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34results about How to "Stimulus responsive" patented technology
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Phenylboronic acid based hydrogel and preparation method thereof
The invention discloses a phenylboronic acid based hydrogel and a preparation method thereof. The hydrogel is obtained by free radical copolymerization of a vinylated functional phenylboronic acid based vinyl monomer and a vinyl monomer. Proportions of raw materials are as follows, in parts by mass: 45-100 parts of water; 0.2-2 parts of a functional monomer; 10-50 parts of a main monomer; 0-0.5 part of a crosslinking agent; and 0.01-0.1 part of an initiator. A free radical copolymerization is initiated by heating: the heating temperature is 45-80 DEG C, and the heating time is 4-48h. According to the invention, the phenylboronic acid based hydrogel is prepared by the free radical copolymerization method, the method is simple, and through changing a hydrogel preparation component content, the method can adjust and control hydrogel performance; the obtained hydrogel has excellent mechanical properties under a relatively low solid content, and has the characteristics of being highly stretchable, having good resilience, having good fatigue resistance and the like; and the obtained hydrogel has stimuli-responsiveness to a glucose concentration and pH.
Owner:ZHEJIANG UNIV
Magnetic compound microsphere of blot gel for biological macromolecular template and its reverse-phase suspension polymerization process for preparing it
InactiveCN1390859AAccurate separationEasy to separateSemi-permeable membranesMicrosphereSeparation technology
A composite magnetic gel microsphere for biological macromolecualr template blot, based on the template blot (molecular blot) technique, is prepared from different biological macromolaculate as template molecule and different metals (or their oxides) as magentic component through reversed-phase suspension polymerization. It can be used for separating biological macromoleculae with high precision and simple process.
Owner:TIANJIN UNIV
Triphenylamine derivatives as well as preparation method and application thereof
ActiveCN103102286AEasy to manufactureThe synthesis method is simpleCarboxylic acid nitrile preparationOrganic compound preparationSodium methoxideHexadecane
The invention discloses triphenylamine derivatives represented by a formula (I) as well as a preparation method and an application thereof in piezochromic organogel. The preparation method comprises the following steps of: mixing an intermediate, para-hexadecyloxy benzaldehyde and sodium methoxide, dissolving with absolute ethyl alcohol, stirring and reacting for 3 hours at room temperature, and separating the reaction liquid after the reaction is complete so as to obtain the triphenylamine derivatives represented by formula (I). The piezochromic organogel is a micromolecule organogel material with multiple simulation responsiveness. The piezochromic organogel is simple in synthesis method, convenient in preparation, strong in simulation responsiveness, and can be applied to fields such as a sensor, anti-fake, store and display.
Owner:ZHEJIANG UNIV OF TECH
Phenylboronic acid hydrogel-based sugar-sensitive microneedle pad and preparation method thereof
InactiveCN109675185AImprove sugar sensitivityPerformance can be adjustedPeptide/protein ingredientsMetabolism disorderConcentrations glucoseN isopropyl acrylamide
The invention discloses a phenylboronic acid hydrogel-based sugar-sensitive microneedle pad and a preparation method thereof. The phenylboronic acid hydrogel-based sugar-sensitive microneedle pad comprises a base and a microneedle array which is located on the base, wherein the base and microneedles are mainly prepared from a vinyl phenylboronic acid monomer and a vinyl monomer through free radical copolymerization; microneedle bodies and the base can both be used for embedding insulin drugs; the phenylboronic acid monomer is selected from 3-acrylamidophenylboronic acid, and the vinyl monomeris selected from N-isopropyl acrylamide and N-vinyl pyrrolidone. The preparation method disclosed by the invention is simple; the obtained phenylboronic acid hydrogel-based sugar-sensitive microneedlepad is regular in structure, has good mechanical performance, is capable of effectively piercing the skin, has stimulus responsiveness to glucose concentration, and is capable of regulating the release rate and the dosage of insulin according to blood sugar concentrations and effectively preventing a risk of hypoglycemia caused by excessive release of the insulin.
Owner:ZHEJIANG UNIV
Ph-responsive nanometer drug delivery system based on dendrimers modified by short-chain alkane and preparation method and application of drug delivery system
InactiveCN105748439AStimulus responsiveOrganic active ingredientsPharmaceutical non-active ingredientsDendrimerAlkane
The invention discloses a nanometer drug delivery system which is self-assembled on the basis of grafting dendrimers modified by short-chain alkane to natural polysaccharide and has a pH-responsive performance, belonging to the field of biomedical materials. The drug delivery system comprises aldehydated hydrophilic natural polysaccharide, dendrimers modified by short-chain alkane, an antitumor drug and a targeting ligand for specific tumor identification; the natural polysaccharide and the dendrimers modified by short-chain alkane are formed into a amphiphilic compound through hydrazone bonds; a hydrophobic drug is wrapped inside a cavity of a self-assembled body by means of the hydrophilicity and the hydrophobicity; the targeting ligand for specific tumor identification and drug-loaded nanoparticles are physically mixed to promote the delivery of the drug in tumor tissues and cells. The nanometer delivery system having the pH-responsive performance can realize active targeting and passive targeting, is beneficial for accumulation of the drug in a tumor site, and can make an intelligent response to a slightly acid environment of lysosome / endosome in the tumor cells, thus releasing the drug and realizing the delivery of the drug in the tumor cells, and therefore, the nanometer delivery system is a multifunctional tumor targeted drug delivery system.
Owner:SICHUAN UNIV
Combined energy absorption method and application thereof
The invention discloses a combined energy absorption method and application thereof. According to the combined energy absorption method, a combined hybrid dynamic polymer containing boron-containing dynamic covalent bonds, other dynamic covalent bonds and optional hydrogen bonds is adopted for energy absorption. According to the combined hybrid dynamic polymer, the boron-containing dynamic covalent bonds with different dynamic properties, other dynamic covalent bonds and optional hydrogen bonds are introduced, so that a dynamic polymer material with a wide controllable range, rich structures and various properties can be prepared. When the polymer material is physically impacted, the polymer material has the effects of absorbing, dissipating and dispersing impact energy. The dynamic polymer is used as an energy absorption material for energy absorption, has the effects of damping, buffering, impact resistance protection, noise elimination, sound insulation, shock absorption and the like, and can be applied to the aspects of body protection of sports and daily life, military police body protection, explosion prevention, airborne landing and airdrop protection, automobile collision prevention, impact resistance protection of electronic and electrical products and the like.
Owner:翁秋梅
Preparation method of supramolecular quadruple hydrogen-bond ureido-pyrimidinone (UPy) unit modified polyvinyl chloride (PVC) special resin
The invention relates to a preparation method of supramolecular quadruple hydrogen-bond ureido-pyrimidinone (UPy) unit modified polyvinyl chloride (PVC) special resin. UPy-containing acrylate crosslinking agents are used for modifying PVC, and UPy-containing styrene crosslinking agents are used for modifying the PVC. Compared with the existing crosslinking agents, the crosslinking agents selectedfor use in the method have the beneficial effects that UPy quadruple hydrogen-bond system can form a self-complementary quadruple hydrogen-bond interaction, and is good in stability, strong in self-polymerization ability and very high in binding constant; furthermore, the strong non-covalent cross-linking effect is reversible and has a self-recovery ability; high molecular polymers are formed by means of self-assembly through the interaction of non-covalent hydrogen bonds; the combination of repeating units is based on the interaction of the hydrogen bonds, so that the repeating units can be separated and recombined under appropriate conditions and are reversible; therefore, the PVC polymer not only has the properties of the traditional polymers, but also has the excellent characteristicsof stimulative responsibility, self-repairing property, easy processing and the like, and can be used as special resin for smart materials and self-healing materials.
Owner:XINJIANG INST OF ENG
Multifunctional self-repairing hydrogel, preparation methodthereof and applicationofmultifunctional self-repairing hydrogelin detection of biogenic amine
ActiveCN110527115AExcellent self-healing performanceStimulus responsiveMaterial analysis by observing effect on chemical indicatorIonChemistry
The invention discloses multifunctional self-repairing hydrogel,a preparation method thereof and applicationof themultifunctional self-repairing hydrogelin detection of biogenic amine.The preparationmethod comprises the steps thatpolyethylene glycolendcapped bysalicylaldehydeis taken and dissolved in a buffer solution, fully shocking is conducted at the room temperature, polyethylene imine is added, evenly mixing is conducted, and the self-repairing hydrogel is obtained.After destroying,original performance of the self-repairing hydrogel recovers completely at the room temperature within 60s,a storage modulus reaches 104Pa, a loss modulus is 103Pa, and pH and ion responsiveness functions are achieved together. According to theprepared hydrogel, the excellent mechanical property is achieved, many functions such as rapid self-repair, ion response, pH response and biogenic amine detection are also achieved,the application range of a polyethylene glycol based self-repairing hydrogel material is widened, and the hydrogel is expected to be applied to food storage, self-repairing materials, fluorescent printing and other industries.
Owner:SOUTH CHINA UNIV OF TECH
Multi-responsive polymer nanocarrier with rapid cell penetrating characteristic as well as synthesis method and application of nanocarrier
InactiveCN106397758AEasy accessEfficient entryEnergy modified materialsPharmaceutical non-active ingredientsNanocarriersSynthesis methods
The invention relates to a multi-responsive polymer nanocarrier with a rapid cell penetrating characteristic. The nanocarrier is formed by self-assembling of a multi-responsive amphipathic triblock copolymer, the nanocarrier adopts an onion structure sequentially comprising an acid-responsive PLLA core, cyanine molecules with a near infrared absorption characteristic, a hydrogen-peroxide-responsive PPI (polyphenyl isocyanide) intermediate layer and a left-handed spiral hydrophilic PPI hydrophilic chain from inside to outside sequentially, wherein the structure of the multi-responsive amphipathic triblock copolymer is shown in the general formula in the specification, R1 is a group with stimulation responsiveness, and R2 is a chiral PEG hydrophilic chain; x ranges from 20 to 50, y ranges from 20 to 50, and z ranges from 30 to 80. The multi-responsive polymer nanocarrier can be used for transporting hydrophobic dye molecules and medicine molecules, can rapidly and efficiently penetrate cell membranes, has multiple stimuli-responsiveness, realizes programmable controlled release of medicines and has a chemical-photothermal collaborative treatment characteristic.
Owner:HEFEI UNIV OF TECH
Protein grafted copolymer and preparation method thereof
InactiveCN106046384AAmphipathicStimulus responsiveEmulsion deliveryMacromolecular non-active ingredientsSide chainCopolymer
The invention relates to a protein grafted copolymer. Protein is taken as a substrate, polymer side chains are grafted and polymerized on main chains of the protein, and the copolymer contains about 14.0%-94.0% by mass of the protein and about 6%-86% by mass of the polymer side chains. The invention relates to a preparation method and an application of the protein grafted copolymer.
Owner:BEIJING CENT FOR PHYSICAL & CHEM ANALYSIS
Multi-stimulation responsive stigmasterol derivative low-molecular-mass gelator, organic gel and preparation methods of low-molecular-mass gelator and organic gel
ActiveCN108440634ADetermining Gel CapacityDetermining Gel StrengthSteroidsGel preparationGlycineAlcohol
The invention discloses a multi-stimulation responsive stigmasterol derivative low-molecular-mass gelator, organic gel and preparation methods of the low-molecular-mass gelator and the organic gel. The stigmasterol-based glycine ferrocene amide gelator is prepared through a three-step synthesis reaction including esterification, BOC removal and amidation for the first time with stigmasterol with arigid framework used as a gelator construction parent, glycine used as a linking arm and ferrocene containing an oxidation activity group as a reaction group, and the problem of lack of research on construction of a super-molecular gel system with stigmasterol and ferrocene derivatives as gelators in the prior art is solved. An organic gel material of the gelator has properties of thixotropy, ultrasonic response, thermal response and alcohol solvent stimulation response besides oxidation stimulation response expected to be obtained through introduction of the ferrocene group, and the gel is expected to have potential value in the aspects of sensors, solvent recognition and the like.
Owner:HARBIN INST OF TECH
Liposome, preparation method thereof, liposome assembly and carrier liposome complex
ActiveCN110540551AImprove playbackStimulus responsiveOrganic active ingredientsGroup 5/15 element organic compoundsPhosphoric acidChemistry
The invention provides a liposome, a preparation method thereof, a liposome assembly and a carrier liposome complex. The liposome provided by the invention has the structure of formula (I), the left side of the L group is the liposome part, and the right side is the choline phosphoric acid structure, and the two are connected with specific L groups to form the liposome with specific structure. Theliposome of the formula (I) provided by the invention has the properties of long circulation, stimulation response, targeting and the like, and has multiple modifiable sites, can be used for preparing biological preparations with various functions, and provides more convenient choices for diagnosis and treatment of diseases.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Magnetic compound microsphere of surface blot gel for biological macromolecular template and its reverse-phase suspension polymerization for preparing its seed
A composite magnetic gel microsphere for surficial biological macromolecular template blot, based on template blot (molecular blot) technique, is prepared from the different biological macromoleculae as template molecule and different metals (or their oxides) as magnetic component through reverse-phase seed suspension polymerization. Its advantages are less consumption of template moleculae and high adsorption capacity. It can be used for separating biological macromoleculae with more precision and simple process.
Owner:TIANJIN UNIV
Triphenylamine derivatives as well as preparation method and application thereof
ActiveCN103102286BEasy to manufactureThe synthesis method is simpleCarboxylic acid nitrile preparationOrganic compound preparationSodium methoxideAlcohol
The invention discloses triphenylamine derivatives represented by a formula (I) as well as a preparation method and an application thereof in piezochromic organogel. The preparation method comprises the following steps of: mixing an intermediate, para-hexadecyloxy benzaldehyde and sodium methoxide, dissolving with absolute ethyl alcohol, stirring and reacting for 3 hours at room temperature, and separating the reaction liquid after the reaction is complete so as to obtain the triphenylamine derivatives represented by formula (I). The piezochromic organogel is a micromolecule organogel material with multiple simulation responsiveness. The piezochromic organogel is simple in synthesis method, convenient in preparation, strong in simulation responsiveness, and can be applied to fields such as a sensor, anti-fake, store and display.
Owner:ZHEJIANG UNIV OF TECH
Plant enzyme responsive controlled-release fertilizer and preparation method thereof, and plant enzyme responsive nano-carrier and preparation method thereof
ActiveCN110885270AImprove absorption and utilizationRelease noneOrganic fertilisersFertilizer mixturesActive enzymeNutrition
The invention relates to the technical field of plant nutrition, in particular to a plant enzyme responsive controlled-release fertilizer and a preparation method thereof, and a plant enzyme responsive nano-carrier and a preparation method thereof. The carrier comprises modified carboxymethyl polysaccharide and an amino modified halloysite nanotube, and a nano-composite carrier with a core-shell structure is formed through esterification reaction. Plant nutrient substances (chemical fertilizers, trace elements and plant growth regulators) are loaded in the tube cavity of the nanotube in a negative pressure adsorption manner, and then the outer layer of the nanotube is coated with a layer of degradable modified carboxymethyl polysaccharide with good biocompatibility through chemical grafting, so that the stability of the fertilizer is improved. The nano-carrier can directly enter crop bodies through plant leaf surfaces, the outer-layer wall material of the nano-carrier is cracked through plant active enzymes in the bodies, so that mesopores or lumen ports in the surface of the nano-carrier are opened, and nutrient substances in lumens are released.
Owner:AGRI PRODS PROCESSING RES INST CHINESE ACAD OF TROPICAL AGRI SCI
A preparation method of smart supramolecular hydrogel for detecting formaldehyde in interior decoration and wastewater
ActiveCN104877184BFluorescentStimulus responsiveFluorescence/phosphorescenceWastewaterBiocompatibility Testing
The invention relates to a preparation method of an intelligent supramolecular aquagel for detecting formaldehyde in interior decoration and wastewater, which comprises the following steps: (1) weighing alpha-cyclodextrin powder, and adding ultrapure water to prepare an alpha-cyclodextrin water solution; (2) adding a Tyloxapol liquid, and adding ultrapure water to prepare a Tyloxapol water solution; and (3) taking the alpha-cyclodextrin water solution and Tyloxapol water solution, adding ultrapure water until the alpha-cyclodextrin concentration in the gel is 90-130 mg.mL<-1> and the Tyloxapol concentration is 15-50 mg.mL<-1>, carrying out ultrasonic dispersion, and standing. The preparation method is simple, and the used raw materials have favorable biocompatibility and are friendly to application environments. The intelligent supramolecular aquagel has the advantages of low cost and no toxic byproducts.
Owner:SHANDONG UNIV
Borate chemotherapy sensitizer with symmetrical structure as well as preparation method and application of borate chemotherapy sensitizer
ActiveCN114848657AStimulus responsiveEasy to retouchInorganic active ingredientsBoron compound active ingredientsPharmacometricsDrug release
The invention belongs to the related fields of pharmacology, functional molecules and the like, and particularly relates to a borate chemosensitizer with a symmetrical structure as well as a preparation method and application of the borate chemosensitizer. The chemotherapy sensitizer prepared by the invention has good biocompatibility, stimuli responsiveness and easy modification, can be used for preparing a small-molecule prodrug, and can weaken an intracellular detoxification system while triggering drug release, so that the chemotherapy sensitizer has a good application prospect in the aspect of overcoming chemotherapy drug resistance.
Owner:ANQING NORMAL UNIV
Hydrogen peroxide responsive polymer nano-carrier with fluorescence ratio characteristic as well as preparation method and application thereof
InactiveCN111803655AEasy accessEfficient entryPharmaceutical non-active ingredientsEmulsion deliveryCopolymerPhotochemistry
The invention relates to a hydrogen peroxide responsive polymer nano-carrier with a fluorescence ratio characteristic. The nano-carrier is of a spherical micelle structure, and is formed by self-assembling of an amphiphilic block copolymer with hydrogen peroxide responsiveness and ratiometric fluorescence imaging characteristics. The structural formula of the amphiphilic block copolymer having hydrogen peroxide responsiveness and ratiometric fluorescence imaging characteristics is as follows: R1 is a group having hydrogen peroxide responsiveness; R2 is a group with an aggregation-induced emission effect; R3 is a PEG hydrophilic chain; and R5 is a group with strong positive charges. The nano-carrier disclosed by the invention can be used for loading, transporting and program releasing of hydrophobic dye molecules and drug molecules as well as cell imaging and fluorescent molecular probes.
Owner:HEFEI UNIV OF TECH
A kind of multi-responsive polymer nano-carrier with the characteristics of fast crossing the cell membrane and its synthesis method and application
InactiveCN106397758BEasy accessEfficient entryEnergy modified materialsPharmaceutical non-active ingredientsNanocarriersSynthesis methods
Owner:HEFEI UNIV OF TECH
A method for preparing hollow microcapsules based on the specific interaction between concanavalin and glycogen
InactiveCN101773813BStimulus responsiveGood biocompatibilityMicroballoon preparationMicrocapsule preparationEthylenediaminePresent method
The invention discloses a method for preparing hollow microcapsules based on the specific interaction between concanavalin and glycogen. This method uses the specific recognition of concanavalin and glucose units contained in glycogen to form a multi-layer film on the surface of carbonate colloidal particles by layer-by-layer assembly, and further uses disodium ethylenediaminetetraacetic acid complexation to remove Carbonate colloidal particles to obtain hollow microcapsules. The microcapsules prepared by this method can produce specific responses to specific monosaccharides and polysaccharides under physiological pH conditions, and have the advantages of low raw material cost, good biocompatibility, biodegradability, etc., and have good application in the field of biomedicine Application prospect.
Owner:ZHEJIANG UNIV
A glutathione-responsive thermosensitive hydrogel, preparation method and application thereof
ActiveCN112759773BReach the gelling temperature requirementReduce the temperatureAerosol deliveryOintment deliveryCross linkerPolymer chemistry
The invention relates to the technical field of polymer material synthesis, in particular to a glutathione-responsive temperature-sensitive hydrogel, a preparation method and its application, comprising the following steps: combining a RAFT chain transfer agent, a monomer, and a cross-linking agent And the initiator is uniformly mixed in the polymerization bottle according to the molar ratio of 1:200:0.37:0.4, and then reacted at 70°C for 8 hours after freezing and evacuating three times to remove oxygen; the polymerization product is chemically deposited in n-hexane, and vacuum-dried to obtain The polymer PON is ready for use; the polymer PON is dissolved in water at 4°C, and the temperature is raised to obtain a glutathione-responsive hydrogel. This glutathione-responsive thermosensitive hydrogel is prepared The hydrogel prepared by the method is in a solution state at low temperature, and when the temperature reaches 37 ° C, the hydrogel is formed in situ, and the hydrogel will be decomposed into a solution state after dropping glutathione (GSH) solution, and It cannot be gelled again, has good biocompatibility, and has great application potential in tumor areas with abundant glutathione secretion.
Owner:HEFEI UNIV OF TECH
A kind of liposome, its preparation method, liposome assembly and carrier liposome complex
ActiveCN110540551BImprove playbackStimulus responsiveOrganic active ingredientsGroup 5/15 element organic compoundsPhosphoric acidNiosome
The invention provides a liposome, a preparation method thereof, a liposome assembly body and a carrier liposome complex body. The liposome provided by the present invention has the structure of formula (I), the L group is the liposome part on the left and the phosphorylcholine structure on the right, and the two are connected by a specific L group to form a liposome with a specific structure. The liposome of formula (I) provided by the present invention has properties such as long circulation, stimuli responsiveness, and targeting, and has multiple modifiable sites, which can be used to prepare biological agents with various functions, and provide More convenient options.
Owner:吉林省思睿德生物科技有限责任公司
Tert-butyloxycarboryl protected acid-sensitive epoxy monomer as well as synthesis method and application thereof
PendingCN114790182AStimulus responsiveRich functionalityOrganic chemistryPhotosensitive materials for photomechanical apparatusEpoxyPolymer science
The invention discloses a t-butyloxycarboryl protected acid-sensitive epoxy monomer, the chemical formula of which is shown as one of formulas (1) to (3), and R3 is one of formulas A to D. The invention also discloses a synthesis method of the t-butyloxycarboryl protected acid-sensitive epoxy monomer, and application of the t-butyloxycarboryl protected acid-sensitive epoxy monomer in preparation of t-butyloxycarboryl protected acid-sensitive polymer. The acid-sensitive epoxy monomer with the tert-butyloxycarboryl protection, provided by the invention, can respond to a pH value, especially an acidic environment, so that an obtained polymer material has stimuli responsiveness. Therefore, the tert-butyloxycarboryl protected acid-sensitive polymer can be used in the field of chemical amplification of photoresists, so that the acid-sensitive polymer is endowed with more functionality and higher additional value.
Owner:ZHEJIANG UNIV
Magnetic compound microsphere of blot gel for biological macromolecular template and its reverse-phase suspension polymerization process
InactiveCN1176110CGood compatibilitySimplified coating processSemi-permeable membranesMicrosphereBiochemistry
A composite magnetic gel microsphere for biological macromolecualr template blot, based on the template blot (molecular blot) technique, is prepared from different biological macromolaculate as template molecule and different metals (or their oxides) as magentic component through reversed-phase suspension polymerization. It can be used for separating biological macromoleculae with high precision and simple process.
Owner:TIANJIN UNIV
Preparation method of intelligent supramolecular aquagel for detecting formaldehyde in interior decoration and wastewater
ActiveCN104877184AGood fluorescent effectAchieve the effect of detecting formaldehydeFluorescence/phosphorescenceBiocompatibility TestingWastewater
The invention relates to a preparation method of an intelligent supramolecular aquagel for detecting formaldehyde in interior decoration and wastewater, which comprises the following steps: (1) weighing alpha-cyclodextrin powder, and adding ultrapure water to prepare an alpha-cyclodextrin water solution; (2) adding a Tyloxapol liquid, and adding ultrapure water to prepare a Tyloxapol water solution; and (3) taking the alpha-cyclodextrin water solution and Tyloxapol water solution, adding ultrapure water until the alpha-cyclodextrin concentration in the gel is 90-130 mg.mL<-1> and the Tyloxapol concentration is 15-50 mg.mL<-1>, carrying out ultrasonic dispersion, and standing. The preparation method is simple, and the used raw materials have favorable biocompatibility and are friendly to application environments. The intelligent supramolecular aquagel has the advantages of low cost and no toxic byproducts.
Owner:SHANDONG UNIV
Monitoring device and monitoring method for growth of bacteria/cells
PendingCN114414645AImprove conductivitySolve the problem of easy formation of titanium dioxide oxide layer with poor conductivityMaterial electrochemical variablesPolypyrroleHemt circuits
The invention relates to a monitoring device and a monitoring method for bacterium / cell growth. The monitoring device comprises a monitoring station and a three-electrode system, in the three-electrode system, a working electrode is a medical polypyrrole electrode, a saturated reference electrode is a calomel electrode, and a counter electrode is a platinum sheet; the test method comprises the following steps: selecting proper frequency and alternating voltage on a medical polypyrrole electrode through an alternating-current impedance technology to obtain an impedance spectrum of bacterial / cell growth, and selecting a proper analog circuit to simulate the impedance spectrum so as to achieve the purpose of monitoring the bacterial / cell growth. The monitoring method is easy to operate and low in cost.
Owner:HEBEI UNIV OF TECH
Multifunctional self-healing hydrogel and its preparation method and application in the detection of biogenic amines
ActiveCN110527115BExcellent self-healing performanceStimulus responsiveMaterial analysis by observing effect on chemical indicatorPolythylene glycolSelf-healing hydrogels
The invention discloses multifunctional self-repairing hydrogel,a preparation method thereof and applicationof themultifunctional self-repairing hydrogelin detection of biogenic amine.The preparationmethod comprises the steps thatpolyethylene glycolendcapped bysalicylaldehydeis taken and dissolved in a buffer solution, fully shocking is conducted at the room temperature, polyethylene imine is added, evenly mixing is conducted, and the self-repairing hydrogel is obtained.After destroying,original performance of the self-repairing hydrogel recovers completely at the room temperature within 60s,a storage modulus reaches 104Pa, a loss modulus is 103Pa, and pH and ion responsiveness functions are achieved together. According to theprepared hydrogel, the excellent mechanical property is achieved, many functions such as rapid self-repair, ion response, pH response and biogenic amine detection are also achieved,the application range of a polyethylene glycol based self-repairing hydrogel material is widened, and the hydrogel is expected to be applied to food storage, self-repairing materials, fluorescent printing and other industries.
Owner:SOUTH CHINA UNIV OF TECH
Targeted traceless release drug conjugate as well as preparation method and application thereof
ActiveCN114533891AWith syntheticStimulus responsiveOrganic chemistryCyclic peptide ingredientsCyclic peptideSide chain
The invention relates to a targeted traceless release drug conjugate as well as a preparation method and application thereof, the targeted traceless release drug conjugate has a structural formula as shown in a formula I. In the formula I, R1 is selected from RGD peptide and cyclic RGD peptide, R2 is selected from one or more cyclic RGD peptides, and R3 is selected from one or more cyclic RGD peptides. An RGDyK cyclic peptide, an RGD peptide derivative or a cyclic RGD peptide derivative, and lysine side chain amino groups of the RGD peptide, the cyclic RGD peptide, the RGDyK cyclic peptide, the RGD peptide derivative or the cyclic RGD peptide derivative form amido bonds in the structural formula shown in the formula I for coupling; r < 2 > is-CH3,-CH2OH (CH3) 3 or-CH2OH; r3 is-CH3 or-CH2OC (CH3) 3; a <-> is CF3CO2 <->, Cl <-> or CH3COO <->. According to the drug conjugate, the specific linker is adopted, and after the specific linker is split, the self-elimination reaction is carried out on aminobenzyl, so that the active drug is released in a traceless manner, the toxicity of the drug is reduced, and the treatment effect is enhanced.
Owner:SHENZHEN INST OF ADVANCED TECH
A kind of hbc compound containing crown ether and its preparation and application
ActiveCN109456301BThe synthesis method is simpleThe preparation process is matureOrganic compound preparationAmino-carboxyl compound preparationHexaphenylbenzeneCombinatorial chemistry
The invention relates to a crown ether-containing HBC compound and its preparation and application. The general formula of the compound is formula: I or II. Preparation: Suzuki coupling reaction between the substituted hexaphenylbenzene intermediate and the monomer is used to obtain the oxidation precursor, and the precursor is catalyzed by ferric chloride to perform Scholl oxidation ring closure to obtain the target compound. The invention can be used as an excellent self-assembled unit molecule in the fields of biological materials, selective separation materials, chiral response materials and the like; the synthesis of raw materials has the advantages of simple method and mature preparation process, and has good application prospects.
Owner:DONGHUA UNIV
Multiple stimuli-responsive stigmasterol derivative small molecule gelling factor, organogel and preparation method thereof
ActiveCN108440634BResponsive to oxidative stimuliStimulus responsiveSteroidsGel preparationFerrocenyl groupFerrocene derivatives
The invention discloses a multi-stimulation responsive stigmasterol derivative low-molecular-mass gelator, organic gel and preparation methods of the low-molecular-mass gelator and the organic gel. The stigmasterol-based glycine ferrocene amide gelator is prepared through a three-step synthesis reaction including esterification, BOC removal and amidation for the first time with stigmasterol with arigid framework used as a gelator construction parent, glycine used as a linking arm and ferrocene containing an oxidation activity group as a reaction group, and the problem of lack of research on construction of a super-molecular gel system with stigmasterol and ferrocene derivatives as gelators in the prior art is solved. An organic gel material of the gelator has properties of thixotropy, ultrasonic response, thermal response and alcohol solvent stimulation response besides oxidation stimulation response expected to be obtained through introduction of the ferrocene group, and the gel is expected to have potential value in the aspects of sensors, solvent recognition and the like.
Owner:HARBIN INST OF TECH
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