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Multifunctional compound drug eluting slow-release system and preparation method thereof

A technology of drug coating and composite coating, which is applied in the field of orthopedic titanium, medical equipment, and magnesium alloy internal implants. It can solve the problems of low bonding strength of the coating, drug burst release, singleness, etc., and achieve good antibacterial effect Effect

Active Publication Date: 2014-04-09
SUZHOU MINIMALLY INVASIVE SPINAL TRAUMA MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, technologies such as coating antibiotics on the surface of implants, preparing a single polymer coating on the alloy surface, a single ceramic coating, using nano-ceramic particles to load drugs, and using ceramics and polymers to prepare three-dimensional bone tissue engineering scaffolds, etc. There are corresponding deficiencies
The single polymer coating drug-loading technology has the disadvantages of low coating bonding strength and explosive release of drugs; the mechanical strength of the three-dimensional bone tissue engineering scaffold prepared by combining ceramics and polymers is lower than that of bone tissue, which needs to be improved. ; A single ceramic coating has a small amount of drug loading and cannot achieve the effect of sustained release of drugs

Method used

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  • Multifunctional compound drug eluting slow-release system and preparation method thereof
  • Multifunctional compound drug eluting slow-release system and preparation method thereof
  • Multifunctional compound drug eluting slow-release system and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Titanium alloy orthopedic implants with porous TiO surface 2 For the transition layer, the degradable polymer is PLA, and the drug is gentamicin.

[0030] Preparation steps:

[0031] 1. Preparation of porous ceramic transition layer:

[0032] Using plasma oxidation technology, a porous ceramic transition layer is prepared on the surface of the titanium or magnesium alloy substrate, and the bottom layer is dense TiO 2 layer, the upper layer is porous TiO 2 layer, the pore size is 100nm-3μm, the coating thickness is 10-50μm, the preparation voltage is 100-500V, the voltage changes step by step, the current is 1-3A, the time is 1-20min, and the oxidizing solution is silicate, phosphate, etc.

[0033] 2. Preparation of drug solution: First, accurately weigh despun polylactic acid (DL-PLA) (PDL04), dissolve it in tetrahydrofuran (THF), add the prepared aqueous solution of gentamicin to the polymer solution to form DL-PLA , a mixed solution of gentamicin. Spray or dip th...

Embodiment 2

[0036] Preparation of Porous TiO on the Surface of Titanium Alloy Orthopedic Implants 2 The transition layer, the degradable coating is a mixture of PLGA and collagen, and the drug is a mixture of gentamicin and vancomycin.

[0037] Preparation:

[0038] 1. Preparation of porous ceramic transition layer:

[0039] Using plasma oxidation technology, a porous ceramic transition layer is prepared on the surface of the metal substrate, and the bottom layer is dense TiO 2 layer, the upper layer is porous TiO 2 layer, the thickness of the coating is 10-50 microns, the preparation voltage is 100-500V, the voltage changes step by step, the current is 1-3A, the time is 1-20min, and the oxidizing solution is silicate, phosphate, etc.

[0040] 2. Preparation and preparation of drug solution: firstly, accurately weigh PLGA, dissolve it in tetrahydrofuran (THF), add the prepared mixed aqueous solution of gentamicin and vancomycin to the polymer solution, and form a mixed solution. Spray...

Embodiment 3

[0043] Preparation of Porous Mg(OH) on the Surface of Magnesium Alloy Orthopedic Implants 2 and MgO transition layer, DL-PLA is selected as the degradable polymer, and the drug is gentamicin.

[0044] Preparation:

[0045] 1. Preparation of porous ceramic transition layer:

[0046] Using plasma oxidation technology, a porous ceramic transition layer is prepared on the surface of the metal substrate, the bottom layer is a dense MgO layer, and the upper layer is porous MgO / Mg(OH) 2 layer, the thickness of the coating is 5-30 microns, the preparation voltage is 20-200V, the voltage changes step by step, the current is 0.1-2A, the time is 1-20min, and the oxidizing solution is silicate, phosphate, etc.

[0047] 2. Preparation and preparation of the drug solution: First, accurately weigh DL-PLA, dissolve it in tetrahydrofuran (THF), add the prepared gentamicin aqueous solution into the polymer solution, and form DL-PLA and gentamicin. mixture. Spray or dip the prepared drug sol...

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Abstract

The invention relates to the field of medical instruments, in particular to the field of titanium and magnesium alloy implanting for the department of orthopedics, and provides a multifunctional compound drug eluting slow-release system and a preparation method thereof. The multifunctional compound drug eluting slow-release system, which is of the multifunctional compound eluting, comprises a porous transitional layer and a degradable eluting layer containing drugs, and facilitates internal fixation while having a bacteriostasis effect.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to the field of orthopedic titanium and magnesium alloy implants. Specifically, the present invention relates to a multifunctional composite drug coating sustained-release system and a preparation method thereof. Background technique [0002] Infection is one of the complications after clinical orthopedic internal fixation surgery. Due to infection leading to internal fixation failure, or the formation of highly resistant biofilms after infection, even if large doses of antibiotics are applied systemically, it is difficult to reach an effective concentration of antibiotics in the local tissue of the lesion, resulting in a long-term infection that is difficult to heal, and eventually the internal fixation has to be removed. Fixed implants; at the same time, there are systemic antimicrobial therapy for prolonged hospitalization, multiple debridement and revision operations, changes in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/68A61M31/00A61L27/30A61L27/28A61L27/54A61L31/08A61L31/10A61L31/16
CPCA61L27/28A61L27/54A61L27/56A61L27/30A61L31/08A61L31/086A61L31/16A61L2300/404A61L2420/08A61L27/306A61L27/34A61L31/088A61L31/10A61L31/146A61L2300/602A61L2300/232A61L2300/25A61L2300/406A61L2300/608A61L2420/02
Inventor 耿芳潘礼存张隽温潇溢林忠
Owner SUZHOU MINIMALLY INVASIVE SPINAL TRAUMA MEDICAL TECH CO LTD
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