42results about How to "The catalytic system is simple" patented technology

The invention discloses a convenient and efficient preparation method of benzofuran or indole. The preparation method comprises the following steps of: reacting various natural or non-natural aldehyde ketone with sulfonylhydrazine to obtain corresponding hydrazone; and reacting the hydrazone with substituted ortho-hydroxybenzene acetylene or substituted ortho-aminobenzene acetylene in a basic condition by using a copper compound as a catalyst in an organic solvent to obtain the derivative of benzofuran or indole. The method has wide substrate adaptability, can be used for synthesizing various benzofuran or indole compounds carrying different substituents, uses the copper compound with low price as a catalyst, has low price and easily available initial raw materials in the reaction, namely aldehyde ketone and ortho-hydroxybenzene acetylene or ortho-aminobenzene acetylene, as well as is convenient operation in the reaction process, and is suitable for large-scale synthesis.

The invention relates to a synthetic method of an asymmetric disulfide compound. According to the method, mercaptan which is convenient and easy to obtain and symmetrical disulfide compounds are usedas raw materials, and the asymmetric disulfide compounds are efficiently synthesized under the catalytic action of palladium salt or copper salt. The method has the advantages of accessible raw materials, simple catalytic system, high functional group compatibility, high yield and the like, and is convenient to operate. The method is particularly suitable for selectively introducing disulfide bonds into complex substrates, and can be widely applied to the industries of medicines, foods and the like.

An organic catalyst system for selectively oxidizing hydrocarbon to obtain oxygen- contained compound (ketone, alcohol, or acid) is proportionally prepared from o-phenanthroline compound, Br moleculae and N-hydroxy phthalic imidine. It has low toxin and low pollution.

The invention discloses indole[3,2-c]quinoline compounds represented by formula I or pharmaceutically acceptable salts thereof, and a preparation method and an application thereof, and belongs to the technical field of the pharmaceutical chemistry. The indole[3,2-c]quinoline compounds or pharmaceutically acceptable salts thereof have a very good tubercle bacillus resisting activity, and the MIC value of the most compounds is 2.5mug / mL.

The invention discloses a method for jointly producing biodiesel and lactic acid, comprising the following steps: mixing grease with short-chain alcohol; preheating the mixture until the temperature of the mixture is 60-90 DEG C; adding the heated mixture into a reactor; utilizing solid base to catalyze an ester exchange reaction, and carrying out phase splitting to obtain coarse biodiesel, byproduct glycerol and solid base catalyst; mixing the byproduct glycerol with water to form a glycerol aqueous solution; adding the roasted sodium silicate, evenly mixing, then causing the mixture to react at the temperature of 200-350 DEG C for 30-120min; causing the reaction product lactate to be replaced to obtain the lactic acid, wherein waste acid liquor is utilized as a compound fertilizer raw material or a building raw material; and the recycled short-chain alcohol and the roasted sodium silicate can be used repeatedly. The method disclosed by the invention has the advantages that reutilization of activity-dip catalyst and the high value-added development of the byproduct glycerol can be realized; an economically feasible process for jointly producing the biodiesel and the lactic acid can be provided; and the preparation process is simple, the byproduct glycerol is converted into the lactic acid, the production cost for the biodiesel can be obviously lowered, and the market competitive power of the biodiesel is enhanced.

The invention discloses a method for preparing biodiesel under catalysis of ionic liquid. The method comprises the following steps of: mixing the ionic liquid, short-chain alcohol and free fatty acid or high-acid-value oil and fat to perform a reaction at a certain temperature; and synthesizing fatty acid methyl ester, namely the biodiesel or synthesizing the biodiesel by a two-step method. The conventional ionic liquid is low in cost and the activity of the ionic liquid is obviously improved within the limited reaction temperature range, so the ionic liquid can be separated, recovered and reused easily after the reaction is finished. The method has the characteristics of simple catalytic system, reusability and simple process.

The invention discloses a preparation method of an amino-acid ester or deuterated amino-acid ester compound, which comprises the following steps of: adding a photosensitizer and an organic solvent into a reaction container by taking imidic ester, silane and water or heavy water as initial raw materials, carrying out stirring reaction under the irradiation of blue light, detecting that the reaction raw material imidic ester completely disappears by TLC thin-layer chromatography, and filtering to obtain the deuterated amino-acid ester compound. And stopping stirring, removing the volatile solvent, carrying out silica gel column chromatography or neutral alumina column chromatography, and carrying out vacuum concentration to obtain the target amino-acid ester or deuterated amino-acid ester compound. According to the method, blue light catalysis is used for replacing traditional precious metal catalysis, silane and water are used for replacing a traditional hydrogen source for the first time, transfer hydrogenation of the imidic ester compounds is achieved, cheap deuterium water is used as a deuterium source, a series of deuterated amino-acid ester compounds can be prepared, and therefore the production cost is greatly reduced; the method provided by the invention has the advantages of mild catalytic conditions, simple catalytic system, high reaction selectivity, high safety and high synthesis efficiency, and is worthy of popularization and application.

The invention belongs to the technical field of pharmaceutical chemistry, and discloses a Toddacoumalone compound or a pharmaceutically acceptable salt and a preparation method and application thereof. The general formula of the molecular structure of the Toddacoumalone compound is shown in the formula I or the formula II or formula II. The provided Toddacoumalone compound has good anti-phosphodiesterase 4 activity. According to the preparation method of the Toddacoumalone compound, a simple and easy-to-obtain quinolinone substrate and an aldehyde compound are used as raw materials, the reaction step is short, and the yield is relatively high. The preparation method has the advantages that the reaction substrate is easy to obtain, a catalytic system is simple, operation is simple, the functional group tolerance is good, the compound is economical and effective and the product structure is diversified and has very important academic value and further application and popularization significance.

The invention discloses a preparation method of a C2-substituted 2H-benzothiazole hydroxyalkylated derivative. The preparation method comprises the following steps: mixing substituted 2H-benzothiazolewith fatty alcohol, taking an organic dye photosensitizer as a catalyst, carrying out a normal-temperature stirring reaction in a solvent under the protection of nitrogen and the irradiation of an LED white light lamp, carrying out TLC monitoring until the reaction is finished, and carrying out separation and purification on a reaction solution to obtain the C2-substituted 2H-benzothiazole hydroxyalkylated derivative. By adopting the technology, a cheap and readily available organic dye is used as the catalyst, the new method for synthesizing the 2H-benzothiazole C2 hydroxyalkylated derivative through visible light induction is simple in catalytic system, mild in reaction condition, cheap and readily available in catalyst and good in yield.

The invention provides a method for preparing lactic acid by hydrolyzing biomass, and the method realizes the purpose of preparing the lactic acid through hydrolization under the action of an acidic catalyst by taking biomass as a raw material, water as a reaction solvent and a salt of trifluoromethanesulfonic acid as a catalyst. The method provided by the invention has the advantages of simple preparation process, easiness for raw material obtaining, quick reaction, high catalyst activity, few byproduct, resource conservation and cost reduction because the catalyst can be recycled through extraction, important application value and suitability for industrialized production and application; and according to the invention, the process is environmentally-friendly without pollution, a catalyzing system is relatively simple, the raw material conversion rate can achieve 100%, and the lactic acid yield can maximally achieve 98.2%.

The invention discloses a preparation method of N-formamide compounds. Carbon dioxide and organic amines are used as raw materials, hydrogen-containing silane is added as a reducing agent, and a 0.1-1.0 mol% salen-type metal complex is used as a catalyst. Under the conditions of 0.1-5.0 MPa and a temperature of 25-100 ° C, with or without adding a co-catalyst, synthesize N-formamide organic compounds; after the reaction, add an organic solvent, centrifuge, separate the catalyst, and pass the supernatant through After the solvent is removed by rotary evaporation, N-formamide compounds are obtained. The preparation method has the advantages of mild reaction conditions, no need to add any organic solvent, simple operation, high catalytic activity, good substrate compatibility, etc., conforms to a green synthesis process, and is suitable for industrial production. In addition, the catalytic system provided by the present invention can be conveniently separated from the reaction system by adding a solvent, so as to realize the recycling of the catalyst.

The invention discloses a Cu 2 S / imidazole compound / TEMPO catalyzes the method that air oxidation alcohol prepares aldehyde, is raw material with alcohol, and air is oxidant, in Cu 2 Under the catalysis of S / imidazole compound / TEMPO, the raw material alcohol is oxidized to obtain the corresponding aldehyde; the present invention utilizes Cu 2 S / imidazole compound / TEMPO catalyzes oxyalcohols to obtain the corresponding aldehydes. The catalytic system is simplified, the operation is simple, the substrate applicability is good, the yield is high, the cost is low, and it is easy for industrial production and the catalyst can be recycled. It is a very economical , Simple method for preparing aldehydes from alcohols.

The invention discloses a C2 substitution 2 H -Preparation method of benzothiazole acylated derivatives. The preparation method is as follows: 2 H - Benzothiazole is mixed with the substituted methylbenzene of the oxidant K 2 S 2 O 8 , carry out the reaction in the air atmosphere, after TLC monitoring to the end of the reaction, the reaction solution is separated and purified to obtain C2 substituted 2 H - Benzothiazole Acylated Derivatives. The present invention uses the above-mentioned technology to achieve K 2 S 2 O 8 Synthetic C2-substituted 2 for oxidizing agent, heated and reacted in air atmosphere H A new method for acylation of benzothiazole derivatives, the method has simple catalytic system, good product yield and wide substrate range, and is suitable for popularization and application.

The invention discloses a method for preparing a 1, 2, 3-triazole compound. The technical scheme of the invention is as follows: the method for preparing the 1, 2, 3-triazole compound comprises the following steps: (1), weighing copper acetate and Pullulan respectively, fully dissolving the copper acetate and the Pullulan in water, wherein the copper acetate is Cu(OAc)2.H2O; and (2), adding a terminal alkyne compound and an azide compound at 70-100 DEG C while stirring, keeping the temperature till the end of reaction, cooling, separating out a solid, filtering, and purifying to obtain the 1, 2, 3-triazole compound. The using amount of the copper in a catalytic system is reasonable and the defect that a ligand is high in toxicity is overcome, so that the method for preparing the 1, 2, 3-triazole compound is an environment-friendly method.

The invention discloses a photocatalytic synthesis method of C2-substituted 2H-benzothiazole hydroxyl alkylated derivatives. It comprises the steps of: mixing substituted 2H-benzothiazole shown in formula (II) with aliphatic alcohol shown in formula (III), adding oxidant Selectfluor, additive trifluoroacetic acid, solvent acetonitrile, under nitrogen protection and LED Carry out stirring reaction at normal temperature under the irradiation of blue light, after TLC monitors to the end of reaction, the reaction solution is separated and purified to obtain C2 substituted 2H-benzothiazole hydroxyalkylated derivatives as shown in formula (I); the invention provides a A new method for the synthesis of 2H-benzothiazole C2 hydroxyalkylated derivatives induced by visible light using Selectfluor as an oxidant, trifluoroacetic acid as an additive, and acetonitrile as a solvent. The method has a simple catalytic system, mild reaction conditions, and a wide range of substrates wide.

The invention discloses a 1,4-disubstituted-1,2,3-triazole compound preparation method which comprises the following steps: (1) adding a catalyst inorganic base in an ionic liquid, wherein the catalyst inorganic base is potassium hydroxide or sodium hydroxide, and the ionic liquid is 1-butyl-3-methylimidazolium tetrafluoroborate, 1-Buthyl-3-methylidazolium bromide or 1-butyl-3-methylimidazolium hexafluorophosphate; (2) adding raw material phenylacetaldehyde or substituted phenylacetaldehyde and pinacolborane in the mixed system formed in the step (1), reacting under the room temperature at the stirring condition, separating out the solid phase after reaction finishing, extracting diethyl ether, and drying to obtain the 1,4-disubstituted-1,2,3-triazole compound. The preparation method has the advantages that the catalytic system is simple, the operation is convenient, the reaction condition is mild, and reactive solvents can be recycled repeatedly.