The invention discloses a conditioning conversion circuit for airborne time sequence and initiating explosive device test and belongs to the field of missile test control. The circuit comprises a multipath twistor switch SK1, a current-limiting resistor R1, a current-limiting resistor R2, a photoelectric coupler U1, a relay K1 and a relay K2, wherein the twistor switch SK1 is a gating device, during the time sequence test, an SK1-1 gear is conducted, and input time sequence signals are subjected to conditioning conversion; and during the initiating explosive device resistance test, an SK1-2 gear is conducted, and input initiating explosive device signals are converted. Compared with the prior art, the conditioning conversion circuit has the beneficial effects that the development cost is saved, the preparation workload before the test is reduced, and the maneuverability of the system is improved; the design thoughts of centralized planning and time sharing application are adopted, the development resource is more centralized, the real-time state monitoring and management is convenient, and the reliable time-sharing completion of conditioning conversion of different signals can be ensured; and the problem of an interface circuit between an airborne electric system and test control equipment is solved, and the effectiveness and the reliability of collected signals are ensured.