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Application of ethambutol hydrochloride in treatment of intractable epilepsy

A technology of ethambutol hydrochloride and refractory epilepsy, which is applied in the field of medicine, can solve the problems of low-dose ethambutol hydrochloride epilepsy patients that have not been reported in the literature, and achieve significant social and economic significance, low dosage, and reduced Toxic effects

Active Publication Date: 2019-07-12
浙江药苑生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no literature report that ethambutol hydrochloride can be used for anti-epileptic, and there is no literature report that low-dose ethambutol hydrochloride is used in the treatment of patients with refractory epilepsy.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: Effect test of ethambutol hydrochloride on cell model of refractory epilepsy

[0015] The newly isolated and planted hippocampal neurons are round, translucent, without protrusions, and are in the state of single-cell suspension. On the third day of culture, the adherent hippocampal neurons elongated several protrusions of uneven thickness, the cell bodies were translucent, fusiform, triangular, etc., and there may be sparse network connections between adjacent neurons. The hippocampal neurons cultured to the 5th day were in good growth state, with obvious three-dimensional sense and refraction, enlarged cell bodies, and elongated processes interwoven into a network. On the 7th day of culture, the cell body of the hippocampal neuron was enlarged and plump, with obvious halo; the neurons had more protrusions, the axons were slender, and the protrusions of the neurons interweaved with each other, forming a dense and complex but evenly distributed neural network...

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PUM

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Abstract

The invention discloses application of ethambutol or a pharmaceutically acceptable salt thereof as an active ingredient in preparation of a drug for treating intractable epilepsy and belongs to the technical field of medicines. Due to the fact that the dosage of the ethambutol hydrochloride is small, toxic and side effects are inevitably reduced, so that the toxic and side effects of medication ofa patient are reduced, meanwhile the medication dependence of the patient is improved, the prior art is enriched, and the potential new drug for resisting intractable epilepsy is added clinically andhas remarkable social significance and economic significance.

Description

technical field [0001] The invention relates to a new application of biological activity of a chemical drug, more specifically relates to the application of ethambutol hydrochloride in the treatment of refractory epilepsy, and belongs to the technical field of medicine. Background technique [0002] Epilepsy is a common neurological disease. It is a syndrome of chronic recurrent transient brain dysfunction, characterized by seizures caused by abnormal discharge of brain neurons. Among them, more than 30% of epilepsy patients are difficult to control their seizures with commonly used antiepileptic drugs in clinical practice, which is called intractable epilepsy. The pathogenesis of epilepsy is very complicated, and its entire mechanism has not been fully understood so far, but some important links of its pathogenesis have been discovered: the electrophysiological basis of epilepsy is highly synchronized abnormal discharge of neurons, and epilepsy is caused by The epileptogen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/133A61P25/08
CPCA61K31/133A61P25/08
Inventor 孙冉闫换褚旭吴兴饶
Owner 浙江药苑生物科技有限公司
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