging unit; and when the system performs fundus imaging, the light path conversion device is removed from the imaging unit. According to the invention, anterior alignment is realized through an anterior alignment unit, fundus alignment is realized through the guide alignment unit, or anterior alignment and fundus alignment are realized directly through the guide alignment unit, so that anterior segment and fundus imaging is realized, a professional technician does not need to be equipped inthe whole operation process, and the whole operation process is autonomously completed by the imaging system. The imaging system is awakened from a dormant state through a signal of a pressure sensorI and is in a dormant state in a non-working period, so that the energy consumption of the system is reduced. Therefore, unattended eye imaging is realized.

An ophthalmologic imaging apparatus includes: a control unit configured to control, based on a pixel value of the optic papilla in an infrared light image of the fundus of a subject's eye to which infrared light is radiated, the light amount of visible light to be radiated onto the subject's eye; and an imaging unit configured to capture an image of the fundus of the subject's eye to which visible light having the controlled light amount is radiated.

The invention discloses a method and glasses for lowering the diopter of eyes. The method is characterized in that a user wears glasses for far vision conventionally at ordinary times but wears glasses for near vision when writing, reading and doing other work requiring near vision, and if eye discomfort occurs during wearing, the user can replace lenses of the glasses for far vision and the glasses for near vision till feeling comfortable. The pair of glasses for far vision comprises a glasses frame, a pair of lens groups is arranged on the glasses frame and comprises prism lenses and optical lenses, the prism lenses are arranged on the side close to the eyes of the user, at least one of the rear surface and the front surface of each optical lens comprises a toroidal surface optical area, and the fundus direction of each prism lens is adjustable. The pair of glasses for near vision comprises a glasses frame, a pair of lens groups is arranged on the glasses frame and comprises prism lenses, additional lenses for near vision and optical lenses, the prism lenses are arranged on the side close to the eyes of the user, and the additional lenses for near vision are arranged between the prism lenses and the optical lenses. The method and the glasses have the beneficial effect that the diopter can be lowered after the user wears the glasses.

An ophthalmologic observation and photographing apparatus capable of photographing a color image and a fluorescence image includes an illumination unit for illuminating a fundus of a subject's eye, an observation and photographing unit for observing and photographing a specified region of the illuminated subject's eye, a barrier filter insertably mounted to the observation and photographing unit and configured to transmit a fluorescence wavelength range and block excitation light, a color photographing unit including a tri-color separation filter and mounted in the observation and photographing unit, and an index projecting unit for projecting an index light to be photographed by superimposing on an image of the specified region of the subject's eye. The index light passes through the barrier filter, includes a wavelength range different from the fluorescence wavelength range, and can pass through a filter having a wavelength range different from a filter which transmits fluorescence through the most among the tri-color separation filter.

The invention relates to an anterior-posterior segment frequency domain optical coherence tomography system, in the anterior segment / posterior segment imaging process, an FD-OCT system adopts the sameoptical path hardware, and conversion of a scanning focus range of probe light from the fundus retina to the cornea is achieved by internally adjusting the position of a scanning conversion assemblyspecially designed in a sample arm. In the anterior segment / posterior segment imaging process of the eye, the frequency domain optical coherence tomography imaging system adopts the same optical pathhardware; by internally adjusting the position of the scanning conversion assembly specially designed in the sample arm, conversion of the scanning focus range of the probe light from the fundus retina to the cornea is achieved, and therefore the anterior segment and posterior segment frequency domain optical coherence tomography system can have the anterior segment imaging function without addingthe FD-OCT system hardware. According to the invention, an anterior segment imaging function of the posterior segment frequency domain optical coherence tomography system can be realized without adding an additional imaging objective lens, and the use and detection operation process and the system structure are simplified.

The invention discloses a cataract OCT image restoration method and system based on machine learning. The cataract OCT image restoration method introduces an optical information processing technology, changes the frequency spectrum of an object through an optical spatial filter, carries out the amplitude, phase or composite filtering of an inputted image, and carries out the fuzzy processing of the image, thus achieving the simulation of a cataract OCT fuzzy image; then the neutral density attenuation sheet is added to an OCT scanner lens to scan healthy eyeballs, a fundus OCT blurred image is obtained to simulate a cataract image, then an OCT clear image of the same person without the attenuation sheet is scanned, and the cataract retina OCT blurred image is restored into a clear image. The ten layers of retina structures can be clearly seen from the restored image, and the number of network models is reduced, so that the workload and the total training time are reduced, and the technology of restoring the blurred image to be clear is realized only by using the Pix2pix model.

The invention relates to an operation intelligent decision-making system suitable for high myopia cataract and an establishment method thereof. The establishment method comprises the following steps:constructing a deep learning model being composed of an evaluation network and a decision network, configuring evaluation network to comprise a LOCSIII grading deep learning model, an Elasticity kernel hardness grading deep learning model and a fundus judgment model, and configuring the decision network to combine the cataract degree and fundus grading with patient basic information, eyesight, intraocular pressure, an A-ultrasonic / IOLmaster report, corneal endothelium counting, corneal astigmatism, a B-ultrasonic report and other information, map the information to a high-dimensional space through a kernel function, and then establish a linear regression model; constructing a training set; and carrying out training learning and parameter adjustment on the model by using a training set. Thesystem comprises a storage device, an evaluation module, a decision module and a test evaluation adjustment module. The method can quickly and accurately identify the cataract degree and fundus conditions of a high myopia cataract patient, provide comprehensive operation decisions for doctors, and improve the prevention and treatment homogeneity.

The invention discloses application of transthyretin in transferring fusion protein into eyes, belonging to the technical field of protein engineering. The invention provides a method for allowing foreign protein to pass through eye barriers and to be conveyed into eyes through fusion expression of transthyretin as shown in SEQ ID NO.1 and the foreign protein. The results of animal experiments prove that as the fusion protein prepared in the invention is used for eye drop treatment on rats and rabbits, foreign protein can be rapidly and effectively conveyed to fundus. The transthyretin used inthe method is derived from a human body, has good biocompatibility and safety in the human body, and has important application prospects when used as a substitute of injection drugs in the field of medicine.

The invention discloses a vision rehabilitation instrument. The vision rehabilitation instrument comprises a shell, a light shield, a sight hole opening and closing device, an eye massage device, a circuit control system, an eyepiece, objective lenses, a lens cone, a loudspeaker, an eyeball movement device and a head fixing band, the sight hole opening and closing device is located in the shell, the eye massage device is arranged on the back of the shell in a sleeving mode, the eyepiece, the objective lenses and the lens cone are located on the same axis, the head fixing band is connected to the two sides of the rear portion of the shell, and the circuit control system controls the sight hole opening and closing device, the eye massage device and the eyeball movement device. The vision rehabilitation instrument is reasonable in structure, accurate in acupoint pressing and stable in pressing force, eye muscles can be exercised by training eyeball movement, fundus visual cells can be stimulated by irradiating fundus with red LED light, growth and development of the visual cells are promoted, shading training and bright and dark training as well as near-looking and distant-looking training are both considered, the adjusting capacity of eyes can be exercised, in the whole training process, the instrument does not make contact with eyes, the eyes cannot be hurt, and the eyesight improving effect is obvious.

The invention provides a combined air pressure type eyestrain recovery instrument. The combined air pressure type eyestrain recovery instrument comprises two spectacle frames, two lenses, two seal supporting rings, a Y-shaped connecting rubber tube, a hollow rubber ball and a fastening belt. The two spectacle frames are connected together through a cross beam. Air generated when the hollow rubber ball is pinched, pressed and loosened can massage the double eyes in a pulse mode, and the good effects of promoting fundus blood circulation, reliving eyestrain and relaxing the eyes are achieved. It is proved through a large number of use data with eyestrain and different lesions that the symptoms of shortsightedness, presbyopia, astigmatism and cataract are relieved, and especially the obvious relieving effect is achieved for the symptoms of dryness, obscurity, itches, blurred vision and the like caused by eye overuse. Power of the instrument is generated by squeezing the hollow rubber ball by a user with the hand, the whole process is quiet and silent, and the instrument can be used at any time. The instrument is completely made of environment-friendly medical materials, no smell or pollution is caused, and environment friendliness is achieved. The weight and size are similar to those of a pair of normal glasses, and the instrument is convenient to carry.

The invention relates to the field of artificial intelligence, and provides a method, a device and equipment for screening an abnormity of a fundus macular area and a storage medium, and the method comprises the steps: receiving an adjustment instruction inputted by a user; scanning a macular area of the eyes of the testee through a single-line scanning mode of the optical coherence tomography scanner to obtain a macular area image and a macular area thickness of the testee; inputting the macular area image into a convolutional neural network, and performing convolution operation on the macular area image to obtain a convolution feature matrix of the macular area image; polling the convolutional feature matrix through a pooling layer of the convolutional neural network to obtain multiple groups of local feature sets; and inputting the thickness category into the convolutional neural network, wherein the convolutional neural network performs weighted summation on the macular region setand the thickness category through the weight of neurons. Automatic screening of macular area anomalies is achieved, the screening efficiency of macular area anomalies is improved, the labor cost is reduced, and no damage is caused to eyes in the screening process.

The invention relates to the technical field of multispectral fundus imaging which can be widely applied to the aspects of ophthalmic imaging, medical diagnosis and the like, and particularly relatesto a hand-held multispectral fundus imaging equipment and system. The equipment comprises a shell, a light source which is provided with an eyepiece and used for generating multispectral light, a single-pixel detector used for imaging and an interactive module used for performing data interaction with a computer; an optical filter, a focusing lens and a second storyboard; a beam splitter group anda spatial light modulator are arranged on a light path from the light source to the eye piece in sequence. Convenience is brought to carrying, imaging is rapid, and the picture resolution is high.

The embodiment of the invention discloses a refraction detection method, a device, computer equipment and a storage medium. The method comprises the steps of acquiring the electronic medical record data of a to-be-tested person, wherein the electronic medical record data comprise the eye axis length and the average corneal refractive power; and predicting the spherical lens degree and the equivalent spherical lens degree according to the electronic medical record data. According to the technical scheme provided by the embodiment of the invention, by collecting the parameters such as the eye axis length and the average corneal refractive power of the to-be-detected person and automatically predicting the spherical lens power and the equivalent spherical lens power of the to-be-detected person, the eye data of the myopia patient can be accurately detected without being influenced by fundus lesions or crystal opacity and the like, and the detection accuracy is improved. Meanwhile, the problem that the paralysis process of ciliary muscles causes side effects and sequelae to the eyes of juveniles is avoided.

An eye surgery surgical system includes a visualization device for visualizing the position of at least one trocar point for a trocar on the sclera of a patient's eye. The trocar serves to introduce a surgical instrument configured for surgical interventions on the fundus of the patient's eye into the patient's eye. The eye surgery surgical system also includes a computer unit which is configured to provide the position of the at least one trocar point to the visualization device. Here, the computer unit contains a trocar point computation routine configured to calculate the position of the at least one trocar point from the location of at least one surgical site in a model of the patient's eye and from geometric data relating to at least one surgical instrument introducible into the patient's eye through the trocar.

The invention discloses a mobile terminal screen brightness adjusting system and method. The system comprises a light collection part, a control part and an adjustment part. According to the method and the system, environment brightness actually observed by the eyes of a user is acquired and calculated, and the environment brightness is divided into multiple sections according to the characteristics of the human eyes to perform screen brightness adjustment of different strategies, so that the human eyes are in the environment with the most comfortable brightness ratio, and the light emitted bya mobile terminal screen does not damage the fundus of the eye.

The invention provides an automatic screening method for diabetic macular edema based on transfer learning, which comprises the following steps: marking whether diabetic macular edema exists through an optical coherence tomography image and fundus color photograph; extracting eye features of a patient by using the trained deep residual neural artificial intelligence model, classifying whether diabetic macular edema exists according to the eye features, and performing polarity adjustment on the deep residual neural artificial intelligence model by using fundus color photograph data set trainingthrough a transfer learning technology; and obtaining a final intelligent screening model of diabetic macular edema based on fundus color photograph. The optical coherence tomography image and the fundus color photograph are used for identifying and classifying patients suffering from diabetic macular edema or not through the fundus color photograph-based intelligent screening model for diabeticmacular edema, so that the screening accuracy and the working efficiency of diabetic macular edema high-risk groups can be improved, and the expenditure of disease diagnosis and treatment of the patients is also reduced; therefore, more patients can be diagnosed and treated in time.