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Medicinal composition for treating cattle endometritis

An endometritis and composition technology, applied in the field of veterinary medicine, can solve the problems of easily increasing the risk of iatrogenic infection, affecting the curative effect, changing the intrauterine environment, etc., reducing the probability of pathogenic microorganism infection, improving the cure rate, release slow effect

Inactive Publication Date: 2010-12-15
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Intrauterine treatment is a commonly used method, but intrauterine treatment has several disadvantages: ①The drug will be diluted when the infection is severe or there is a large amount of exudate in the uterus, which will affect the curative effect; ②The effect of the drug may be affected by purulent debris and can produce β-lactamase is weakened by microorganisms or other factors (such as hypoxia); ③ easy to increase the risk of iatrogenic infection; ④ intrauterine perfusion of antiseptic and disinfectant is not excreted in time, easy to change the intrauterine environment

Method used

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  • Medicinal composition for treating cattle endometritis
  • Medicinal composition for treating cattle endometritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Made from the following raw materials:

[0021] Chloramphenicol: 3g;

[0022] Tetracycline hydrochloride: 3g;

[0023] Vitamin C: 0.1g;

[0024] Procaine: 0.5g;

[0025] Make up to 100ml with 1,2-propanediol.

[0026] Preparation:

[0027] Weigh chloramphenicol, tetracycline hydrochloride, vitamin C and procaine in the formula, dissolve them in 1,2-propanediol, pack them into sterile brown bottles, press caps, and package; make compound long-acting uterine perfusion Oil agent.

Embodiment 2

[0029] Made from the following raw materials:

[0030] Chloramphenicol: 4.5g;

[0031] Tetracycline hydrochloride: 4.5g;

[0032] Vitamin C: 0.3g;

[0033] Procaine: 1.0g;

[0034] Make up to 100ml with 1,2-propanediol.

[0035] Preparation:

[0036] Weigh chloramphenicol, tetracycline hydrochloride, vitamin C and procaine in the formula, dissolve them in 1,2-propanediol, pack them into sterile brown bottles, press caps, and package; make compound long-acting uterine perfusion Oil agent.

Embodiment 3

[0038] Made from the following raw materials:

[0039] Chloramphenicol: 6g;

[0040] Tetracycline hydrochloride: 6g;

[0041] Vitamin C: 0.5g;

[0042] Procaine: 1.5g;

[0043] Make up to 100ml with 1,2-propanediol.

[0044] Preparation:

[0045] Weigh chloramphenicol, tetracycline hydrochloride, vitamin C and procaine in the formula, dissolve them in 1,2-propanediol, pack them into sterile brown bottles, press caps, and package; make compound long-acting uterine perfusion Oil agent.

[0046] The efficacy of the medicine of the present invention will be further verified below through specific experimental examples.

[0047] experimental animals

[0048] 60 cows suffered from postpartum acute endometritis in a cattle farm in Jilin City, and the illness time was 6-10 days after delivery.

[0049] experimental drug

[0050] Chloramphenicol, tetracycline hydrochloride, procaine, vitamin C, compound infusion (the content of each 100g medicinal powder is: oxytetracycline 30...

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PUM

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Abstract

The invention relates to a medicinal composition for treating cattle endometritis and belongs to the field of veterinary medicaments. The composition is prepared from 3 to 6g of chloramphenicol, 3 to 6g of quadracycline, 0.1 to 0.5g of vitamin C and 0.5 to 1.5g of procaine, and the volume of the composition is fixed to 100ml by 1,2-propylene glycol. The medicinal composition has the advantages of achieving a wider antimicrobial spectrum by combining two broad-spectrum antibiotics, protecting mucous membrane from the damage caused by the pessimal stimulation of medicaments by adding the procaine into oiling agents formed by dissolving the medicinal composition in the 1,2-propylene glycol, slowing down the release rate of the medicaments, reducing acute toxicity, prolonging the absorbing time of the medicaments and the preservation time of tetracycline hydrochloride and making the content of the medicaments more stable.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and is especially suitable for treating bovine acute endometritis, and can be used as veterinary medicine. Background technique [0002] Endometritis is caused by a variety of factors and pathogens. It is a common reproductive organ disease in postpartum cows. The incidence of endometritis is very high all over the world. It is 5.6%-10.9% in Australia and 10.1% in the United Kingdom. , South Korea is 47.6%, the United States is 53%, while the incidence of endometritis in my country is 20% to 40%, which seriously affects estrus, ovulation and pregnancy, and is one of the main reasons for infertility and early elimination of dairy cows. [0003] The treatment principles of endometritis are: antibacterial and anti-inflammatory, promote the discharge of pathological products and restore uterine function. At present, the treatment methods for endometritis include systemic treatment and local anti-in...

Claims

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Application Information

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IPC IPC(8): A61K31/65A61K31/165A61K47/22A61K47/18A61P15/00A61P31/04
Inventor 王国卿王洪海张乃生王海霞郭梦尧
Owner JILIN UNIV
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