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The invention belongs to the field of pharmacy and particularly relates to a medicinal preparation of palbociclib and a preparing method thereof. The medicinal preparation comprises palbociclib, an acidic adjuvant and an optional hydrophily high-molecular material. Compared with a conventional preparation, the medicinal preparation has more excellent solubility and in-vitro dissolution property, and can be used for enhancing in-vivo adsorption and bioavailability of palbociclib.

The invention provides a wood semigloss varnish composition which comprises the following raw materials in parts by weight: 40 to 60 parts of modified short oil alkyd resin, 5 to 15 parts of scuffing-resistance powder, 0 to 30 parts of assistant for varnish and 15 to 20 parts of solvent, wherein the modified short oil alkyd resin is short oil alkyd resin which is modified by castor oil and has oil length of 35 to 45; and the scuffing-resistance powder has Moh's hardness of not lower than 8 and the mesh number of not lower than 1,250 meshes.

The invention relates to the field of medical instruments, in particular to the field of titanium and magnesium alloy implanting for the department of orthopedics, and provides a multifunctional compound drug eluting slow-release system and a preparation method thereof. The multifunctional compound drug eluting slow-release system, which is of the multifunctional compound eluting, comprises a porous transitional layer and a degradable eluting layer containing drugs, and facilitates internal fixation while having a bacteriostasis effect.

The invention belongs to the field of medical equipment, and particularly relates to a medicine balloon and a preparation method of the medicine balloon. The medicine balloon is characterized in that permanent magnetic material is arranged in an inner tube of the balloon; medicine exists on the surface of the balloon in a form of medicine-load magnetic particles, so that a medicine coating based on a magnetic triggering mechanism is formed. According to the medicine balloon, the medicine coating is arranged, so that the medicine loss is enabled to be reduced as far as possible in a balloon conveying process, and the medicine is enabled to be sufficiently, rapidly and efficiently released and absorbed at a diseased region.

The invention relates to a polyether / aminopolysiloxane block copolymer and use thereof. The polyether / aminopolysiloxane block copolymer is prepared mainly by reacting a compound shown in a formula I with a compound shown in a formula II at 50 to 90 DEG C, and has the viscosity of 2,000 mPa.S to 7,500 mPa.S at 25 DEG C. The block copolymer can be used as a textile softening finishing agent. In theformulae I and II, R1 is H, C1 to C6 are linear or branched chain alkyls or hydroxyls, a is an integer from 0 to 20, m is 4 to 13, and n is 12 to 25.

The invention relates to a method for preparing C.I. pigment yellow 139. The method comprises the following steps of: (1) preparing 1,3-diiminoisoindoline from phthalonitrile; (2) reacting the 1,3-diiminoisoindoline with barbituric acid to prepare a crude C.I. pigment yellow 139 product; and (3) performing pigmentation on the crude C.I. pigment yellow 139 product. The method is characterized in that ammonia water is added or ammonia gas is introduced in the reaction in the step (1). The yield of the C.I. pigment yellow 139 is improved, and the obtained pigment has high performance (such as high coloring power, bright color, high dispersibility, extremely high light fastness and weathering fastness and the like).

The invention provides a method and a device for monitoring infusion of an insulin pen. The method integrates first detecting, second detecting and third detecting. The first detecting is used for detecting whether an infusion requirement unit is finished. The second detecting is used for detecting whether the infusion is unfinished in a timing mode or whether a motor continues infusion after normal time required by infusion. The third detecting is used for detecting whether motor and control data faults occur in real time in an infusion process. As long as any detecting is effectively, conditions requiring closing or stopping infusion can be detected timely, and the infusion can be closed or stopped timely so that infusion risks can be prevented better. In addition, implementation price of the monitoring method is low, and the method is easy to achieve and can be applied to various insulin pens in the market flexibly.

The invention relates to a hybrid of a dedoping-state polyaniline / metallic oxide, which is prepared by the following steps of: carrying out oxidation polymerization on an aniline monomer for 3 hours to 12 hours at10 DEG C-30 DEG C, in the presence of an oxidant and the water-soluble inorganic strong acid salt of quadrivalent titanium or tin, and processing an obtained polymer by ammonia water and finally drying at 150 DEG C-200 DEG C. The hybrid is an electrode material and assembled as a super capacitor, 1 M of H2SO4 is uses as an electrolyte solution, and when current density is enhanced from 0.5 A g-1 to 30 A g-1, the capacity retention rate of the super capacitor exceeds 70 percent; besides, the hybrid shows good oxidation / reduction reversibility in an aqueous medium with pH value not more than 5 and can be used for preparing the electrode material of the super capacitor.

The invention discloses a catalytic conversion technology for carbon tetrachloride. The technology is implemented in an autoclave. The technology is characterized in that: a catalyst comprises Ag, AgCl or composition thereof serving as active ingredients; a catalyst carrier comprises silicon dioxide, titanium dioxide, active carbon or mesoporous carbon or composition thereof; and under the action of the catalyst, aids are added into a mixture of carbon tetrachloride and methanol, and a part of carbon tetrachloride is converted into dichloromethane. By the method, the conversion rate of carbon tetrachloride can be improved, the reaction time is shortened, and the selectivity of dichloromethane is improved.

The present invention relates to a composition comprising vesicles released from activated T lymphocytes, and methods for its production and application. The vesicles contain a series of biologically active molecules that confer upon them notable properties such as: antigen recognition, antigen presentation, and other regulatory and effector functions. The present invention also relates to the transfer or delivery of antigenic molecules (such as peptides, peptide / MHC complexes, TCR and its subunits, etc.) using the above-mentioned vesicles to antigen-presenting cells (APCs) to induce specific immune responses, especially specific CTLs method of answering. The present invention also relates to methods for selectively or specifically delivering molecules to target cells using the above-mentioned vesicles.

The invention belongs to the field of medical instruments, and particularly relates to a drug eluting stent. The drug eluting stent comprises a stent body, a stent magnetic bottom layer, a stent outer surface coating and a stent inner surface coating, wherein the stent outer surface coating comprises a biodegradable polymer and an active medicament; the stent inner surface coating comprises magnetic nanoparticles and an active medicament. The drug eluting stent realizes the design of different functional medicinal coatings on the inner and outer surfaces of the stent and further realizes double-target release of different functional medicaments.

The invention relates to an amino modified polysiloxane copolymer with a modified group amino on a polysiloxane copolymer backbone and a application thereof. The amino modified polysiloxane copolymer comprises a polyamine chain segment, a polyether chain segment and a polysiloxane chain segment, wherein the viscosity of the amino modified polysiloxane copolymer is 38, 591-10, 272 cp (25 DEG C). The amino modified polysiloxane copolymer provided by the invention can be used as organic pigment (in particular heterocyclic or azo organic pigments) dispersants.

The invention belongs to the field of biopharmacy and in particular relates to a peripheral brain derived neurotrophic factor (proBDNF) for regulating pain as an inflammatory medium. The invention discloses a binding molecule having neutralization or inhibitory activity on the proBDNF or a signal transmission molecule thereof, and the binding molecule can be used for relieving, inhibiting or treating the pain. A polyclonal antibody neutralizes the proBDNF, and the pain is weakened in different inflammatory pain models.

The invention relates to the field of medical appliances, and particularly relates to a method for treating an animal-derived collagen fiber material. The method is performed by treating the animal-derived collagen fiber material with a salt solution containing polyethylene glycol and oxidants. After a biological valve treated by the method provided by the invention is implanted to an acceptor, immune inflammation reaction is not generated.

The invention discloses a spinal column pressurizing device used for nuclear magnetic resonance imaging. The device structurally comprises components of detachable shorts, connecting belts, shoulder straps, a waist belt, shoulder spherical bags, a waist spherical bag, a load measuring instrument, a connecting hook-and-loop fastener, leg hook-and-loop fasteners and the like; non-metal materials areadopted by the components, and therefore the components have no influence on the nuclear magnetic resonance imaging. The detachable shorts are connected with the shoulder straps through the connecting belts, the connecting belts can be bonded at different positions through a hook-and-loop fastener connecting manner, and people with different body shapes can conveniently worn and adapt. The connecting belts are provided with pulling force load measuring instruments, and the pressurized magnitude on a spinal column can be displayed in real time by adopting an indicator and a ruler. Pressurizingair bags are arranged on the shoulders and the waist so that the pressurized magnitude can be adjusted at will when nuclear magnetic resonance inspection is conducted, and the force bearing states inwhich a tested person feels uncomfortable of painful when bearing loads are simulated. The pressurizing device has the advantages that the pressurizing device can be adapted to tested people with different heights and shapes, and the free adjusting of the pressurizing magnitude on the spinal column performed by the tested person when the nuclear magnetic resonance inspection is conducted is convenient.

The invention belongs to the field of pharmaceuticals and particularly relates to a palbociclib oral emulsion and a preparation method of the palbociclib oral emulsion. The oral emulsion comprises thefollowing materials by mass: 0.1-1% of palbociclib free alkali or a pharmaceutical salt, 0.1-5% of a medicinal acid ingredient, 0.1-5% of a sweetening agent, 0.01-0.5% of an antioxidant, 0.1-10% of medicinal oil, and 1-10% of a medicinal emulsifier. Compared with the conventional preparation, the palbociclib oral emulsion has a better oral absorption property, and can be used to reduce the oral absorption difference of the palbociclib and improve the bioavailability.

The invention relates to a metal and / or its oxide in situ doped silica compound and its use. The target product is prepared through metal or / and its oxide in situ doping of a silica compound and a hydrothermal synthesis process, and the specific surface area (BET) of the target product is 100-800m<2> / g. 100% of the metal or / and its oxide in situ doped silica compound contains 1-20wt% of metallic nickel or / and its oxide, 0-5wt% of rare earth metals or / and oxides thereof, 0-10wt% of rare earths or / and oxides thereof, 0-5wt% of alkali metals or / and oxides thereof, and the balance silica. The invention also provides an application of the metal or / and its oxide in situ doped silica compound as a catalyst for preparing methane from synthetic gas.

The invention belongs to the field of medical instruments, and particularly relates to a drug eluting stent. The drug eluting stent comprises a stent body, a stent magnetic bottom layer, a stent outer surface coating and a stent inner surface coating, wherein the stent outer surface coating comprises a biodegradable polymer and an active medicament; the stent inner surface coating comprises magnetic nanoparticles and an active medicament. The drug eluting stent realizes the design of different functional medicinal coatings on the inner and outer surfaces of the stent and further realizes double-target release of different functional medicaments.

The invention provides a film-laminating thickness control system, a film laminating machine comprising the same, and a film-laminating thickness control method. The film-laminating thickness control system comprises a shell, a light-emitting diode array, middle support parts and a photosensitive device array, wherein the light-emitting diode array, the middle support parts and the photosensitive device array are assembled in the shell in sequence; the light-emitting diode array is used for emitting light; the middle support parts comprise an upper through hole array, a lower through hole array, a slot and a control circuit; the upper through hole array and the lower through hole array correspond to the light-emitting diode array; the slot is formed between and communicated with the upper through hole array and the lower through hole array; a film passes through the slot; the light-emitting diode array is assembled in the upper through hole array; the photosensitive device array is assembled in the lower through hole array and used for converting received light to terminal voltage; the control circuit is used for comparing a standard voltage with terminal voltage of the photosensitive device array and controlling a stepping motor for feeding the film based on a comparison result to obtain suitable film thickness. The film-laminating thickness control system is capable of judging whether the thickness of a polymer film is suitable when the film is fed by the film laminating machine in real time and correspondingly controlling the stepping motor based on a judgment result so as to adjust the thickness of the film to be suitable.

The invention relates to a polyether / aminopolysiloxane block copolymer and use thereof. The polyether / aminopolysiloxane block copolymer is prepared mainly by reacting a compound shown in a formula I with a compound shown in a formula II at 50 to 90 DEG C, and has the viscosity of 2,000 mPa.S to 7,500 mPa.S at 25 DEG C. The block copolymer can be used as a textile softening finishing agent. In the formulae I and II, R1 is H, C1 to C6 are linear or branched chain alkyls or hydroxyls, a is an integer from 0 to 20, m is 4 to 13, and n is 12 to 25.

The invention provides a film-laminating thickness control system, a film laminating machine comprising the same, and a film-laminating thickness control method. The film-laminating thickness control system comprises a shell, a light-emitting diode array, middle support parts and a photosensitive device array, wherein the light-emitting diode array, the middle support parts and the photosensitive device array are assembled in the shell in sequence; the light-emitting diode array is used for emitting light; the middle support parts comprise an upper through hole array, a lower through hole array, a slot and a control circuit; the upper through hole array and the lower through hole array correspond to the light-emitting diode array; the slot is formed between and communicated with the upper through hole array and the lower through hole array; a film passes through the slot; the light-emitting diode array is assembled in the upper through hole array; the photosensitive device array is assembled in the lower through hole array and used for converting received light to terminal voltage; the control circuit is used for comparing a standard voltage with terminal voltage of the photosensitive device array and controlling a stepping motor for feeding the film based on a comparison result to obtain suitable film thickness. The film-laminating thickness control system is capable of judging whether the thickness of a polymer film is suitable when the film is fed by the film laminating machine in real time and correspondingly controlling the stepping motor based on a judgment result so as to adjust the thickness of the film to be suitable.

The invention relates to a de-doped polyaniline / metal oxide hybrid. The hybrid compound is obtained by oxidatively polymerizing aniline monomers for 3 to 12 hours at 10°C to 30°C in the presence of an oxidant and a water-soluble inorganic strong salt of tetravalent titanium or tin. It can be prepared by treating with ammonia water and drying at 150℃~200℃. Using the hybrid compound described in the present invention as the electrode material to assemble a supercapacitor, 1M H2SO4 as the electrolyte solution, when the current density increases from 0.5A g-1 to 30A g-1, the capacity retention rate exceeds 70%. In addition, the hybrids exhibit good oxidation / reduction reversibility in aqueous media with pH ≤ 5. The hybrid compound described in the invention can be used in the preparation of electrode materials for supercapacitors.

The invention discloses a catalytic conversion technology for carbon tetrachloride. The technology is implemented in an autoclave. The technology is characterized in that: a catalyst comprises Ag, AgCl or composition thereof serving as active ingredients; a catalyst carrier comprises silicon dioxide, titanium dioxide, active carbon or mesoporous carbon or composition thereof; and under the action of the catalyst, aids are added into a mixture of carbon tetrachloride and methanol, and a part of carbon tetrachloride is converted into dichloromethane. By the method, the conversion rate of carbon tetrachloride can be improved, the reaction time is shortened, and the selectivity of dichloromethane is improved.

A seal member (110) for a joint between a pivot member (114) movable about a rotational axis (RA) of a shaft (112) includes a ring (130), a flange (132), and a resiliently flexible intermediate portion (134) interposed therebetween. The ring (130) includes annular distal and proximal ring faces (210, 212) disposed in spaced relationship to each other along a longitudinal axis (LA). The flange (132) includes a pair of flange faces (230, 231) disposed in spaced relationship to each other along the longitudinal axis (LA). The flange (132) includes outer and inner flange surfaces (233, 237) extending along the longitudinal axis (LA) between the pair of flange faces (230, 231) at, respectively, outer and inner flange perimeters (235, 238) thereof. The intermediate portion (134) is connected to the proximal ring face (212) of the ring (130) and to the inner circumferential flange surface (237) of the flange (132) such that the ring (130) is relatively movable with respect to the flange (132).

The invention relates to a silicon dioxide compound doped with metal and / or its oxide in situ and its application. The silicon dioxide composite is obtained by in-situ doping of metal or / and its oxide and by hydrothermal synthesis, and the specific surface area (BET) of the target is 100m2 / g-800m2 / g. Based on the total weight of the silicon dioxide compound doped with metal or / and its oxide as 100wt%, the doping amount of metal nickel or / and its oxide is 1wt%~20wt%, and the rare earth metal or / and The doping amount of its oxide is 0wt%~5wt%, the doping amount of "rare metal" or / and its oxide is 0wt%~10wt%; the doping amount of alkali metal or / and its oxide is 0wt% ~5wt%, the balance is silica. The application of the silicon dioxide compound doped with metal or / and its oxide as a catalyst for the reaction of preparing methane from synthesis gas provided by the invention.

The invention belongs to the field of medical devices, and in particular relates to a drug balloon and a preparation method thereof. The drug balloon of the present invention is characterized in that: the inner tube of the balloon has a permanent magnetic material, and the drug exists on the surface of the balloon in the form of drug-loaded magnetic particles to form a drug coating based on a magnetic trigger mechanism. The drug coating of the invention can not only ensure the least drug loss during the delivery process of the balloon, but also ensure sufficient, rapid and efficient release and absorption of the drug in the diseased part.