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Quadrigeminal compound preparation of anti-tuberculosis medicines and preparation method thereof

A compound preparation and anti-tuberculosis technology, applied in the field of medicine, can solve the problems of irregular drug use, difficulty in completing regular chemotherapy, and lack of systems and measures for strict management of tuberculosis patients.

Inactive Publication Date: 2015-01-14
ANHUI BIOCHEM BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In recent years, the problem of drug resistance has become more and more prominent. Informal drug use is the main cause of drug resistance, and the lack of strict management systems and measures for tuberculosis patients is an important reason for irregular drug use.
In addition, the current anti-tuberculosis drugs have a large dosage, large dosage forms, and cumbersome administration methods, which are also factors that cannot be ignored because it is difficult to obtain close cooperation from patients and complete regular chemotherapy.

Method used

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  • Quadrigeminal compound preparation of anti-tuberculosis medicines and preparation method thereof
  • Quadrigeminal compound preparation of anti-tuberculosis medicines and preparation method thereof
  • Quadrigeminal compound preparation of anti-tuberculosis medicines and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029]

[0030] Coating prescription

[0031] Coating powder: 40g

[0032] Water: Appropriate amount

[0033] Preparation:

[0034] (1) Sieve

[0035] Rifampicin is passed through a 80-mesh sieve, and other raw materials are passed through a 20-mesh sieve for subsequent use;

[0036] (2) Mixed granulation

[0037] Weigh isoniazid, ethambutol hydrochloride, pyrazinamide, PVPP (additional part), MCC, PVPK30 according to the prescription amount, mix in a high-speed wet mixer for 10 minutes (stirring speed 500-800r·min - 1 ), adding an appropriate amount of water to make soft materials, 40-mesh sieve to make granules, drying at 60±5°C, and controlling the moisture content below 1.5%;

[0038] (3) whole grain

[0039] Use a 65-mesh stainless steel sieve for granulation;

[0040] (4) mixed

[0041] Put the granulated material in a three-dimensional mixer, add the prescribed amount of rifampicin, sodium lauryl sulfate, PVPP, SIO2, MS and mix for 15 minutes;

[0042] (5) ...

Embodiment 2

[0049]

[0050] Coating prescription

[0051] Coating powder: 40g

[0052]Water: Appropriate amount

[0053] Preparation:

[0054] (1) Sieve

[0055] Rifampicin is passed through a 80-mesh sieve, and other raw materials are passed through a 20-mesh sieve for subsequent use;

[0056] (2) Mixed granulation

[0057] Weigh isoniazid, ethambutol hydrochloride, pyrazinamide, PVPP (additional part), MCC, PVPK30 according to the prescription amount, mix in a high-speed wet mixer for 10 minutes (stirring speed 500-800r·min - 1 ), adding an appropriate amount of water to make soft materials, 40-mesh sieve to make granules, drying at 60±5°C, and controlling the moisture content below 1.5%;

[0058] (3) whole grain

[0059] Use a 65-mesh stainless steel sieve for granulation;

[0060] (4) mixed

[0061] Put the granulated material in a three-dimensional mixer, add the prescribed amount of rifampicin, sodium lauryl sulfate, PVPP, SIO2, MS and mix for 15 minutes;

[0062] (5) I...

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Abstract

The invention belongs to the technical field of medicines, and relates to a quadrigeminal compound preparation of anti-tuberculosis medicines and a preparation method thereof. The compound preparation is prepared by combining anti-tuberculosis first-line medicines rifampin, isoniazid, pyrazinamide and ethambutol hydrochloride according to a specific ratio. The compound preparation is a gastric-dissolved dressed tablet, and is characterized by being prepared according to the following steps: firstly preparing a quadrigeminal base tablet, wherein the quadrigeminal base tablet comprises proper amount of a stabilizing agent, a disintegrating agent, an adhesive, a filler, a flow aid and a lubricant; sieving rifampin by using a 80 mesh sieve, sieving the other raw materials and auxiliary materials by using a 20 mesh sieve; weighing the prescription amount of isoniazid, pyrazinamide and ethambutol hydrochloride, adding the disintegrating agent, the adhesive and the filler, mixing uniformly, and preparing an integral particle by employing a wet process; then adding the prescription amount of rifampin, the stabilizing agent, the flow aid and the lubricant and mixing uniformly; and tabletting and dressing, so as to obtain the preparation. The method is convenient in operation, simple in technology, free of equipment reconstruction and low in cost, and has important social and economic benefit.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a quadruple compound preparation of anti-tuberculosis drugs and a preparation method thereof. Background technique [0002] Tuberculosis is a chronic infectious disease that seriously endangers people's health. At present, about 2 billion people are infected in the world. There are about 8-10 million new tuberculosis patients every year, and about 2-3 million deaths due to tuberculosis every year. It is mainly caused by Mycobacterium tuberculosis, which can invade many organs, and pulmonary tuberculosis is the most common form of lung involvement. At present, the annual incidence of tuberculosis in my country is about 1.3 million, and the number of deaths due to tuberculosis reaches 130,000 per year, exceeding the total number of deaths from other infectious diseases. my country is one of the 22 countries with severe tuberculosis epidemics in the world, and it is also one of the ...

Claims

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Application Information

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IPC IPC(8): A61K31/4965A61K9/28A61P31/06A61K31/4409A61K31/496A61K31/133
CPCA61K31/4965A61K9/28A61K31/133A61K31/4409A61K31/496
Inventor 沈蔡月朱礼根白中稳
Owner ANHUI BIOCHEM BIO PHARMA
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