40 results about "Endarteritis" patented technology

Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn's disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies.

The use of a compound of formula (I): an isomer thereof, a prodrug of said compound or isomer, or a pharmaceutically acceptable salt of said compound, isomer or prodrug, in the manufacture of a medicament for the palliative, prophylactic or curative treatment of negative energy balance in ruminants. The use of a compound of formula (I), in the manufacture of a medicament for the palliative, prophylactic or curative treatment of ruminant disease associated with negative energy balance in ruminants, wherein, preferably, the ruminant disease associated with negative energy balance in ruminants is selected from fatty liver syndrome, dystocia, immune dysfunction, impaired immune function, toxification, primary ketosis, secondary ketosis, downer cow syndrome, indigestion, inappetence, retained placenta, displaced abomasum, mastitis, (endo-)-metritis, infertility, low fertility, and lameness.

Spiroindoline derivatives, process for their preparation and pharmaceutical compositions thereof, their use for the treatment and / or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and / or prophylaxis of diseases, especially sex-hormone-related diseases in both men and women, in particularly those selded from the group of endometriosis, uterine fibroids, polycystic ovarian disease, hirsutism, precocious puberty, gonadal steroid-dependent neoplasia such as cancers of the prostate, breast and ovary, gonadotrope pituitary adenomas, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hypertrophy, contraception and infertility (e.g., assisted reprodudive therapy such as in vitro fertilization). The present application relates in particular to spiroindoline derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists.

The invention provides a method for in vitro screening and detection of anti-cow endometritis drugs, which is to induce an inflammatory reaction in cow endometrial epithelial cells cultured in vitro, and then add the drug to be tested, and detect the inflammatory protein in the cells relative to the internal reference Changes in protein expression accurately reflect the anti-inflammatory activity of the drug to be tested: if the relative expression of the inflammatory protein decreases, the drug to be tested has anti-inflammatory activity, and the relative decrease in expression is the relative anti-inflammatory activity of the drug to be tested; otherwise Then there is no anti-inflammatory activity; wherein, the inflammatory protein is an integrin-linked kinase. The method for screening and detecting the anti-cow endometritis drug in vitro of the present invention can realize simple and rapid screening and detection of the anti-cow endometritis activity of the drug to be tested in vitro. When multi-well plates are used, high-throughput screening and detection can be achieved, and the screening and detection results have important reference value for the modern clinical application and modern development of traditional Chinese medicine.

According to certain embodiments, the present disclosure provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds a Staphylococcus species target antigen and a second antigen binding domain that binds a complement component. In certain embodiments, the bispecific antigen-binding molecules of the present disclosure are capable of binding to the Staphylococcus species target antigen with an EC50 of about 10 nM or less, and / or are capable of promoting complement deposition on the Staphylococcus species with an EC50 of about 10 nM. The antibodies of the disclosure are useful for treating diseases in which inhibition or reduction of the growth of a Staphylococcus species is desired and / or therapeutically beneficial, for example, for treating staphylococcal infections including a skin infection, cellulitis, pneumonia, meningitis, urinary tract infection, toxic shock syndrome, endocarditis, osteomyelitis, bacteremia, or sepsis, or for preventing or treating a staphylococcus infection that occurs as a result of a surgical procedure.

The invention relates to a Chinese herbal medicine preparation for curing the endometrial disease, the infertility and the habitual abortion. The Chinese herbal medicine preparation is prepared through decocting the following Chinese herbal medicines with water: angelica sinensis, astragalus membranaceus, rubus idaeus, ciliatenerve knotweed root, spiranthes sinensis ames, polygonum perfoliatum, kalimeris indica root, herba lycopi, achyranthes aspera, ginseng, rubus pluribracteatus, rubus parvifolius root, rhizoma polygonat, solanum lyratum, cyperus rotundus, cistanche, daughters red, crneate lespedeza, Chinese rose, galium aparine, achyranthes root, sagina subulata, gold rattan, crowndaisy chrysanthemum, herba leonuri, sargentgloryvine stem, semen cuscutae, semen euryales and the like. The Chinese herbal medicine preparation is beneficial for the recovery of the physical function and the organ function, has no any toxic or side effects, achieves more than 93% of effective rate in treating the female infertility and the habitual abortion, achieves more than 94% of effective rate in treating the endometritis and the pelvic inflammation, achieves more than 89.4% of effective rate in treating the cervical hypertrophy, the cervical erosion, the xeromenia, the inflammatory mass, the uterine fibroid, the ovarian cyst and other gynecological diseases, and achieves more than 94.1% of effective rate in treating sterility due to oligozoospermia and the necrospermia.

The invention relates to a perfusion agent for treating cow endometritis, and further relates to a preparation method for the perfusion agent. Components of each 100 L of the perfusion agent comprise: 5-10 kg of povidone iodine; 5-10 kg of borneol; 0.1-0.5 kg of a suspending agent, the balance of polyethylene glycol-400. The perfusion agent is prepared through the following method: (1) respectively weighing the povidone iodine, the borneol and the suspending agent, then uniformly mixing to obtain a mixture I for later use; (2) adding 40-60 L of the polyethylene glycol-400 to the mixture I while stirring; after uniformly stirring, placing the resulting mixture containing the polyethylene glycol-400 in a grinder to carry out grinding for twice until the drug emulsion fineness is 200 mum to obtain a mixture II; (3) further adding the polyethylene glycol-400 to the mixture II until the total volume is 100 L, uniformly stirring and packing. According to the present invention, the perfusionagent adopts the combination method of the traditional Chinese drug and the western medicine, provides a significant therapeutic effect for the cow endometritis; and the drug resistance is difficult to be generated and the perfusion agent is easy to be used.

The invention discloses application of sophocarpine or pharmaceutical salts thereof to preparation of medicament for treating cardiovascular diseases caused by coxsackie virus B. The sophocarpine or pharmaceutical salts thereof can be used as medicaments for treating dilated cardiomyopathy, viral endocarditis, viral valvulitis, viral pericarditis, viral coronary arteritis and hypertrophic cardiomyopathy caused by the coxsackie virus B. According to the sophocarpine or pharmaceutical salts thereof, the cure rate can be improved, the death rate can be reduced; and the sophocarpine or pharmaceutical salts thereof have no obvious toxic effects of cells, simpleness and convenience for preparation and low cost and are suitable for industrial production; meanwhile, medical resources of the sophocarpine are abundant.

The invention relates to an externally-used Chinese preparation for treating gynaecologic diseases and process for preparation, which comprises the following components (by weight ratio): yellow corktree bark 5-40 parts, borneol 0.1-10 parts, mercury monochloride 1-10 parts, orpiment 0.1-10 parts and centipede 0.1-6 parts. The medicament can be prepared into externally-used common medicinal herble usual dose through the conventional preparing processes.

The invention relates to a traditional Chinese medicine composition for treating endometritis and a preparation method thereof. The traditional Chinese medicine composition comprises the following components in parts by weight: 7.69 parts of picriafel-terrae lour, 11.54 parts of elephantopus scaber, 7.69 parts of radix angelicae sinensis, 11.54 parts of millettia dielsiana, 11.54 parts of zanthoxylum nitidum, 11.54 parts of membranaceous beautyleaf root, 11.54 parts of persimmon leaves, 11.54 parts of herba thlaspis and 15.38 parts of ficus simplicissima lour. The method for preparing the traditional Chinese medicine composition comprises the following steps: carrying out alcohol extraction on the picriafel-terrae lour, the elephantopus scaber, the herba thlaspis and the ficus simplicissima lour, and carrying out aqueous extraction on the herb residue after the alcohol extraction and the rest five components. The effect of the traditional Chinese medicine composition provided by the invention is verified by a manner of putting foreign bodies in uterine to prepare a rat endometritis model. The traditional Chinese medicine composition provided by the invention has the effect on treating gynecologic inflammation, in particular on treating endometritis; and the effect is better than the prior art.

A method for preparing a traditional Chinese medicine microecological preparation for preventing and treating dairy cow endometritis, which is prepared according to the following method: superfinely pulverize motherwort, safflower, peach kernel, honeysuckle, pulsatilla, echinacea, gynostemma, astragalus, and licorice, add water to a boil, Keep warm on low heat, cool and filter, collect the filtrate, add sugar to boil, cool down to room temperature, inoculate the probiotics fermented by Lactobacillus, Kombucha and yeast, and give the probiotics to cows in proportion. The traditional Chinese medicine microecological preparation of the present invention has the effects of promoting blood circulation and removing blood stasis, clearing away heat and detoxifying, sterilizing and reducing inflammation, etc., is rich in active substances of Chinese herbal medicine, active small peptides, lactic acid and probiotics, has good therapeutic effect, and replaces traditional antibiotic treatment methods. The preparation method of the present invention is simple, easy to use, free of drug residue, free of any toxic and side effects, high in live drug content, suitable for industrial production, and has a good market prospect, and also has a good effect on endometritis infertility in dairy cows. treatment effect.