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102results about How to "Prevent and inhibit" patented technology

Compositions for inhibiting macrophage activity

Use of an agent capable of inhibiting the interaction between SIRP1alpha and CD47, in the preparation of a composition for the inhibition of macrophage involvement in autoimmune disease. The invention further relates to a method for the treatment of an autoimmune disease with macrophage involvement, comprising administering to a mammal an effective amount of an agent which inhibits the interaction between CD47 and SIRP1alpha. The invention also relates to a method for identifying an agent capable of inhibiting the interaction between CD47 and SIRP1alpha, comprising the steps of exposing one or more test compounds to CD47 and / or SIRP1alpha, and monitoring the ability of the test compound to inhibit their interaction.
Owner:MEDICAL RESEARCH COUNCIL

Controlled and Localized Release of Retinoids to Improve Neointimal Hyperplasia

InactiveUS20100036476A1Prevent or inhibitTreat, prevent, or inhibit thrombosis and neointimal hyperplasiaSurgeryAntithrombogenic treatmentLeiomyocyteNitric oxide
Controlled release vascular implants, such as vascular grafts, stents, wraps, and gels comprising a biocompatible polymer and all trans retinoic acid (ATRA), or its derivatives, can be used to treat, prevent, or inhibit thrombosis and / or neointimal hyperplasia which may otherwise be induced by prosthetic implantation. In particular, the implants herein can inhibit smooth muscle cell proliferation, neointimal hyperplasia, and upregulate antithrombotic genes and nitric oxide production in the vasculature. Further, the implants are capable of delivering controlled and predictable localized concentrations of ATRA.
Owner:VESSELTEK BIOMEDICAL

Biotinylated-chemokine antibody complexes

Biotinylated pharmacologically active agents and complexes containing same are disclosed. In particular, biotinylated-chemokines are described. The complexes further include an anti-biotin antibody that selectively binds to biotin. The complex can be dissociated by contact with free biotin. The complexes are particularly useful for enhancing an immune response to tumor cells and virus-infected cells, in vivo or in vitro.
Owner:MILLENNIUM PHARMA INC

Medicine feeding apparatus

ActiveUS20050115634A1Reduces kinetic energyDischarge medicineLiquid fillingSolid materialDrugKinetic energy
An object of the invention is to provide a medicine feeding apparatus in which it is possible to prevent a medicine from being broken by well absorbing and reducing a kinetic energy at a time of discharging the medicine even in the case that a downsizing and a densification are promoted for making a discharge speed of the medicine higher, and it is possible to efficiently guide the medicine to an outlet portion of a hopper. Further, the medicine feeding apparatus is provided with a main body, a plurality of tablet cases receiving medicines, a chute received in the main body and through which the medicine discharged from the tablet case comes down, a hopper received in the main body, provided in correspondence to a lower side of the chute and collecting the medicines, and a filling apparatus received in the main body and filling the medicines collected by the hopper in a drug packing paper or a container. The hopper has a curtain for preventing the medicine passing through the chute from jumping up or rotating in the hopper caused by drop and absorbing a kinetic energy.
Owner:PHC HLDG CORP

Cutter and printer with cutter

InactiveUS20100221055A1Ease of use be particularly goodPrevent or inhibitOther printing apparatusMetal working apparatusEngineeringKnife cuts
A printer with a cutter is provided that can discharge cut-offs in a stable condition. A printer includes a transportation path, a transportation mechanism that conveys a recording medium along the transportation path, a fixed knife having a cutting edge, a movable knife having a cutting edge and moving between a standby position and a cutting-completed position, and an exit disposed along the transportation path. The exit includes a narrow opening defined by a first elongated side offset from the transportation path beyond the movable-knife cutting edge in the cutting-completed position, and a second elongated side opposite the first elongated side and offset from the transportation path opposite to the first elongated side. The second elongated side can be located immediately adjacent to the transportation path, for example, by less than or equal to 2 mm.
Owner:SEIKO EPSON CORP

Methods and apparatuses for inhibiting rotational misalignment of assemblies in expandable well tools

A gripper for use in a downhole tool is provided. The gripper can include an actuator, an engagement assembly, and an expandable assembly. The engagement assembly can comprise a leaf-spring like elongate continuous beam. The expandable assembly can comprise a linkage including a plurality of links. The linkage can be coupled to the actuator such that the actuator expands the expandable assembly which in turn expands the engagement assembly. One or more keyed connections can inhibit rotational misalignment of the expandable assembly from the engagement assembly. In operation, during one stage of expansion radial forces are transmitted to the engagement assembly through both interaction of a rolling mechanism on the engagement assembly with the expandable assembly and pressure of the linkage assembly directly on an inner surface of the engagement assembly. The one or more keyed connections can preferably facilitate full retraction of the expandable and engagement assemblies.
Owner:WWT NORTH AMERICA HLDG
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