The invention discloses an intelligent unit load device applicable to high-speed railway vehicle transportation. The intelligent unit load device comprises an angle beam (1) and long beams (2), wide beams (4), folding line or a wave-shaped box plates (3), a box bottom plate (10) is welded with the wide beams (4) and the long beams (2) at the bottom of the unit load device; a box door (7) is arranged on the non-closed side surface of the unit load device, and a cargo hold (49) capable of containing cargoes is formed; an interlayer frame (6) is arranged in the cargo hold (49), and a sealing cavity is separated into a new different shelf area (50); an environment adjusting system comprises a light supplementing device, a humidifying device, a humidity sensor (20), a temperature sensor (21) and a controller; an equipment cabin is internally provided with a heating device, a refrigerating device and a controller. According to the unit load device, the structural universality is high, different kinds and shapes of dry goods, animals, plants, medical medicines and the like can be met, the environment adjusting system is provided, so that environmental adjustment such as temperature, humidity, illumination and the like in the unit load device can be realized.