The invention discloses a highly antibacterial absorbable medical suture. The raw materials include: 100-120 parts of carboxymethyl chitosan, 20-30 parts of polyglycolic acid, hyaluronic acid 6‑10 parts of acid, 6‑12 parts of silk fibroin, 8‑12 parts of salmon collagen, 1‑2 parts of glutaraldehyde, 2‑4 parts of genipin, 1‑3 parts of mannitol, 1‑2 parts of glycerin, 2-7 parts of coating; Wherein, the preparation method of coating is: in ice bath, chitosan is added in the concentrated sulfuric acid and dissolves, and sorbyl chloride is added dropwise, stirs, and cooling, insulation, purification, obtains modified chitosan; The modified chitosan is dissolved in a mixed solvent to obtain a solution B; the temperature is raised, a silver nitrate solution is added, the mixture is kept stirring, a reducing agent is added dropwise, the mixture is kept stirred, and purified to obtain a coating. The invention has good antibacterial and anti-inflammatory properties and good mechanical properties.