43results about How to "Small residual" patented technology

A harvesting system for harvesting aquatic plants in or floating on a culture medium a harvesting bed configured to be circulated in and out of the culture medium. An actuator circulates the harvesting bed, a scraper positioned against a surface of the harvesting bed scraps the aquatic plants on the harvesting bed and a channel transports the aquatic plants removed by the scraper toward a collection vat. The collection vat receives the aquatic plants transported via the channel.

The invention relates to a method for improving the anti-aging performance of film-controlled sustained-release pellets coated with water dispersion, in particular to a method for improving the film-controlled slow-release pellets coated with water dispersion by adopting high-swellability pellet cores. A method for releasing the anti-aging properties of pellets, the core of which contains high expansibility auxiliary materials. The method can be used to prepare film-controlled slow-release micropills that can maintain stable release performance within the validity period of the drug without being limited by storage time. The invention also provides the use of the polymer swelling agent for improving the anti-aging performance of the film-controlled sustained-release pellets coated with the water dispersion. In addition, the invention provides a film-controlled sustained-release pellet coated with an anti-aging performance, and the pellet core is an expandable pellet core containing a polymer expander.

The present invention relates to a kind of tolterodine tartrate film-controlled slow-release pellet capsule, the slow-release film of its pellet adopts the mixture of water dispersion Eurdragit RL 30D:Eurdragit RS 30D=9:1 weight ratio as film-forming material, The ball core contains low-substituted hydroxypropyl cellulose with high expansibility, and excipients commonly used in pharmaceutically acceptable sustained-release pellets. The excipients are preferably microcrystalline cellulose and lactose, wherein the low-substituted hydroxypropyl cellulose in the ball core Propylene cellulose accounts for 10-40% by weight of the ball core. The sustained-release coating film comprises a mixture of water dispersion film-forming materials Eurdragit RL 30D and Eurdragit RS 30D, plasticizer triethyl citrate and anti-sticking agent talc, the ratio of which is preferably Eurdragit RL 30D: Eurdragit RS 30D: citric acid Triethyl ester:talc powder=27:3:2:4, and the coating weight gain is preferably 19-34%. Because the ball core contains low-substituted hydroxypropyl cellulose with high water swelling, it will swell obviously after absorbing water, resulting in the expansion of the slow-release coating film, the thickness becomes thinner, the pore size of the water-permeable micropores becomes larger, and the permeability is improved. It has become better and compensated for the decrease in permeability caused by membrane aging, so that the release rate in the middle and late stages is basically constant, and the residual at the end is small, and it can always maintain a stable release performance within the validity period.

The invention relates to a cefaclor film-controlled sustained-release pellet capsule, the sustained-release film of the pellet adopts the mixture of water dispersion Eurdragit RL 30D:Eurdragit RS 30D=4:1 (weight ratio) as the film-forming material, the pellet The core contains high-expandability sodium carboxymethyl starch, and the commonly used excipients of pharmaceutically acceptable sustained-release pellets. The excipients are preferably microcrystalline cellulose and lactose, wherein the sodium carboxymethyl starch in the ball core is It accounts for 5-20% of the weight of the ball core. The sustained-release coating film comprises a mixture of water dispersion film-forming materials Eurdragit RL 30D and Eurdragit RS 30D, a plasticizer triethyl citrate and an anti-sticking agent talc, and the ratio is preferably Eurdragit RL 30D: Eurdragit RS 30D: citric acid Triethyl ester: talcum powder = 24:6:2:4, and the coating weight gain is preferably 23-40%. Because the ball core contains sodium carboxymethyl starch, which has high water swelling property, it will swell obviously after absorbing water, resulting in the expansion of the slow-release coating film, the thickness becomes thinner, the pore size of the water-permeable micropores becomes larger, and the permeability becomes better. , which compensates for the decrease in permeability caused by membrane aging, so that the release rate in the middle and late stages is basically constant, and the residue in the end stage is small, which can always maintain a stable release performance within the validity period.

The invention discloses a punching collector ring nozzle device, comprising a base, a flushing mechanism that moves up and down is installed on the top of the base, a fixed plate is matched and connected to the lower end of the flushing mechanism, and a limited separation mechanism is matched to the lower end of the fixed plate. The bottom of the base is provided with a bearing mechanism corresponding to the limit separation mechanism. The limit separation mechanism is used to press and separate the workpieces to be processed on the bearing mechanism. In this way of separating the product from the nozzle, there is no punching knife, and there is no problem that the punching knife is too close to the product, which directly avoids damage to the product, and through this method of punching the nozzle, the nozzle of the product is naturally broken, and the entire ring The nozzle material will fall off, and the residual margin is very small, which avoids the increase of secondary processing in the subsequent process.

The invention relates to a salbutamol sulfate film-controlled sustained-release pellet capsule. The sustained-release film of the pellet adopts Kollicoat SR30D as a film-forming material, and the pellet core contains high-expandability sodium carboxymethyl starch, and pharmaceutically acceptable The commonly used excipients of the sustained-release pellets, the excipient is preferably microcrystalline cellulose, wherein, the sodium carboxymethyl starch in the pellet core accounts for 5-20% of the weight of the pellet core. The sustained-release coating film comprises Kollicoat SR30D, plasticizer triethyl citrate and anti-sticking agent talcum powder, and its ratio is preferably Kollicoat SR 30D: triethyl citrate: talcum powder=30:1:4, coating weight gain Preferably it is 19 to 38%. Because the ball core contains sodium carboxymethyl starch, which has high water swelling property, it will swell obviously after absorbing water, resulting in the expansion of the slow-release coating film, the thickness becomes thinner, the pore size of the water-permeable micropores becomes larger, and the permeability becomes better. , which compensates for the decrease in permeability caused by membrane aging, so that the release rate in the middle and late stages is basically constant, and the residue in the end stage is small, which can always maintain a stable release performance within the validity period.

The invention relates to a venlafaxine hydrochloride film-controlled slow-release pellet capsule. A slow-release film of the venlafaxine hydrochloride film-controlled slow-release pellet utilizes Kollicoat SR30D as a film-formation material. A pellet core of the venlafaxine hydrochloride film-controlled slow-release pellet contains low-substituted hydroxyprepyl cellulose having high expansibility, and also contains a pharmaceutically-acceptable common excipient for the slow-release pellet, wherein preferably, the excipient comprises microcrystalline cellulose, and the pellet core comprises 10 to 40wt% of low-substituted hydroxyprepyl cellulose. The slow-release film comprises Kollicoat SR30D, triethyl citrate as a plasticizer and talcum powder as an antiplastering aid, wherein preferably, a ratio of Kollicoat SR30D to triethyl citrate to talcum powder is 30: 1: 4 and a film weight increasing ratio is in a range of 21 to 39%. The venlafaxine hydrochloride film-controlled slow-release pellet comprises the pellet core containing low-substituted hydroxyprepyl cellulose having high water expansibility and thus after absorbing water, the venlafaxine hydrochloride film-controlled slow-release pellet obviously expands so that the slow-release film is stretched; the thickness of the slow-release film is reduced; the water-permeable micropore size is increased; and permeability is improved and the permeability reduction caused by film aging is counteracted. Therefore, in middle and later stages, the venlafaxine hydrochloride film-controlled slow-release pellet release rate is basically constant; in the last stage, residues are less; and stable release performances can be kept in the period of validity.

The invention relates to an isosorbide mononitrate sustained-release pellet, and an isosorbide mononitrate quick-release and sustained-release pellet capsule adopting it. The sustained-release film of the sustained-release pellet adopts Eurdragit RS 30D as a film forming material, the core of the sustained-release pellet contains high-expansibility sodium carboxymethyl starch and a pharmaceutically-acceptable excipient commonly used for sustained-release pellets, and optimally, the excipient is microcrystalline cellulose, wherein the weight percentage of sodium carboxymethyl starch in the core of the sustained-release pellet is 5-20%. The sustained-release film of the sustained-release pellet includes the Eurdragit RS 30D, a plasticizer triethyl citrate and an anti-adherent talcum powder, the optimal ratio of the Eurdragit RS 30D to triethyl citrate to the talcum powder is 30:3:4, and the optimal coating weight gain is 19-38%. The core will obviously expand after absorbing water because of the containment of sodium carboxymethyl starch highly expanding after contacting with water, so the sustained-release film is stretched, the thickness of the film is thinned, the apertures of water-pervious micro-pores are increased, the permeability is good, and the permeability decrease caused by film ageing is compensated, thereby the middle and later stage release speed is basically constant, the last stage residue is small, and a stable release performance is always maintained prior to the expiration date.