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Drug for clinically treating pulmonary tuberculosis

A technology for clinical treatment of pulmonary tuberculosis, which is applied in the field of medicine and can solve problems such as obvious toxic and side effects

Inactive Publication Date: 2018-01-16
郝涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ethambutol is currently one of the commonly used drugs for the treatment of tuberculosis, but the side effects caused by it are obvious

Method used

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  • Drug for clinically treating pulmonary tuberculosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0008] Embodiment 1: The drug for the clinical treatment of pulmonary tuberculosis is made of 22 g of ethambutol, 18 g of starch, and 41 g of biological agent. Put the ethambutol, starch, and biological preparations in the above parts by weight in a high-speed mixing granulator, dry-mix quickly for 5 minutes, add an appropriate amount of 10% starch slurry and stir at a low speed for 3 minutes, and quickly make wet granules. The wet granules are sent to a fluidized bed of a fluidized drier and dried at 60°C for 20 minutes. After drying, the moisture content is controlled to 7%, and the dried granules are collected after cooling. Put the dry granules into a granulator, pass through a 14-mesh sieve for granulation, add magnesium stearate with 1% of the total weight of the granules, put them into a three-dimensional motion mixer and mix for 10 minutes before weighing and pressing. bottle packaging. The biological preparation is prepared by soaking 100g of Rosa obtuse leaf, 21g of...

Embodiment approach 2

[0009] Embodiment 2: The drug for the clinical treatment of pulmonary tuberculosis is made of 24 g of ethambutol, 21 g of starch, and 44 g of biological preparations, and the preparation method is the same as that of Embodiment 1.

Embodiment approach 3

[0010] Embodiment 3: The drug for the clinical treatment of pulmonary tuberculosis is made from 26 g of ethambutol, 24 g of starch, and 47 g of biological preparations, and the preparation method is the same as that of Embodiment 1.

[0011] Quality inspection of pharmaceutical tablet of the present invention

[0012] In this study, three batches of test products were prepared, and the disintegration time limit, dissolution rate and stability were investigated according to the methods of "Chinese Pharmacopoeia".

[0013] ①Disintegration time limit inspection

[0014] According to the method under the method of disintegration time limit inspection method in Appendix X A of the 2005 edition of the Chinese Pharmacopoeia, the average disintegration time limits of the three batches were (8.06±2.21) min, (8.13±2.19) min, (8.08 ±2.21)min, all within 15min, complying with the regulations.

[0015] ②Dissolution test

[0016] According to "Chinese Pharmacopoeia" 2005 edition two appe...

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PUM

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Abstract

The invention discloses a drug for clinically treating pulmonary tuberculosis and belongs to the technical field of drugs. The drug is prepared from ethambutol, starch and a biological agent. Clinicaltests prove that the drug better solves the problem that ethambutol hydrochloride sold in the market easily has side effects when used for treating pulmonary tuberculosis clinically.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to medicines for clinically treating pulmonary tuberculosis. Background technique [0002] The causative bacterium of tuberculosis is Mycobacterium tuberculosis, mainly human and bovine. Mycobacterium tuberculosis infection has the highest incidence rate. Clinically referred to tuberculosis mostly caused by the above two types. Tuberculosis is mainly transmitted through the respiratory tract, and can also be infected through the digestive tract, and a few are infected through skin wounds. Respiratory transmission is the most common and important route. Tuberculosis patients (mainly cavitary tuberculosis) discharge a large number of bacteria-carrying droplets from the respiratory tract, and inhalation of these bacteria-carrying droplets can cause infection. Pulmonary tuberculosis is called "pulmonary tuberculosis" and "tuberculosis" in traditional Chinese medicine. The main cli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/738A61K9/20A61P11/00A61P31/06A61K31/133
Inventor 郝涛刘柱杨震
Owner 郝涛
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