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34 results about "Ethambutol Hydrochloride" patented technology
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The hydrochloride salt form of ethambutol, an ethylenediamine derivative with antibacterial activity, specifically effective against mycobacteria. Although the exact mechanism of action of ethambutol hydrochloride is unknown, ethambutol hydrochloride inhibits the transfer of mycolic acids into the cell wall of bacteria, which impedes bacterial cell growth. This agent may also interfere with RNA synthesis or inhibit other cell metabolism, thereby preventing cell multiplication and causing cell death.
Medicine-release system of compound Rifampicin
The present invention relates to a compound rifampin preparation, in particular, it relates to a medicine-releasing system of compound rifampin. Said system comprises rifampin and isoniazid, and further selectively can include pyrazinamide or pyrazinamide and etambol, which is characterized by that the isoniazid, pyrazinamide and etambol are gastric soluble, and the rifampin is enteric soluble orisoniazid is enteric soluble, and others are gastric soluble. Said preparation can be made into capsule, granules, tablet, multi-layer table and suspension preparation. Said invention also provides its preparation method.
Owner:SICHUAN LONG MARCH PHARMA CO LTD
Antituberculosis pharmaceutical composition
InactiveCN1602872AAvoid selective resistanceAvoid irregular medicationAntibacterial agentsOrganic active ingredientsPatient complianceHydrazine compound
The invention relates to an antituberculosis drug combination, prepared of rifampicin, isonicotinyl hydrazine, pyrazinamide, ethambutol hydrochloride and other auxiliaries, able to effectively overcome problems of drug resistance, improving compliance of patient, etc. It is applied in a compound form, which can avoid curing by single antituberculosis drug, thus avoiding selective drug resistance caused by single drug; the patients are willing to accept this, avoiding irregular drug application caused by simultaneously taking several drugs and different numbers of drug tablets, or taking more or less drugs.
Owner:浙江南洋药业有限公司
Compound preparation of antituberculosis medicaments, and preparation method thereof
ActiveCN101524355AEasy to measureAccurate measurementAntibacterial agentsOrganic active ingredientsDirect observationAntituberculous drugs
The invention belongs to the technical field of medicines, and provides a compound preparation of antituberculosis medicaments, and a preparation method thereof. Rifampicin, isoniazid, pyrazinamide and ethambutol hydrochloride as four leading antituberculosis medicaments are prepared into the compound preparation according to specific mixture ratio. The method comprises the steps of evenly mixing the leading drugs with an appropriate quantity of disintegrant and diluent, performing dry-process granulation, finishing granules, adding other auxiliary materials to the granules and preparing the obtained product into a suitable preparation. The invention solves the problems that patients are difficult to cooperate closely and complete normal chemotherapys because the antituberculosis medicaments are high in dosage, large in dosage form and troublesome in medicine-taking method, and the compound preparation and the preparation method accord with global tuberculosis direct-observation short-range supervision chemotherapy strategy (DOTS) recommended by the WHO. The antituberculosis fixed-dose compound preparation has important significance for simplifying medicine-taking method, carrying out the DOTS and controlling tuberculosis prevalence.
Owner:SHENYANG HONGQI PHARMA
Preparation method of composite rifampicin micro-tablet capsule
InactiveCN1864681ALow costSo temptingAntibacterial agentsOrganic active ingredientsEthambutol HydrochlorideBiomedical engineering
The preparation process of compound rifampicin micro tablet capsule features that during compounding rifampicin, isoniazide, pyrazinamide and ethambutol hydrochloride, at least one of the medicine components is first formed into micro tablet before encapsulating. During the preparation process, the micro tablet is coated to avoid the excess contact between rifampicin and other medicine components inside the compound capsule and to raised the stability of the compound rifampicin preparation further.
Owner:高华
Methods for preparing ethambutol and ethambutol hydrochloride
ActiveCN103772214AEasy to recycleHigh recovery rateOrganic compound preparationAmino-hyroxy compound preparationOrganic solventBoiling point
The invention provides methods for preparing ethambutol and ethambutol hydrochloride. The method for preparing the ethambutol comprises the step of utilizing (S)-2-aminobutanol and 1,2-dichloroethane to perform condensation reaction to prepare the ethambutol, wherein the condensation reaction is carried out in a low-boiling organic solvent, and HCl produced in the ammonia gas neutralization reaction process is utilized. Through the utilization of the method, the ethambutol of which the yield coefficient is improved can be obtained, so that the ethambutol hydrochloride of which the yield coefficient is improved can be obtained. Besides, the methods are simple in technology, safe, stable, low in cost and super-high in practical value in the industry.
Owner:NEW FOUNDER HLDG DEV LLC +2
A preparation method of compound rifampicin preparation
InactiveCN1864683ALow costIncrease attractivenessAntibacterial agentsOrganic active ingredientsEthambutol HydrochlorideOrganic chemistry
The preparation process of new compound rifampicin preparation features that rifampicin, isoniazide, pyrazinamide and ethambutol hydrochloride are first prepared into granule, then coated and finally encapsulated. The preparation process can isolate the medicine components at most to avoid the avoid close contact of medicine components in the solid preparation environment so as to ensure the stability of the compound rifampicin preparation.
Owner:高华
Compound antituberculous coating core tablet and preparing method
ActiveCN102552204AImprove bioavailabilityEasy to takeAntibacterial agentsOrganic active ingredientsIsoniazidPyrazine
The invention relates to a compound antituberculous coating core tablet and a preparing method, and is characterized by improving bioavailability, overcoming drug-resistance and being convenient to take by patients. The compound antituberculous double-release preparation is designed and developed according to the optimum absorbing parts of rifampicin and isoniazide and interaction of the two, the isoniazide and excipient are tabletted in a wet granulation mode and are subjected to enteric coating to be taken as a tablet core, the rifampicin(or the rifampicin and ethambutol hydrochloride, or rifampicin, ethambutol hydrochloride and pyrazinamide) is used as the internal layer which is subjected to dry granulation with the excipient and then is pressed into the compound antituberculous coating core tablet with isoniazide enteric-coated tablet core, so that isoniazide can be released in the small intestine at fixed position, rifampicin can be rapidly disintegrated and released in the stomach, and absorption reduction caused by interaction of rifampicin and isoniazide in the stomach can be effectively avoided. The invention is particularly suitable for being taken by patients suffered from tuberculosis.
Owner:SHENYANG PHARMA UNIVERSITY
Pharmaceutical composition for treating intractable epilepsy and application thereof
ActiveCN109966277AHigh dependenceSmall toxicityNervous disorderAnhydride/acid/halide active ingredientsSide effectActive component
The invention discloses a pharmaceutical composition for treating intractable epilepsy and application thereof. The active components of the pharmaceutical composition comprise sodium valproate or divalproex sodium and ethambutol or medicinal salt thereof. The pharmaceutical composition has the advantages that the fact that low-dose ethambutol hydrochloride has an anti-epileptic effect is discovered for the first time, the ethambutol hydrochloride is combined with the sodium valproate or divalproex sodium to treat the intractable epilepsy, the pharmaceutical composition is evident in anti-epileptic effect, and the toxic and side effects of the pharmaceutical composition are lowered evidently.
Owner:AFFILIATED HOSPITAL OF JINING MEDICAL UNIV
Rifampicin antituberculosis drug compound preparation and preparation method thereof
InactiveCN102727497AGood curative effectConvenient reserve managementAntibacterial agentsOrganic active ingredientsAntituberculous drugsEthambutol Hydrochloride
The invention belongs to the field of medicine technology, and relates to a preparation method of an antituberculosis drug compound preparation containing rifampicin, isoniazid, pyrazinamide and ethambutol hydrochloride. The method comprises steps of: first granulating rifampin by a dry granulation technology; granulating two or three selected from isoniazid, pyrazinamide and ethambutol hydrochloride by a wet or a dry granulation technology; and compressing the granules into four layer tablets containing rifampin, isoniazid, pyrazinamide and ethambutol hydrochloride. The aim of the method is to avoid degradation caused or accelerated by close contact of the rifampicin and other drugs in the preparation, thus ensuring the stability of the compound rifampicin preparation.
Owner:SHENYANG PHARMA UNIVERSITY
Pharmaceutical preparation for resisting tuberculosis and preparation method thereof
ActiveCN102106855BImprove bioavailabilityResolve interactionAntibacterial agentsOrganic active ingredientsAntituberculous drugsEthambutol Hydrochloride
Owner:HAINAN PULIN PHARMA +1
Salt formation crystallization method of ethambutol hydrochloride
ActiveCN103435501AHigh purityLow costOrganic compound preparationAmino-hyroxy compound preparationPhysical chemistryEthambutol Hydrochloride
The invention discloses a salt formation crystallization method of ethambutol hydrochloride. According to the salt formation crystallization method of ethambutol hydrochloride, the system temperature, the cooling rate and the falling temperature are strictly controlled during the salt formation, so that the purity of ethambutol hydrochloride can be increased, ethambutol hydrochloride meeting pharmacopeia standards can be produced through adopting ethambutol bulk drug with lower purity, and the higher yield is achieved. Through adoption of the salt formation crystallization method of ethambutol hydrochloride, an approach which is simple, convenient, and lower in cost is provided for synthesis of ethambutol hydrochloride.
Owner:GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
Pharmaceutical preparation for resisting tuberculosis and preparation method thereof
ActiveCN102106855AImprove bioavailabilityResolve interactionAntibacterial agentsOrganic active ingredientsAntituberculous drugsBioavailability
The invention relates to a pharmaceutical preparation for resisting tuberculosis, which comprises rifampin, isoniazid, pyrazinamide and ethambutol hydrochloride, wherein the rifampin or the isoniazid is prepared into micropills and residual materials are prepared into granules. According to the invention, one of the rifampin and the isoniazid is prepared into micropills which are separated by isolation gown and the other one is prepared into granules, so that the rifampin and the isoniazid cannot be mutually influenced, the rifampin is ensured to not be basically degraded in the use process, and the bioavailability of the rifampin is improved.
Owner:HAINAN PULIN PHARMA +1
Drug for clinically treating pulmonary tuberculosis
The invention discloses a drug for clinically treating pulmonary tuberculosis and belongs to the technical field of drugs. The drug is prepared from ethambutol, starch and a biological agent. Clinicaltests prove that the drug better solves the problem that ethambutol hydrochloride sold in the market easily has side effects when used for treating pulmonary tuberculosis clinically.
Owner:郝涛
Slow-release medicine system of compound rifampicin
Owner:SICHUAN LONG MARCH PHARMA CO LTD
Oral solid formulation of compound Anti-tubercular drug and preparation method thereof
InactiveUS20140127294A1Improve bioavailabilityImprove solubilityAntibacterial agentsBiocideCoated tabletsBULK ACTIVE INGREDIENT
Provided is an oral solid preparation of a compound anti-tubercular drug, wherein the active ingredients are rifampicin, isoniazid, pyrazinamide and ethambutol hydrochloride. The compound oral solid preparation is a coated tablet with coated core or a coated three-layer tablet, wherein the two active ingredients rifampicin and isoniazid do not contact directly. The compound oral solid preparation not only improves the stability of the compound preparation, but also improves the bioavailability of rifampicin.
Owner:ZHEJIANG HISUN PHARMA CO LTD
Application of ethambutol hydrochloride in the treatment of refractory epilepsy
ActiveCN109999016BAdvantages and Notable ImprovementsHas antiepileptic effectOrganic active ingredientsNervous disorderNew medicationsUse medication
The invention discloses the application of ethambutol or a pharmaceutically acceptable salt thereof as an active ingredient in the preparation of a drug for treating intractable epilepsy, and belongs to the technical field of medicine. Because the dosage of ethambutol hydrochloride is low, the toxic and side effects must be reduced, thereby reducing the toxic and side effects of the patient's medication. The new anti-refractory epilepsy drug has very significant social and economic significance.
Owner:浙江药苑生物科技有限公司
A kind of ethambutol hydrochloride salt crystallization method
ActiveCN103435501BHigh purityLow costOrganic compound preparationAmino-hyroxy compound preparationEthambutol HydrochlorideActive ingredient
Owner:GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
Sensitive method for determining ethambutol in blood plasma through liquid chromatography-tandem mass spectrometry
InactiveCN111595966AHigh sensitivityImprove securityComponent separationChromatographic separationGradient elution
The invention discloses a sensitive method for determining ethambutol in blood plasma through liquid chromatography-tandem mass spectrometry, and belongs to the technical field of drug analysis. According to the invention, a method for determining ethambutol in human plasma by liquid chromatography-tandem mass spectrometry is established, a plasma sample is treated by a protein precipitation method, quick gradient elution chromatographic separation is carried out by using an Atantis-dC18 chromatographic column, and detection is carried out by using a tandem quadrupole mass spectrometer. The ion reaction is monitored to be m / z 205.2 to 116.2 (ethambutol) and m / z 209.2 to 120.2 (internal standard ethambutol-d4) by mass spectrometry. The method provided by the invention can realize quick andsensitive detection of ethambutol in blood plasma, and can be applied to bioequivalence research of ethambutol hydrochloride tablets with a specification of 250 mg.
Owner:苏州必宜生物科技有限公司
Fixed dose compound preparation of antitubercular drug and its preparing method
ActiveCN100571704CGood curative effectReduce errorsAntibacterial agentsOrganic active ingredientsParticle mixingPolypill
The invention is a fixed-dose anti-tuberculosis drug compound preparation and a preparation method thereof, which has the characteristics of reducing the number of times of taking the medicine, reducing the occurrence of drug resistance, improving the curative effect of the medicine, and making the storage and transportation of the medicine more convenient. It is a fixed-dose compound preparation containing rifampicin, isoniazid, pyrazinamide and ethambutol hydrochloride, which also contains an appropriate amount of disintegrants, binders, lubricants, diluents and water-soluble packets. Clothing powder. First sieve rifampicin alone, pass through a 100 mesh sieve, and pass through a 60 mesh sieve, add binder, disintegrating agent and diluent, mix evenly, dry granulate, and then use disintegrating agent and diluent to mix with the above-mentioned The granules are mixed evenly and pressed into tablets to obtain the finished product. The invention is especially suitable for use by tuberculosis patients.
Owner:SHENYANG HONGQI PHARMA
Application of ethambutol hydrochloride in treatment of intractable epilepsy
ActiveCN109999016AAdvantages and Notable ImprovementsHas antiepileptic effectOrganic active ingredientsNervous disorderSide effectBULK ACTIVE INGREDIENT
The invention discloses application of ethambutol or a pharmaceutically acceptable salt thereof as an active ingredient in preparation of a drug for treating intractable epilepsy and belongs to the technical field of medicines. Due to the fact that the dosage of the ethambutol hydrochloride is small, toxic and side effects are inevitably reduced, so that the toxic and side effects of medication ofa patient are reduced, meanwhile the medication dependence of the patient is improved, the prior art is enriched, and the potential new drug for resisting intractable epilepsy is added clinically andhas remarkable social significance and economic significance.
Owner:浙江药苑生物科技有限公司
Ethambutol hydrochloride synthesis method
ActiveCN108218723ALow residue on ignitionImprove qualityOrganic compound preparationOrganic chemistry methodsAlcoholSynthesis methods
The application of the invention discloses an ethambutol hydrochloride preparation process. The ethambutol hydrochloride preparation process comprises the following steps: 1) mixing S-(+)-2-amino-1-butanol and 1,2-dichloroethane, reacting to form a reaction discharge material; 2) separating S-(+)-2-amino-1-butanol from the reaction discharge material in a separating system, returning to a reactor;3) adding HCl into the separation system; 4) crystalizing to obtain a first mother solution and precipitated ethambutol hydrochloride; 5) concentrating the first mother solution at the normal pressure to recycle alcohol, crystalizing to obtain a second mother solution and the ethambutol hydrochloride, enabling the ethambutol hydrochloride to return to the separation system; 6) adding an alkali into the second mother solution to regulate the pH value, separating the alcohol and the S-(+)-2-amino-1-butanol not completely separated in the step 2), and dehydrating the separated S-(+)-2-amino-1-butanol in the step, and enabling the S-(+)-2-amino-1-butanol to return to the reactor.
Owner:WUHAN WUYAO PHARMA
Process system for preparing ethambutol hydrochloride
PendingCN106824005AFast fullPrevent flammable and explosive accidentsOrganic compound preparationFeed devicesProcess systemsDistillation
The invention relates to a process system for preparing ethambutol hydrochloride. The process system comprises, in an upstream-to-downstream arrangement, comprises a reaction kettle (1), a distillation kettle (2), a dissolving kettle (3) and a press filter (4), and also a recovery tank (5) which is located downstream of the distillation kettle (2), a collection tank (6) which is located downstream of the press filter (4), and a nitrogen protection device comprising a nitrogen inlet pipe (7), and pressure alarm devices (10). The nitrogen inlet pipe (7) is connected with the top of the reaction kettle (1) by means of a pipe, and also connected with a blowdown pipe (8) and a discharge pipe (9) of the reaction kettle (1) by means of pipes. The pressure alarm devices (10) are located on a connecting pipe between the nitrogen inlet pipe (7) and the blowdown pipe (8) and on a connecting pipe between the nitrogen inlet pipe (7) and the discharge pipe (9). The process system is applicable to process preparation of ethambutol hydrochloride.
Owner:JIANGSU CHENGXIN PHARMA
Preparation method for ethambutol hydrochloride
InactiveCN110143887ALow costIncreased reaction yield at normal pressureOrganic compound preparationAmino-hyroxy compound preparationSpecific rotationEthane Dichloride
The invention discloses a preparation method for ethambutol hydrochloride. The preparation method comprises the following steps: 1) mixing S-(+)-2-amino-1-butanol with the specific rotation of +8.3 degrees to +9.3 degrees and 1,2-dichloroethane in a reactor and reacting to obtain a reaction discharged material; 2) transferring the reaction discharged material into a separation system; after addingalkali, separating out the S-(+)-2-amino-1-butanol and returning the separated S-(+)-2-amino-1-butanol back to the reactor; 3) adding alcohol into a separation system again to obtain an alcohol solution containing ethambutol; 4) separating the obtained alcohol solution of the ethambutol to remove salt, so as to obtain a desalted alcohol solution containing the ethambutol; 5) cooling the desaltedalcohol solution containing the ethambutol and separating to remove impurities, so as to obtain an impurity-removed alcohol solution of the ethambutol; 6) adding the alcohol solution of the ethambutolinto water to regulate the water content of a system; then adding the alcohol and hydrogen chloride to obtain an alcohol solution containing the ethambutol hydrochloride; and 7) separating the ethambutol hydrochloride through crystallization, so as to obtain the ethambutol hydrochloride.
Owner:WUHAN WUYAO PHARMA
A kind of method of synthesizing ethambutol hydrochloride
ActiveCN108218724BLow residue on ignitionImprove qualityOrganic compound preparationOrganic chemistry methodsAlcoholEthambutol Hydrochloride
Owner:WUHAN WUYAO PHARMA
A pharmaceutical composition for treating intractable epilepsy and its application
ActiveCN109966277BHigh dependenceSmall toxicityNervous disorderAnhydride/acid/halide active ingredientsSide effectSodium divalproex
The invention discloses a pharmaceutical composition for treating intractable epilepsy and its application. The active ingredients of the pharmaceutical composition are: (1) sodium valproate or divalproex sodium; and (2) ethylamine Butanol or a pharmaceutically acceptable salt thereof. The present invention finds for the first time that low-dose ethambutol hydrochloride has an anti-epileptic effect, and the drug is used together with sodium valproate or divalproex sodium for the treatment of refractory epilepsy, the anti-epileptic effect is significant, and the side effects are obvious reduce.
Owner:AFFILIATED HOSPITAL OF JINING MEDICAL UNIV
Compound antituberculous coating core tablet and preparing method
ActiveCN102552204BImprove bioavailabilityEasy to takeAntibacterial agentsOrganic active ingredientsIsoniazidPyrazine
Owner:SHENYANG PHARMA UNIVERSITY
Compound preparation of antituberculosis medicaments, and preparation method thereof
ActiveCN101524355BEasy to measureAccurate measurementAntibacterial agentsOrganic active ingredientsDirect observationAntituberculous drugs
The invention belongs to the technical field of medicines, and provides a compound preparation of antituberculosis medicaments, and a preparation method thereof. Rifampicin, isoniazid, pyrazinamide and ethambutol hydrochloride as four leading antituberculosis medicaments are prepared into the compound preparation according to specific mixture ratio. The method comprises the steps of evenly mixingthe leading drugs with an appropriate quantity of disintegrant and diluent, performing dry-process granulation, finishing granules, adding other auxiliary materials to the granules and preparing the obtained product into a suitable preparation. The invention solves the problems that patients are difficult to cooperate closely and complete normal chemotherapys because the antituberculosis medicaments are high in dosage, large in dosage form and troublesome in medicine-taking method, and the compound preparation and the preparation method accord with global tuberculosis direct-observation short-range supervision chemotherapy strategy (DOTS) recommended by the WHO. The antituberculosis fixed-dose compound preparation has important significance for simplifying medicine-taking method, carryingout the DOTS and controlling tuberculosis prevalence.
Owner:SHENYANG HONGQI PHARMA
Process for preparing ethambutol and ethambutol hydrochloride
ActiveCN103772214BEasy to recycleHigh recovery rateOrganic compound preparationAmino-hyroxy compound preparationOrganic solventBoiling point
The invention provides methods for preparing ethambutol and ethambutol hydrochloride. The method for preparing the ethambutol comprises the step of utilizing (S)-2-aminobutanol and 1,2-dichloroethane to perform condensation reaction to prepare the ethambutol, wherein the condensation reaction is carried out in a low-boiling organic solvent, and HCl produced in the ammonia gas neutralization reaction process is utilized. Through the utilization of the method, the ethambutol of which the yield coefficient is improved can be obtained, so that the ethambutol hydrochloride of which the yield coefficient is improved can be obtained. Besides, the methods are simple in technology, safe, stable, low in cost and super-high in practical value in the industry.
Owner:NEW FOUNDER HLDG DEV LLC +2
Novel method for preparing ethambutol hydrochloride
InactiveCN112575042AAlternative Synthetic ProcessOrganic compound preparationCarboxylic acid amides preparationThreonineAmidogen
According to the invention, cheap and easily available L-threonine is used as a raw material to synthesize L-2-aminobutyric acid, and then the L-2-aminobutyric acid is used as an intermediate to synthesize ethambutol hydrochloride. Firstly, an enzyme catalysis method is used, L-threonine is used as a raw material, and L-2-aminobutyric acid (D-2-aminobutanol and L-2-aminobutyric acid are both in Sconfiguration) is prepared through a 'one-pot method'; the intermediate reacts with oxalyl chloride to generate a dicarboxylic acid compound containing diamide groups, and then cobalt catalytic hydrogenation reduction is conducted to obtain ethambutol; and hydrogen chloride gas is introduced to generate ethambutol hydrochloride. The process has the characteristics of low cost, simplicity and convenience in operation, environmental friendliness, high conversion rate and high optical purity of the product.
Owner:HUBEI GRAND LIFE SCI & TECH CO LTD
Quadrigeminal compound preparation of anti-tuberculosis medicines and preparation method thereof
The invention belongs to the technical field of medicines, and relates to a quadrigeminal compound preparation of anti-tuberculosis medicines and a preparation method thereof. The compound preparation is prepared by combining anti-tuberculosis first-line medicines rifampin, isoniazid, pyrazinamide and ethambutol hydrochloride according to a specific ratio. The compound preparation is a gastric-dissolved dressed tablet, and is characterized by being prepared according to the following steps: firstly preparing a quadrigeminal base tablet, wherein the quadrigeminal base tablet comprises proper amount of a stabilizing agent, a disintegrating agent, an adhesive, a filler, a flow aid and a lubricant; sieving rifampin by using a 80 mesh sieve, sieving the other raw materials and auxiliary materials by using a 20 mesh sieve; weighing the prescription amount of isoniazid, pyrazinamide and ethambutol hydrochloride, adding the disintegrating agent, the adhesive and the filler, mixing uniformly, and preparing an integral particle by employing a wet process; then adding the prescription amount of rifampin, the stabilizing agent, the flow aid and the lubricant and mixing uniformly; and tabletting and dressing, so as to obtain the preparation. The method is convenient in operation, simple in technology, free of equipment reconstruction and low in cost, and has important social and economic benefit.
Owner:ANHUI BIOCHEM BIO PHARMA
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