83results about How to "Preventing or" patented technology

A pharmaceutical composition is disclosed, which composition comprises an oligonucleotide as an active agent, the oligonucleotide being adapted to target nucleic acids encoding CD40 thereby to modulate the expression of CD40 in mammalian cells, and a liposome as an excipient. Said liposome is an amphoteric liposome. Also disclosed is a method for the treatment or prophylaxis of a disease or condition associated with the expression of CD40 in a human or non-human animal patient by administering to said patient a therapeutically or prophylactically effective amount of such a composition.

An organic light emitting display apparatus capable of preventing or reducing an IR drop and a decrease in a contrast ratio, and a method of manufacturing the same. The organic light emitting display apparatus includes: a substrate; a plurality of thin film transistors on the substrate; a plurality of organic light emitting diodes, each of the organic light emitting diodes including: a pixel electrode electrically connected to a corresponding one of the thin film transistors, a portion of an opposite electrode, the opposite electrode being above the substrate and covering all of the substrate, and an intermediate layer between the pixel electrode and the opposite electrode and comprising at least an organic light emitting layer; an opposite electrode bus line between adjacent pixel electrodes of the organic light emitting diodes on the opposite electrode of the organic light emitting diodes; and a black matrix surrounding the opposite electrode bus line.

Mold- and moisture-resistant gypsum boards and methods for making them are disclosed. The boards comprise a gypsum core overlayed with facing sheets (e.g., multi-ply paper). One or preferably both of these sheets is impregnated with a thermoset resin (e.g., a phenol-formaldehyde resin) in an amount effective to (i) allow water vapor passage through the facing sheet when the thermoset resin is in its uncured state and (ii) provide mold and moisture resistance to the facing sheet when the thermoset resin is in its cured state. Advantageously, the method of manufacturing such gypsum boards requires little or no modification of existing manufacturing lines, due to the ability of the thermoset resin to cure during the normal gypsum core drying process, without significantly interfering with this process.

A display device includes a substrate including a bent area, and a flat area including a plurality of pixels, a plurality of island-shaped inorganic insulating patterns arranged on the substrate in the bent area to be separate from each other, an organic insulating layer including a concavo-convex surface covering the inorganic insulating patterns in the bent area, and wiring lines arranged on the organic insulating layer and overlapping the inorganic insulating patterns.

A safety bed including a bed frame, pivotally attached guard rails, and a vertically adjustable mattress support structure. The mattress support structure capable of being lowered within the confines of the bed frame to prevent a patient from crawling out of the safety bed. The mattress support structure capable of being raised within the bed frame to grant a health care provider access to the patient.

A sensor device for detecting at least one property of a flowing fluid medium includes: at least one moisture sensor; and at least one application device for applying the flowing fluid medium to the moisture sensor. The application device includes at least one diaphragm and at least one protective device which has at least one guide rib structure.

A once-through steam generator comprises a duct having an inlet end in communication with a source of a hot gas; and a tube bundle installed in the duct and comprising multiple heat transfer tubes. The tube bundle has an economizer section, an evaporator section, and a superheater section. A steam separating device may be positioned between the evaporator section and the superheater section, wherein, as part of a wet start-up, hot water collected by the steam separating device is delivered from the steam separating device to mix with cold feedwater before it is introduced into the economizer section. A start-up module may be positioned in the duct near the inlet end, wherein, as part of a dry start-up, cold feedwater is delivered into the start-up module to generate hot water that is then mixed into the feedwater stream before it is introduced into the economizer section.

Disclosed are compositions and methods for preventing, treating, or reducing symptoms associated with a myocardial or related disorder such as an infarction. In one embodiment, the method includes administering a therapeutically effective amount of a nucleic acid encoding at least one morphogen; or an effective fragment thereof. Preferred morphogens include the human Sonic Hedghog (Shh), human Desert Hedgehog (Dhh), and human Indian Hedgehog (Ihh) proteins. The methods can be used alone or in combination with other methods involving administration of an angiogenic protein, hematopoietic protein, or endothelial precursor cells (EPCs).

The invention relates to a drum winch (100) that is arranged to allow “free fall” of an anchor secured by rode to a drum (116) of the drum winch (100). The drum winch (100) includes a mounting bracket (112) and a drive shaft (114) arranged to be mounted to the mounting bracket (112) and coupled to the drive unit (118). The drum (116) is arranged relative to the drive shaft (1114) so that in a first mode of operation of the drum winch (100), the drum (116) can be rotated by rotation of the drive shaft (114). In a second mode of operation of the drum winch (100), the drum (116) is free to rotate relative to the drive shaft (114) so as to enable “free fall” of the anchor. The drum winch (100) further includes means for actuating (150) either the first mode of operation or the second mode of operation.

The present invention relates to an N-substituted benzothiophenesulfonamide derivative or a pharmaceutically acceptable salt thereof and applications thereof. Furthermore, it provides an agent for preventing or treating cardiac or circulatory disease and so on caused by abnormal increase of production of angiotensin II or endothelin I based on chymase activity, or by activation of mast cell, and an agent for preventing adhesion after surgery, wherein the agent has a selective inhibitory action on chymase.

The invention relates to a method of managing the steering of aircraft undercarriage wheels carried by a steerable bottom portion of the undercarriage, the bottom portion being associated with steering control including a steering member suitable for steering the bottom portion of the undercarriage in response to a steering order. According to the invention, the method comprises the steps of:monitoring the pressures of the tires carried by the wheels, and in response to detecting at least one of the following events:the pressure of one of the tires is less than a first predetermined threshold; andthe difference between the pressures of two of the tires is greater than a second determined threshold;activating the steering control, if the steering control is not activated; andimplementing a steering control relationship that is modified compared with a nominal control relationship used when the tires are properly inflated.

A safety bed including a bed frame with a head board, side boards and a footboard, pivotally attached guard members, and a vertically adjustable mattress support structure which is attached to the side boards. The mattress support structure is capable of being lowered within the confines of the bed frame to prevent a patient from crawling out of the safety bed. The mattress support structure capable of being raised within the bed frame to grant a health care provider access to the patient. The raising and lowering of the mattress support frame does not affect height of the side boards or guard members.

The present invention provides novel methods and formulations for treating anxiety disorders, including Post Traumatic Stress Disorder, in human subjects employing coordinate treatment using α and β blockers alone or in combination with additional psychotherapeutic medications to treat the anxiety disorder and reduce symptomology in treated subjects.

Exemplary methods for the characterization of proton dissociation and transport for hydrophilic components of hydrated Polymer Electrolyte Membranes (PEM's) is described. Disclosed features and specifications may be variously implemented, controlled, adapted or otherwise optionally modified to improve differential hydrophilicity of the sidechain of any ionomeric PEM material. A representative embodiment of the present invention generally provides for the amelioration of electro-osmotic drag of water by protons, for example, in Direct Methanol Fuel Cells.

An electro-optical device includes a plurality of storage capacitors each in a corresponding pixel. Each storage capacitor includes a first capacitor electrode and a second capacitor electrode with a dielectric film therebetween. The first capacitor electrode is made of the same film as one of the semiconductor films in pixel transistors. The second capacitor electrode is provided at a layer over the gate electrode of the pixel transistors. The second capacitor electrode has a first main portion opposite to the first capacitor electrode and an extending portion that extends from the first main portion to at least partially cover the second junction region. An interlayer insulation film insulates the extending portion from the pixel transistor.

An apparatus for separating solids from a suspension includes a hollow cylindrical column having a central axis therethrough. The column has an interior with a cross-section, perpendicular to said axis, that is constant along said axis, and that extends from a first end to a second end of the column; one central tube axially disposed in said column and extending from said one end toward said opposite end, said central tube having an outer wall of constant diameter, said cylindrical column and said central tube defining an annular zone between them, extending axially from said first end of the column to at least near said second end of the column; at least one filter in said outer wall of the said central tube, forming the only direct communication between the said annular zone and the interior of the tube and at least one filter in the outer wall of said hollow cylindrical column; means for supplying a suspension to said first end of the column; means for removing suspension at said second end of the column; said interior defining a concentration zone means communicating with the interior of said central tube for removing liquid passed through said filter in said outer wall of the said central tube and means for removing liquid passed through the filter in the outer wall of said hollow cylindrical column; means acting on the liquid of said suspension for urging said liquid through said annular zone towards said filters.

A pharmaceutical for preventing or treating a disorder accompanied by ocular angiogenesis and / or increased ocular vascular permeability, constituted by a combination of an anti-VEGF agent, and a hydantoin derivative represented by a general formula (I): (in the formula, X represents a halogen atom or a hydrogen atom, and R1 and R2 simultaneously or individually represent a hydrogen atom or an optionally substituted C1-6 alkyl group), or a pharmacologically acceptable salt thereof.

The invention relates to a drum winch (100) that is arranged to allow “free fall” of an anchor secured by rode to a drum (116) of the drum winch (100). The drum winch (100) includes a mounting bracket (112) and a drive shaft (114) arranged to be mounted to the mounting bracket (112) and coupled to the drive unit (118). The drum (116) is arranged relative to the drive shaft (1114) so that in a first mode of operation of the drum winch (100), the drum (116) can be rotated by rotation of the drive shaft (114). In a second mode of operation of the drum winch (100), the drum (116) is free to rotate relative to the drive shaft (114) so as to enable “free fall” of the anchor. The drum winch (100) further includes means for actuating (150) either the first mode of operation or the second mode of operation.

The present invention is a novel lanyard system for a piece releaseably connected to a tool by a piece receiver that includes a lanyard assembly with a two ended strap and a retraction system fixed to the tool in a storage region of the tool. In particular, one end of the strap is connected to the piece and the other strap end is connected to one end of the retraction system. The other end of the retraction system is connected to the tool. The strap is of sufficient length for the retraction system to retract a piece to the storage region after disconnection from the piece receiver. It is contemplated that the retraction system includes at least one spring (coil or helical) to cause the lanyard system to remain under tension while the piece is mounted in a piece receiver, thereby preventing or at least reducing the strap from interfering with the task at hand, the piece, the piece receiver or tool itself. The retraction system has sufficient tensional force to cause the retraction of a piece to the storage region once released from the work region of the tool.

A process for treating fruits or vegetables to minimize browning upon subsequent processing, handling, and storage, the method comprising: (a) separating edible pulp tissue from inedible tissue of the fruit or vegetable; (b) blanching said edible pulp tissue in steam for a pre-determined blanching time period at a blanching pressure that is less than or equal to atmospheric pressure; (c) cooling the blanched pulp tissue and extracting residual heat from the blanched pulp tissue; (d) freezing the cooled pulp tissue to obtain at least partially frozen pulp tissue; wherein the frozen pulp tissue obtained from step (d) possesses substantially similar organoleptic properties as freshly separated pulp tissue in (a).

The present invention provides methods and compositions for treating or preventing bacterial infections, where a pharmaceutically acceptable iron chelator that reduces biological availability of iron for one or more strains of bacteria, such as VK28 or an analog or derivative thereof is administered to a patient in need of treatment. The method also provides methods and compositions where an iron chelator and an antibiotic are administered to a patient in need of treatment for a bacterial infection.

The invention relates to methods of preventing, treating, and ameliorating asthma, allergen-induced respiratory symptoms, and / or an allergic or inflammatory condition of the lung or respiratory system in a patient by administering B Lymphocyte Stimulator antagonists. In addition, the invention provides a method of reducing total serum IgE levels in a patient suffering from asthma, and / or an allergic or inflammatory condition of the lung or respiratory system by administering B Lymphocyte Stimulator antagonists. The invention further provides a method of treating, preventing or ameliorating an allergen-induced airway hyper responsiveness or increase in mucus-containing cells and / or mucus accumulation or production in the airway epithelium of a patient by administering B Lymphocyte Stimulator antagonist.

Disclosed is the unexpected finding that enantiomers of phenothiazines, preferably the (+) enantiomer of promethazine, are particularly effective in inhibiting the bone resorbing cells, osteoclasts, thus providing new uses and methods for reducing bone loss and, e.g., treating periodontitis and osteoporosis. The invention provides a range of such uses, methods, medicaments and associated compositions and kits.

The invention relates to support structure, comprising: a first body; a second body; a first support having a first stiffness; a second support having a second stiffness, wherein the second body supports the first body at a first location via the first support, wherein the second body supports the first body at a second location via the second support; a position measurement system arranged to generate a deformation signal representative of a difference of deformation of the first body and the second body relative to each other; a first actuator to apply a force between the first body and the second body at or near the first location; a second actuator to apply a force between the first body and the second and body at or near the second location; wherein the support structure comprises a controller arranged to determine a deformation compensation signal on the basis of the first stiffness, the second stiffness and the deformation signal and to drive at least one of the first actuator and the second actuator on the basis of the deformation compensation signal to prevent or at least reduce deformation of the first body.