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Method for treating animal-derived collagen fiber material

A collagen fiber, animal-derived technology, applied in the field of medical devices, can solve the problems of reducing inflammatory response, not teaching the combination of PEG and oxidant, and dealing with biological valves

Inactive Publication Date: 2012-02-15
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] However, the prior art does not teach the combination of PEG and oxidants to treat biological valves and reduce the inflammatory response

Method used

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  • Method for treating animal-derived collagen fiber material
  • Method for treating animal-derived collagen fiber material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1. Soak the bioprosthetic valve in 50% ethanol solution for 10 days.

[0041] 2. Put the artificial biological valve treated in step 1 into polyethylene glycol, concentration 5%, molecular weight 2000D; sodium chloride, concentration 2.5mol / L; phosphate buffer, concentration 0.04mol / L, pH value 7; Hydrogen peroxide, in a solution with a concentration of 1%, the treatment time is 80 hours.

Embodiment 2

[0043] 1. Soak the bioprosthetic valve in 50% ethanol solution for 20 days.

[0044] 2. Put the artificial biological valve treated in step 1 into polyethylene glycol, concentration 5%, molecular weight 6000D; sodium chloride, concentration 2.5mol / L; phosphate buffer, concentration 0.02mol / L, pH value 7; Hydrogen peroxide, concentration 1% solution, treatment time is 90 hours.

[0045] 3. Put the bioprosthetic valve treated in step 2 into a solution of 50% ethanol; indomethacin with a concentration of 100 mg / L, and the treatment time is 30 hours.

Embodiment 3

[0047] 1. Soak the bioprosthetic valve in 50% ethanol solution for 30 days.

[0048] 2. Put the bioprosthetic valve treated in step 1 into polyethylene glycol, concentration 15%, molecular weight 8000D; sodium chloride, concentration 4.5mol / L; phosphate buffer, concentration 0.1mol / L, pH value 7; Hydrogen peroxide, concentration 2% solution, treatment time is 96 hours.

[0049] 3. Put the bioprosthetic valve treated in step 2 into a solution of 50% ethanol; indomethacin with a concentration of 200 mg / L, and the treatment time is 30 hours.

[0050] 4. Put the bioprosthetic valve treated in step 3 into a solution of 50% ethanol; enoxaparin with a concentration of 1000 IU / ml, and the treatment time is 24 hours.

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Abstract

The invention relates to the field of medical appliances, and particularly relates to a method for treating an animal-derived collagen fiber material. The method is performed by treating the animal-derived collagen fiber material with a salt solution containing polyethylene glycol and oxidants. After a biological valve treated by the method provided by the invention is implanted to an acceptor, immune inflammation reaction is not generated.

Description

technical field [0001] The invention relates to the field of medical instruments. More specifically, the present invention relates to a method of processing collagen fibrous material of animal origin. Background technique [0002] Animal-derived collagen fiber materials include tendons, corneas, heart valves, ligaments, skin, and diaphragms, etc., and are mainly composed of collagen fibers, elastic fibers, and proteoglycans. The elastic fiber layer is reticularly distributed in the whole layer of the pericardium, and the collagen fiber is in a wavy multi-layered structure. Heart valve (heart valve) is composed of animal pericardium components, mainly divided into serosal layer, fibrous layer and outer pericardial connective tissue layer, which is a kind of animal-derived collagen fiber material. [0003] Biological heart valve is a biomaterial used for the treatment of heart diseases. Compared with mechanical valves, it has the advantages of no long-term anticoagulation an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/60A61F2/24A61F2/14A61F2/08A61F2/02
CPCA61L27/24A61L27/3604A61L27/362A61L27/3625A61L27/3687A61L2430/40
Inventor 陈大凯李雨房圆田聪董教明周玲刘翔陈国明乐承筠罗七一
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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