43 results about "Brain infarctions" patented technology

Pipecolic acid derivative-containing liposome preparations which are excellent in the immediate action and thus usable in an urgent situation such as brain infarction. These preparations are characterized by containing pipecolic acid derivatives or pharmaceutically acceptable salts thereof, which comprise the components as described in the description, as the active ingredient and lecithin as the major component of lipids forming liposomes, without resort to cholesterol as a stabilizer.

The present invention relates to host cells that can function as neurons which are obtained by introducing and expressing von Hippel-Lindau gene in cancer cells, such as neuroblastoma cells and anaplastic oncocytes derived from the nerve system, or embryonic stem cells. The obtained hosts that have grown in vitro are grafted to the central nerve system or peripheral nerves to take so as to allow the host cells to function as neurons, thereby treating intractable neuronal diseases associated with neurological functional disorder, such as Parkinson's disease, amyotrophic lateral sclerosis, Huntington's chorea, Alzheimer's disease, brain infarction, spinal cord injury, brain contusion or malignant tumor.

The present invention relates to an amide derivative of the formula (1), having a C5a receptor antagonistic actionwherein each symbol is as defined in the specification.The above-mentioned amide derivative, an optically active form thereof and a pharmaceutically acceptable salt thereof are promising as an agent for the treatment or prophylaxis of diseases or syndromes caused by inflammation caused by C5a [e.g., autoimmune diseases such as rheumatism, systemic lupus erythematosus and the like, sepsis, adult respiratory distress syndrome, chronic obstructive pulmonary disease, allergic diseases such as asthma and the like, atherosclerosis, cardiac infarction, brain infarction, psoriasis, Alzheimer's disease and serious organ injury (e.g., pneumonia, nephritis, hepatitis and pancreatitis and the like) due to activation of leukocytes caused by ischemia reperfusion, trauma, burn, surgical invasion and the like]. Moreover, they are useful as a therapeutic or prophylactic agent for the infectious diseases caused by bacteria and virus that invade via a C5a receptor.

The invention discloses a semiconductor laser synthesizer therapeutic instrument. The semiconductor laser synthesizer therapeutic instrument comprises a semiconductor laser synthesizer and a control system. The semiconductor laser synthesizer comprises a laser dielectric crystal (4), a semiconductor laser unit (1), an optical coupling system (2), a reflector (3), an output mirror (5), a frequency-doubling crystal (6), a feedback mirror (7), a transmission optical fiber (9) and a focusing lens (8), wherein a laser resonant cavity is formed by the laser dielectric crystal (4), the reflector (3) and the output mirror (5), the frequency-doubling crystal (6) is placed between the output mirror (5) and the feedback mirror (7), and the focusing lens (8) is arranged behind the feedback mirror. The control system comprises a power module, a semiconductor laser synthesizer stable operation module and a system control module. According to the semiconductor laser synthesizer therapeutic instrument, the cavity-outside frequency doubling and fundamental wave feedback technology is adopted in cooperation with a circuit control system, so that the purpose of taking both efficiency and stability into consideration is well achieved; the semiconductor laser synthesizer therapeutic instrument can be effectively used for photodynamic therapy, and is used for carrying out laser irradiation on a nasal cavity or acupoints, and carrying out therapy on vascular headaches, brain infarction, post-traumatic brain syndromes and chronic cardiovascular and cerebrovascular diseases.

Intractable neuronal diseases are treated by inducing differentiation of neural stem cells into neurons without accompanying a risk such as cytotoxicity and infection. Intractable neuronal diseases, such as Parkinson's disease, cerebral infarction, Alzheimer's disease, spinal cord injury, brain contusion, amyotropic lateral sclerosis, Huntington's disease, malignant tumor, and the like, are treated by regeneration therapy by transferring VHL peptides which can induce differentiation of neural stem cell into neurons into neural stem cells to induce differentiation of neural stem cells into neurons or by administering VHL peptides directly into a human body to induce differentiation of endogeneous stem cells into neurons.

Provided is an amino acid derivative prodrug represented by general formula (I-A) that is a prodrug form of an amino acid derivative which is a group 2 metabotropic glutamate receptor antagonist, or a pharmaceutically acceptable salt thereof.More specifically, provided is an amino acid derivative prodrug represented by general formula (I-A) that is a preventive or therapeutic drug for mood disorders (including depression and bipolar disorder), anxiety disorder, cognitive disorders, developmental disorders, Alzheimer's disease, Parkinson's disease, movement disorders associated with muscular rigidity, sleep disorders, Huntington's chorea, eating disorders, drug dependence, epilepsy, brain infarction, cerebral ischemia, cerebral insufficiency, cerebral edema, spinal cord disorders, head trauma, inflammation and immune-related diseases, and so on.

The invention discloses a Chinese medicinal composition for treating brain infarction and its after-effects, which is prepared from the following Chinese medicinal herbs: gastrodia tuber 10g, hooked uncaria 10-30g, abalone shell 10-30g, white mustard seed 10-20g, fragrant solomonseal rhizome 10-30g, kudzuvine root 10-30g, Ligusticum wallichii 10-30g, spatholobus stem 10-30g, frankincense 5-15g, myrrh 5-15g, earthworm 5-10g, buthus martensi kirsch 6-10g, white-stiff silkworm 10-15g, giant typhonium tuber 5-10g, curcuma root 10-30g, Acorus calamus 5-10g, achyranthes and cyathula root 10-30g, licorice root 5-10g and leech 3-10g.

The present disclosure provides an operating method of an automatic brain infarction detection system on magnetic resonance imaging (MRI), which includes steps as follows. Images corresponding to different slices of a brain of a subject are received from the MRI machine. The image mask process is performed on first and second images of the images. It is determined whether the cerebellum image intensity and the brain image intensity in the first image are matched. When the cerebellum image intensity and the brain image intensity are not matched, the cerebellar image intensity in the first image is adjusted. The first image is processed through a nonlinear regression to obtain a third image. A neural network identify an infarct region by using the first, second and third images that are cut. By means of the technical scheme, the position of the focus on magnetic resonance imaging is accurately detected, and diagnosis quantification of a physician on magnetic resonance imaging is more efficiently helped clinically.